Max G Bachem

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. ncbi request reprint Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
    Max G Bachem
    Department of Clinical Chemistry, University of Ulm, D 89070 Ulm, Germany
    Gastroenterology 128:907-21. 2005
  2. ncbi request reprint Depending on their concentration oxidized low density lipoproteins stimulate extracellular matrix synthesis or induce apoptosis in human coronary artery smooth muscle cells
    M G Bachem
    Department of Clinical Chemistry and Pathobiochemistry, University Hospital of Ulm, Germany
    Clin Chem Lab Med 37:319-26. 1999
  3. doi request reprint Pancreatic stellate cells--role in pancreas cancer
    Max G Bachem
    Department Clinical Chemistry and Central Laboratory, University of Ulm, Ulm, Germany
    Langenbecks Arch Surg 393:891-900. 2008
  4. doi request reprint PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio
    Ling Li
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    Eur J Clin Invest 41:151-8. 2011
  5. ncbi request reprint Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay
    Wilhelm Schneiderhan
    Department of Clinical Chemistry and Pathobiochemistry, University of Ulm, Robert Koch Str 8, 89081 Ulm, Germany
    J Cell Sci 120:512-9. 2007
  6. doi request reprint Low intensity pulsed ultrasound accelerates macrophage phagocytosis by a pathway that requires actin polymerization, Rho, and Src/MAPKs activity
    Shaoxia Zhou
    Department of Clinical Chemistry, University of Ulm, 89081 Ulm, Germany
    Cell Signal 20:695-704. 2008
  7. doi request reprint Role of activated neutrophils in chest trauma-induced septic acute lung injury
    Mario Perl
    Department of Trauma, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 38:98-106. 2012
  8. ncbi request reprint Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis
    Max G Bachem
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    J Gastroenterol Hepatol 21:S92-6. 2006
  9. ncbi request reprint Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype
    Malte Buchholz
    Department of Internal Medicine I, University Hospital of Ulm, Germany
    J Mol Med (Berl) 83:795-805. 2005
  10. doi request reprint Pancreatitis-associated protein inhibits human pancreatic stellate cell MMP-1 and -2, TIMP-1 and -2 secretion and RECK expression
    Ling Li
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    Pancreatology 9:99-110. 2009

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
    Max G Bachem
    Department of Clinical Chemistry, University of Ulm, D 89070 Ulm, Germany
    Gastroenterology 128:907-21. 2005
    ..The aims of this study were to examine the cellular and molecular mechanisms of fibrogenesis associated with pancreatic adenocarcinomas...
  2. ncbi request reprint Depending on their concentration oxidized low density lipoproteins stimulate extracellular matrix synthesis or induce apoptosis in human coronary artery smooth muscle cells
    M G Bachem
    Department of Clinical Chemistry and Pathobiochemistry, University Hospital of Ulm, Germany
    Clin Chem Lab Med 37:319-26. 1999
    ..The profibrogenic effect might be relevant in the formation of atherosclerotic plaques, and the proapoptotic effect might contribute to an increased plaque vulnerability...
  3. doi request reprint Pancreatic stellate cells--role in pancreas cancer
    Max G Bachem
    Department Clinical Chemistry and Central Laboratory, University of Ulm, Ulm, Germany
    Langenbecks Arch Surg 393:891-900. 2008
    ..Carcinoma cells are surrounded by a dense stroma consisting of myofibroblast-like cells, collagens, and fibronectin...
  4. doi request reprint PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio
    Ling Li
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    Eur J Clin Invest 41:151-8. 2011
    ..Assuming a protective role of this stress protein, we investigated its effects on human PSC...
  5. ncbi request reprint Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay
    Wilhelm Schneiderhan
    Department of Clinical Chemistry and Pathobiochemistry, University of Ulm, Robert Koch Str 8, 89081 Ulm, Germany
    J Cell Sci 120:512-9. 2007
    ..1-3.7-fold. Our findings support the assumption that the interaction of stellate cells and cancer cells promotes progression of pancreatic cancer...
  6. doi request reprint Low intensity pulsed ultrasound accelerates macrophage phagocytosis by a pathway that requires actin polymerization, Rho, and Src/MAPKs activity
    Shaoxia Zhou
    Department of Clinical Chemistry, University of Ulm, 89081 Ulm, Germany
    Cell Signal 20:695-704. 2008
    ..Depolymerization of actin by cytochalasin D prevented US-induced Src, ERK, and p38 activation. Our data provide a new insight into the cellular and molecular mechanisms by which low intensity pulsed US promotes tissue repair...
  7. doi request reprint Role of activated neutrophils in chest trauma-induced septic acute lung injury
    Mario Perl
    Department of Trauma, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 38:98-106. 2012
    ..In particular, the depletion of neutrophils substantially mitigated the extent of lung injury, indicating a pathomechanistic role for neutrophils in chest trauma-induced septic ALI...
  8. ncbi request reprint Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis
    Max G Bachem
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    J Gastroenterol Hepatol 21:S92-6. 2006
    ..The induction of the activated phenotype of PSC has been shown to involve a number of diverse extra- and intracellular effector molecules, including inflammatory cytokines, growth factors, ethanol, acetaldehyde, and oxidative stress...
  9. ncbi request reprint Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype
    Malte Buchholz
    Department of Internal Medicine I, University Hospital of Ulm, Germany
    J Mol Med (Berl) 83:795-805. 2005
    ..Despite this high degree of similarity, distinct differences in expression patterns were observed between HSCs and PSCs, reflecting organ-specific variations of the common stellate cell-specific phenotype...
  10. doi request reprint Pancreatitis-associated protein inhibits human pancreatic stellate cell MMP-1 and -2, TIMP-1 and -2 secretion and RECK expression
    Ling Li
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    Pancreatology 9:99-110. 2009
    ..Pancreatitis-associated protein (PAP), an acute-phase protein, is dramatically upregulated during acute and chronic pancreatitis. Assuming a protective role of PAP, we investigated its effects on human PSCs...
  11. doi request reprint Divergent effects of activated neutrophils on inflammation, Kupffer cell/splenocyte activation, and lung injury following blunt chest trauma
    Mario Perl
    Department of Trauma, University of Ulm, Germany
    Shock 37:210-8. 2012
    ..Thus, keeping in mind potential inflammatory adverse effects, modulation of neutrophil activation or trafficking might be a reasonable therapeutic approach in chest trauma-induced lung injury...
  12. ncbi request reprint The immunosuppressive drug mycophenolic acid reduces endothelin-1 synthesis in endothelial cells and renal epithelial cells
    Cornelia Haug
    Institute of Clinical Chemistry, University Hospital Ulm, Robert Koch Strasse 8, D 89070 Ulm, Germany
    Clin Sci (Lond) 103:76S-80S. 2002
    ..The present results might explain the clinical observation that renal function often improves when CsA or tacrolimus is replaced by mycophenolate mofetil...
  13. ncbi request reprint Evaluation of two modified cardiac troponin I enzyme immunoassays
    Cornelia Haug
    Institute of Clinical Chemistry, University Hospital, Ulm, Germany
    Clin Chem Lab Med 40:837-9. 2002
    ..These data emphasize the need for cTnI assay standardization and for further optimization at clinical decision levels...
  14. ncbi request reprint In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas
    Cornelia Hasel
    Department of Pathology, University of Ulm, Ulm, and the Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Lab Invest 83:825-36. 2003
    ....
  15. doi request reprint Pulmonary contusion induces alveolar type 2 epithelial cell apoptosis: role of alveolar macrophages and neutrophils
    Daniel H Seitz
    Department of Trauma, Hand, Plastic and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 30:537-44. 2008
    ..In summary, blunt chest trauma induced apoptosis in AT-2 cells, possibly involving the extrinsic death receptor pathway. Furthermore, mediators released by AMs appeared to be involved in the induction of AT-2 cell apoptosis...
  16. ncbi request reprint Oxidized low-density lipoproteins stimulate extracellular matrix metalloproteinase Inducer (EMMPRIN) release by coronary smooth muscle cells
    Cornelia Haug
    Central Department Clinical Chemistry, University Hospital Ulm, Robert Koch Strasse 8, D 89070 Ulm, Germany
    Arterioscler Thromb Vasc Biol 24:1823-9. 2004
    ..We have investigated the influence of oxidized low-density lipoproteins (oxLDLs) on EMMPRIN expression in human coronary artery smooth muscle cells (HCA-SMCs)...
  17. ncbi request reprint Molecular mechanisms of low intensity pulsed ultrasound in human skin fibroblasts
    Shaoxia Zhou
    Department of Clinical Chemistry, University of Ulm, D 89081 Ulm, Germany
    J Biol Chem 279:54463-9. 2004
    ..In conclusion, our data demonstrate for the first time that US promotes cell proliferation via activation of integrin receptors and a Rho/ROCK/Src/ERK signaling pathway...
  18. ncbi request reprint Overexpressed decorin in pancreatic cancer: potential tumor growth inhibition and attenuation of chemotherapeutic action
    Jörg Köninger
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 10:4776-83. 2004
    ..The aim of this study was to investigate the expression and significance of decorin in pancreatic cancer...
  19. ncbi request reprint A very low toxic agent induces apoptosis and reduces growth of human hepatocellular carcinoma cells
    Guido Schumacher
    Department of General, Visceral, and Transplantation Surgery, Humboldt University, Charite Campus Virchow Klinikum, Berlin, Germany
    J Gastroenterol Hepatol 21:1207-12. 2006
    ..To examine the efficacy on growth inhibition of 2-methoxyestradiol (2-ME) on human hepatocellular carcinoma in vitro...
  20. ncbi request reprint IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells
    Philippe Mathurin
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles 90089, USA
    Am J Physiol Gastrointest Liver Physiol 282:G981-90. 2002
    ..This shows concomitant induction of IL-10R but not CRF2-4 to that of IL-10 by activated HSC in vitro and in vivo and associated acquisition of the responsiveness to IL-10, entailing complex effects on HSC...
  21. ncbi request reprint Pancreatic tumor cells influence the composition of the extracellular matrix
    Jörg Köninger
    Department of General Surgery, University of Heidelberg, Germany
    Biochem Biophys Res Commun 322:943-9. 2004
    ..These findings indicate that malignant cells can actively influence the composition of the ECM through TGFbeta1 and other soluble factors, altering their microenvironment in a tumor-favorable way...