Sönke Arlt

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Genetic risk factors for depression in Alzheimer`s disease patients
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistr 52, Building W 37, 20246 Hamburg, Germany
    Curr Alzheimer Res 10:72-81. 2013
  2. doi request reprint Effect of one-year vitamin C- and E-supplementation on cerebrospinal fluid oxidation parameters and clinical course in Alzheimer's disease
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Neurochem Res 37:2706-14. 2012
  3. doi request reprint Dimethylarginines, homocysteine metabolism, and cerebrospinal fluid markers for Alzheimer's disease
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Alzheimers Dis 31:751-8. 2012
  4. ncbi request reprint [Lipid peroxidation as a common pathomechanism in coronary heart disease and Alzheimer disease]
    S Arlt
    Institut für Medizinische Biochemie und Molekularbiologie Abt Molekulare Zellbiologie Universitätsklinikum Hamburg Eppendorf Martinistr 52 20246 Hamburg, Germany
    Z Gerontol Geriatr 34:461-5. 2001
  5. doi request reprint Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Dement Geriatr Cogn Disord 26:58-64. 2008
  6. ncbi request reprint The patient with dementia, the caregiver and the doctor: cognition, depression and quality of life from three perspectives
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, Centre of Psychosocial Medicine, University Medical Center Hamburg Eppendorf, Germany
    Int J Geriatr Psychiatry 23:604-10. 2008
  7. ncbi request reprint Increased lipid peroxidation in cerebrospinal fluid and plasma from patients with Creutzfeldt-Jakob disease
    Sönke Arlt
    Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neurobiol Dis 10:150-6. 2002
  8. ncbi request reprint Lipid peroxidation in neurodegeneration: new insights into Alzheimer's disease
    Sönke Arlt
    Department of Molecular Cell Biology, Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, Germany
    Curr Opin Lipidol 13:289-94. 2002
  9. doi request reprint B-spline-based stereotactical normalization of brain FDG PET scans in suspected neurodegenerative disease: impact on voxel-based statistical single-subject analysis
    Fabian Wenzel
    Digital Imaging Department, Philips Research, Hamburg, Germany
    Neuroimage 50:994-1003. 2010
  10. ncbi request reprint Detecting depression in Alzheimer's disease: evaluation of four different scales
    Tomas Müller-Thomsen
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Arch Clin Neuropsychol 20:271-6. 2005

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Genetic risk factors for depression in Alzheimer`s disease patients
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistr 52, Building W 37, 20246 Hamburg, Germany
    Curr Alzheimer Res 10:72-81. 2013
    ..The aetiology of depression in AD has not sufficiently been characterized, but biological aspects due to neurodegeneration and/ or genetic risk factors may play a plausible role and may distinguish it from common depressive disorders...
  2. doi request reprint Effect of one-year vitamin C- and E-supplementation on cerebrospinal fluid oxidation parameters and clinical course in Alzheimer's disease
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Neurochem Res 37:2706-14. 2012
    ..We conclude that supplementation with vitamins E and C did not have a significant effect on the course of AD over 1 year despite of a limited antioxidant effect that could be observed in CSF...
  3. doi request reprint Dimethylarginines, homocysteine metabolism, and cerebrospinal fluid markers for Alzheimer's disease
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Alzheimers Dis 31:751-8. 2012
    ..Functional and interventional studies are needed to further proof this hypothesis...
  4. ncbi request reprint [Lipid peroxidation as a common pathomechanism in coronary heart disease and Alzheimer disease]
    S Arlt
    Institut für Medizinische Biochemie und Molekularbiologie Abt Molekulare Zellbiologie Universitätsklinikum Hamburg Eppendorf Martinistr 52 20246 Hamburg, Germany
    Z Gerontol Geriatr 34:461-5. 2001
    ..The clinical effect of this therapeutical approach remains to be proved in long-term studies...
  5. doi request reprint Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer's disease
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Dement Geriatr Cogn Disord 26:58-64. 2008
    ..Concerning Alzheimer's disease (AD), there are reports on altered cerebral NO metabolism, but only few studies on ADMA concentrations in plasma and cerebrospinal fluid (CSF)...
  6. ncbi request reprint The patient with dementia, the caregiver and the doctor: cognition, depression and quality of life from three perspectives
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, Centre of Psychosocial Medicine, University Medical Center Hamburg Eppendorf, Germany
    Int J Geriatr Psychiatry 23:604-10. 2008
    ..In addition to the assessment of cognitive impairment, the importance of evaluating not only depressive symptoms but also health related quality of life (HRQOL) in clinical research and practice in dementia has increased...
  7. ncbi request reprint Increased lipid peroxidation in cerebrospinal fluid and plasma from patients with Creutzfeldt-Jakob disease
    Sönke Arlt
    Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Neurobiol Dis 10:150-6. 2002
    ..These results support the hypothesis that oxidative mechanisms are involved in the pathogenesis of CJD and provide a rationale for the use of antioxidants in the therapy of this disease...
  8. ncbi request reprint Lipid peroxidation in neurodegeneration: new insights into Alzheimer's disease
    Sönke Arlt
    Department of Molecular Cell Biology, Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg Eppendorf, Germany
    Curr Opin Lipidol 13:289-94. 2002
    ....
  9. doi request reprint B-spline-based stereotactical normalization of brain FDG PET scans in suspected neurodegenerative disease: impact on voxel-based statistical single-subject analysis
    Fabian Wenzel
    Digital Imaging Department, Philips Research, Hamburg, Germany
    Neuroimage 50:994-1003. 2010
    ....
  10. ncbi request reprint Detecting depression in Alzheimer's disease: evaluation of four different scales
    Tomas Müller-Thomsen
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Arch Clin Neuropsychol 20:271-6. 2005
    ..We conclude that in our study population CSDD and MADRS were the most consistent tools for detecting depression in AD independently of the severity of dementia...
  11. doi request reprint Association between FDG uptake, CSF biomarkers and cognitive performance in patients with probable Alzheimer's disease
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Nucl Med Mol Imaging 36:1090-100. 2009
    ..There is still uncertainty regarding any association between decreased FDG uptake and alterations in CSF markers...
  12. doi request reprint Association between fully automated MRI-based volumetry of different brain regions and neuropsychological test performance in patients with amnestic mild cognitive impairment and Alzheimer's disease
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Medical Center Hamburg Eppendorf, Martinistr 52, W 37, 20246 Hamburg, Germany
    Eur Arch Psychiatry Clin Neurosci 263:335-44. 2013
    ..Because of the high level of automation, MRI-based volumetry may easily be integrated into clinical routine to complement the current diagnostic procedure...
  13. pmc Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers
    Holger Jahn
    Department of Psychiatry, University Hospital Hamburg Eppendorf, Hamburg, Germany
    PLoS ONE 6:e26540. 2011
    ....
  14. ncbi request reprint Depression in Alzheimer's disease might be associated with apolipoprotein E epsilon 4 allele frequency in women but not in men
    Thomas Müller-Thomsen
    Department of Psychiatry and Psychotherapy, University of Hamburg, Germany
    Dement Geriatr Cogn Disord 14:59-63. 2002
    ..This effect remained stable in stepwise regression analysis when depression as the dependent variable was tested against the independent variables age, age of onset, duration of disease, cognitive status and years of school education...
  15. ncbi request reprint Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication
    Carsten Buhmann
    Neurological Department, University Clinic Hamburg Eppendorf, D 20246 Hamburg, Germany
    Neurobiol Dis 15:160-70. 2004
    ..These data support the concept of oxidative stress as a factor in the pathogenesis of PD and might be an indicator of a potential prooxidative role of LD and a possible antioxidative effect of DA in PD treatment...
  16. ncbi request reprint Pharmacological treatment of non-Alzheimer dementias
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, University Hospital Hamburg Eppendorf UKE, Hamburg, Germany
    Curr Opin Psychiatry 19:642-8. 2006
    ..Millions of patients, however, suffer from other dementias and search for help beyond diagnosis...
  17. doi request reprint Adherence to medication in patients with dementia: predictors and strategies for improvement
    Sönke Arlt
    Department of Psychiatry and Psychotherapy, Centre of Psychosocial Medicine, University Clinic Hamburg Eppendorf, Hamburg, Germany
    Drugs Aging 25:1033-47. 2008
    ..However, comprehensive assessment of the individual patient and careful consideration of all potential drug-related problems will probably help facilitate adherence and prevent compromised health outcomes in patients with dementia...
  18. doi request reprint Prevention and treatment options for postoperative delirium in the elderly
    Julius Popp
    Department of Psychiatry, Division of Old Age Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland
    Curr Opin Psychiatry 25:515-21. 2012
    ..To review recent findings and developments in strategies for prevention and treatment of postoperative delirium...