I Bach

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex
    I Bach
    Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Nat Genet 22:394-9. 1999
  2. ncbi request reprint The LIM domain: regulation by association
    I Bach
    Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 85, 20246, Hamburg, Germany
    Mech Dev 91:5-17. 2000
  3. ncbi request reprint Orchestrating nuclear functions: ubiquitin sets the rhythm
    Ingolf Bach
    Zentrum für Molekulare Neurobiologie ZMNH, Universitat Hamburg, Germany
    Trends Biochem Sci 28:189-95. 2003
  4. ncbi request reprint A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins
    I Bach
    Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Genes Dev 11:1370-80. 1997
  5. ncbi request reprint Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors
    H P Ostendorff
    Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 85, Hamburg, 20251, Germany
    Genomics 69:120-30. 2000
  6. pmc P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1
    I Bach
    Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Proc Natl Acad Sci U S A 92:2720-4. 1995
  7. pmc Proteasomal selection of multiprotein complexes recruited by LIM homeodomain transcription factors
    Cenap Güngör
    Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 104:15000-5. 2007
  8. ncbi request reprint Dynamic expression of LIM cofactors in the developing mouse neural tube
    Heather P Ostendorff
    Zentrum fur Molekulare Neurobiologie Hamburg, Universitat Hamburg, Martinistr 85, 20251 Hamburg, Germany
    Dev Dyn 235:786-91. 2006
  9. pmc The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones
    Baris Tursun
    Zentrum fur Molekulare Neurobiologie Hamburg, Universitat Hamburg, 20251 Hamburg, Germany
    Genes Dev 19:2307-19. 2005
  10. pmc Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
    Mugdha Bhati
    School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
    EMBO J 27:2018-29. 2008

Collaborators

  • B Andersen
  • S J Rhodes
  • P Lichter
  • Jacqueline M Matthews
  • Martin Scheffner
  • Michael Rosenfeld
  • Christopher Lee
  • Bernd Groner
  • A Bhushan
  • Heather P Ostendorff
  • Thomas Becker
  • Baris Tursun
  • Mugdha Bhati
  • Michael Bossenz
  • Anne Schlüter
  • Catherina G Becker
  • Marvin A Peters
  • Cenap Güngör
  • Alexander Drung
  • Mihwa Lee
  • J Mitchell Guss
  • Bertrand Mollé
  • Oliver H Kramer
  • Reto I Peirano
  • Dimitrios Gimnopoulos
  • H P Ostendorff
  • Vanessa J Craig
  • Amy Louise Nancarrow
  • Joel P Mackay
  • Amy L Nancarrow
  • Naoko Taniguchi-Ishigaki
  • Hong Ma
  • Kerstin Cornils
  • Ora Bernard
  • Michaela Schweizer
  • Steven A Johnsen
  • Juliana Soosairajah
  • Birte Viehweger
  • Stéphane Père
  • Vieri Failli
  • Sylvie Retaux
  • Jens Tiefenbach
  • Boris Brill
  • Ping Zhu
  • Martin Göttlicher
  • Martin Golebiewski
  • Thorsten Heinzel
  • Melitta Schachner
  • A Mincheva
  • N A Jenkins
  • D J Gilbert
  • M Bossenz
  • N G Copeland

Detail Information

Publications18

  1. ncbi request reprint RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex
    I Bach
    Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Nat Genet 22:394-9. 1999
    ..We conclude that Rlim is a novel corepressor that recruits histone deacetylase-containing complexes to the LIM domain...
  2. ncbi request reprint The LIM domain: regulation by association
    I Bach
    Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 85, 20246, Hamburg, Germany
    Mech Dev 91:5-17. 2000
    ..Furthermore, the identification and characterization of factors that interact with LIM domains illuminates mechanisms of combinatorial developmental regulation...
  3. ncbi request reprint Orchestrating nuclear functions: ubiquitin sets the rhythm
    Ingolf Bach
    Zentrum für Molekulare Neurobiologie ZMNH, Universitat Hamburg, Germany
    Trends Biochem Sci 28:189-95. 2003
    ..Protein modification by ubiquitin is proving to be a crucial tool for nuclear functioning, and is emerging as a decisive mechanism that enables the concerted regulation of nuclear pathways...
  4. ncbi request reprint A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins
    I Bach
    Howard Hughes Medical Institute, Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Genes Dev 11:1370-80. 1997
    ..Our results link LIM homeodomain proteins and members of the Otx class of transcription factors in gene activation events during embryogenesis via the actions of specific cofactors...
  5. ncbi request reprint Functional characterization of the gene encoding RLIM, the corepressor of LIM homeodomain factors
    H P Ostendorff
    Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 85, Hamburg, 20251, Germany
    Genomics 69:120-30. 2000
    ..By fluorescence in situ hybridization and interspecific backcross analysis, we have localized the Rnf12 gene to the central regions of mouse and human chromosome X...
  6. pmc P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1
    I Bach
    Eukaryotic Regulatory Biology Program, University of California, San Diego, School of Medicine, La Jolla 92093 0648, USA
    Proc Natl Acad Sci U S A 92:2720-4. 1995
    ..The LIM domain of P-Lim specifically interacts with the Pit-1 POU domain and is required for synergistic interactions with Pit-1, but not for basal transcriptional activation events...
  7. pmc Proteasomal selection of multiprotein complexes recruited by LIM homeodomain transcription factors
    Cenap Güngör
    Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 104:15000-5. 2007
    ..Together, our results indicate a combinatorial code that selects specific multiprotein complexes via proteasomal degradation in cells with broad implications for the assembly and specificity of multiprotein complexes...
  8. ncbi request reprint Dynamic expression of LIM cofactors in the developing mouse neural tube
    Heather P Ostendorff
    Zentrum fur Molekulare Neurobiologie Hamburg, Universitat Hamburg, Martinistr 85, 20251 Hamburg, Germany
    Dev Dyn 235:786-91. 2006
    ....
  9. pmc The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones
    Baris Tursun
    Zentrum fur Molekulare Neurobiologie Hamburg, Universitat Hamburg, 20251 Hamburg, Germany
    Genes Dev 19:2307-19. 2005
    ..Thus, these results assign a specific role for Rnf6 in the control of cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics...
  10. pmc Implementing the LIM code: the structural basis for cell type-specific assembly of LIM-homeodomain complexes
    Mugdha Bhati
    School of Molecular and Microbial Biosciences, The University of Sydney, New South Wales, Australia
    EMBO J 27:2018-29. 2008
    ..The resulting alternate protein complexes can target different genes to regulate key biological events...
  11. ncbi request reprint Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development
    Thomas Becker
    Zentrum fur Molekulare Neurobiologie Hamburg, Universitat Hamburg, Martinistrasse 85, 20251 Hamburg, Germany
    Mech Dev 117:75-85. 2002
    ..Our results demonstrate multiple roles of the CLIM cofactor family for the development of entire organs, axonal outgrowth of specific neurons and protein expression levels...
  12. ncbi request reprint Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors
    Heather P Ostendorff
    Zentrum für Molekulare Neurobiologie Hamburg ZMNH, Universitat Hamburg, Martinistrasse 85, 20251 Hamburg, Germany
    Nature 416:99-103. 2002
    ..Our data provide a mechanistic basis for cofactor exchange on DNA-bound transcription factors, and probably represent a general mechanism of transcriptional regulation...
  13. ncbi request reprint Comparing protein stabilities during zebrafish embryogenesis
    Thomas Becker
    Zentrum für Molekulare Neurobiologie ZMNH, Universitat Hamburg, Martinistr 85, 20251 Hamburg, Germany
    Methods Cell Sci 25:85-9. 2003
    ..Thus, this method may be used more widely for the study of developmental protein stability...
  14. ncbi request reprint Lhx9 and lhx9alpha: differential biochemical properties and effects on neuronal differentiation
    Bertrand Mollé
    UPR 2197 Développement, Evolution, Plasticité du Système Nerveux, Institut de Neurobiologie Alfred Fessard, C N R S, Gif sur Yvette Cedex, France
    DNA Cell Biol 23:761-8. 2004
    ..Thus, Lhx9 and Lhx9alpha isoforms could be implicated in regulating various aspects of neuronal differentiation...
  15. ncbi request reprint Expression of the zebrafish recognition molecule F3/F11/contactin in a subset of differentiating neurons is regulated by cofactors associated with LIM domains
    Dimitrios Gimnopoulos
    Zentrum fur Molekulare Neurobiologie Hamburg, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Gene Expr Patterns 2:137-43. 2002
    ..These results and the spatiotemporal correlation of F3 expression with axonal differentiation in a subset of primary neurons suggest an important role of F3 for axon growth...
  16. ncbi request reprint 1H, 15N and 13C assignments of an intramolecular Lhx3:ldb1 complex
    Christopher Lee
    J Biomol NMR 33:198. 2005
  17. pmc Crystallization of an Lhx3-Isl1 complex
    Mugdha Bhati
    School of Molecular and Microbial Biosciences, The University of Sydney, Australia
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:297-9. 2008
    ..The monoclinic crystals belong to space group C2, with unit-cell parameters a = 119, b = 62.2, c = 51.9 A, beta = 91.6 degrees , and diffract to 2.05 A resolution...
  18. pmc The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2
    Oliver H Kramer
    Georg Speyer Haus, Paul Ehrlich Strasse 42 44, D 60596 Frankfurt, Germany
    EMBO J 22:3411-20. 2003
    ..Thus, poly-ubiquitination and proteasomal degradation provide an isoenzyme-selective mechanism for downregulation of HDAC2...