H Arai

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi [Your help is needed! Autopsy brings new knowledge regarding Alzheimer dementia]
    K Burger
    Psychiatrische Klinik und Poliklinik der Universität München
    MMW Fortschr Med 142:40-1. 2000
  2. ncbi Cerebrospinal fluid tau protein shows a better discrimination in young old (<70 years) than in old old patients with Alzheimer's disease compared with controls
    K Bürger née Buch
    Department of Psychiatry, Geriatric Psychiatry Branch, Dementia Research Section and Memory Clinic, Ludwig Maximilian University, Munich, Germany
    Neurosci Lett 277:21-4. 1999
  3. ncbi Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Am J Psychiatry 160:376-9. 2003
  4. ncbi [Late onset Huntington's disease - a differential diagnosis of Alzheimer's disease]
    K Burger
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Demenzforschungsstation und Gedächtnissprechstunde, Alzheimer Gedächtnis Zentrum, Ludwig Maximilians Universitat Munchen, Germany
    Nervenarzt 73:870-3. 2002
  5. ncbi CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects
    K Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neurology 59:627-9. 2002
  6. ncbi Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Arch Neurol 59:1267-72. 2002
  7. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
  8. ncbi No evidence of association between apolipoprotein E gene regulatory region polymorphism and Alzheimer's disease in Japanese
    M Kimura
    Division of Clinical Research, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
    J Neural Transm 107:1449-56. 2000
  9. ncbi Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression
    T Ohrui
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Neurology 63:1324-5. 2004
  10. ncbi No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome
    S Matsushita
    Department of Clinical Research, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
    Neurobiol Aging 22:569-74. 2001

Detail Information

Publications52

  1. ncbi [Your help is needed! Autopsy brings new knowledge regarding Alzheimer dementia]
    K Burger
    Psychiatrische Klinik und Poliklinik der Universität München
    MMW Fortschr Med 142:40-1. 2000
    ..Brain-Net, the German brain bank, is a unique approach to provide organisational support for such a concerted action...
  2. ncbi Cerebrospinal fluid tau protein shows a better discrimination in young old (<70 years) than in old old patients with Alzheimer's disease compared with controls
    K Bürger née Buch
    Department of Psychiatry, Geriatric Psychiatry Branch, Dementia Research Section and Memory Clinic, Ludwig Maximilian University, Munich, Germany
    Neurosci Lett 277:21-4. 1999
    ..We suggest that the effect of age should be considered in studies investigating CSF tau as a diagnostic marker for neurodegenerative disorders...
  3. ncbi Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Am J Psychiatry 160:376-9. 2003
    ..The authors asked whether p-tau(231) levels improve the differential diagnosis between geriatric major depression and Alzheimer's disease...
  4. ncbi [Late onset Huntington's disease - a differential diagnosis of Alzheimer's disease]
    K Burger
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Demenzforschungsstation und Gedächtnissprechstunde, Alzheimer Gedächtnis Zentrum, Ludwig Maximilians Universitat Munchen, Germany
    Nervenarzt 73:870-3. 2002
    ..This case shows the relevance of an accurate differential diagnosis of cognitive disturbances in order to detect rare causes of dementia...
  5. ncbi CSF tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects
    K Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
    Neurology 59:627-9. 2002
    ..Independently, old age and APOE-epsilon 4 carrier status were predictive as well. Our data indicate that an increased p-tau(231) level is a potential risk factor for cognitive decline in patients with MCI...
  6. ncbi Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231
    Katharina Buerger
    Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
    Arch Neurol 59:1267-72. 2002
    ....
  7. ncbi Mild cognitive impairment--beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
    B Winblad
    Division of Geriatric Medicine, Neurotec Department, Karolinska Institutet, 11382 Stockholm, Sweden
    J Intern Med 256:240-6. 2004
    ....
  8. ncbi No evidence of association between apolipoprotein E gene regulatory region polymorphism and Alzheimer's disease in Japanese
    M Kimura
    Division of Clinical Research, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
    J Neural Transm 107:1449-56. 2000
    ..These results suggest that -491 polymorphism does not independently confer susceptibility to AD, but that this polymorphism is in partial linkage disequilibrium with the APOE epsilon2/3/4 polymorphism...
  9. ncbi Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression
    T Ohrui
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Neurology 63:1324-5. 2004
  10. ncbi No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome
    S Matsushita
    Department of Clinical Research, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
    Neurobiol Aging 22:569-74. 2001
    ....
  11. ncbi Cerebrospinal fluid amyloid beta(1-42) levels in the mild cognitive impairment stage of Alzheimer's disease
    M Maruyama
    Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Miyagi, 980-8574, Japan
    Exp Neurol 172:433-6. 2001
    ..We propose that CSF-tau and CSF-A beta(1-42) must be used as two distinct biomarkers that should be applied appropriately in clinical settings...
  12. ncbi Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease
    N Itoh
    Department of Neurology, Mie University School of Medicine, Tsu, Japan
    Ann Neurol 50:150-6. 2001
    ..Thus, we suggest that CSF/phospho-tau199 may be a novel and logical biomarker in supporting antemortem diagnosis of AD...
  13. ncbi Cognitive impairment and diffuse white matter atrophy in alcoholics
    H Mochizuki
    Department of Neurology, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
    Clin Neurophysiol 116:223-8. 2005
    ....
  14. ncbi Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease
    T Hamaguchi
    Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Takara machi, Kanazawa, Japan
    Neurology 64:643-8. 2005
    ..No method for the clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease (sCJD) has been established except for pathologic examination...
  15. ncbi ACE activity in CSF of patients with mild cognitive impairment and Alzheimer disease
    M He
    Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan
    Neurology 67:1309-10. 2006
  16. ncbi Analysis of potential diagnostic biomarkers in cerebrospinal fluid of idiopathic normal pressure hydrocephalus by proteomics
    X Li
    Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan
    Acta Neurochir (Wien) 148:859-64; discussion 864. 2006
    ..The present study investigated the disease-specific proteins that aid in the diagnosis and treatment of INPH and thus to study their role in the disease process...
  17. ncbi Endodermal cyst of the quadrigeminal cistern: case report
    M Nakajima
    Department of Neurosurgery, Second Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Surg Neurol 56:385-8; discussion 388-9. 2001
    ..An endodermal cyst should be removed as completely as possible because its cells have the ability to grow and produce secretions...
  18. pmc Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine
    M Tagawa
    Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Br J Clin Pharmacol 52:501-9. 2001
    ....
  19. pmc Delayed-onset ataxia in mice lacking alpha -tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress
    T Yokota
    Department of Neurology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Proc Natl Acad Sci U S A 98:15185-90. 2001
    ..Moreover, alpha-TTP(-/-) mice may prove to be excellent animal models of delayed onset, slowly progressive neuronal degeneration caused by chronic oxidative stress...
  20. ncbi Amniotic epithelial cells transform into neuron-like cells in the ischemic brain
    H Okawa
    Department of Neurosurgery, Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421, Japan
    Neuroreport 12:4003-7. 2001
    ..These results suggest that intracerebral transplantation of amniotic epithelial cells may have therapeutic potential for the treatment of ischemic damage in neuronal disorders...
  21. ncbi Automated discrimination between very early Alzheimer disease and controls using an easy Z-score imaging system for multicenter brain perfusion single-photon emission tomography
    H Matsuda
    Department of Nuclear Medicine, Saitama Medical University Hospital, Japan
    AJNR Am J Neuroradiol 28:731-6. 2007
    ....
  22. pmc Relationship between asthma severity and progression of Alzheimer's disease
    T Ohrui
    Thorax 57:561. 2002
  23. ncbi Association between two types of vitamin d receptor gene polymorphism and bone status in premenopausal Japanese women
    M Kubota
    Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, 111 Kuboki Soja City Okayama 719 1197, Japan
    Calcif Tissue Int 68:16-22. 2001
    ..Therefore, the M polymorphism of the VDR gene is a stronger genetic indicator of osteoporosis than the B polymorphism in premenopausal Japanese woman...
  24. pmc Intracranial cerebrospinal fluid measurement studies in suspected idiopathic normal pressure hydrocephalus, secondary normal pressure hydrocephalus, and brain atrophy
    A Tsunoda
    Department of Neurosurgery, Koshigaya Municipal Hospital, Koshigaya City, Saitama, Japan
    J Neurol Neurosurg Psychiatry 73:552-5. 2002
    ..To investigate intracranial cerebrospinal fluid (CSF) distribution in patients with a clinical diagnosis of idiopathic normal pressure hydrocephalus (INPH)...
  25. ncbi Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease
    S Matsushita
    Division of Clinical Research, National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
    J Neural Transm 112:703-11. 2005
    ..0 vs. 4.4%, p = 0.035) or positive for AD family history (2.8 vs. 7.1%, p = 0.046). These findings suggest that BDNF gene polymorphisms play some role in the development of AD...
  26. ncbi Expression cloning of a novel scavenger receptor from human endothelial cells
    H Adachi
    Laboratory of Bioorganic Chemistry, The Institute of Physical and Chemical Research RIKEN, Wako Shi, Saitama 351 01, Japan
    J Biol Chem 272:31217-20. 1997
    ....
  27. ncbi Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium
    I G McKeith
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Neurology 65:1863-72. 2005
    ....
  28. ncbi CSF tau protein: a new prognostic marker for Guillain-Barré syndrome
    K Jin
    Department of Neurology, Kohnan Hospital, Japan
    Neurology 67:1470-2. 2006
    ..0005). The higher levels of CSF tau may reflect axonal degeneration and could predict a poor clinical outcome in Guillain-Barré syndrome...
  29. ncbi Successful transarterial glue embolisation by wedged technique for a tentorial dural arteriovenous fistula presenting with a conjunctival injection
    Y Iizuka
    Department of Radiology, Juntendo University, School of Medicine, Tokyo, Japan
    Neuroradiology 43:677-9. 2001
    ..After three sessions, a complete cure was achieved. We present a useful method which has not been reported previously...
  30. ncbi Gas6 induces mesangial cell proliferation via latent transcription factor STAT3
    M Yanagita
    Department of Geriatric Medicine, and the Department of Artificial Kidneys, Kyoto University, Kyoto 606-8507, Japan
    J Biol Chem 276:42364-9. 2001
    ..Therefore, STAT3 might be a new therapeutic target for kidney disease induced by mesangial proliferation...
  31. ncbi Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum
    Y Sekine-Aizawa
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
    Eur J Neurosci 13:935-48. 2001
    ....
  32. ncbi No evidence of association between a dopamine transporter gene polymorphism (1215A/G) and Parkinson's disease
    M Kimura
    Ann Neurol 49:276-7. 2001
  33. ncbi High expression of apolipoprotein E mRNA in the brains with sporadic Alzheimer's disease
    K Yamagata
    Division of Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, Yonago, Japan
    Dement Geriatr Cogn Disord 12:57-62. 2001
    ..05). Our result did not indicate the possibility that the promoter polymorphisms modulate the apoE mRNA level. The higher level of apoE mRNA in AD with apoE epsilon4 may play an important role in the development of AD...
  34. ncbi Induction of intracellular interleukin-1 beta signals via type II interleukin-1 receptor in human gingival fibroblasts
    H H Chou
    Department of Periodontology and Endodontology, Okayama University Dental School, Japan
    J Dent Res 79:1683-8. 2000
    ..These results suggest that the IL-1RII may regulate HGFs expression of cytokine mRNA upon IL-1 beta stimulation, possibly by altering the IL-1RI-dependent signals...
  35. pmc Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides
    N Tamura
    Department of Medicine, Kyoto University Faculty of Medicine, Japan
    J Clin Invest 94:1059-68. 1994
    ..Cardiomyopathic hamsters, therefore, are useful models to investigate the implication of BNP in human cardiovascular diseases...
  36. ncbi Expression of beta-amyloid precursor protein in the developing human spinal cord
    H Arai
    Department of Neurology, Motojima General Hospital, Gunma, Japan
    Brain Res 642:132-6. 1994
    ....
  37. ncbi [Preparation of monoclonal antibodies agglutinating group A, type 4 streptococci]
    H Arai
    National Institute of Health
    Kansenshogaku Zasshi 65:909-12. 1991
    ..From these data, we thought that the MAb preparations were not directed to M-protein but to T-protein of type 4, group A streptococci...
  38. ncbi C-type natriuretic peptide (CNP) in rats and humans
    Y Komatsu
    Department of Medicine, Kyoto University School of Medicine, Japan
    Endocrinology 129:1104-6. 1991
    ....
  39. ncbi Human C-type natriuretic peptide. Characterization of the gene and peptide
    Y Ogawa
    Second Division, Kyoto University School of Medicine, Japan
    Hypertension 19:809-13. 1992
    ....
  40. ncbi Functional hemizygosity of PAFAH1B3 due to a PAFAH1B3-CLK2 fusion gene in a female with mental retardation, ataxia and atrophy of the brain
    H G Nothwang
    Max Planck Institut fur Molekulare Genetik, Ihnestrasse 73, D 14195 Berlin Dahlem, Germany
    Hum Mol Genet 10:797-806. 2001
    ..These data emphasize the importance of PAF-AH1B in brain development and functioning and demonstrate the first fusion gene apparently not associated with cancer...
  41. ncbi [18F]FDG-PET study in dementia with Lewy bodies and Alzheimer's disease
    N Okamura
    Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 25:447-56. 2001
    ..3. These findings suggest that functional neuroimaging techniques, including FDG-PET, will provide a valuable diagnostic aid to differentiate DLB from AD, and this will help detect DLB patients in the early stage of the disease...
  42. pmc Monocyte chemoattractant protein 1 causes differential signalling mediated by proline-rich tyrosine kinase 2 in THP-1 cells
    M Yamasaki
    Department of Geriatric Medicine, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    Biochem J 355:751-6. 2001
    ..Our results indicate that Pyk2 forms a complex with paxillin, Grb2 and Lyn in THP-1 cells. However, Pyk2 is not always involved in MCP-1-mediated signalling pathways...
  43. ncbi Role of hypertension, dyslipidemia and diabetes mellitus in the development of coronary atherosclerosis in Japan
    M Washio
    Department of Preventive Medicine, Postgraduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Jpn Circ J 65:731-7. 2001
    ..These results indicate that in Japan DM, low HDL-C and hypertriglyceridemia may be more important CAD risk factors than hypercholesterolemia...
  44. ncbi Risk factors of aspiration pneumonia in Alzheimer's disease patients
    H Wada
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Gerontology 47:271-6. 2001
    ..As soon as the behavioral and psychiatric problems are resolved, drug tapering or discontinuation should be considered in order to prevent life-threatening aspiration pneumonia...
  45. ncbi Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids
    K Hayashi
    Department of Neuroscience, Osaka University Graduate School of Medicine, Osaka, Japan
    Circ Res 89:251-8. 2001
    ..Thus, this report demonstrates the first finding that unsaturated LPAs, but not saturated LPAs, specifically induce VSMC phenotypic modulation, suggesting that these molecules could function as atherogenic factors...
  46. ncbi Intracranial cerebrospinal fluid distribution and its postoperative changes in normal pressure hydrocephalus
    A Tsunoda
    Department of Neurosurgery, Koshigaya Municipal Hospital, Koshigaya City, Saitama, Japan
    Acta Neurochir (Wien) 143:493-9. 2001
    ..Shunting led to dramatic improvement in our patients. It is likely that CSF measurement can provide valuable information in the management of patients with NPH...
  47. ncbi MRA demonstration of "periarteritis" in Tolosa-Hunt syndrome
    T Ozawa
    Department of Neurosurgery, Brain Research Institute, Niigata University, Japan
    Acta Neurochir (Wien) 143:309-12. 2001
    ..INTERPRETATION: MRA may help prompt the noninvasive diagnosis in certain cases of Tolosa-Hunt syndrome with little inflammatory reaction in the cavernous sinus but with predominant intra- and juxta-cavernous periarteritis...
  48. ncbi Impairment of gingival fibroblast adherence by IL-6/sIL-6R
    K Naruishi
    Department of Patho-Physiology, Periodontal Science, Okayama University Graduate School of Medicine and Dentistry, Japan
    J Dent Res 80:1421-4. 2001
    ..These results suggest that the expression of VLA-5 and actin was down-regulated in HGF through an IL-6 signaling pathway, resulting in impairment of HGF adherence...
  49. ncbi Microsatellite instability of papillary subtype of human gastric adenocarcinoma and hMLH1 promoter hypermethylation in the surrounding mucosa
    R J Guo
    First Department of Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Pathol Int 51:240-7. 2001
    ..Inactivation of hMLH1 expression by promoter hypermethylation may be an early event in carcinogenesis of this type of gastric cancer, preceding the development of the clear MSI phenotype of papillary carcinoma...
  50. ncbi Elevated plasma homocysteine levels and risk of silent brain infarction in elderly people
    T Matsui
    Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan
    Stroke 32:1116-9. 2001
    ..CONCLUSIONS: pHcy level is associated with age and nutritional and other lifestyle factors, and it contributes to a risk for SBI...
  51. ncbi Heterogeneity of host immunological risk factors in patients with aggressive periodontitis
    K Takahashi
    Department of Periodontology and Endodontology, Okayama University Dental School, Okayama, Japan
    J Periodontol 72:425-37. 2001
    ..These results indicate the difficulty of explaining the pathogenesis of EOP based on a single host risk factor and also emphasize the importance of critical assessment of not only EOP patient groups, but also individual patients...
  52. ncbi Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide
    S Suga
    Department of Medicine, Kyoto University School of Medicine, Japan
    Endocrinology 130:229-39. 1992
    ..These findings on the receptor selectivity of the natriuretic peptide family provide a new insight into the understanding of the physiological and clinical implications of the natriuretic peptide system...