Research Topics
Genomes and GenesSpecies | M AumailleySummaryAffiliation: University of Cologne Country: Germany Publications
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Detail Information
Publications
Molecular basis of inherited skin-blistering disorders, and therapeutic implicationsMonique Aumailley
Center for Biochemistry, Medical Faculty, and Center for Molecular Medicine Cologne, University of Cologne, Germany
Expert Rev Mol Med 8:1-21. 2006....
The laminin familyMonique Aumailley
Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
Cell Adh Migr 7:48-55. 2013....- Effects of constitutively active GTPases on fibroblast behaviorZ-G Zhang
Institute for Biochemistry II, Joseph-Stelzmann-Strasse 52, 50931 Cologne, Germany
Cell Mol Life Sci 63:82-91. 2006..In conclusion, the action of Rho GTPases appears to depend on the task cells are performing... - The role of laminins in basement membrane functionM Aumailley
Institut für Biochemie II, Medical Faculty, Cologne, Germany
J Anat 193:1-21. 1998..The consequent phenotypes highlight the pivotal role of laminins in determining heterogeneity in basement membrane functions... - Laminin 5 processing and its integration into the ECMMonique Aumailley
Institute for Biochemistry, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, Germany
Matrix Biol 22:49-54. 2003.... - Altered synthesis of laminin 1 and absence of basement membrane component deposition in (beta)1 integrin-deficient embryoid bodiesM Aumailley
Institute II for Biochemistry, University of Cologne, Germany
J Cell Sci 113:259-68. 2000.... - Laminins of the dermo-epidermal junctionM Aumailley
Institut II für Biochemie, Medical Faculty, Cologne, Germany
Matrix Biol 18:19-28. 1999..Furthermore, they are signaling molecules providing adjacent cells with diverse information by interacting with cell surface components... - The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexesV Wixler
Institute for Biochemistry II, Medical Faculty, University of Cologne, Joseph Stelzmann Strasse 52, 50931 Cologne, Germany
J Biol Chem 275:33669-78. 2000..These results, together with the fact that full-length DRAL/FHL2 is found in cell adhesion complexes, suggest that it is an adaptor/docking protein involved in integrin signaling pathways... - Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domainsV Wixler
Institute for Biochemistry II, Medical Faculty of the University of Cologne, Germany
FEBS Lett 445:351-5. 1999..The conserved membrane proximal region of the alpha3A chain was identified as the binding site for all four proteins. They, therefore, may be involved in the regulation of general functions of integrins... - Fibroblasts contribute to the deposition of laminin 5 in the extracellular matrixAbdallah Elkhal
Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
Exp Cell Res 296:223-30. 2004..These studies show that, although laminin 5 is a product of epithelial cells, fibroblasts contribute to its integration into the extracellular matrix architecture... - Defective laminin 5 processing in cylindroma cellsLucy Tunggal
Department of Dermatology, Medical Faculty, Institute for Biochemistry II, University of Cologne, Joseph-Stelzmann-Strasse 52, , Germany
Am J Pathol 160:459-68. 2002..Together, the results show that multiple molecular defects, including alteration of laminin 5 and its integrin receptors, contribute to structural aberrations of the basement membrane and associated structures in cylindromas... - Mechanical tension and integrin alpha 2 beta 1 regulate fibroblast functionsBeate Eckes
Department of Dermatology, University of Cologne, Cologne, Germany
J Investig Dermatol Symp Proc 11:66-72. 2006..Unraveling the integrated functions of fibroblasts, collagen integrin receptors, collagen fibrils, and mechanical tension will be important to understand the molecular mechanisms underlying tissue repair and fibrosis... - Interactions of primary fibroblasts and keratinocytes with extracellular matrix proteins: contribution of alpha2beta1 integrinZhi Gang Zhang
Department of Dermatology, Medical Faculty, University of Cologne, 50931 Cologne, Germany
J Cell Sci 119:1886-95. 2006..The deficits observed for alpha2-deficient fibroblasts appeared to be linked to alterations in the distribution of force-bearing focal adhesions and deregulation of Rho-GTPase activation... - Dissociation of the complex between CD151 and laminin-binding integrins permits migration of epithelial cellsGretel Chometon
Center for Biochemistry, Medical Faculty, University of Cologne, Germany
Exp Cell Res 312:983-95. 2006..Together, these results strongly suggest that dissociation of the CD151-integrin complex permits remodeling of epithelial cell interactions with the extracellular matrix and cell migration... - A simplified laminin nomenclatureMonique Aumailley
Center for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany
Matrix Biol 24:326-32. 2005..The chain origin of a domain is specified by the chain nomenclature, such as alpha1L4a. The abbreviation LM is suggested for laminin. Otherwise, the nomenclature remains unaltered... - Characterization of recombinant and natural forms of the human LIM domain-containing protein FHL2Haquima El Mourabit
Center for Biochemistry, Faculty of Medicine, University of Cologne, Joseph Stelzmann Str 52, Cologne 50931, Germany
Protein Expr Purif 32:95-103. 2003..The results show that both the recombinant and the natural proteins are post-translationally modified and indicate that such modifications may lead to an abnormal electrophoretic behavior of natural human FHL2... - Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytesCorinna Herz
Department of Dermatology, University Medical Center Freiburg, Hauptstrasse 7, 79104 Freiburg, Germany
J Biol Chem 281:36082-90. 2006..It is involved in organization and anchorage of the actin cytoskeleton to integrin-associated signaling platforms... - Keratinocytes from patients lacking collagen XVII display a migratory phenotypeKaisa Tasanen
Department of Dermatology, University of Oulu, Oulu, Finland
Am J Pathol 164:2027-38. 2004..Together, the results unravel an unexpected role of collagen XVII in the regulation of keratinocyte migration... - Integrin-linked kinase is required for epidermal and hair follicle morphogenesisKatrin Lorenz
Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
J Cell Biol 177:501-13. 2007..We conclude that ILK plays important roles for epidermis and hair follicle morphogenesis by modulating integrin-mediated adhesion, actin reorganization, and plasma membrane dynamics in keratinocytes... - Subpopulations of human dendritic cells display a distinct phenotype and bind differentially to proteins of the extracellular matrixKristine Kohl
Department of Dermatology, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
Eur J Cell Biol 86:719-30. 2007..In summary, subpopulations of CD34DCs and MoDCs are phenotypically related to each other, but not identical and display differential binding to components of the extracellular matrix... - Activities of the matrix metalloproteinase stromelysin-2 (MMP-10) in matrix degradation and keratinocyte organization in wounded skinMonika Krampert
Department of Biology, Institute of Cell Biology, Eidgenössishe Technische Hochschule Zurich, 8093 Zurich, Switzerland
Mol Biol Cell 15:5242-54. 2004..These results suggest that a tightly regulated expression level of stromelysin-2 is required for limited matrix degradation at the wound site, thereby controlling keratinocyte migration...