Max G Bachem

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. doi Pancreatic stellate cells--role in pancreas cancer
    Max G Bachem
    Department Clinical Chemistry and Central Laboratory, University of Ulm, Ulm, Germany
    Langenbecks Arch Surg 393:891-900. 2008
  2. ncbi Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis
    Max G Bachem
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    J Gastroenterol Hepatol 21:S92-6. 2006
  3. ncbi Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
    Max G Bachem
    Department of Clinical Chemistry, University of Ulm, D 89070 Ulm, Germany
    Gastroenterology 128:907-21. 2005
  4. ncbi Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay
    Wilhelm Schneiderhan
    Department of Clinical Chemistry and Pathobiochemistry, University of Ulm, Robert Koch Str 8, 89081 Ulm, Germany
    J Cell Sci 120:512-9. 2007
  5. doi PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio
    Ling Li
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    Eur J Clin Invest 41:151-8. 2011
  6. doi Role of activated neutrophils in chest trauma-induced septic acute lung injury
    Mario Perl
    Department of Trauma, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 38:98-106. 2012
  7. doi Low intensity pulsed ultrasound accelerates macrophage phagocytosis by a pathway that requires actin polymerization, Rho, and Src/MAPKs activity
    Shaoxia Zhou
    Department of Clinical Chemistry, University of Ulm, 89081 Ulm, Germany
    Cell Signal 20:695-704. 2008
  8. doi Pancreatitis-associated protein inhibits human pancreatic stellate cell MMP-1 and -2, TIMP-1 and -2 secretion and RECK expression
    Ling Li
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    Pancreatology 9:99-110. 2009
  9. doi Divergent effects of activated neutrophils on inflammation, Kupffer cell/splenocyte activation, and lung injury following blunt chest trauma
    Mario Perl
    Department of Trauma, University of Ulm, Germany
    Shock 37:210-8. 2012
  10. doi Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells
    Christian Haag
    University Children s Hospital, Ulm, Germany
    Gut 60:225-37. 2011

Collaborators

Detail Information

Publications17

  1. doi Pancreatic stellate cells--role in pancreas cancer
    Max G Bachem
    Department Clinical Chemistry and Central Laboratory, University of Ulm, Ulm, Germany
    Langenbecks Arch Surg 393:891-900. 2008
    ..Carcinoma cells are surrounded by a dense stroma consisting of myofibroblast-like cells, collagens, and fibronectin...
  2. ncbi Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis
    Max G Bachem
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    J Gastroenterol Hepatol 21:S92-6. 2006
    ..The induction of the activated phenotype of PSC has been shown to involve a number of diverse extra- and intracellular effector molecules, including inflammatory cytokines, growth factors, ethanol, acetaldehyde, and oxidative stress...
  3. ncbi Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells
    Max G Bachem
    Department of Clinical Chemistry, University of Ulm, D 89070 Ulm, Germany
    Gastroenterology 128:907-21. 2005
    ..The aims of this study were to examine the cellular and molecular mechanisms of fibrogenesis associated with pancreatic adenocarcinomas...
  4. ncbi Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay
    Wilhelm Schneiderhan
    Department of Clinical Chemistry and Pathobiochemistry, University of Ulm, Robert Koch Str 8, 89081 Ulm, Germany
    J Cell Sci 120:512-9. 2007
    ..1-3.7-fold. Our findings support the assumption that the interaction of stellate cells and cancer cells promotes progression of pancreatic cancer...
  5. doi PSP/reg inhibits cultured pancreatic stellate cell and regulates MMP/ TIMP ratio
    Ling Li
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    Eur J Clin Invest 41:151-8. 2011
    ..Assuming a protective role of this stress protein, we investigated its effects on human PSC...
  6. doi Role of activated neutrophils in chest trauma-induced septic acute lung injury
    Mario Perl
    Department of Trauma, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 38:98-106. 2012
    ..In particular, the depletion of neutrophils substantially mitigated the extent of lung injury, indicating a pathomechanistic role for neutrophils in chest trauma-induced septic ALI...
  7. doi Low intensity pulsed ultrasound accelerates macrophage phagocytosis by a pathway that requires actin polymerization, Rho, and Src/MAPKs activity
    Shaoxia Zhou
    Department of Clinical Chemistry, University of Ulm, 89081 Ulm, Germany
    Cell Signal 20:695-704. 2008
    ..Depolymerization of actin by cytochalasin D prevented US-induced Src, ERK, and p38 activation. Our data provide a new insight into the cellular and molecular mechanisms by which low intensity pulsed US promotes tissue repair...
  8. doi Pancreatitis-associated protein inhibits human pancreatic stellate cell MMP-1 and -2, TIMP-1 and -2 secretion and RECK expression
    Ling Li
    Department of Clinical Chemistry, University Hospital Ulm, Ulm, Germany
    Pancreatology 9:99-110. 2009
    ..Pancreatitis-associated protein (PAP), an acute-phase protein, is dramatically upregulated during acute and chronic pancreatitis. Assuming a protective role of PAP, we investigated its effects on human PSCs...
  9. doi Divergent effects of activated neutrophils on inflammation, Kupffer cell/splenocyte activation, and lung injury following blunt chest trauma
    Mario Perl
    Department of Trauma, University of Ulm, Germany
    Shock 37:210-8. 2012
    ..Thus, keeping in mind potential inflammatory adverse effects, modulation of neutrophil activation or trafficking might be a reasonable therapeutic approach in chest trauma-induced lung injury...
  10. doi Identification of c-FLIP(L) and c-FLIP(S) as critical regulators of death receptor-induced apoptosis in pancreatic cancer cells
    Christian Haag
    University Children s Hospital, Ulm, Germany
    Gut 60:225-37. 2011
    ..Here, the role of c-FLIP in the regulation of death receptor-mediated apoptosis in pancreatic cancer was investigated...
  11. doi Pulmonary contusion induces alveolar type 2 epithelial cell apoptosis: role of alveolar macrophages and neutrophils
    Daniel H Seitz
    Department of Trauma, Hand, Plastic and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 30:537-44. 2008
    ..In summary, blunt chest trauma induced apoptosis in AT-2 cells, possibly involving the extrinsic death receptor pathway. Furthermore, mediators released by AMs appeared to be involved in the induction of AT-2 cell apoptosis...
  12. ncbi Molecular mechanisms of low intensity pulsed ultrasound in human skin fibroblasts
    Shaoxia Zhou
    Department of Clinical Chemistry, University of Ulm, D 89081 Ulm, Germany
    J Biol Chem 279:54463-9. 2004
    ..In conclusion, our data demonstrate for the first time that US promotes cell proliferation via activation of integrin receptors and a Rho/ROCK/Src/ERK signaling pathway...
  13. ncbi In chronic pancreatitis, widespread emergence of TRAIL receptors in epithelia coincides with neoexpression of TRAIL by pancreatic stellate cells of early fibrotic areas
    Cornelia Hasel
    Department of Pathology, University of Ulm, Ulm, and the Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Lab Invest 83:825-36. 2003
    ....
  14. ncbi Oxidized low-density lipoproteins stimulate extracellular matrix metalloproteinase Inducer (EMMPRIN) release by coronary smooth muscle cells
    Cornelia Haug
    Central Department Clinical Chemistry, University Hospital Ulm, Robert Koch Strasse 8, D 89070 Ulm, Germany
    Arterioscler Thromb Vasc Biol 24:1823-9. 2004
    ..We have investigated the influence of oxidized low-density lipoproteins (oxLDLs) on EMMPRIN expression in human coronary artery smooth muscle cells (HCA-SMCs)...
  15. ncbi Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotype
    Malte Buchholz
    Department of Internal Medicine I, University Hospital of Ulm, Germany
    J Mol Med (Berl) 83:795-805. 2005
    ..Despite this high degree of similarity, distinct differences in expression patterns were observed between HSCs and PSCs, reflecting organ-specific variations of the common stellate cell-specific phenotype...
  16. ncbi Overexpressed decorin in pancreatic cancer: potential tumor growth inhibition and attenuation of chemotherapeutic action
    Jörg Köninger
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 10:4776-83. 2004
    ..The aim of this study was to investigate the expression and significance of decorin in pancreatic cancer...
  17. ncbi IL-10 receptor and coreceptor expression in quiescent and activated hepatic stellate cells
    Philippe Mathurin
    Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles 90089, USA
    Am J Physiol Gastrointest Liver Physiol 282:G981-90. 2002
    ..This shows concomitant induction of IL-10R but not CRF2-4 to that of IL-10 by activated HSC in vitro and in vivo and associated acquisition of the responsiveness to IL-10, entailing complex effects on HSC...