D Atanackovic

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. pmc CD8(+) T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients
    Sacha Gnjatic
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:11813-8. 2002
  2. ncbi request reprint Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation
    Djordje Atanackovic
    Department of Oncology Hematology, Institute for Biochemistry and Molecular Biology, University Medical Center Hamburg Eppendorf, Germany
    Blood 109:1103-12. 2007
  3. pmc Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients
    J Panse
    Department of Oncology Hematology, Center of Oncology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany
    Br J Cancer 99:930-8. 2008
  4. doi request reprint Acute psychological stress increases peripheral blood CD3+CD56+ natural killer T cells in healthy men: possible implications for the development and treatment of allergic and autoimmune disorders
    Djordje Atanackovic
    Department of Internal Medicine II, Oncology Hematology Stem Cell Transplantation, Center of Oncology, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, Martinistrasse 52, Hamburg, Germany
    Stress 16:421-8. 2013
  5. doi request reprint Role of interleukin 16 in multiple myeloma
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    J Natl Cancer Inst 104:1005-20. 2012
  6. ncbi request reprint Characterization of effusion-infiltrating T cells: benign versus malignant effusions
    Djordje Atanackovic
    Oncology Hematology, Department of Medicine, University Hospital Eppendorf, Hamburg, Germany
    Clin Cancer Res 10:2600-8. 2004
  7. doi request reprint The local cytokine and chemokine milieu within malignant effusions
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Tumour Biol 29:93-104. 2008
  8. pmc Cancer-testis antigens MAGE-C1/CT7 and MAGE-A3 promote the survival of multiple myeloma cells
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology, University Medical Center, Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Haematologica 95:785-93. 2010
  9. ncbi request reprint Patients with solid tumors treated with high-temperature whole body hyperthermia show a redistribution of naive/memory T-cell subtypes
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R585-94. 2006
  10. ncbi request reprint Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, Hamburg, and Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Germany
    J Neuroimmunol 176:141-52. 2006

Collaborators

Detail Information

Publications42

  1. pmc CD8(+) T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients
    Sacha Gnjatic
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:11813-8. 2002
    ....
  2. ncbi request reprint Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation
    Djordje Atanackovic
    Department of Oncology Hematology, Institute for Biochemistry and Molecular Biology, University Medical Center Hamburg Eppendorf, Germany
    Blood 109:1103-12. 2007
    ..Immune responses induced by alloSCT could be boosted by active CT antigen-specific immunotherapy, which might help to achieve long-lasting remissions in patients with MM...
  3. pmc Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients
    J Panse
    Department of Oncology Hematology, Center of Oncology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg 20246, Germany
    Br J Cancer 99:930-8. 2008
    ....
  4. doi request reprint Acute psychological stress increases peripheral blood CD3+CD56+ natural killer T cells in healthy men: possible implications for the development and treatment of allergic and autoimmune disorders
    Djordje Atanackovic
    Department of Internal Medicine II, Oncology Hematology Stem Cell Transplantation, Center of Oncology, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, Martinistrasse 52, Hamburg, Germany
    Stress 16:421-8. 2013
    ..We suggest that in the case of frequent stress exposure, this might result in the promotion of, for example, allergic conditions...
  5. doi request reprint Role of interleukin 16 in multiple myeloma
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    J Natl Cancer Inst 104:1005-20. 2012
    ..Interleukin 16 (IL-16) is involved in regulating the migration and proliferation of normal leukocytes. However, the role of IL-16 in human cancers, including multiple myeloma, is unclear...
  6. ncbi request reprint Characterization of effusion-infiltrating T cells: benign versus malignant effusions
    Djordje Atanackovic
    Oncology Hematology, Department of Medicine, University Hospital Eppendorf, Hamburg, Germany
    Clin Cancer Res 10:2600-8. 2004
    ..We analyzed whether deficient numbers of effector-type T cells within the malignant effusion might contribute to tumor escape from immunosurveillance...
  7. doi request reprint The local cytokine and chemokine milieu within malignant effusions
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Tumour Biol 29:93-104. 2008
    ..In contrast, effector T cells expressing chemokine receptors typical for Th1 cells, such as CCR5, showed a diminished homing into malignant effusions...
  8. pmc Cancer-testis antigens MAGE-C1/CT7 and MAGE-A3 promote the survival of multiple myeloma cells
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology, University Medical Center, Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    Haematologica 95:785-93. 2010
    ..Surprisingly, the biological role of cancer-testis genes in myeloma remains poorly understood...
  9. ncbi request reprint Patients with solid tumors treated with high-temperature whole body hyperthermia show a redistribution of naive/memory T-cell subtypes
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Am J Physiol Regul Integr Comp Physiol 290:R585-94. 2006
    ..Although the exercise group may not be an appropriate control to proof the effect of WBH, these changes were not seen in the healthy volunteers performing physical exercise...
  10. ncbi request reprint Acute psychological stress alerts the adaptive immune response: stress-induced mobilization of effector T cells
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, Hamburg, and Department of Rheumatology and Clinical Immunology, Charite University Hospital, Humboldt University of Berlin, Germany
    J Neuroimmunol 176:141-52. 2006
    ..Thus, acute stress seems to promote the retention of less mature T cells within lymphoid tissue or skin while effector-type T cells are mobilized into the blood in order to be able to rapidly migrate into peripheral tissues...
  11. doi request reprint CD4+CD25+FOXP3+ T regulatory cells reconstitute and accumulate in the bone marrow of patients with multiple myeloma following allogeneic stem cell transplantation
    Djordje Atanackovic
    Department of Medicine II, Oncology Hematology, University Medical Center, Hamburg Eppendorf Martinistr 52, 20246 Hamburg, Germany
    Haematologica 93:423-30. 2008
    ....
  12. ncbi request reprint Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Cancer Biol Ther 5:1218-25. 2006
    ..In conclusion, we demonstrate here that HNSCC frequently express CT antigens. Furthermore, a relatively high percentage of tumors express more than one CT antigen opening the perspective for polyvalent antigen-specific immunotherapy...
  13. ncbi request reprint [Vaccination strategies for solid tumors--fundamentals, limitations, and recent results]
    D Atanackovic
    II Medizinische Klinik, Universitätsklinik Hamburg Eppendorf
    Ther Umsch 61:389-96. 2004
    ..At the same time, future vaccination studies should include patients in earlier stages of their disease or in the adjuvant setting in order to avoid on overwhelming effect of mechanisms that help tumors to evade immunosurveillance...
  14. ncbi request reprint Acute psychological stress induces a prolonged suppression of the production of reactive oxygen species by phagocytes
    Djordje Atanackovic
    Department of Oncology Hematology, Medical University Clinic Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Neuroimmunol 142:159-65. 2003
    ..Especially under conditions of chronic stress, this finding may be of importance for the host's defense against infectious diseases...
  15. doi request reprint Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia
    Djordje Atanackovic
    Center of Oncology, Department of Internal Medicine II, Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg, Germany
    Am J Hematol 86:918-22. 2011
    ..Therefore, we propose that CTA-specific immunotherapy for AML should preferentially target PRAME and/or should be combined with the application of demethylating agents opening the perspective for alternative targets like CTA SSX-2...
  16. doi request reprint Longitudinal analysis and prognostic effect of cancer-testis antigen expression in multiple myeloma
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 15:1343-52. 2009
    ....
  17. doi request reprint Lenalidomide as salvage therapy after allo-SCT for multiple myeloma is effective and leads to an increase of activated NK (NKp44(+)) and T (HLA-DR(+)) cells
    M Lioznov
    Department for Stem Cell Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Bone Marrow Transplant 45:349-53. 2010
    ....
  18. doi request reprint Toxicity-reduced, myeloablative allograft followed by lenalidomide maintenance as salvage therapy for refractory/relapsed myeloma patients
    N Kroger
    Department of Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Bone Marrow Transplant 48:403-7. 2013
    ..Toxicity-reduced myeloablative allograft followed by lenalidomide maintenance is feasible and effective in relapsed patients with MM, but the induction of GvHD should be considered...
  19. ncbi request reprint Impact of genetic abnormalities on survival after allogeneic hematopoietic stem cell transplantation in multiple myeloma
    G Schilling
    Department of Oncology and Hematology, Medical Clinic II, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Leukemia 22:1250-5. 2008
    ..Translocation t(4;14) might be overcome by allogeneic HSCT, which will have implication for risk-adapted strategies...
  20. ncbi request reprint 41.8 degrees C whole body hyperthermia as an adjunct to chemotherapy induces prolonged T cell activation in patients with various malignant diseases
    Djordje Atanackovic
    Department of Oncology and Hematology, University Clinic Eppendorf, Hamburg, Germany
    Cancer Immunol Immunother 51:603-13. 2002
    ..Since similar changes were not observed in patients receiving chemotherapy alone, this is the first study to provide evidence for prolonged WBH-CT-induced activation of human T cells...
  21. ncbi request reprint Coinhibitory molecule PD-1 as a potential target for the immunotherapy of multiple myeloma
    D Atanackovic
    Department of Oncology Hematology Bone Marrow Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Leukemia 28:993-1000. 2014
    ....
  22. ncbi request reprint Reduced-toxicity conditioning with treosulfan, fludarabine and ATG as preparative regimen for allogeneic stem cell transplantation (alloSCT) in elderly patients with secondary acute myeloid leukemia (sAML) or myelodysplastic syndrome (MDS)
    N Kroger
    Department of Bone Marrow Transplantation, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Bone Marrow Transplant 37:339-44. 2006
    ..02). The treatment-related mortality at day 100 was 28%. The 2-year estimated overall and disease-free survival was 36-34%, respectively. No difference in survival was seen between unrelated and related SCT...
  23. doi request reprint Clinical impact of human Jurkat T-cell-line-derived antithymocyte globulin in multiple myeloma patients undergoing allogeneic stem cell transplantation
    Francis Ayuk
    Dept of Stem cell Transplantation, University Medical Center Hamburg Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Haematologica 93:1343-50. 2008
    ..In vitro studies suggest that antithymocyte globulin, besides causing T-cell depletion, has strong anti-myeloma activity...
  24. pmc Booster vaccination of cancer patients with MAGE-A3 protein reveals long-term immunological memory or tolerance depending on priming
    Djordje Atanackovic
    Department of Oncology Hematology, University Medical Center Hamburg Eppendorf, 20246 Hamburg, Germany
    Proc Natl Acad Sci U S A 105:1650-5. 2008
    ..These data provide an immunological rationale for vaccine design in light of recently reported favorable clinical responses in NSCLC patients after vaccination with MAGE-A3 protein plus adjuvant AS02B...
  25. ncbi request reprint Bortezomib after dose-reduced allogeneic stem cell transplantation for multiple myeloma to enhance or maintain remission status
    Nicolaus Kroger
    Department of Bone Marrow Transplantation, Transplant Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 34:770-5. 2006
    ..3 mg/m(2) intravenously, days 1, 4, 8, and 11) after dose-reduced allogeneic stem cell transplantation (SCT) on toxicity, CD3(+) cells, graft-versus-host disease (GvHD), and response in patients with multiple myeloma...
  26. doi request reprint Post-transplant immunotherapy with donor-lymphocyte infusion and novel agents to upgrade partial into complete and molecular remission in allografted patients with multiple myeloma
    Nicolaus Kroger
    Department for Stem Cell Transplantation, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 37:791-8. 2009
    ..To investigate post-transplant immunotherapy with escalating donor-lymphocyte infusions (DLI) and novel agents (thalidomide, bortezomib, and lenalidomide) to target complete remission (CR)...
  27. ncbi request reprint An optimized assay for the enumeration of antigen-specific memory B cells in different compartments of the human body
    Yanran Cao
    Department of Internal Medicine II Oncology, Haematology, Stem Cell Transplantation, University Cancer Centre Hamburg Hubertus Wald Tumorzentrum, Hamburg, Germany
    J Immunol Methods 358:56-65. 2010
    ..In the framework of our current study we set out to develop an optimized assay for the quantification of antigen-specific B cells in different compartments of the human body...
  28. doi request reprint The cytokine/chemokine pattern in the bone marrow environment of multiple myeloma patients
    Yanran Cao
    Department of Internal Medicine II Oncology Hematology Stem Cell Transplantation, University Cancer Center Hamburg Hubertus Wald Tumorzentrum, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Hematol 38:860-7. 2010
    ..We aimed at answering the question which cytokines, chemokines, and growth factors are typically found in the BM of untreated MM patients as well as in MM patients after allogeneic stem cell transplantation (alloSCT)...
  29. ncbi request reprint Effects of whole body hyperthermia (41.8 degrees C) on the frequency of tumor cells in the peripheral blood of patients with advanced malignancies
    Susanna Hegewisch-Becker
    Department of Oncology Hematology, University Hospital Hamburg Eppendorf, Hamburg D 20246, Germany
    Clin Cancer Res 9:2079-84. 2003
    ..Here we investigated whether the hyperdynamic state of the circulation as a consequence of WBH may stimulate dissemination of malignant cells...
  30. ncbi request reprint Immune parameters in patients with anxiety or depression during psychotherapy
    D Atanackovic
    Department of Oncology and Hematology, Medical University Clinic Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Affect Disord 81:201-9. 2004
    ..It is also unknown whether treatment with psychotherapy alone has any influence on immunological variations in patients with psychiatric disorders...
  31. ncbi request reprint Peripheral T cells of patients with B cell non-Hodgkin's lymphoma show a shift in their memory status
    Djordje Atanackovic
    Department of Medicine, Oncology Hematology, University Hospital Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Leuk Res 29:1019-27. 2005
    ..Tumor-infiltrating T cells have a positive influence on the clinical course of B cell non-Hodgkin's lymphoma (NHL). T cells in the peripheral blood of patients with B cell NHL, however, have so far rarely been examined...
  32. ncbi request reprint Pleural effusion of a second neoplasm in a patient with B-CLL: two immunological compartments
    D Atanackovic
    Department of Oncology and Hematology, University Clinic Eppendorf, Hamburg, Germany
    Am J Hematol 73:184-9. 2003
    ..This phenomenon might have contributed to the development of two highly different immunological compartments in this patient with CLL and pleural effusion of a solid tumor...
  33. ncbi request reprint Whole-body hyperthermia (41.8 degrees C) combined with bimonthly oxaliplatin, high-dose leucovorin and 5-fluorouracil 48-hour continuous infusion in pretreated metastatic colorectal cancer: a phase II study
    S Hegewisch-Becker
    Department of Oncology Hematology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Ann Oncol 13:1197-204. 2002
    ....
  34. doi request reprint Expression and prognostic relevance of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of patients with multiple myeloma
    Caroline Pabst
    Department of Oncology Hematology Bone Marrow Transplantation with the Section Pneumology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Exp Mol Pathol 89:175-81. 2010
    ..013). Our results, therefore, suggest that expression of MAGE-C1/CT7 and MAGE-C2/CT10 in osteolytic lesions of myeloma patients can be used for diagnostic, prognostic, as well as immunotherapeutic purposes...
  35. doi request reprint Expression, epigenetic regulation, and humoral immunogenicity of cancer-testis antigens in chronic myeloid leukemia
    Tim Luetkens
    Department of Oncology and Hematology, Center of Oncology, Hamburg, Germany
    Leuk Res 34:1647-55. 2010
    ..However, a broad picture of the expression of CT antigens and associated humoral immune responses in chronic myeloid leukemia (CML) is still missing...
  36. doi request reprint Intraperitoneal VEGF inhibition using bevacizumab: a potential approach for the symptomatic treatment of malignant ascites?
    Sebastian Kobold
    Department of Oncology Hematology Bone Marrow Transplantation with the Section Pneumology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Oncologist 14:1242-51. 2009
    ..Because such an effect would result in significant relief for patients, future clinical studies should stringently assess the effectiveness of this targeted therapy for the treatment of malignant i.p. effusions...
  37. pmc IFN-gamma enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation
    Mitsutoshi Matsuo
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:14467-72. 2004
    ..This model of conditional cross-presentation establishes an original level of action for IFN-gamma as an effective immune modulator and supports the use of IFN-gamma in protein vaccination strategies targeting LCs...
  38. ncbi request reprint Vaccine-induced CD4+ T cell responses to MAGE-3 protein in lung cancer patients
    Djordje Atanackovic
    Ludwig Institute for Cancer Research, and Department of Human Immunogenetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 172:3289-96. 2004
    ..This development provides the framework for further evaluating integrated immune responses in vaccine settings and for optimizing these responses for clinical benefit...
  39. ncbi request reprint HLA-DP4 expression and immunity to NY-ESO-1: correlation and characterization of cytotoxic CD4+ CD25- CD8- T cell clones
    Eduardo Huarte
    II Medizinische Klinik, Hämatologie Onkologie, Krankenhaus Nordwest, Frankfurt, Germany
    Cancer Immun 4:15. 2004
    ..The Th1 phenotype and effector functions of the CD4+ T cell clones described here provide an important rationale for the activation of antigen-specific CD4+ T cells along with CD8+ T cells in cancer vaccination strategies...
  40. ncbi request reprint Monitoring CD4+ T cell responses against viral and tumor antigens using T cells as novel target APC
    Djordje Atanackovic
    Ludwig Institute for Cancer Research, Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 32, New York, NY 10021, USA
    J Immunol Methods 278:57-66. 2003
    ..This approach makes it possible to monitor CD4+ T cells in large series of patients, regardless of HLA haplotype, against the full peptide repertoire of a given antigen...
  41. pmc Survey of naturally occurring CD4+ T cell responses against NY-ESO-1 in cancer patients: correlation with antibody responses
    Sacha Gnjatic
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:8862-7. 2003
    ....
  42. ncbi request reprint Cross-presentation of HLA class I epitopes from exogenous NY-ESO-1 polypeptides by nonprofessional APCs
    Sacha Gnjatic
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 170:1191-6. 2003
    ..e., HLA eligibility criteria and knowledge of epitope, while allowing for facilitated immunogenicity in the presence of helper epitopes...