S Aulmann

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. ncbi request reprint Clonality of lobular carcinoma in situ (LCIS) and metachronous invasive breast cancer
    Sebastian Aulmann
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 107:331-5. 2008
  2. ncbi request reprint CTCF gene mutations in invasive ductal breast cancer
    Sebastian Aulmann
    Department of Pathology, University of Heidelberg, Germany
    Breast Cancer Res Treat 80:347-52. 2003
  3. pmc c-myc amplifications in primary breast carcinomas and their local recurrences
    S Aulmann
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    J Clin Pathol 59:424-8. 2006
  4. ncbi request reprint Immunohistochemical and cytogenetic characterization of acantholytic squamous cell carcinoma of the breast
    Sebastian Aulmann
    Department of Pathology, University of Heidelberg, INF 220 221, 69120 Heidelberg, Germany
    Virchows Arch 446:305-9. 2005
  5. ncbi request reprint Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas
    S Aulmann
    Institute of Pathology, Heidelberg University, Heidelberg, Germany
    Histopathology 50:881-6. 2007
  6. pmc Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40
    F Bergmann
    Institute of Pathology and Department of Surgery, University of Heidelberg, Heidelberg, Germany
    J Clin Pathol 59:580-4. 2006
  7. ncbi request reprint [Concepts and problems of lobular neoplasia]
    H P Sinn
    Pathologisches Institut, Universitatsklinikum, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Pathologe 27:373-80. 2006
  8. pmc The location of KIT and PDGFRA gene mutations in gastrointestinal stromal tumours is site and phenotype associated
    R Penzel
    The Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D 69120 Heidelberg, Germany
    J Clin Pathol 58:634-9. 2005
  9. doi request reprint Outcome analysis of patients with primary breast cancer initially treated at a certified academic breast unit
    J Heil
    Breast Unit, University of Heidelberg, Voss Strasse 9, D 69115 Heidelberg, Germany
    Breast 21:303-8. 2012
  10. doi request reprint [Ductal and lobular preneoplasia: role in breast cancer development]
    S Aulmann
    Pathologisches Institut, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Deutschland
    Pathologe 32:316-20. 2011

Detail Information

Publications39

  1. ncbi request reprint Clonality of lobular carcinoma in situ (LCIS) and metachronous invasive breast cancer
    Sebastian Aulmann
    Department of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Breast Cancer Res Treat 107:331-5. 2008
    ..Thus, LCIS represents both an indicator lesion for an increased risk of subsequent invasive breast cancer and in some cases a precursor of ILC...
  2. ncbi request reprint CTCF gene mutations in invasive ductal breast cancer
    Sebastian Aulmann
    Department of Pathology, University of Heidelberg, Germany
    Breast Cancer Res Treat 80:347-52. 2003
    ..Concordant with the antiproliferative effects of the CTCF protein in vivo, CTCF may be involved in tumour initiation or proliferation in individual cases of invasive ductal breast carcinoma...
  3. pmc c-myc amplifications in primary breast carcinomas and their local recurrences
    S Aulmann
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    J Clin Pathol 59:424-8. 2006
    ..To evaluate the role of c-myc oncogene amplifications in the progression of invasive breast carcinomas...
  4. ncbi request reprint Immunohistochemical and cytogenetic characterization of acantholytic squamous cell carcinoma of the breast
    Sebastian Aulmann
    Department of Pathology, University of Heidelberg, INF 220 221, 69120 Heidelberg, Germany
    Virchows Arch 446:305-9. 2005
    ..Furthermore, the overexpressed EGFR could be a possible therapeutic target for individual cases of this aggressive tumor type...
  5. ncbi request reprint Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas
    S Aulmann
    Institute of Pathology, Heidelberg University, Heidelberg, Germany
    Histopathology 50:881-6. 2007
    ..The aim of this study was to analyse the chromosomal breakpoints in paraffin-embedded tissue...
  6. pmc Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40
    F Bergmann
    Institute of Pathology and Department of Surgery, University of Heidelberg, Heidelberg, Germany
    J Clin Pathol 59:580-4. 2006
    ..Pancreatic ductal adenocarcinoma (PDAC) rarely affects people under 40...
  7. ncbi request reprint [Concepts and problems of lobular neoplasia]
    H P Sinn
    Pathologisches Institut, Universitatsklinikum, Im Neuenheimer Feld 220, 69120, Heidelberg, Germany
    Pathologe 27:373-80. 2006
    ..The molecular characteristics of LN are similar to those of invasive lobular carcinomas, indicating the nature of LN as a precursor lesion...
  8. pmc The location of KIT and PDGFRA gene mutations in gastrointestinal stromal tumours is site and phenotype associated
    R Penzel
    The Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, D 69120 Heidelberg, Germany
    J Clin Pathol 58:634-9. 2005
    ..To assess the relation between KIT and PDGFRA mutations and the site of origin, histological phenotype, and pathomorphologically determined risk assessment in gastrointestinal stromal tumours (GISTs)...
  9. doi request reprint Outcome analysis of patients with primary breast cancer initially treated at a certified academic breast unit
    J Heil
    Breast Unit, University of Heidelberg, Voss Strasse 9, D 69115 Heidelberg, Germany
    Breast 21:303-8. 2012
    ..Evaluation of oncological outcome and prognostic factors of patients with primary breast cancer treated at a certified academic breast unit...
  10. doi request reprint [Ductal and lobular preneoplasia: role in breast cancer development]
    S Aulmann
    Pathologisches Institut, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg, Deutschland
    Pathologe 32:316-20. 2011
    ..The aim of the present study was to evaluate the biological potential of these early low-grade lesions in the development of breast cancer...
  11. ncbi request reprint Quality of life after emergency vs. elective esophagectomy with cervical reconstruction
    L Schneider
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Scand J Surg 99:3-8. 2010
    ..The aim of this study was to explore a potential difference in QOL between elective and emergency esophagectomy with collar reconstruction...
  12. doi request reprint [Clonal association of flat epithelial atypia and tubular breast cancer]
    S Aulmann
    Pathologisches Institut, Universitat Heidelberg, Im Neuenheimer Feld 220 221, 69120 Heidelberg
    Pathologe 29:353-6. 2008
    ..Our data indicate a possible precursor role of FEA in the development of tubular breast cancer...
  13. ncbi request reprint Chromosomal imbalances in sporadic neuroendocrine tumours of the thymus
    Ralf J Rieker
    Department of Pathology, University of Heidelberg, INF 220 221, 69120 Heidelberg, Germany
    Cancer Lett 223:169-74. 2005
    ..These CGH data show a degree of overlap with chromosomal imbalances commonly observed in advanced thymomas...
  14. doi request reprint Reduction of CD44(+)/CD24(-) breast cancer cells by conventional cytotoxic chemotherapy
    Sebastian Aulmann
    Institute of Pathology, Heidelberg University, 69120 Heidelberg, Germany
    Hum Pathol 41:574-81. 2010
    ..In conclusion, our findings challenge the proposed role of CD44(+)/CD24(-) cells as cancer stem cells in tumor resistance to chemotherapy as they apparently are not selected by conventional cytotoxic agents...
  15. doi request reprint Palliative radiotherapy of retrobulbar orbit metastases due to breast cancer
    Felix Zwicker
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Onkologie 31:529-33. 2008
    ..The clinical symptoms are quite different. Impairment of vision, exophthalmus, double vision, vertigo, and pain reduce patients' quality of life...
  16. ncbi request reprint Comparison of 99mtechnetium-pertechnetate and 123iodide SPECT with FDG-PET in patients suspicious for breast cancer
    Inga Buchmann
    Department of Nuclear Medicine, University of Heidelberg, Heidelberg, Germany
    Cancer Biother Radiopharm 22:779-89. 2007
    ....
  17. doi request reprint Late enhancement in cardiac amyloidosis: correlation of MRI enhancement pattern with histopathological findings
    Waldemar Hosch
    Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, Heidelberg, Germany
    Amyloid 15:196-204. 2008
    ..LE seems to be associated with fibrosis due to ischemia of cardiomyocytes by small vessel amyloid deposition rather than with amyloid deposition in CA, suggesting that amyloid deposition might be present prior to LE detection...
  18. doi request reprint Invasive tubular carcinoma of the breast frequently is clonally related to flat epithelial atypia and low-grade ductal carcinoma in situ
    Sebastian Aulmann
    Institute of Pathology, Heidelberg University, Heidelberg, Germany
    Am J Surg Pathol 33:1646-53. 2009
    ..Our data indicate, that in the majority of cases lg-DCIS and FEA are directly related to tubular breast cancer with a possible precursor role...
  19. ncbi request reprint Huge primitive neuroectodermal tumor of the pancreas: report of a case and review of the literature
    Thilo Welsch
    Deptartment of Surgery, University of Heidelberg, D 69120 Heidelberg, Germany
    World J Gastroenterol 12:6070-3. 2006
    ..This alarming case particularly illustrates that PNET in the pancreas although in an advanced stage can present with only a short history of mild symptoms...
  20. ncbi request reprint Expression of cell cycle-related gene products in different forms of primary versus recurrent PVNS
    Helgard Weckauf
    Institute of Pathology, Ruprecht Karls University, Heidelberg, Germany
    Cancer Lett 210:111-8. 2004
    ..Ki-67 proliferation rate was elevated in recurrent tumors...
  21. ncbi request reprint Oncogenetic tree models based on cytogenetic data: new insights into the development of epithelial tumors of the thymus
    Ralf J Rieker
    Department of Pathology, University of Heidelberg, INF 220 221, 69120 Heidelberg, Germany
    Cancer Genet Cytogenet 158:75-80. 2005
    ..Oncogenetic tree models are a helpful means to determine developmental pathways of tumors arising from the same progenitor cell, as shown here for thymomas...
  22. ncbi request reprint Loss of SMAD4 function in small intestinal adenocarcinomas: comparison of genetic and immunohistochemical findings
    Hendrik Blaker
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, Heidelberg 69120, Germany
    Pathol Res Pract 200:1-7. 2004
    ..Furthermore, our results show that SMAD4 immunohistochemistry may serve as a surrogate for analysis of homozygous gene deletions. However, the method fails to identify SMAD4 inactivation due to missense mutations...
  23. ncbi request reprint Comparison of immunohistological parameters in primary breast cancers and corresponding locoregional recurrences
    Joachim Rom
    Department of Gynecology and Obstetrics, University Hospital Heidelberg, Heidelberg, Germany
    Pathol Res Pract 202:125-30. 2006
    ..The expression or changes of c-erbB2, CD44v6, and p53 were not related to the recurrence-free time intervals. Therefore, for treatment, it seems important to consider a possible loss of hormone receptors during tumor progression...
  24. ncbi request reprint Cystic thymoma
    Ralf J Rieker
    Department of General Pathology, University Hospital, Heidelberg 69120, Germany
    Pathol Oncol Res 11:57-60. 2005
    ..We report a case of a micronodular thymoma with lymphoid stroma, which was completely built of small cysts, discuss the pathologic features of this tumor type and review the etiology and other aspects of thymic cysts...
  25. ncbi request reprint Induction of remission in a patient with metastatic breast cancer refractory to trastuzumab and chemotherapy following treatment with gefitinib ('Iressa', ZD1839)
    Andreas Schneeweiss
    Departments of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany
    Anticancer Drugs 15:235-8. 2004
    ..Thus, for patients with MBC whose tumors co-express EGFR and HER2, gefitinib in combination with trastuzumab may prevent receptor cross-talk, improving the outcome of MBC...
  26. doi request reprint [Lobular neoplasms and invasive lobular breast cancer]
    H P Sinn
    Pathologisches Institut, Universitat Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland
    Pathologe 35:45-53. 2014
    ..Important parameters for the prognostic assessment of ILC are tumor grading and the recognition of morphological variants. ..
  27. doi request reprint Gains of chromosome region 3q26 in intraepithelial neoplasia and invasive squamous cell carcinoma of the vulva are frequent and independent of HPV status
    S Aulmann
    Institute of Pathology, University of Heidelberg, Germany
    J Clin Pathol 61:1034-7. 2008
    ..The aim of this study was to investigate the presence of chromosome 3q26 gains in the spectrum of precancerous lesions and invasive squamous cell carcinomas (SCCs) of the vulva...
  28. ncbi request reprint Mutational activation of the RAS-RAF-MAPK and the Wnt pathway in small intestinal adenocarcinomas
    H Blaker
    Institute of Pathology, University of Heidelberg, Germany
    Scand J Gastroenterol 39:748-53. 2004
    ..The aim of this study on small intestinal carcinomas was to analyze alternative mechanisms of activation of pathways that are typically affected in colorectal cancer...
  29. ncbi request reprint Clusters of chromosomal imbalances in thymic epithelial tumours are associated with the WHO classification and the staging system according to Masaoka
    Roland Penzel
    Department of Pathology, University of Heidelberg, Heidelberg, Germany
    Int J Cancer 105:494-8. 2003
    ..Furthermore, chromosomal imbalances detected in some type A thymomas might be responsible for the aggressive behaviour described in a few cases of this thymoma subtype...
  30. doi request reprint Prognostic significance of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in patients with breast cancer
    Tom M Ganten
    Division of Apoptosis Regulation D040, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Mol Med (Berl) 87:995-1007. 2009
    ....
  31. doi request reprint [Villous adenoma within an urachal diverticulum associated with long-term mucusuria]
    S Macher-Goeppinger
    Institut fur Pathologie, Universitat Heidelberg, Im Neuenheimer Feld 220, 69120, Heidelberg
    Pathologe 29:305-7. 2008
    ..After surgical resection histologic examination showed a mucus producing, intestinally differentiated adenoma within the diverticulum. This finding explains both the recurrent infections and the 10-year history of mucusuria...
  32. doi request reprint Invasive ductal breast cancer within a malignant phyllodes tumor: case report and assessment of clonality
    Stephan Macher-Goeppinger
    Institute of Pathology, Heidelberg University, 69120 Heidelberg, Germany
    Hum Pathol 41:293-6. 2010
    ..Although our data are compatible with a previously postulated common origin of epithelial and stromal components of phyllodes tumors, the coexisting invasive ductal carcinoma appears to represent a true collision tumor...
  33. doi request reprint [Diagnostics of benign ductal epithelial cell proliferation of the breast in biopsy material]
    H P Sinn
    Pathologisches Institut, Universitat Heidelberg, Im Neuenheimer Feld 224, 69120, Heidelberg, Deutschland
    Pathologe 35:18-25. 2014
    ..This review provides an overview of the diagnostic criteria, the current terminology and the differential diagnosis of these lesions. The clinical management and the prognosis of the lesions are discussed. ..
  34. ncbi request reprint Apoptosis resistance in pigmented villonodular synovitis
    I Berger
    Institute of Pathology, University of Heidelberg, 69120 Heidelberg, Germany
    Histol Histopathol 20:11-7. 2005
    ..Pigmented villonodular synovitis (PVNS) is a proliferative lesion originating from synovial tissue with a locally aggressive behaviour. We analysed the pathogenetic role of apoptosis resistance for sustained cell proliferation in PVNS...
  35. doi request reprint A mathematical approach predicting the number of events in different tumors
    Ralf J Rieker
    Department of Pathology, University Hospital, University of Heidelberg, INF 220 221, 69120, Heidelberg, Germany
    Pathol Oncol Res 14:199-204. 2008
    ....
  36. pmc Cystic duct dilatations and proliferative epithelial lesions in mouse mammary glands upon keratin 5 promoter-driven overexpression of cyclooxygenase-2
    Karin Muller-Decker
    Deutsches Krebsforschungszentrum, INF 280, 69120 Heidelberg, Germany
    Am J Pathol 166:575-84. 2005
    ....
  37. ncbi request reprint C-myc oncogene amplification in ductal carcinoma in situ of the breast
    Sebastian Aulmann
    Department of Pathology, University of Heidelberg, Germany
    Breast Cancer Res Treat 74:25-31. 2002
    ..045), a 43% larger tumour size (p = 0.029) and the otherwise rare micropapillary subtype (p = 0.0005). Concluding the c-myc oncogene appears to be involved in the development of a more aggressive phenotype of DCIS...
  38. doi request reprint Prognostic value of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and TRAIL receptors in renal cell cancer
    Stephan Macher-Goeppinger
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 15:650-9. 2009
    ..Here, we studied a possible association between the expression of TRAIL/TRAIL-Rs and the prognosis in patients with renal cell carcinomas (RCC)...
  39. pmc Decoy receptor 3 is a prognostic factor in renal cell cancer
    Stephan Macher-Goeppinger
    Institute of Pathology, University of Heidelberg, Im Neuenheimer Feld 220, 69120 Heidelberg, Germany
    Neoplasia 10:1049-56. 2008
    ..Decoy receptor 3 (DcR3) is a soluble protein that binds to and inactivates the death ligand CD95L. Here, we studied a possible association between DcR3 expression and prognosis in patients with renal cell carcinomas (RCCs)...