P Augat

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. ncbi Glucocorticoid-treated sheep as a model for osteopenic trabecular bone in biomaterials research
    Peter Augat
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstr 14, 89081 Ulm, Germany
    J Biomed Mater Res A 66:457-62. 2003
  2. ncbi Mechanics and mechano-biology of fracture healing in normal and osteoporotic bone
    Peter Augat
    Institute for Orthopaedic Research and Biomechanics, University of Ulm, Germany
    Osteoporos Int 16:S36-43. 2005
  3. ncbi Predictive value of bone mineral density and morphology determined by peripheral quantitative computed tomography for cancellous bone strength of the proximal femur
    N J Wachter
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Bone 28:133-9. 2001
  4. ncbi Distal radius fractures: mechanisms of injury and strength prediction by bone mineral assessment
    P Augat
    Osteoporosis and Arthritis Research Group, Department of Radiology, University of California, San Francisco, USA
    J Orthop Res 16:629-35. 1998
  5. ncbi Accuracy of cortical and trabecular bone measurements with peripheral quantitative computed tomography (pQCT)
    P Augat
    Department of Radiology, University of California San Francisco, USA
    Phys Med Biol 43:2873-83. 1998
  6. ncbi Local tissue properties in bone healing: influence of size and stability of the osteotomy gap
    P Augat
    Department of Orthopaedic Research and Biomechanics, University of Ulm, Germany
    J Orthop Res 16:475-81. 1998
  7. ncbi Mechanical stimulation by external application of cyclic tensile strains does not effectively enhance bone healing
    P Augat
    Institute of Orthopedic Research and Biomechanics, University of Ulm, Germany
    J Orthop Trauma 15:54-60. 2001
  8. ncbi Assessment of bone mineral at appendicular sites in females with fractures of the proximal femur
    P Augat
    Department of Radiology, University of California San Francisco, USA
    Bone 22:395-402. 1998
  9. ncbi High-resolution magnetic resonance imaging: three-dimensional trabecular bone architecture and biomechanical properties
    S Majumdar
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143 1290, USA
    Bone 22:445-54. 1998
  10. ncbi Prediction of strength of cortical bone in vitro by microcomputed tomography
    N J Wachter
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm, Steinhovelstr 9, 89075 Ulm, Germany
    Clin Biomech (Bristol, Avon) 16:252-6. 2001

Detail Information

Publications64

  1. ncbi Glucocorticoid-treated sheep as a model for osteopenic trabecular bone in biomaterials research
    Peter Augat
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstr 14, 89081 Ulm, Germany
    J Biomed Mater Res A 66:457-62. 2003
    ....
  2. ncbi Mechanics and mechano-biology of fracture healing in normal and osteoporotic bone
    Peter Augat
    Institute for Orthopaedic Research and Biomechanics, University of Ulm, Germany
    Osteoporos Int 16:S36-43. 2005
    ..This review will focus on the effects of biomechanical factors on fracture repair as well as the effects of age and osteoporosis...
  3. ncbi Predictive value of bone mineral density and morphology determined by peripheral quantitative computed tomography for cancellous bone strength of the proximal femur
    N J Wachter
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Bone 28:133-9. 2001
    ..However, quantification of cancellous bone structure by image analysis of CT scans may provide additional qualitative information for the analysis of bone strength...
  4. ncbi Distal radius fractures: mechanisms of injury and strength prediction by bone mineral assessment
    P Augat
    Osteoporosis and Arthritis Research Group, Department of Radiology, University of California, San Francisco, USA
    J Orthop Res 16:629-35. 1998
    ..Cortical bone, therefore, contributes significantly to the strength of the distal radius and may play an important role in the prediction of osteoporotic wrist fractures...
  5. ncbi Accuracy of cortical and trabecular bone measurements with peripheral quantitative computed tomography (pQCT)
    P Augat
    Department of Radiology, University of California San Francisco, USA
    Phys Med Biol 43:2873-83. 1998
    ....
  6. ncbi Local tissue properties in bone healing: influence of size and stability of the osteotomy gap
    P Augat
    Department of Orthopaedic Research and Biomechanics, University of Ulm, Germany
    J Orthop Res 16:475-81. 1998
    ..Our finding that large gaps between bone segments were not as well healed as were smaller gaps suggests that it is advantageous to avoid large gaps in fracture treatment...
  7. ncbi Mechanical stimulation by external application of cyclic tensile strains does not effectively enhance bone healing
    P Augat
    Institute of Orthopedic Research and Biomechanics, University of Ulm, Germany
    J Orthop Trauma 15:54-60. 2001
    ..To determine whether an externally induced interfragmentary movement enhances the healing process of a fracture under flexible fixation...
  8. ncbi Assessment of bone mineral at appendicular sites in females with fractures of the proximal femur
    P Augat
    Department of Radiology, University of California San Francisco, USA
    Bone 22:395-402. 1998
    ..The risk assessment appears not to be improved by including information of cortical or geometric properties of the forearm...
  9. ncbi High-resolution magnetic resonance imaging: three-dimensional trabecular bone architecture and biomechanical properties
    S Majumdar
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143 1290, USA
    Bone 22:445-54. 1998
    ..Further studies are clearly warranted to establish the role of architecture in predicting overall bone quality, and the role of trabecular architecture measures in clinical practice. (ABSTRACT TRUNCATED)..
  10. ncbi Prediction of strength of cortical bone in vitro by microcomputed tomography
    N J Wachter
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm, Steinhovelstr 9, 89075 Ulm, Germany
    Clin Biomech (Bristol, Avon) 16:252-6. 2001
    ..The aim of this study was to evaluate the predictive value of bone mineral density and intracortical porosity measured by microcomputed tomography for the strength of cortical bone biopsies...
  11. ncbi Anisotropy of the elastic modulus of trabecular bone specimens from different anatomical locations
    P Augat
    Department of Radiology, University of California, San Francisco 94143, USA
    Med Eng Phys 20:124-31. 1998
    ..The data suggest that BMD can be most successfully applied to determine the mechanical properties in the principal loading direction, which from a clinical perspective may be most relevant...
  12. ncbi Predictive value of Singh index and bone mineral density measured by quantitative computed tomography in determining the local cancellous bone quality of the proximal femur
    N J Wachter
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm, Steinhoevelstr 9, D 89075 Ulm, Germany
    Clin Biomech (Bristol, Avon) 16:257-62. 2001
    ..The purpose of this study was to assess the predictive value of the Singh index as well as quantitative computed tomography for the in vitro local mechanical competence of the cancellous bone of the proximal femur...
  13. ncbi Volumetric quantitative computed tomography of the proximal femur: precision and relation to bone strength
    T F Lang
    Department of Radiology, University of California, San Francisco 94143 1250, USA
    Bone 21:101-8. 1997
    ..Thus, trabecular BMD measurements were reproducible and highly correlated to biomechanical strength measurements. These results support further exploration of quantitative CT for assessment of osteoporosis at the proximal femur...
  14. ncbi Prediction of cortical bone porosity in vitro by microcomputed tomography
    N J Wachter
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Calcif Tissue Int 68:38-42. 2001
    ..76, P <0.0001). We consider the measurement of porosity by mCT as a very potent procedure for assessing intracortical porosity and parameters related to porous structures of cortical bone nondestructively in vitro...
  15. ncbi Biomechanical comparison of two side plate fixation techniques in an unstable intertrochanteric osteotomy model: Sliding Hip Screw and Percutaneous Compression Plate
    G D Krischak
    Centre of Surgery, Clinic for Traumatology, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Steinhoevelstrasse 9, 89075 Ulm, Germany
    Clin Biomech (Bristol, Avon) 22:1112-8. 2007
    ....
  16. ncbi Fractal analysis of radiographs: assessment of trabecular bone structure and prediction of elastic modulus and strength
    S Majumdar
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco 94143, USA
    Med Phys 26:1330-40. 1999
    ..Thus, fractal based texture analysis of radiographs are technique dependent, but may be used to quantify trabecular structure and have a potentially valuable impact in the study of osteoporosis...
  17. ncbi Degradation behavior of composite pins made of tricalcium phosphate and poly(L,DL-lactide)
    A A Ignatius
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Germany
    J Biomater Sci Polym Ed 12:185-94. 2001
    ..It was concluded that the mechanical requirements for a pin for the fixation of small bony fragments with improved biocompatibility were fulfilled by the composite pin with 10% TCP but not by the pin with 30% TCP...
  18. ncbi Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur. Magnetic Resonance Science Center and Osteoporosis and Arthritis Research Group
    S Majumdar
    Department of Radiology, and Department of Internal Medicine, University of California, San Francisco, California, USA
    Osteoporos Int 10:231-9. 1999
    ..87) when radius and calcaneus structure was included. Measures of trabecular architecture derived from MR images combined with BMD measures improve the discrimination between subjects with hip fractures and normal age-matched controls...
  19. ncbi The effects of non-steroidal anti-inflammatory drug application on incisional wound healing in rats
    G D Krischak
    Department of Traumatology, Hand, Plastic and Reconstructive Surgery, University of Ulm, Ulm, Germany
    J Wound Care 16:76-8. 2007
    ..We investigated the influence of diclofenac, a non-selective NSAID, on incisional wound healing...
  20. ncbi The non-steroidal anti-inflammatory drug diclofenac reduces appearance of osteoblasts in bone defect healing in rats
    G D Krischak
    Clinic for Traumatology, Hand, Plastic, and Reconstructive Surgery, Centre for Surgery, University of Ulm, Steinhoevelstr 9, 89075 Ulm, Germany
    Arch Orthop Trauma Surg 127:453-8. 2007
    ..We studied whether diclofenac, a non-selective NSAID, also impairs appearance of osteoblasts in vivo during the early phase of healing (at 10 days)...
  21. ncbi In vivo investigations on composites made of resorbable ceramics and poly(lactide) used as bone graft substitutes
    A A Ignatius
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Biomed Mater Res 58:701-9. 2001
    ..It is concluded that the new composites cannot yet be used for clinical application. An improvement in biocompatibility might be reached by a better coordination of the degradation times of the polymer and the ceramic component...
  22. ncbi Correlation of bone mineral density with strength and microstructural parameters of cortical bone in vitro
    N J Wachter
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Bone 31:90-5. 2002
    ....
  23. ncbi Image-based assessment of spinal trabecular bone structure from high-resolution CT images
    C L Gordon
    Department of Radiology, University of California, San Francisco, USA
    Osteoporos Int 8:317-25. 1998
    ..These findings suggest that an assessment of vertebral trabecular structure from high-resolution CT images is useful in discriminating subjects with vertebral fractures and potentially useful for predicting future fractures...
  24. ncbi A new bioresorbable polymer for screw augmentation in the osteosynthesis of osteoporotic cancellous bone: a biomechanical evaluation
    A A Ignatius
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Biomed Mater Res 58:254-60. 2001
    ..It was concluded that augmentation by the new resorbable polymer significantly enhanced the anchorage of bone screws in cancellous bone. The mechanical efficiency of the new polymer was comparable to that of PMMA cement...
  25. ncbi Noninvasive assessment of bone density and structure using computed tomography and magnetic resonance
    T Lang
    Department of Radiology, University of California, San Francisco, 94143 1250, USA
    Bone 22:149S-153S. 1998
    ..High resolution MR measurements may be employed for assessment of the trabecular texture at a range of peripheral sites, including the calcaneus, distal radius, and phalanges...
  26. ncbi Predictive value of bone mineral density and Singh index for the in vitro mechanical properties of cancellous bone in the femoral head
    G D Krischak
    Department of Orthopaedic Research, University of Ulm, Helmholtzstr 14, 89081, Ulm, Germany
    Clin Biomech (Bristol, Avon) 14:346-51. 1999
    ..The purpose of this study was to assess the validity of two methodically different radiological parameters, bone mineral density and Singh Index, for the prediction of mechanical properties in femoral cancellous bone...
  27. ncbi Quantitative bone mineral assessment at the forearm: a review
    P Augat
    Department of Radiology, University of California, San Francisco, USA
    Osteoporos Int 8:299-310. 1998
    ..The monitoring of treatment at the distal forearm appears to require a longer follow-up time due to its decreased responsiveness compared with such highly trabecular load-bearing sites as the spine and the proximal femur...
  28. ncbi Composites made of rapidly resorbable ceramics and poly(lactide) show adequate mechanical properties for use as bone substitute materials
    A A Ignatius
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Biomed Mater Res 57:126-31. 2001
    ..It was concluded that the composites show adequate mechanical properties in the range of cancellous bone and a suitable degradation characteristic to be used as bone substitute materials...
  29. ncbi Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing
    A Beck
    Department of Trauma, Hand and Reconstructive Surgery, University Hospital, Steinhoevelstrasse 9, 89075 Ulm, Germany
    Arch Orthop Trauma Surg 123:327-32. 2003
    ..This animal experiment was performed to determine the influence of NSAR on the process of fracture healing. As an alternative, tramadol, the centrally acting analgetic without peripheral effects, was included in this experiment...
  30. ncbi Influence of the stiffness of bone defect implants on the mechanical conditions at the interface--a finite element analysis with contact
    U Simon
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Biomech 36:1079-86. 2003
    ..5 microm). However, for both implants peak stresses and micromotion were in a range that predicts adequate conditions for the osseointegration. This was confirmed by the histological results from the animal studies...
  31. ncbi In vivo assessment of trabecular bone structure using fractal analysis of distal radius radiographs
    S Majumdar
    Department of Radiology, University of California, San Francisco 94143 1290, USA
    Med Phys 27:2594-9. 2000
    ....
  32. ncbi [Mechanical modification of callus healing]
    L Claes
    Institut für Unfallchirurgische Forschung und Biomechanik, Universitat Ulm
    Chirurg 71:989-94. 2000
    ..External mechanical stimulation, however, has not been shown to effectively enhance the healing process under flexible fixation or in load-bearing patients...
  33. ncbi Influence of size and stability of the osteotomy gap on the success of fracture healing
    L Claes
    Abteilung Unfallchirurgische Forschung und Biomechanik, Universitat Ulm, Germany
    J Orthop Res 15:577-84. 1997
    ..The experimental fracture model for the metatarsus showed that the healing process was inferior when the gap was larger than 2 mm...
  34. ncbi Extension of a state-of-the-art optimization criterion to predict co-contraction
    E Forster
    Institute of Orthopaedics Research and Biomechanics, University of Ulm, Germany
    J Biomech 37:577-81. 2004
    ..In conclusion, this study presents a novel approach to predict co-contraction when using optimization techniques to determine muscle forces by introducing a shift parameter for the optimization criterion...
  35. ncbi A numerical model of the fracture healing process that describes tissue development and revascularisation
    U Simon
    Scientific Computing Centre Ulm, Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstraße 20, Ulm, Germany
    Comput Methods Biomech Biomed Engin 14:79-93. 2011
    ..A revascularisation sensitivity analysis demonstrated the potential of the model to account for different conditions regarding the blood supply...
  36. ncbi The role of cortical bone and its microstructure in bone strength
    Peter Augat
    Trauma Centre Murnau, Prof Kuentscher Strasse 8, 82418 Murnau, Germany
    Age Ageing 35:ii27-ii31. 2006
    ..This review provides an overview of a variety of features of cortical bone known to provide mechanical competence and how these features may be applied for fracture risk prediction...
  37. ncbi Effects of diclofenac on periosteal callus maturation in osteotomy healing in an animal model
    Gert D Krischak
    Department of Traumatology, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Steinhoevelstr 9, 89075 Ulm, Germany
    Arch Orthop Trauma Surg 127:3-9. 2007
    ..Our hypothesis was that callus formation is delayed in animals treated with the non-specific NSAID diclofenac...
  38. ncbi Moderate soft tissue trauma delays new bone formation only in the early phase of fracture healing
    Lutz Claes
    Institute for Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Orthop Res 24:1178-85. 2006
    ..A fast recovery of blood flow and callus formation took place in the F + STT group, which led to similar histological and biomechanical results in fracture healing observed after 28 days between the two groups...
  39. ncbi Interfragmentary movement in diaphyseal tibia fractures fixed with locked intramedullary nails
    Peter Augat
    Biomechanics Research Laboratory, Paracelsus Medical University, Salzburg, Austria
    J Orthop Trauma 22:30-6. 2008
    ..Biomechanical study on cadaveric bones using physiological loading conditions to quantify interfragmentary movements in a tibial shaft fracture model fixed by intramedullary nailing...
  40. ncbi Cervical anterior transpedicular screw fixation (ATPS)--Part II. Accuracy of manual insertion and pull-out strength of ATPS
    Heiko Koller
    Department for Traumatology and Sport Injuries, Paracelsus Medical University Salzburg, 5020, Salzburg, Austria
    Eur Spine J 17:539-55. 2008
    ..The use of ATPS shows the potential to increase construct rigidity in terms of screw-plate pull-out resistance. It might diminish construct failures during anterior-only reconstructions of the highly unstable decompressed cervical spine...
  41. ncbi Temporary distraction and compression of a diaphyseal osteotomy accelerates bone healing
    Lutz Claes
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Orthop Res 26:772-7. 2008
    ..There was a significantly higher bone formation rate in the TD group than in the C group. This study demonstrated the feasibility of fracture healing stimulation by the temporary application of distraction and compression...
  42. ncbi Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions
    Klaus Engelke
    Institute of Medical Physics, University of Erlangen, Germany Synarc, Hamburg, Germany
    J Clin Densitom 11:123-62. 2008
    ..Measurements at the hip may have clinical relevance, as this is an important fracture site; however, due to limited medical evidence, definitive advice on its use in clinical practice cannot be provided until more data emerge...
  43. ncbi Validation of a femoral critical size defect model for orthotopic evaluation of bone healing: a biomechanical, veterinary and trauma surgical perspective
    Inga Drosse
    Experimental Surgery and Regenerative Medicine, Department of Surgery, University of Munich, Munich, Germany
    Tissue Eng Part C Methods 14:79-88. 2008
    ..In conclusion, the evaluated model for stabilizing a CSD in a rat's femur can reliably be used for standardized bone regeneration studies in small animals...
  44. ncbi Increased cortical remodeling after osteotomy causes posttraumatic osteopenia
    Peter Augat
    Biomechanics Research Laboratory, Paracelsus Medical University, 5020 Salzburg, Austria
    Bone 43:539-43. 2008
    ..This post-traumatic bone loss is likely to contribute significantly to frequently observed healing complications like refracture, failure of implant fixation, implant loosening, or cut out...
  45. ncbi Bone formation in a long bone defect model using a platelet-rich plasma-loaded collagen scaffold
    Michael R Sarkar
    Department for Trauma, Hand and Reconstructive Surgery, University of Ulm, Ulm D-89070, Germany
    Biomaterials 27:1817-23. 2006
    ..Such bone defects might require more potent stimuli, e.g. combinations of functional biomaterials or autografts, precursor cells or osteoinductive growth factors...
  46. ncbi Trabecular bone fracture healing simulation with finite element analysis and fuzzy logic
    Sandra J Shefelbine
    Institute for Orthopaedics and Biomechanics, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Biomech 38:2440-50. 2005
    ..A single model that can simulate bone healing and remodelling may prove to be a useful tool in predicting musculoskeletal tissue differentiation in different vascular and mechanical environments...
  47. ncbi Inhibition of cortical and cancellous bone formation in glucocorticoid-treated OVX sheep
    Sandra Schorlemmer
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstr 14, 89081 Ulm, Germany
    Bone 37:491-6. 2005
    ..The purpose of this study was to explore the effects of glucocorticoid treatment on cortical bone density, strength, and formation of new bone in ovariectomized sheep and to compare it to cancellous bone...
  48. ncbi The effect of mechanical stability on local vascularization and tissue differentiation in callus healing
    Lutz Claes
    Institute for Orthopaedic Research and Biomechanics, University of Ulm, Germany
    J Orthop Res 20:1099-105. 2002
    ..Whereas the large vessels showed maximum density in the medullary cavity, the small vessels showed the highest frequency in the peripheral part of the periosteal callus...
  49. ncbi Measuring power during the sit-to-stand transfer
    Ulrich Lindemann
    Bethesda Geriatric Hospital Ulm, Academic Centre at the University of Ulm, Zollernring 26, 89073 Ulm, Germany
    Eur J Appl Physiol 89:466-70. 2003
    ..As it is inexpensive and portable, its use in clinical practice and research contexts, including home-bound individuals, is feasible...
  50. ncbi The fracture gap size influences the local vascularization and tissue differentiation in callus healing
    Lutz Claes
    Institute for Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    Langenbecks Arch Surg 388:316-22. 2003
    ..The aim of the study was to determine quantitatively the revascularization and tissue differentiation in an animal model with different fracture gaps and controlled biomechanical conditions...
  51. ncbi Influence of haemorrhagic shock on fracture healing
    Mark Bumann
    Department of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    Langenbecks Arch Surg 388:331-8. 2003
    ..The purpose of the study was to evaluate the effect of haemorrhagic shock on the outcome of fracture healing...
  52. ncbi Shear movement at the fracture site delays healing in a diaphyseal fracture model
    Peter Augat
    Department of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstr 14, 89081 Ulm, Germany
    J Orthop Res 21:1011-7. 2003
    ..05). In summary, fixation that allows excessive shear movement significantly delayed the healing of diaphyseal osteotomies compared to healing under axial movement of the same magnitude...
  53. ncbi Influence of preoperative mechanical bone quality and bone mineral density on aseptic loosening of total hip arthroplasty after seven years
    Gert D Krischak
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm, Steinhoevelstrasse 9, D 89075 Ulm, Germany
    Clin Biomech (Bristol, Avon) 18:916-23. 2003
    ..To test mechanical bone quality and bone mineral density of the femoral head at the day of implantation as indicators for femoral prosthesis loosening...
  54. ncbi Glucocorticoid treatment of ovariectomized sheep affects mineral density, structure, and mechanical properties of cancellous bone
    Sandra Schorlemmer
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Ulm, Germany
    J Bone Miner Res 18:2010-5. 2003
    ..Reduction in bone quality and bone formation rate persisted after the cessation of steroid administration. Glucocorticoid treatment of ovariectomized sheep may therefore serve as a large animal model for steroid-induced osteopenia...
  55. ncbi Mechanical regulation of HB-GAM expression in bone cells
    Astrid Liedert
    Institute of Orthopedic Research and Biomechanics, University of Ulm, Germany
    Biochem Biophys Res Commun 319:951-8. 2004
    ..Furthermore, integrity of the cytoskeleton, stretch-activated, and voltage-sensitive Ca(2+) channels as well as gap junctional communication are necessary for the downregulation of HB-GAM expression by mechanical loading...
  56. ncbi Biocompatibility and functionality of the degradable polymer alkylene bis(dilactoyl)-methacrylate for screw augmentation in vivo
    Anita A Ignatius
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Biomed Mater Res B Appl Biomater 75:128-36. 2005
    ..It was concluded that the material has poor biocompatibility and cannot be recommended for clinical application as screw augmentation material...
  57. ncbi Prediction of fracture callus mechanical properties using micro-CT images and voxel-based finite element analysis
    Sandra J Shefelbine
    Institute for Orthopaedic Research and Biomechanics, Ulm, Germany
    Bone 36:480-8. 2005
    ..Using FEA to predict mechanical properties of the callus could prove to be a useful tool in fracture-healing studies...
  58. ncbi Intact fibula improves fracture healing in a rat tibia osteotomy model
    Sandra J Shefelbine
    Institute for Orthopaedics and Biomechanics, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Orthop Res 23:489-93. 2005
    ..These results indicate that torsional stability considerably affects the healing process. In a fracture model, it is critical to characterize the mechanical environment of the fracture...
  59. ncbi Osseointegration of alumina with a bioactive coating under load-bearing and unloaded conditions
    Anita Ignatius
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    Biomaterials 26:2325-32. 2005
    ..It was suggested that the osseointegration of Al(2)O(3) could be improved by the coating under load-bearing conditions, under which uncoated Al(2)O(3) ceramics cannot directly bind to bone...
  60. ncbi A modified hip screw incorporating injected cement for the fixation of osteoporotic trochanteric fractures
    Peter Augat
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Helmholtzstrasse 14, 89081 Ulm, Germany
    J Orthop Trauma 16:311-6. 2002
    ..CONCLUSIONS: This modified hip screw augmented with bone cement can significantly enhance the initial fixation stability of trochanteric fractures in osteoporotic femurs...
  61. ncbi Effects of one-plane and two-plane external fixation on sheep osteotomy healing and complications
    Gert D Krischak
    Department of Orthopaedic Surgery, University of Ulm, Steinhovelstrasse 9, Germany
    Clin Biomech (Bristol, Avon) 17:470-6. 2002
    ..Comparison of one-plane and two-plane external fixation in terms of successful healing, incidence of complications, and biomechanical stability in a sheep model...
  62. ncbi Critical issues in translational and clinical research for the study of new technologies to enhance bone repair
    Jörg Goldhahn
    Department of Research, Schulthess Klinik, Lengghalde 2, Zurich 8008, Switzerland
    J Bone Joint Surg Am 90:43-7. 2008
    ..The guidelines should be harmonized between European and American regulatory authorities to ensure comparability of results of studies and to foster global harmonization of regulatory requirements...
  63. ncbi Clinical evaluation of medicinal products for acceleration of fracture healing in patients with osteoporosis
    Jörg Goldhahn
    Schulthess Clinic Zurich and Clinical Priority Program Fracture Fixation in Osteoporotic, Bone of AO Foundation, Davos, Switzerland
    Bone 43:343-7. 2008
    ..The study design should be randomized, parallel, double-blind, and placebo-controlled, and all fracture subjects should receive a standardized method of fracture fixation, defined as Standard of Care...
  64. ncbi Influence of thread design on pedicle screw fixation. Laboratory investigation
    Michael Hannes Krenn
    Department for Spine Surgery, Paracelsus Medical University Hospital, Salzburg, Austria
    J Neurosurg Spine 9:90-5. 2008
    ..The authors conducted a study to determine the thread properties that provide optimal screw fixation in cancellous bone, when screws of the same external screw diameter are used...