M Anlauf

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi [Clinical experience with percutaneus large-core needle biopsies of the breast and evaluation of cytopathological and histopathological results]
    M Anlauf
    Institut für allgemeine Pathologie und pathologische Anatomie, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Zentralbl Gynakol 125:353-61. 2003
  2. doi Primary lymph node gastrinoma or occult duodenal microgastrinoma with lymph node metastases in a MEN1 patient: the need for a systematic search for the primary tumor
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 32:1101-5. 2008
  3. ncbi Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinico-pathological and epidemiological features
    Martin Anlauf
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    World J Gastroenterol 12:5440-6. 2006
  4. ncbi Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome
    Martin Anlauf
    Departments of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Am J Surg Pathol 30:560-74. 2006
  5. ncbi Vesicular monoamine transporter 2 (VMAT2) expression in hematopoietic cells and in patients with systemic mastocytosis
    Martin Anlauf
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    J Histochem Cytochem 54:201-13. 2006
  6. ncbi Hereditary neuroendocrine tumors of the gastroenteropancreatic system
    Martin Anlauf
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S29-38. 2007
  7. ncbi Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas
    Martin Anlauf
    Department of Pathology, Univeristy of Kiel, Germany
    Gastroenterology 128:1187-98. 2005
  8. ncbi Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changes
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 29:524-33. 2005
  9. ncbi [Tumors of the endocrine pancreas]
    M Anlauf
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:46-51. 2005
  10. ncbi Endocrine precursor lesions and microadenomas of the duodenum and pancreas with and without MEN1: criteria, molecular concepts and clinical significance
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Pathobiology 74:279-84. 2007

Detail Information

Publications33

  1. ncbi [Clinical experience with percutaneus large-core needle biopsies of the breast and evaluation of cytopathological and histopathological results]
    M Anlauf
    Institut für allgemeine Pathologie und pathologische Anatomie, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Zentralbl Gynakol 125:353-61. 2003
    ..Core needle biopsy (CNB) allows a microinvasive diagnosis of breast lesions. We investigated whether imprint cytology of CNB specimens is a useful method of rapidly obtaining additional diagnostic information...
  2. doi Primary lymph node gastrinoma or occult duodenal microgastrinoma with lymph node metastases in a MEN1 patient: the need for a systematic search for the primary tumor
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 32:1101-5. 2008
    ..It is concluded that duodenal gastrinomas that give rise to lymph node metastases may be so tiny that they are easily overlooked in a routine examination and that systematic tissue monitoring is required to identify them...
  3. ncbi Sporadic versus hereditary gastrinomas of the duodenum and pancreas: distinct clinico-pathological and epidemiological features
    Martin Anlauf
    Department of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    World J Gastroenterol 12:5440-6. 2006
    ..A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas...
  4. ncbi Microadenomatosis of the endocrine pancreas in patients with and without the multiple endocrine neoplasia type 1 syndrome
    Martin Anlauf
    Departments of Pathology, University of Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Am J Surg Pathol 30:560-74. 2006
    ..In addition, a monohormonal type of pancreatic microadenomatosis was identified that consisted of either insulinomas or glucagon-producing tumors and was not associated with MEN1 or VHL...
  5. ncbi Vesicular monoamine transporter 2 (VMAT2) expression in hematopoietic cells and in patients with systemic mastocytosis
    Martin Anlauf
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    J Histochem Cytochem 54:201-13. 2006
    ....
  6. ncbi Hereditary neuroendocrine tumors of the gastroenteropancreatic system
    Martin Anlauf
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S29-38. 2007
    ..In addition, GEP-NETs clustering in individual families or associated with other malignancies without known genetic background are discussed...
  7. ncbi Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas
    Martin Anlauf
    Department of Pathology, Univeristy of Kiel, Germany
    Gastroenterology 128:1187-98. 2005
    ..Precursor lesions may precede the development of duodenal gastrinomas because, in contrast to sporadic gastrinomas, these tumors are usually multiple...
  8. ncbi Persistent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblastosis: diagnostic criteria, incidence, and characterization of beta-cell changes
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 29:524-33. 2005
    ..As approximately 4% of adult patients with PHH are affected by diffuse nesidioblastosis, this disease is not as rare as it has been thought to be. Pathogenetically, the defective insulin secretion could be based on a molecular defect...
  9. ncbi [Tumors of the endocrine pancreas]
    M Anlauf
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:46-51. 2005
    ..In recent years the percentage of non-functional tumors has increased...
  10. ncbi Endocrine precursor lesions and microadenomas of the duodenum and pancreas with and without MEN1: criteria, molecular concepts and clinical significance
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Pathobiology 74:279-84. 2007
    ..Whether these types of microadenomatosis represent novel disease entities and how to diagnose and treat these patients remains to be clarified by further studies...
  11. pmc Allelic deletion of the MEN1 gene in duodenal gastrin and somatostatin cell neoplasms and their precursor lesions
    M Anlauf
    Department of Pathology W, University of Kiel, Michaelisstr 11, 24105 Kiel, Germany
    Gut 56:637-44. 2007
    ..Patients with a multiple endocrine neoplasia type 1 (MEN1)-associated Zollinger-Ellison syndrome (ZES) show multifocal duodenal gastrinomas and precursor lesions...
  12. ncbi [Cystic pancreas tumors and their classification: features old and new]
    M Kosmahl
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:22-30. 2005
    ..This review discusses the most important cystic tumors and tumor-like lesions, presents a new classification, and summarizes the immunohistochemical differential diagnosis...
  13. ncbi Continuation with cotrimoxazole prophylaxis for the prevention of opportunistic infections in HIV-infected persons in rural Zimbabwe: feasibility, obstacles and opportunities
    I Alkatout
    Department of Pathology, University Hospital of Schleswig Holstein, Kiel, Germany
    AIDS Care 19:478-81. 2007
    ..Results also reflect the constrained feasibility of CTM prophylaxis in rural Africa as well as the need to target subpopulations, such as young people, patients and their spouses for focused HIV/AIDS education initiatives...
  14. ncbi Adult diffuse nesidioblastosis: genetically or environmentally induced?
    Gunter Kloppel
    Department of Pathology, University of Kiel, 24105 Kiel, Germany
    Hum Pathol 39:3-8. 2008
    ....
  15. ncbi Site-specific biology and pathology of gastroenteropancreatic neuroendocrine tumors
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Virchows Arch 451:S9-27. 2007
    ..In addition, a tumor/nodes/metastases classification and a grading system are presented. In the light of these criteria, the various GEP-NET entities are reviewed...
  16. ncbi Gastrinoma--morphological aspects
    Gunter Kloppel
    Department of Pathology, University of Kiel, Kiel, Germany
    Wien Klin Wochenschr 119:579-84. 2007
    ..The prognosis of duodenal gastrinomas is better than that of pancreatic gastrinomas, since despite early lymph node metastasis they progress slowly to liver metastasis...
  17. doi Somatostatin-producing neuroendocrine tumors of the duodenum and pancreas: incidence, types, biological behavior, association with inherited syndromes, and functional activity
    Nele Garbrecht
    Department of Pathology, University of Kiel, Michaelisstr 11, Kiel, Germany
    Endocr Relat Cancer 15:229-41. 2008
    ..MEN1-associated SOM-NETs and GCPGs follow a benign course, while somatostatin-producing pdNECs are aggressive neoplasms. The occurrence of the so-called somatostatinoma syndrome appears to be extremely uncommon...
  18. ncbi Endocrine precursor lesions of gastroenteropancreatic neuroendocrine tumors
    Gunter Kloppel
    Department of Pathology, University of Kiel, Michaelisstr 11, 24105, Kiel, Germany
    Endocr Pathol 18:150-5. 2007
    ..The endocrine cell hyperplasia in the colon described in inflammatory bowel disease has neither a genetic nor a definite hormonal background...
  19. ncbi Epidemiology, tumour biology and histopathological classification of neuroendocrine tumours of the gastrointestinal tract
    Gunter Kloppel
    Department of Pathology, University Hospital of Kiel, Germany
    Best Pract Res Clin Gastroenterol 19:507-17. 2005
    ....
  20. ncbi Pancreatic ductal adenocarcinomas with cystic features: neither rare nor uniform
    Markus Kosmahl
    Department of Pathology, University of Kiel, Germany
    Mod Pathol 18:1157-64. 2005
    ..Moreover, not all of the cystic structures we observed were neoplastic in nature. They may also represent non-neoplastic changes, such as retention cysts and inflammatory pseudocysts...
  21. ncbi [Solid pseudopapillary neoplasms. Enigmatic entity with female preponderance]
    M Kosmahl
    Institut für Allgemeine Pathologie, Universitätsklinikum Schleswig Holstein Campus Kiel, Michaelisstrasse 11, 24105 Kiel, Germany
    Pathologe 26:41-5. 2005
    ..Predicting malignancy histologically is not yet possible. The most important differential diagnosis to consider is neuroendocrine tumor of the pancreas. The etiology and pathogenesis of SPN are obscure...
  22. doi Fatal pneumocystis jirovecii pneumonia in a case of ectopic Cushing's syndrome due to neuroendocrine carcinoma of the kidney
    A Arlt
    1st Department of Medicine, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Exp Clin Endocrinol Diabetes 116:515-9. 2008
    ....
  23. doi Insulinomatosis: a multicentric insulinoma disease that frequently causes early recurrent hyperinsulinemic hypoglycemia
    Martin Anlauf
    Department of Pathology, University of Kiel, Kiel, Germany
    Am J Surg Pathol 33:339-46. 2009
    ..Multicentric insulinoma disease was characterized with regard to its histopathology, multiple endocrine neoplasia type 1 (MEN1) status, precursor lesions, and the risk of hyperinsulinemic hypoglycemia recurrence...
  24. doi Glucagon cell adenomatosis: a newly recognized disease of the endocrine pancreas
    Tobias Henopp
    Department of Pathology, University of Tubingen, Liebermeisterstr 8, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 94:213-7. 2009
    ..We observed a previously undescribed multicentric glucagon-producing tumor disease that is not related to MEN1...
  25. doi Islet 1 (Isl1) expression is a reliable marker for pancreatic endocrine tumors and their metastases
    Anja M Schmitt
    Department of Pathology, Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    Am J Surg Pathol 32:420-5. 2008
    ....
  26. ncbi WHO 2004 criteria and CK19 are reliable prognostic markers in pancreatic endocrine tumors
    Anja M Schmitt
    Department of Pathology, Institute of Surgical Pathology, University of Zurich, Zurich, Switzerland
    Am J Surg Pathol 31:1677-82. 2007
    ..Our aim was to test retrospectively the predictive value of these 2004 WHO criteria and of CK19, CD99, COX2, and p27 immunohistochemistry in a large series of patients with long-term follow-up...
  27. ncbi Diffuse nesidioblastosis as a cause of hyperinsulinemic hypoglycemia in adults: a diagnostic and therapeutic challenge
    Andreas Raffel
    Department of General and Visceral Surgery, Heinrich Heine University, Dusseldorf, Germany
    Surgery 141:179-84; discussion 185-6. 2007
    ....
  28. ncbi Multiple endocrine neoplasia type 1 (MEN1): loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas
    Aurel Perren
    Institute of Surgical Pathology, Department of Pathology, University Hospital Zurich, 8091 Zurich, Switzerland
    J Clin Endocrinol Metab 92:1118-28. 2007
    ..To date, it is unknown whether small islet-like endocrine cell clusters found in MEN1 patients are neoplastic or rather hyperplastic. It is also unclear whether microadenomas develop from islets...
  29. ncbi The vesicular monoamine transporter 2 (VMAT2) is expressed by normal and tumor cutaneous mast cells and Langerhans cells of the skin but is absent from Langerhans cell histiocytosis
    Martin Anlauf
    Department of Molecular Neuroscience, Institute of Anatomy and Cell Biology, Philipps University, Marburg, Germany
    J Histochem Cytochem 52:779-88. 2004
    ..Absence of VMAT2 in neoplastic Langerhans cells indicates a loss of monoamine handling capacity of these cells during tumorigenesis...
  30. ncbi Expression of the two isoforms of the vesicular monoamine transporter (VMAT1 and VMAT2) in the endocrine pancreas and pancreatic endocrine tumors
    Martin Anlauf
    Department of Molecular Neuroscience, Institute of Anatomy and Cell Biology, Philipps University of Marburg, Marburg, Germany
    J Histochem Cytochem 51:1027-40. 2003
    ..Monoamine storage mediated by VMAT1 in EC cells is apparently maintained in EC cell tumors. In contrast, many insulinomas appear to lose their ability to accumulate monoamines via VMAT2...
  31. ncbi Xenin-immunoreactive cells and extractable xenin in neuroendocrine tumors of duodenal origin
    Gerhard E Feurle
    DRK Krankenhaus Neuwied, Philipps Universitat Marburg, Germany
    Gastroenterology 123:1616-26. 2002
    ..Xenin is a 25-amino acid peptide produced by specific endocrine cells of the duodenal mucosa. We investigated whether xenin is expressed in neuroendocrine tumors...
  32. ncbi Molecular profiles of gastroenteropancreatic endocrine tumors
    Aurel Perren
    Department of Pathology, University Hospital Zurich, Zurich, Switzerland
    Virchows Arch 451:S39-46. 2007
    ..It is therefore conceivable that the gastroenteropancreatic neuroendocrine tumors also differ in their molecular profile. This review summarizes and discusses the available data in this field...
  33. pmc Coexpression of cholinergic and noradrenergic phenotypes in human and nonhuman autonomic nervous system
    Eberhard Weihe
    Department of Molecular Neuroscience, Institute of Anatomy and Cell Biology, Philipps University Marburg, 35033 Marburg, Germany
    J Comp Neurol 492:370-9. 2005
    ....