Thomas Arendt

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Expression of cell cycle-related proteins in developing and adult mouse hippocampus
    Stefanie Schmetsdorf
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Int J Dev Neurosci 23:101-12. 2005
  2. pmc Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress
    A Suttkus
    University of Leipzig, Department for Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research, Jahnallee 59, Leipzig 04109, Germany
    Cell Death Dis 5:e1119. 2014
  3. doi request reprint Neuronal plasticity in hibernation and the proposed role of the microtubule-associated protein tau as a "master switch" regulating synaptic gain in neuronal networks
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Universitat Leipzig, Germany
    Am J Physiol Regul Integr Comp Physiol 305:R478-89. 2013
  4. pmc Neuronal aneuploidy in health and disease: a cytomic approach to understand the molecular individuality of neurons
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, University of Leipzig, Germany
    Int J Mol Sci 10:1609-27. 2009
  5. doi request reprint Cell cycle activation and aneuploid neurons in Alzheimer's disease
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Universitat Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Mol Neurobiol 46:125-35. 2012
  6. ncbi request reprint Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109, Leipzig, Germany
    Prog Neurobiol 71:83-248. 2003
  7. ncbi request reprint Neuronal activation of Ras regulates synaptic connectivity
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, D 04109 Leipzig, Germany
    Eur J Neurosci 19:2953-66. 2004
  8. ncbi request reprint Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals
    Thomas Arendt
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Neurosci 23:6972-81. 2003
  9. ncbi request reprint Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease
    T Arendt
    Department of Neuranatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, D 04109, Leipzig, Germany
    Int J Dev Neurosci 19:231-45. 2001
  10. ncbi request reprint Neurodegeneration and plasticity
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, Jahnallee 59, D 04109 Leipzig, Germany
    Int J Dev Neurosci 22:507-14. 2004

Detail Information

Publications125 found, 100 shown here

  1. ncbi request reprint Expression of cell cycle-related proteins in developing and adult mouse hippocampus
    Stefanie Schmetsdorf
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Int J Dev Neurosci 23:101-12. 2005
    ..Thus, they may have supplementary functions in differentiated neurons that might be associated with neuronal plasticity...
  2. pmc Aggrecan, link protein and tenascin-R are essential components of the perineuronal net to protect neurons against iron-induced oxidative stress
    A Suttkus
    University of Leipzig, Department for Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research, Jahnallee 59, Leipzig 04109, Germany
    Cell Death Dis 5:e1119. 2014
    ....
  3. doi request reprint Neuronal plasticity in hibernation and the proposed role of the microtubule-associated protein tau as a "master switch" regulating synaptic gain in neuronal networks
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Universitat Leipzig, Germany
    Am J Physiol Regul Integr Comp Physiol 305:R478-89. 2013
    ..If this condition lasts too long, however, it may eventually turn into a pathological trigger, driving a cascade of events leading to neurodegeneration, as in Alzheimer's disease or other "tauopathies". ..
  4. pmc Neuronal aneuploidy in health and disease: a cytomic approach to understand the molecular individuality of neurons
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, University of Leipzig, Germany
    Int J Mol Sci 10:1609-27. 2009
    ....
  5. doi request reprint Cell cycle activation and aneuploid neurons in Alzheimer's disease
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Universitat Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Mol Neurobiol 46:125-35. 2012
    ..It defines a molecular signature for neuronal vulnerability and directs our attention to a failure of neuronal differentiation control as a critical pathogenetic event and potential therapeutic target in AD...
  6. ncbi request reprint Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109, Leipzig, Germany
    Prog Neurobiol 71:83-248. 2003
    ..Preventing cell cycle activation by locking neurons in a differentiated but still highly plastic phenotype will, thus, be crucial to prevent neurodegeneration...
  7. ncbi request reprint Neuronal activation of Ras regulates synaptic connectivity
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, D 04109 Leipzig, Germany
    Eur J Neurosci 19:2953-66. 2004
    ..We conclude that neuronal Ras is a common switch of plasticity in adult mammalian brain sculpturing neuronal architecture and synaptic connectivity in concert with tuning synaptic efficacy...
  8. ncbi request reprint Reversible paired helical filament-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals
    Thomas Arendt
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Neurosci 23:6972-81. 2003
    ..Hibernation will, therefore, be a valuable model to study the regulation of PHF-like tau-phosphorylation and its cell biological sequelae under physiological in vivo conditions...
  9. ncbi request reprint Disturbance of neuronal plasticity is a critical pathogenetic event in Alzheimer's disease
    T Arendt
    Department of Neuranatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, D 04109, Leipzig, Germany
    Int J Dev Neurosci 19:231-45. 2001
    ..Mechanisms of molecular and cellular control of neuronal differentiation and proliferation might, thus, not only play a role during development but critically involved in the pathogenesis of neurodegeneration...
  10. ncbi request reprint Neurodegeneration and plasticity
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, Jahnallee 59, D 04109 Leipzig, Germany
    Int J Dev Neurosci 22:507-14. 2004
    ..These findings implicate an essential link between neuronal plasticity and PHF-like phosphorylation of tau, potentially involved in neurofibrillary degeneration...
  11. pmc Selective cell death of hyperploid neurons in Alzheimer's disease
    Thomas Arendt
    D Sc, University of Leipzig, Paul Flechsig Institute for Brain Research Jahnallee 59, 04109 Leipzig, Germany
    Am J Pathol 177:15-20. 2010
    ..Hyperploidy of neurons thus represents a direct molecular signature of cells prone to death in AD and indicates that a failure of neuronal differentiation is a critical pathogenetic event in AD...
  12. ncbi request reprint Activated mitogenic signaling induces a process of dedifferentiation in Alzheimer's disease that eventually results in cell death
    T Arendt
    Paul Flechsig Institute for Brain Research, Department of Neuroanatomy, University of Leipzig, 04109 Leipzig, Germany
    Ann N Y Acad Sci 920:249-55. 2000
    ..This hypothesis might be of heuristic value for the development of a therapeutic strategy...
  13. ncbi request reprint Alzheimer's disease as a disorder of dynamic brain self-organization
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Prog Brain Res 147:355-78. 2005
    ..Preventing cell cycle activation by locking neurons in a differentiated but still highly plastic phenotype will, thus, be crucial to prevent neurodegeneration...
  14. ncbi request reprint Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization
    T Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109, Leipzig, Germany
    Neuroscience 102:723-65. 2001
    ....
  15. doi request reprint Synaptic degeneration in Alzheimer's disease
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Acta Neuropathol 118:167-79. 2009
    ..The molecular mechanisms involved in cell cycle activation might, thus, link aberrant synaptic changes to cell death...
  16. ncbi request reprint Alzheimer's disease as a loss of differentiation control in a subset of neurons that retain immature features in the adult brain
    T Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109, Leipzig, Germany
    Neurobiol Aging 21:783-96. 2000
    ..Cell-cycle and differentiation control might thus provide the link between structural brain self-organization and neurodegeneration that both are unique to human...
  17. ncbi request reprint Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity
    Thomas Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Biochim Biophys Acta 1772:413-21. 2007
    ..This might result in cell cycle activation, DNA-replication and de-repression of apoptotic programmes. ORC subunits might, thus, provide a direct molecular link between synaptic plasticity, DNA replication and cell death...
  18. doi request reprint A putative role for cell cycle-related proteins in microtubule-based neuroplasticity
    Stefanie Schmetsdorf
    Paul Flechsig Institute for Brain Research, Department for Molecular and Cellular Mechanisms of Neurodegeneration, University of Leipzig, Leipzig, Germany
    Eur J Neurosci 29:1096-107. 2009
    ....
  19. ncbi request reprint Activation of Ras in neurons modifies synaptic vesicle docking and release
    Gudrun Seeger
    Paul Flechsig Institute for Brain Research, Department of Neuroanatomy, University Leipzig, D 04109 Leipzig, Germany
    Neuroreport 15:2651-4. 2004
    ..We, therefore, conclude that neuronal Ras activity contributes to the regulation of synaptic plasticity in adult mammalian brain at the presynaptic level...
  20. doi request reprint Transcriptional control of cell cycle-dependent kinase 4 by Smad proteins--implications for Alzheimer's disease
    Uwe Ueberham
    Department for Molecular and Cellular Mechanisms of Neurodegeneration, Universitat Leipzig, Paul Flechsig Institute of Brain Research, Leipzig, D 04109, Jahnallee 59, Germany
    Neurobiol Aging 33:2827-40. 2012
    ..The results identify Smad proteins as direct transcriptional regulators of Cdk4 and add further evidence to a Smad-dependent deregulation of Cdk4 in AD, giving rise to neuronal dedifferentiation and cell death...
  21. ncbi request reprint Constitutive expression of p21H-ras(Val12) in pyramidal neurons results in reorganization of mouse neocortical afferents
    Alan Alpar
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Neurobiol 60:263-74. 2004
    ..Moreover, expression of p21H-ras(Val12) in pyramidal cells induces an enhanced establishment of efferent boutons...
  22. ncbi request reprint Hibernation model of tau phosphorylation in hamsters: selective vulnerability of cholinergic basal forebrain neurons - implications for Alzheimer's disease
    Wolfgang Hartig
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Eur J Neurosci 25:69-80. 2007
    ..This indicates a more general link between PHF-like phosphorylation of tau and the adaptation of neurons under conditions of a 'vita minima'...
  23. doi request reprint FAD-mutation of APP is associated with a loss of its synaptotrophic activity
    Gudrun Seeger
    Department for Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, Leipzig D 04109, Germany
    Neurobiol Dis 35:258-63. 2009
    ..This suggests that not only "too much Abeta" but also "too less functional intact APP" might be relevant for synaptic pathology and degeneration in AD...
  24. ncbi request reprint Constitutive Ras activity induces hippocampal hypertrophy and remodeling of pyramidal neurons in synRas mice
    Ulrich Gärtner
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany
    J Neurosci Res 77:630-41. 2004
    ..The data presented here suggest a critical involvement of Ras dependent signaling in morphoregulatory processes during the maturation and in the maintenance of hippocampal pyramidal neurons...
  25. ncbi request reprint Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease
    Birgit Mosch
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, D 04109 Leipzig, Germany
    J Neurosci 27:6859-67. 2007
    ..It is, however, not elevated in AD. In addition, in AD some neurons have re-entered the cell cycle and entirely passed through a functional interphase with a complete DNA replication...
  26. ncbi request reprint Amyloid deposition in APP23 mice is associated with the expression of cyclins in astrocytes but not in neurons
    Ulrich Gärtner
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, 04109, Leipzig, Germany
    Acta Neuropathol 106:535-44. 2003
    ..The results support the assumption that the neuronal re-expression of cell cycle components in AD is not a consequence of Abeta formation and deposition...
  27. ncbi request reprint Differentially expressed cortical genes contribute to perivascular deposition in transgenic mice with inducible neuron-specific expression of TGF-beta1
    Uwe Ueberham
    Paul Flechsig Institute for Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Int J Dev Neurosci 24:177-86. 2006
    ..It is suggested, that these genes might contribute to the perivascular depositions in the TGF-beta1 expressing mice...
  28. doi request reprint Perineuronal nets are largely unaffected in Alzheimer model Tg2576 mice
    Markus Morawski
    Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Neurobiol Aging 31:1254-6. 2010
    ..We conclude that the aggrecan-based extracellular matrix of PNs is not enzymatically altered in peripheral plaque territories and is only removed after neuronal death...
  29. ncbi request reprint Inducible neuronal expression of transgenic TGF-beta1 in vivo: dissection of short-term and long-term effects
    Uwe Ueberham
    Paul Flechsig Institute for Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Eur J Neurosci 22:50-64. 2005
    ..Neuroprotective effects were observed after short-term expression of TGF-beta1. Death of striatal neurons induced by 3-nitropropionic acid was markedly reduced after induced TGF-beta1 expression...
  30. ncbi request reprint Expression of the embryonal isoform (0N/3R) of the microtubule-associated protein tau in the adult rat central nervous system
    Torsten Bullmann
    Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, 04109 Leipzig, Germany
    J Comp Neurol 518:2538-53. 2010
    ..The retention of a juvenile phenotype in some neurons might be associated with a functionally significant neuronal plasticity...
  31. ncbi request reprint Enhanced Ras activity in pyramidal neurons induces cellular hypertrophy and changes in afferent and intrinsic connectivity in synRas mice
    Ulrich Gärtner
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Int J Dev Neurosci 22:165-73. 2004
    ..It is concluded that expression of Val12-Ha-Ras in pyramidal neurons results in remodelling of neocortical structuring which strongly implicates a crucial involvement of Ras in cortical plasticity...
  32. doi request reprint Pattern of tau isoforms expression during development in vivo
    Torsten Bullmann
    Paul Flechsig Institute of Brain Research, Department of Cellular and Molecular Mechanisms of Neurodegeneration, University of Leipzig, Jahnallee 59, 04019 Leipzig, Germany
    Int J Dev Neurosci 27:591-7. 2009
    ..The tau isoform shift shows an apparent disconnect to neurogenesis, migration and volume growth, but coincides with the formation of synapses and the appearance of stable microtubules...
  33. doi request reprint Smad2 isoforms are differentially expressed during mouse brain development and aging
    Uwe Ueberham
    Department for Molecular and Cellular Mechanisms of Neurodegeneration, University of Leipzig, Paul Flechsig Institute of Brain Research, Leipzig 04109, Germany
    Int J Dev Neurosci 27:501-10. 2009
    ..Moreover, Smad2(Deltaexon3) predominates in the nuclear fraction of neurons, suggesting special function during brain differentiation. Our data indicate that there may be a specific role for Smad2(Deltaexon3) in neurons...
  34. ncbi request reprint Inverse association of Pin1 and tau accumulation in Alzheimer's disease hippocampus
    Max Holzer
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Acta Neuropathol 104:471-81. 2002
    ..Granular accumulation of Pin1 may correspond to an absence of neurofibrillary lesions in these cells and might be associated with other mechanisms of neuronal degeneration...
  35. pmc The physiological link between metabolic rate depression and tau phosphorylation in mammalian hibernation
    Jens T Stieler
    Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    PLoS ONE 6:e14530. 2011
    ....
  36. doi request reprint Transgenic expression of human wild-type amyloid precursor protein decreases neurogenesis in the adult hippocampus
    Nicole Naumann
    Institute of Biology II, Universitat Leipzig, Leipzig, Germany
    Hippocampus 20:971-9. 2010
    ..In summary, the results reveal a dual effect of APP on adult hippocampal neurogenesis, comprising antiproliferative and prosurvival activities...
  37. ncbi request reprint Age- and stage-dependent accumulation of advanced glycation end products in intracellular deposits in normal and Alzheimer's disease brains
    Hans Joachim Lüth
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Cereb Cortex 15:211-20. 2005
    ..Many, but not all, neurons show a co-localization of AGEs with other markers of neurodegeneration, such as nNOS and caspase-3...
  38. ncbi request reprint Immunochemical crossreactivity of antibodies specific for "advanced glycation endproducts" with "advanced lipoxidation endproducts"
    Torsten Richter
    Neuroimmunological Cell Biology Unit, Interdisciplinary Center of Clinical Research IZKF, Leipzig, Germany
    Neurobiol Aging 26:465-74. 2005
    ..In conclusion, AGE-antibodies might not only detect sugar-derived AGEs but also structures derived from lipid peroxidation products (serving as markers of oxidative stress)...
  39. doi request reprint Changes in neuronal DNA content variation in the human brain during aging
    Hans Georg Fischer
    Paul Flechsig Institute for Brain Research, Universitat Leipzig, Germany
    Aging Cell 11:628-33. 2012
    ..Alternatively, a potential selection bias of "healthy aging brains" needs to be considered, assuming that DNA content variation above a certain threshold associates with Alzheimer's disease...
  40. ncbi request reprint Simultaneous detection of tau phospho-epitopes with haptenylated antibodies
    Wolfgang Hartig
    Paul Flechsig Institute for Brain Research, University of Leipzig, Germany
    Neuroreport 17:869-74. 2006
    ....
  41. ncbi request reprint Adaptive morphological changes of neocortical interneurons in response to enlarged and more complex pyramidal cells in p21H-Ras(Val12) transgenic mice
    Alan Alpar
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    Brain Res Bull 62:335-43. 2004
    ..The findings of the present study demonstrate the morphogenetic capacity of interneurons for adapting to morphological alterations of principal neurons in the cerebral cortex...
  42. ncbi request reprint Constitutive expression of functionally active cyclin-dependent kinases and their binding partners suggests noncanonical functions of cell cycle regulators in differentiated neurons
    Stefanie Schmetsdorf
    Paul Flechsig Institute for Brain Research, Department of Neuroanatomy, University of Leipzig, 04109 Leipzig, Germany
    Cereb Cortex 17:1821-9. 2007
    ....
  43. doi request reprint RVG peptide as transfection reagent for specific cdk4 gene silencing in vitro and in vivo
    Susanne Rohn
    Department for Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, Universitat Leipzig, Leipzig, Germany
    J Drug Target 20:381-8. 2012
    ....
  44. ncbi request reprint Expression of embryonic tau protein isoforms persist during adult neurogenesis in the hippocampus
    Torsten Bullmann
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    Hippocampus 17:98-102. 2007
    ..A model for studying shifts in tau isoform expression in a defined subset of neurons might help to understand the etiology of tauopathies, when isoform composition is crucial for neurodegeneration, as in Pick's disease or FTDP-17...
  45. ncbi request reprint Structural correlates of mild cognitive impairment
    Henrike Wolf
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Neurobiol Aging 25:913-24. 2004
    ..Widespread brain atrophy may be the step to determine the transition from MCI to dementia. Brain volume reserve effects appear to be involved in both of these steps...
  46. ncbi request reprint Morphometry of the amygdala in patients with questionable dementia and mild dementia
    Anke Hensel
    Department of Psychiatry, University of Leipzig, Germany
    J Neurol Sci 238:71-4. 2005
    ..There was no significant correlation between the longitudinal annual change in MMSE and the baseline amygdala volume in any of the three groups...
  47. pmc Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease
    Markus Morawski
    University of Leipzig, Leipzig, Germany
    Acta Neuropathol 120:195-207. 2010
    ..Our results may explain the high vulnerability of defined subcortical neuronal populations and their central target areas in AD as a consequence of QC expression and pE-Abeta formation...
  48. ncbi request reprint Altered subcellular location of phosphorylated Smads in Alzheimer's disease
    Uwe Ueberham
    Paul Flechsig Institute for Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Eur J Neurosci 24:2327-34. 2006
    ..Our data suggest a critical role of Smad proteins in the pathogenesis of AD...
  49. ncbi request reprint Perineuronal nets in the rhesus monkey and human basal forebrain including basal ganglia
    I Adams
    Paul Flechsig Institute for Brain Research, University of Leipzig, Germany
    Neuroscience 108:285-98. 2001
    ..The absence of nets around cholinergic basal forebrain neurons may be related to their slow modulatory activity but may also contribute to their susceptibility to degeneration in Alzheimer's disease...
  50. ncbi request reprint Perineuronal nets potentially protect against oxidative stress
    Markus Morawski
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D 04109, Germany
    Exp Neurol 188:309-15. 2004
    ....
  51. pmc Involvement of perineuronal and perisynaptic extracellular matrix in Alzheimer's disease neuropathology
    Markus Morawski
    Paul Flechsig Institute of Brain Research, Faculty of Medicine, Universitat Leipzig, Germany
    Brain Pathol 22:547-61. 2012
    ..We conclude that the loss of brevican is associated with the loss of synapses, whereas PNs and related matrix components resist disintegration and may protect neurons from degeneration...
  52. ncbi request reprint Enhanced Ras activity promotes spine formation in synRas mice neocortex
    Ulrich Gärtner
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Neuroreport 16:149-52. 2005
    ..The proportions of different morphological types of spines remained unchanged. It is concluded that Ras might be critically involved in mechanisms that mediate and regulate dendritic spine formation in the adult brain...
  53. ncbi request reprint Constitutive expression of p21H-Ras(Val12) in neurons induces increased axonal size and dendritic microtubule density in vivo
    Gudrun Seeger
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    J Neurosci Res 74:868-74. 2003
    ..The present results extend previous findings on neuronal hypertrophy as a consequence of p21H-RasVal12 expression and suggest a profound influence on the dendritic microtubule network...
  54. doi request reprint Cytotoxicity of advanced glycation endproducts in human micro- and astroglial cell lines depends on the degree of protein glycation
    Katrin Bigl
    Interdisciplinary Centre of Clinical Research IZKF, Faculty of Medicine, University of Leipzig, Inselstr 22, 04103, Leipzig, Germany
    J Neural Transm 115:1545-56. 2008
    ..This indicates that apoptotic events may be involved in the change of physiological parameters...
  55. ncbi request reprint PHF-like tau phosphorylation in mammalian hibernation is not associated with p25-formation
    Jens Thorsten Stieler
    Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, 04109, Leipzig, Germany
    J Neural Transm 116:345-50. 2009
    ..Instead we suggest that the truncation of p35 to p25 represents a characteristic of pathological alterations and may contribute to aggregation and deposition of hyperphosphorylated tau...
  56. doi request reprint Chondroitin sulfate proteoglycan-based extracellular matrix in chicken (Gallus domesticus) brain
    Markus Morawski
    Paul Flechsig Institute of Brain Research, Faculty of Medicine, University of Leipzig, Germany
    Brain Res 1275:10-23. 2009
    ..The early appearance of perineuronal nets in the precocial birds' brain is probably due to the rapid establishment of neuronal morphology and function which is required for the immediate functional and behavioural performance of chicken...
  57. ncbi request reprint Serum lipids and hippocampal volume: the link to Alzheimer's disease?
    Henrike Wolf
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Ann Neurol 56:745-8. 2004
    ..This is compatible with protective effects of high-density lipoprotein cholesterol on hippocampal atrophy and Alzheimer's disease...
  58. ncbi request reprint Reelin-immunoreactive Cajal-Retzius cells: the entorhinal cortex in normal aging and Alzheimer's disease
    Anett Riedel
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Acta Neuropathol 106:291-302. 2003
    ..Nevertheless, CR cells seem to be partially affected by the formation of paired helical filaments, indicating subtle changes that are suggested to be a result rather than a cause of the pathogenetic cascade of AD...
  59. doi request reprint On the quantification of intracellular proteins in multifluorescence-labeled rat brain slices using slide-based cytometry
    Anja Reinert
    Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute for Brain Research, Faculty of Medicine, University of Leipzig, Germany
    Cytometry A 79:485-91. 2011
    ..Using this novel method, we were able to detect a relative difference in protein concentration as low as 12% between the two subpopulations of neurons in the neuronal population of the rat parietal cortex...
  60. ncbi request reprint Correlation between cortical theta activity and hippocampal volumes in health, mild cognitive impairment, and mild dementia
    M Grunwald
    University of Leipzig, Department of Psychiatry, EEG-Research Laboratory and Memory Clinic, Leipzig, Germany
    J Clin Neurophysiol 18:178-84. 2001
    ..The results support the assumption about a relationship between hippocampal atrophy and theta power, and may be helpful for a better understanding of the course of Alzheimer's disease...
  61. ncbi request reprint Methylglyoxal, glyoxal, and their detoxification in Alzheimer's disease
    Björn Kuhla
    Interdisciplinary Centre of Clinical Research IZKF, Neuroimmunological Cell Biology Unit, University of Leipzig, Inselstrasse 22, D 04103 Leipzig, Germany
    Ann N Y Acad Sci 1043:211-6. 2005
    ..Our findings suggest that glyoxalase I is upregulated in AD in a compensatory manner to maintain physiological methylglyoxal and glyoxal levels...
  62. ncbi request reprint Degeneration of beta-amyloid-associated cholinergic structures in transgenic APP SW mice
    Hans Joachim Lüth
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Brain Res 977:16-22. 2003
    ....
  63. pmc Tau oligomers impair artificial membrane integrity and cellular viability
    Katharina Flach
    Department of Molecular and Cellular Mechanisms of Neurodegeneration, Paul Flechsig Institute of Brain Research, Faculty of Medicine, Jahnallee 59, University of Leipzig, 04109 Leipzig, Germany
    J Biol Chem 287:43223-33. 2012
    ..Our data integrate Tau protein into the class of amyloidogenic proteins and enforce the hypothesis of a common toxicity-mediating mechanism for amyloidogenic proteins...
  64. ncbi request reprint The expression of cell cycle proteins in neurons and its relevance for Alzheimer's disease
    Uwe Ueberham
    Paul Flechsig Institute for Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Curr Drug Targets CNS Neurol Disord 4:293-306. 2005
    ..Here we attempt to summarise recent evidence for a dysfunction of cell cycle regulators in Alzheimer's disease, considering the potential functions of these molecules beyond cell cycle regulation...
  65. ncbi request reprint Laser scanning cytometry in human brain slices
    Birgit Mosch
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    Cytometry A 69:135-8. 2006
    ..The Laser Scanning Cytometry (LSC) offers quantitative fluorescence analysis of cell suspensions and tissue sections...
  66. doi request reprint The cholinergic system in aging and neuronal degeneration
    Reinhard Schliebs
    Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    Behav Brain Res 221:555-63. 2011
    ..Therefore, an early onset of an anti β-amyloid strategy may additionally be potential in preventing aging-associated cholinergic deficits and cognitive impairments...
  67. ncbi request reprint Complementary distribution of vesicular glutamate transporters 1 and 2 in the nucleus accumbens of rat: Relationship to calretinin-containing extrinsic innervation and calbindin-immunoreactive neurons
    Wolfgang Hartig
    Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Comp Neurol 465:1-10. 2003
    ....
  68. ncbi request reprint Activation of mitogen-activated protein kinase cascade and phosphorylation of cytoskeletal proteins after neurone-specific activation of p21ras. II. Cytoskeletal proteins and dendritic morphology
    M Holzer
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, Germany
    Neuroscience 105:1041-54. 2001
    ..However, further studies on aged transgenic mice will be necessary to establish potential effects on neuronal viability...
  69. ncbi request reprint Cell cycle related signaling in Neuro2a cells proceeds via the receptor for advanced glycation end products
    A Schmidt
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Leipzig, Germany
    J Neural Transm 114:1413-24. 2007
    ..Our results demonstrate that S100B and AGE may serve as mitogenic sources for the stimulation of neurons to progress through the cell cycle whereby signaling proceeds via RAGE --> p42/44 MAPK --> cyclin D(1)/cdk4...
  70. ncbi request reprint Expression of constitutively active p21H-rasval12 in postmitotic pyramidal neurons results in increased dendritic size and complexity
    Alan Alpar
    Department of Neuroanatomy, Paul Flechsig Institut for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Comp Neurol 467:119-33. 2003
    ..The data presented here suggest an important role of p21Ras-dependent signaling in the final differentiation and maintenance of dendritic morphology...
  71. ncbi request reprint Hyperphosphorylated protein tau is restricted to neurons devoid of perineuronal nets in the cortex of aged bison
    W Hartig
    University of Leipzig, Paul Flechsig Institute for Brain Research, Jahnallee 59, 04109 Leipzig, Germany
    Neurobiol Aging 22:25-33. 2001
    ..In conclusion, the low susceptibility of different types of neurons to the abnormal phosphorylation of tau corresponds to high proportions of certain chondroitin sulphate proteoglycans in their microenvironment...
  72. ncbi request reprint Electron microscopic evidence for different myelination of rat septohippocampal fibres
    U Gartner
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Germany
    Neuroreport 12:17-20. 2001
    ..It can be concluded that differences in conduction velocities, presence or absence of myelin sheaths and differences axonal diameters are correlated in the septohippocampal pathway...
  73. doi request reprint Multivariate analysis of differential lymphocyte cell cycle activity in Alzheimer's disease
    Jens Stieler
    Paul Flechsig Institute for Brain Research, University of Leipzig, Germany
    Neurobiol Aging 33:234-41. 2012
    ..Present findings suggest that with further development this analytical and multivariate modeling procedure could aid the current differential diagnosis of Alzheimer's disease...
  74. ncbi request reprint Comparison of results of the CellTiter Blue, the tetrazolium (3-[4,5-dimethylthioazol-2-yl]-2,5-diphenyl tetrazolium bromide), and the lactate dehydrogenase assay applied in brain cells after exposure to advanced glycation endproducts
    Katrin Bigl
    Interdisciplinary Centre of Clinical Research IZKF, University of Leipzig, Inselstr 22, 04103 Leipzig, Germany
    Toxicol In Vitro 21:962-71. 2007
    ..To gain a deeper understanding of the cellular responses after exposure of cells to AGEs, the present study compares results obtained when using the CTB, the MTT or the LDH assay in identically AGE treated cells...
  75. ncbi request reprint Oval cell proliferation in p16INK4a expressing mouse liver is triggered by chronic growth stimuli
    Elke Ueberham
    Institute of Biochemistry, University of Leipzig, Medical Faculty, Leipzig, Germany
    J Cell Mol Med 12:622-38. 2008
    ..We could show that the liver specific expression of p16(INK4a) leads to a faster differentiation of hepatocytes and an activation of oval cells already in postnatal mice without negative consequences on liver function...
  76. doi request reprint An inexpensive technique for dot blotting in a 96-well format
    Mario Lange
    Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    Anal Biochem 398:129-31. 2010
    ..Dots produced by this technique were applied to reproducible immunoquantification of proteins such as beta-actin and doublecortin...
  77. ncbi request reprint Cyclin C expression is involved in the pathogenesis of Alzheimer's disease
    Uwe Ueberham
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D 04109, Leipzig, Germany
    Neurobiol Aging 24:427-35. 2003
    ..Colocalization of cyclin C and its preferred binding partner, Cdk8, was only observed in astrocytes but not in neurons. The present observations suggest different cellular functions of cyclin C in neurons and astrocytes in AD...
  78. ncbi request reprint Theta-power differences in patients with mild cognitive impairment under rest condition and during haptic tasks
    Martin Grunwald
    University of Leipzig, Department of Psychiatry, EEG Research Laboratory and Memory Clinic, Leipzig, Germany
    Alzheimer Dis Assoc Disord 16:40-8. 2002
    ..The results show that haptic tasks are sensitive to early perceptive-cognitive and functional deficits in patients with MCI...
  79. ncbi request reprint Tau gene (MAPT) sequence variation among primates
    Max Holzer
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Gene 341:313-22. 2004
    ..Sequencing of Saitohin revealed an intact open reading frame in chimpanzee and gorilla, but not in gibbon or macaque...
  80. ncbi request reprint [Galantamine, an acetylcholinesterase inhibitor with various actions]
    Clemens Allgaier
    Rudolf Böhm Institut für Pharmakologie und Toxikologie der Universität Leipzig
    Med Monatsschr Pharm 27:223-7. 2004
  81. ncbi request reprint Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells
    Björn Kuhla
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Neurosci Res 83:1591-600. 2006
    ..In summary, our data suggest that a reduced glyoxalase I activity mimics some changes associated with neurodegeneration, such as neurite retraction and apoptotic cell death...
  82. ncbi request reprint Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation
    Hans Joachim Lüth
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Brain Res 953:135-43. 2002
    ..In view of the wide range of isoform-specific NOS inhibitors, the determination of the most responsible isoform of NOS for the formation of peroxynitrite in AD could be of therapeutic importance in the treatment of Alzheimer's disease...
  83. ncbi request reprint Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology
    H J Lüth
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Brain Res 913:57-67. 2001
    ....
  84. ncbi request reprint Association between global brain volume and the rate of cognitive change in elderly humans without dementia
    A Hensel
    Karolinska Institute, Neurotec, Division of Clinical Geriatrics, Huddinge University Hospital, Stockholm, Sweden
    Dement Geriatr Cogn Disord 19:213-21. 2005
    ..Global brain volume, grey matter volume and white matter volume were the only significant independent predictors of the rate of cognitive change...
  85. ncbi request reprint Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer's disease
    A Wong
    Neuroimmunological Cell Biology, IZKF Leipzig, Johannisallee 30a, 04103, Leipzig, Germany
    Brain Res 920:32-40. 2001
    ..Hence activation of microglia and astrocytes by AGEs with subsequent oxidative stress and cytokine release may be an important progression factor in AD...
  86. ncbi request reprint Immunofluorescence and immunoelectron microscopic evidence for differences in myelination of GABAergic and cholinergic septohippocampal fibres
    U Gartner
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D 04109, Leipzig, Germany
    Int J Dev Neurosci 19:347-52. 2001
    ..Accordingly, our results are correlated with the well-known differences in conduction velocities between the GABAergic and cholinergic fibres of the septohippocampal pathway, which depend on myelination and axon calibre...
  87. ncbi request reprint Modulation of APP processing and secretion by okadaic acid in primary guinea pig neurons
    M Holzer
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Federal Republic of Germany
    J Neural Transm 107:451-61. 2000
    ..These results show that OA treatment of guinea pig primary cultures might be used as a model to study the effects of modulation of signal transduction on secretion and processing of APP...
  88. doi request reprint Aggrecan-based extracellular matrix shows unique cortical features and conserved subcortical principles of mammalian brain organization in the Madagascan lesser hedgehog tenrec (Echinops telfairi Martin, 1838)
    M Morawski
    Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Neuroscience 165:831-49. 2010
    ....
  89. ncbi request reprint Activation of mitogen-activated protein kinase cascade and phosphorylation of cytoskeletal proteins after neurone-specific activation of p21ras. I. Mitogen-activated protein kinase cascade
    M Holzer
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, Germany
    Neuroscience 105:1031-40. 2001
    ..Activity of p70S6 kinase was unaltered. The present model might be useful to study the effects of activation of the MAPK cascade on tau phosphorylation and its cell biological sequelae...
  90. doi request reprint Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease
    M Morawski
    Department of Molecular and Cellular Mechanisms of Neurodegeneration, Medical Faculty, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Neuroscience 169:1347-63. 2010
    ..The aggrecan-based extracellular matrix of PNs may thus, be involved in neuroprotection...
  91. ncbi request reprint Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly
    H Wolf
    Department of Psychiatry, University of Leipzig, Leipzig, Germany
    Neurobiol Aging 22:177-86. 2001
    ..We conclude that hippocampal atrophy is sensitive to detect cognitive dysfunction and subjects at risk for Alzheimer's disease in the elderly population...
  92. ncbi request reprint Aggrecan-based extracellular matrix is an integral part of the human basal ganglia circuit
    G Bruckner
    Paul Flechsig Institute for Brain Research, Department of Neuroanatomy, Medical Faculty, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Neuroscience 151:489-504. 2008
    ....
  93. ncbi request reprint Guinea-pig primary cell cultures provide a model to study expression and amyloidogenic processing of endogenous amyloid precursor protein
    M Beck
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Germany
    Neuroscience 95:243-54. 2000
    ..It should be especially useful in screening experiments for secretase inhibiting compounds...
  94. ncbi request reprint Synergistic effects of tetrahydroaminoacridine and lithium on cholinergic function after excitotoxic basal forebrain lesions in rat
    T Arendt
    Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Germany
    Pharmacopsychiatry 32:242-7. 1999
    ..Similar approaches of combination therapy might prove useful for the management of mental disorders associated with cholinergic dysfunction...
  95. ncbi request reprint Two distinct populations of cholinergic neurons in the septum of raccoon (Procyon lotor): evidence for a separate subset in the lateral septum
    K Brauer
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    J Comp Neurol 412:112-22. 1999
    ..Brain Res [1990] 533:165-170) in the ventrolateral septal region of rat and monkey. Their participation in the functions of the lateral septum remains to be elucidated...
  96. ncbi request reprint NGF increases cell survival rates under serum deprived conditions
    H Knüpfer
    University Leipzig, Paul Flechsig Institute for Brain Research, Department of Neuroanatomy, Germany
    Anticancer Res 21:2797-802. 2001
    ....
  97. ncbi request reprint Phosphorylation of the tau protein sequence 199-205 in the hippocampal CA3 region of Syrian hamsters in adulthood and during aging
    W Hartig
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    Brain Res 1056:100-4. 2005
    ..Furthermore, the presented data allow analyses whether tau phosphorylation is reversible in these facultative hibernators and versatile laboratory animal as it was recently shown for the hibernation cycle of European ground squirrels...
  98. pmc Morphometry of the corpus callosum in patients with questionable and mild dementia
    A Hensel
    Memory Clinic, Department of Psychiatry, University of Leipzig, Emilienstrasse 14, 04107 Leipzig, Germany
    J Neurol Neurosurg Psychiatry 73:59-61. 2002
    ..The severity of white matter changes did not differ between the groups...
  99. ncbi request reprint Phosphorylation of tau, Abeta-formation, and apoptosis after in vivo inhibition of PP-1 and PP-2A
    T Arendt
    Paul Flechsig Institute of Brain Research, Department of Neuroanatomy, University of Leipzig, Germany
    Neurobiol Aging 19:3-13. 1998
    ..It is hypothesized that perturbations of the axonal transport might also be critically involved in the formation of paired helical filaments and amyloid deposits in Alzheimer's disease...
  100. ncbi request reprint Different myelination of rat septohippocampal fibres as revealed by immunofluorescence double-labelling
    K Brauer
    Department of Neuroanatomy, Paul Flechsig Institute for Brain Research, University of Leipzig, D 04109 Leipzig, Germany
    Brain Res 878:188-93. 2000
    ..Accordingly, our results confirm the expectation that conduction velocities and presence or absence of myelin sheaths are also correlated in the septohippocampal pathway...
  101. ncbi request reprint The significance of the cholinergic system in the brain during aging and in Alzheimer's disease
    R Schliebs
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany
    J Neural Transm 113:1625-44. 2006
    ....