Jurgen Angerer

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Acrylamide exposure via the diet: influence of fasting on urinary mercapturic acid metabolite excretion in humans
    Melanie I Boettcher
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Arch Toxicol 80:817-9. 2006
  2. doi request reprint Hemoglobin adducts and mercapturic acid excretion of acrylamide and glycidamide in one study population
    Eva C Hartmann
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    J Agric Food Chem 56:6061-8. 2008
  3. ncbi request reprint Human biomonitoring: state of the art
    Jurgen Angerer
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Int J Hyg Environ Health 210:201-28. 2007
  4. doi request reprint Preliminary observations on perfluorinated compounds in plasma samples (1977-2004) of young German adults from an area with perfluorooctanoate-contaminated drinking water
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, 44801 Bochum, Germany
    Int J Hyg Environ Health 212:142-5. 2009
  5. doi request reprint Monoarylamines in the general population--a cross-sectional population-based study including 1004 Bavarian subjects
    Birgitta Kütting
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nuremberg, Schillerstr 25 29, D 91054 Erlangen, Germany
    Int J Hyg Environ Health 212:298-309. 2009
  6. ncbi request reprint Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine
    Thomas Schettgen
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nurnberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Toxicol Lett 134:65-70. 2002
  7. ncbi request reprint Pilot study on the perfluorooctanesulfonate and perfluorooctanoate exposure of the German general population
    Oliver Midasch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Int J Hyg Environ Health 209:489-96. 2006
  8. ncbi request reprint Current external and internal exposure to naphthalene of workers occupationally exposed to polycyclic aromatic hydrocarbons in different industries
    Ralf Preuss
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Int Arch Occup Environ Health 78:355-62. 2005
  9. ncbi request reprint Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population
    Melanie Isabell Boettcher
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Mutat Res 580:167-76. 2005
  10. ncbi request reprint One-year follow-up of perfluorinated compounds in plasma of German residents from Arnsberg formerly exposed to PFOA-contaminated drinking water
    Jurgen Holzer
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, 44801 Bochum, Germany
    Int J Hyg Environ Health 212:499-504. 2009

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Acrylamide exposure via the diet: influence of fasting on urinary mercapturic acid metabolite excretion in humans
    Melanie I Boettcher
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Arch Toxicol 80:817-9. 2006
    ..This confirms that the diet is the main source of environmental AA exposure in humans, apart from smoking. Other possible AA sources could be of minor quantitative importance only...
  2. doi request reprint Hemoglobin adducts and mercapturic acid excretion of acrylamide and glycidamide in one study population
    Eva C Hartmann
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    J Agric Food Chem 56:6061-8. 2008
    ..The ratio GAMA/AAMA is significantly higher in the group of young children (6-10 years) with a median level of 0.5. A gender-related difference in internal exposure and metabolism was not observed...
  3. ncbi request reprint Human biomonitoring: state of the art
    Jurgen Angerer
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Int J Hyg Environ Health 210:201-28. 2007
    ..For the evaluation of HBM results the German HBM Commission elaborates reference- and HBM-values...
  4. doi request reprint Preliminary observations on perfluorinated compounds in plasma samples (1977-2004) of young German adults from an area with perfluorooctanoate-contaminated drinking water
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, 44801 Bochum, Germany
    Int J Hyg Environ Health 212:142-5. 2009
    ..There was a close association between PFOS and PFOA-plasma levels. From this pilot study there are no indications for an increased exposure to PFCs of residents in Arnsberg in the years 1977-2004 prior to the contamination in 2006...
  5. doi request reprint Monoarylamines in the general population--a cross-sectional population-based study including 1004 Bavarian subjects
    Birgitta Kütting
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nuremberg, Schillerstr 25 29, D 91054 Erlangen, Germany
    Int J Hyg Environ Health 212:298-309. 2009
    ....
  6. ncbi request reprint Hemoglobin adducts of ethylene oxide, propylene oxide, acrylonitrile and acrylamide-biomarkers in occupational and environmental medicine
    Thomas Schettgen
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nurnberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Toxicol Lett 134:65-70. 2002
    ..6 microg/l) in non-smokers compared with 89 pmol/g globin (or 2.4 microg/l) in smokers. Correlations were found between smoking habits and adduct levels of CEV and AAV...
  7. ncbi request reprint Pilot study on the perfluorooctanesulfonate and perfluorooctanoate exposure of the German general population
    Oliver Midasch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    Int J Hyg Environ Health 209:489-96. 2006
    ..The ubiquitous internal exposure of the general population to PFOS and PFOA must lead to further activities primarily regarding clarification of sources, metabolism, pharmacokinetics, and health effects...
  8. ncbi request reprint Current external and internal exposure to naphthalene of workers occupationally exposed to polycyclic aromatic hydrocarbons in different industries
    Ralf Preuss
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Int Arch Occup Environ Health 78:355-62. 2005
    ..Furthermore, a control collective from the general population was investigated...
  9. ncbi request reprint Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population
    Melanie Isabell Boettcher
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Mutat Res 580:167-76. 2005
    ..From these results compared to the mercapturic acids, we deduce a steady state for AA uptake, and we demonstrate a higher reactivity of GA in comparison to AA towards haemoglobin compared to glutathione in humans...
  10. ncbi request reprint One-year follow-up of perfluorinated compounds in plasma of German residents from Arnsberg formerly exposed to PFOA-contaminated drinking water
    Jurgen Holzer
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, 44801 Bochum, Germany
    Int J Hyg Environ Health 212:499-504. 2009
    ..The observed decline in PFOA-concentrations indicates a slow elimination in humans. This finding in groups of the general population is in agreement with data on long elimination half-lives observed in occupationally exposed workers...
  11. ncbi request reprint A first approach to estimate the internal exposure to acrylamide in smoking and non-smoking adults from Germany
    Thomas Schettgen
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nurnberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Int J Hyg Environ Health 206:9-14. 2003
    ..6 x 10(-3). Our results confirm a body burden to AA even in persons from the non-smoking general population in Germany that is most probably caused by dietary uptake. Smoking habits considerably contribute to the level of this adduct...
  12. ncbi request reprint Determination of haemoglobin adducts of acrylamide and glycidamide in smoking and non-smoking persons of the general population
    Thomas Schettgen
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nuremberg, Germany
    Int J Hyg Environ Health 207:531-9. 2004
    ..Furthermore, our results might indicate that the dose-response curve for acrylamide is not linear. This would be in line with the results of animal experiments on rodents...
  13. ncbi request reprint External and internal exposure to polycyclic aromatic hydrocarbons (PAH) among workers in the production of fire-proof materials - proposal of a biological monitoring guidance value
    Ralf Preuss
    University of Erlangen Nuremberg, Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Erlangen, Germany
    Int J Hyg Environ Health 209:575-80. 2006
    ..The following BMGVs for the non-smokers of this branch of industry are proposed: for 1-hydroxypyrene 18microg/g creatinine and for the sum of hydroxyphenanthrenes 77microg/g creatinine in urine measured at the end of the shift...
  14. ncbi request reprint Penetration of beta-naphthylamine and o-toluidine through human skin in vitro
    Lars Lüersen
    Institute and Out Patient Clinic of Occupational, Social and Environmental Medicine, University Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Arch Toxicol 80:644-6. 2006
    ..2 vs. 0.8 h) and in high percentages (54 vs. 50%, respectively, of the applied dose within 24 h). A skin notation is therefore justified for these substances...
  15. ncbi request reprint N-Acetyl-S-(1-carbamoyl-2-hydroxy-ethyl)-L-cysteine (iso-GAMA) a further product of human metabolism of acrylamide: comparison with the simultaneously excreted other mercaptuic acids
    Eva C Hartmann
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Arch Toxicol 83:731-4. 2009
    ..We show that dietary doses of acrylamide (AA) cause an overload of detoxification via AAMA and lead to the formation of carcinogenic glycidamide (GA) in the human body...
  16. ncbi request reprint Contribution to the evaluation of reference values for PFOA and PFOS in plasma of children and adults from Germany
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 212:56-60. 2009
    ....
  17. ncbi request reprint Internal phthalate exposure over the last two decades--a retrospective human biomonitoring study
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Germany
    Int J Hyg Environ Health 210:319-33. 2007
    ....
  18. ncbi request reprint Acrylamide as environmental noxious agent: a health risk assessment for the general population based on the internal acrylamide burden
    Birgitta Kütting
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nuremberg, Schillerstr 25 29, D 91054 Erlangen, Germany
    Int J Hyg Environ Health 212:470-80. 2009
    ..However, carcinogenicity and mutagenicity are possible hazardous health effects for the general population...
  19. ncbi request reprint Analysis of ethenoguanine adducts in human urine using high performance liquid chromatography-tandem mass spectrometry
    Luis Mariano Gonzalez-Reche
    Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Friedrich Alexander University Erlangen Nuremberg, Schillerstr 25, D 91054 Erlangen, Germany
    Toxicol Lett 134:71-7. 2002
    ..The background level of the general population has to be taken into account, especially in the investigation of persons occupationally exposed to etheno-adduct forming chemicals...
  20. ncbi request reprint Naphthalene--an environmental and occupational toxicant
    Ralf Preuss
    University of Erlangen Nuremberg, Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Int Arch Occup Environ Health 76:556-76. 2003
    ..Naphthoquinones play an important role in this context. Their adducts with macromolecules may be the parameters of choice for the estimation of effects to human health...
  21. ncbi request reprint Exposure of nursery school children and their parents and teachers to di-n-butylphthalate and butylbenzylphthalate
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054, Erlangen, Germany
    Int Arch Occup Environ Health 78:223-9. 2005
    ..To obtain an estimate of internal exposure to DnBP and BBzP we compared the excretion of their metabolites in the urine of nursery school children with that of their teachers and parents...
  22. ncbi request reprint New metabolites of di(2-ethylhexyl)phthalate (DEHP) in human urine and serum after single oral doses of deuterium-labelled DEHP
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054, Erlangen, Germany
    Arch Toxicol 79:367-76. 2005
    ..All secondary metabolites are unsusceptible to contamination. Furthermore, there are strong hints that the secondary oxidised DEHP metabolites-not DEHP or MEHP-are the ultimate developmental toxicants...
  23. ncbi request reprint Development and verification of a toxicokinetic model of polychlorinated biphenyl elimination in persons working in a contaminated building
    Horst Christoph Broding
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander Universität Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Chemosphere 68:1427-34. 2007
    ..Despite a worldwide reduction, environmental exposure remains an issue; the assessment of an individual's level of exposure at a given time in retrospect requires valid toxicokinetic modeling of the different PCB congeners...
  24. ncbi request reprint Excretion of mercapturic acids of acrylamide and glycidamide in human urine after single oral administration of deuterium-labelled acrylamide
    Melanie I Boettcher
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, Erlangen 91054, Germany
    Arch Toxicol 80:55-61. 2006
    ..Consequently a genotoxic potency of AA mediated by GA could be supposed to be comparable in rats and humans...
  25. doi request reprint Dermal uptake and excretion of 4,4'-methylenedianiline during rotor blade production in helicopter industry--an intervention study
    Tobias Weiss
    Institute and Outpatient Clinic of Occupational, Social, and Environmental Medicine, Friedrich Alexander University Erlangen Nürnberg IPASUM, Schillerstr 25 29, 91054 Erlangen, Germany
    Ann Occup Hyg 55:886-92. 2011
    ..The aim of the study presented here was to assess the internal dose of MDA and the suitability of various personal protection measures at the workplace...
  26. ncbi request reprint Daily intake of di(2-ethylhexyl)phthalate (DEHP) by German children -- A comparison of two estimation models based on urinary DEHP metabolite levels
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Enironmental Medicine, University of Erlangen Nuremberg, Germany
    Int J Hyg Environ Health 210:35-42. 2007
    ..Younger children seem to be more severely burdened, which may be due to a higher food consumption related to their bw, mouthing behaviour and/or playing near the ground...
  27. doi request reprint Subjective complaints in persons under chronic low-dose exposure to lower polychlorinated biphenyls (PCBs)
    Horst Christoph Broding
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander Universität Erlangen Nuremberg, Schillerstrasse 25 and 29, 91054 Erlangen, Germany
    Int J Hyg Environ Health 211:648-57. 2008
    ..Subjects working in a PCB-contaminated building report more subjective complaints in comparison to non-exposed subjects, but the complaints are not related to current PCB plasma concentrations...
  28. ncbi request reprint Influence of industrial sources on children's health--hot spot studies in North Rhine Westphalia, Germany
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 210:591-9. 2007
    ....
  29. doi request reprint Excretion of 2,3-dihydroxy-propionamide (OH-PA), the hydrolysis product of glycidamide, in human urine after single oral dose of deuterium-labeled acrylamide
    Eva C Hartmann
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nurnberg, Schillerstr 25 29, 91054, Erlangen, Germany
    Arch Toxicol 85:601-6. 2011
    ....
  30. ncbi request reprint Internal exposure of the general population to DEHP and other phthalates--determination of secondary and primary phthalate monoester metabolites in urine
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, Erlangen D 91054, Germany
    Environ Res 93:177-85. 2003
    ..0 microg/L, for monoethylphthalate (MEP) 90.2 microg/L and for mono-n-octylphthalate (MOP)<1.0 microg/L (LOQ). These results will help to perform health risk assessments for the phthalate exposure of the general population...
  31. ncbi request reprint New reference value and the background exposure for the PAH metabolites 1-hydroxypyrene and 1- and 2-naphthol in urine of the general population in Germany: basis for validation of human biomonitoring data in environmental medicine
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Bochum, Germany
    Int J Hyg Environ Health 211:447-53. 2008
    ..Therefore, the commission recommends the following upper margins of background exposures for adult non-smokers: 1-naphthol less than 30 microg/l, 2-naphthol less than 20 microg/l...
  32. doi request reprint 1,2-Dihydroxynaphthalene as biomarker for a naphthalene exposure in humans
    Katrin Klotz
    University of Erlangen Nuremberg, Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Int J Hyg Environ Health 214:110-4. 2011
    ..Seven isomeric dihydroxynaphthalenes (DHN) were examined for their suitability as biomarkers in human biomonitoring and to get insights in human naphthalene metabolism...
  33. ncbi request reprint Pilot study on the naphthalene exposure of German adults and children by means of urinary 1- and 2-naphthol levels
    Ralf Preuss
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Hyg Environ Health 207:441-5. 2004
    ..2 microg/g creatinine (non-smoking adults) and 23.5 microg/g creatinine (young children). It is concluded that 1- and 2-naphthol levels in urine are suitable for human biomonitoring of the naphthalene exposure in environmental medicine...
  34. ncbi request reprint Biological monitoring of the five major metabolites of di-(2-ethylhexyl)phthalate (DEHP) in human urine using column-switching liquid chromatography-tandem mass spectrometry
    Ralf Preuss
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25, D 91054 Erlangen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 816:269-80. 2005
    ..It will help to further explore the human metabolism of DEHP-an occupational and environmental toxicant of great concern...
  35. ncbi request reprint An estimation of the daily intake of di(2-ethylhexyl)phthalate (DEHP) and other phthalates in the general population
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen, Erlangen, Germany
    Int J Hyg Environ Health 206:77-83. 2003
    ..The transgressions of the TDI and RfD for DEHP are accompanied by considerable ubiquitous exposures to DnBP and BbzP, two phthalates under scrutiny for similar toxicological mechanisms...
  36. ncbi request reprint Intravenous exposure to di(2-ethylhexyl)phthalate (DEHP): metabolites of DEHP in urine after a voluntary platelet donation
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Arch Toxicol 79:689-93. 2005
    ..Especially women in their reproductive age need to be protected from DEHP exposures exceeding the above mentioned preventive limit values...
  37. ncbi request reprint Pyrethroid exposure of the general population-is this due to diet
    Thomas Schettgen
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich Alexander University of Erlangen Nurnberg, Schillerstrasse 25 29, D 91054, Erlangen, Germany
    Toxicol Lett 134:141-5. 2002
    ..3 and 0.27 microg/l, respectively. The metabolic pattern found for these samples points out that pyrethroids are probably ingested orally with daily diet...
  38. ncbi request reprint Determination of the major mercapturic acids of acrylamide and glycidamide in human urine by LC-ESI-MS/MS
    Melanie Isabell Boettcher
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25, Erlangen D 91054, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 824:283-94. 2005
    ..The method therefore provides better insight into the metabolism of acrylamide in humans and furthermore supports risk assessments...
  39. ncbi request reprint Human biomonitoring studies in North Rhine-Westphalia, Germany
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Universitatsstrasse 150, 44801 Bochum, Germany
    Int J Hyg Environ Health 210:307-18. 2007
    ..More recent studies suggest that there still is an increased internal exposure to metals, PAH and DNA damaging agents in children and women living very close to industrial sources...
  40. pmc Biomonitoring of perfluorinated compounds in children and adults exposed to perfluorooctanoate-contaminated drinking water
    Jurgen Holzer
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    Environ Health Perspect 116:651-7. 2008
    ..40,000 residents in Arnsberg, Germany, had been exposed to drinking water contaminated with perfluorinated compounds (PFCs). Internal exposure of the residents of Arnsberg to six PFCs was assessed in comparison with reference areas...
  41. ncbi request reprint Internal exposure of nursery-school children and their parents and teachers to di(2-ethylhexyl)phthalate (DEHP)
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstr 25 29, D 91054 Erlangen, Germany
    Int J Hyg Environ Health 207:15-22. 2004
    ..To date no information on the biological activity and toxicity of oxidative metabolites of DEHP is available. Since these are the major metabolites of DEHP toxicological data on these metabolites is urgently needed...
  42. ncbi request reprint Identification of DNA adducts of methylglyoxal
    Matthias Frischmann
    Institute of Pharmacy and Food Chemistry, University of Erlangen Nuremberg, Schuhstrasse 19, D 91052 Erlangen, Germany
    Chem Res Toxicol 18:1586-92. 2005
    ..Thereby, CEdG proved to be the most sensitive and suitable marker for the reaction of DNA with MG (negative MRM mode, three mass transitions [M - 1](-) 338-->178, 338-->106, and 338-->149)...
  43. ncbi request reprint Di(2-ethylhexyl)phthalate (DEHP) exposure of voluntary plasma and platelet donors
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Int J Hyg Environ Health 208:489-98. 2005
    ..At present, discontinuous-flow devices should be preferred to avert conceivable health risks from plateletpheresis donors. Strategies to avoid DEHP exposure of donors during apheresis need to be developed...
  44. doi request reprint Reassessment of critical lead effects by the German Human Biomonitoring Commission results in suspension of the human biomonitoring values (HBM I and HBM II) for lead in blood of children and adults
    Michael Wilhelm
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    Int J Hyg Environ Health 213:265-9. 2010
    ..We conclude that any setting of an "effect threshold" for blood lead levels would be arbitrary and therefore unjustified. As a consequence the Commission suspends the HBM values for lead in blood of children and adults...
  45. ncbi request reprint Simultaneous determination of various aromatic amines and metabolites of aromatic nitro compounds in urine for low level exposure using gas chromatography-mass spectrometry
    Tobias Weiss
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nurnberg, Schillerstrasse 25, D 91054 Erlangen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 778:179-92. 2002
    ..05 microg/l; 0.12 microg/l). We did not detect alpha- or beta-naphtylamine, 4-aminobiphenyl or metabolites of explosives in the samples...
  46. ncbi request reprint Influence of diet on exposure to acrylamide--reflections on the validity of a questionnaire
    Birgitta Kütting
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friederich Alexander University, Erlangen Nuremberg, Germany
    Ann Nutr Metab 49:173-7. 2005
    ..Acrylamide is a toxic substance classified by the International Agency of Research on Cancer, as well as the Deutsche Forschungsgemeinschaft, as a probable human carcinogen...
  47. ncbi request reprint Di-n-butylphthalate and butylbenzylphthalate - urinary metabolite levels and estimated daily intakes: pilot study for the German Environmental Survey on children
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Erlangen, Germany
    J Expo Sci Environ Epidemiol 17:378-87. 2007
    ..For both phthalates and independent of the model, we found increasing daily intakes with decreasing age. Between 25% (creatinine model) and 50% (volume model) of the 2-4-year old children had daily intakes for DnBP above the TDI...
  48. ncbi request reprint On-line clean-up by multidimensional liquid chromatography-electrospray ionization tandem mass spectrometry for high throughput quantification of primary and secondary phthalate metabolites in human urine
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstr 25 29, D 91054, Erlangen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 784:169-82. 2003
    ..Since secondary, functionalized metabolites of DEHP are included in the method an enduring problem of the past is excluded: sample contamination in the pre-analytical and analytical phase by both di- and monoesters...
  49. ncbi request reprint Phthalates: metabolism and exposure
    Matthias Wittassek
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Int J Androl 31:131-8. 2008
    ..Therefore, the concept of a cumulative TDI value may be more appropriate for the consideration of the overall exposure and the potential human health risks resulting from everyday and simultaneous exposure to several phthalates...
  50. ncbi request reprint Di(2-ethylhexyl)phthalate (DEHP) metabolites in human urine and serum after a single oral dose of deuterium-labelled DEHP
    Holger M Koch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Arch Toxicol 78:123-30. 2004
    ..0 to 9.3. The excretion ratio of 5OH-MEHP to 5oxo-MEHP remained constant through time at 1.7 in the mean. After 44 h, 47% of the DEHP dose was excreted in urine, comprising MEHP (7.3%), 5OH-MEHP (24.7%) and 5oxo-MEHP (14.9%)...
  51. ncbi request reprint Simultaneous determination of 1- and 2-naphthol in human urine using on-line clean-up column-switching liquid chromatography-fluorescence detection
    Ralf Preuss
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25, D 91054 Erlangen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 801:307-16. 2004
    ..2 microg/l and 2-naphthol: 23.7 microg/l) in comparison to non smokers (n=32; 1-naphthol: 5.6 microg/l, 2-naphthol: 5.6 microg/l)...
  52. ncbi request reprint Strategic biomonitoring initiatives: moving the science forward
    Jurgen Angerer
    Institute of Occupational, Social, and Environmental Medicine, University of Erlangen, D 91054 Erlangen, Germany
    Toxicol Sci 93:3-10. 2006
    ..As efforts and resources are expended to improve the ability to apply biomonitoring exposure data in the risk assessment process, it is equally important to communicate the significance of such data to the public...
  53. ncbi request reprint Determination of secondary, oxidised di-iso-nonylphthalate (DINP) metabolites in human urine representative for the exposure to commercial DINP plasticizers
    Holger M Koch
    Institut und Poliklinik für Arbeits, Sozial und Umweltmedizin, Schillerstrasse 25 29, 91054 Erlangen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 847:114-25. 2007
    ..9microg/l OH-MINP, 8.9microg/l oxo-MINP and 16.4microg/l carboxy-MINP. Metabolites strongly correlated with each other over all samples analyzed (R>0.99, p<0.0001)...
  54. ncbi request reprint Investigations on permeation of mitomycin C through double layers of natural rubber gloves
    Gintautas Korinth
    Institute and Out Patient Clinic of Occupational, Social and Environmental Medicine of the University Erlangen Nuremberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Ann Occup Hyg 51:593-600. 2007
    ..However, occupational exposure to antineoplastic drugs should be minimized, since there is insufficient knowledge regarding harmful effects from a long-term exposure to low doses...
  55. ncbi request reprint Evidence for increased internal exposure to lower chlorinated polychlorinated biphenyls (PCB) in pupils attending a contaminated school
    Bernhard Liebl
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine of the University of Erlangen Nuremberg, Germany
    Int J Hyg Environ Health 207:315-24. 2004
    ..Compared to background levels the detected excess body burden was very low indicating no additional health risk. Exposure was not associated to any specific subjective complaints...
  56. ncbi request reprint Enhancement of percutaneous penetration of aniline and o-toluidine in vitro using skin barrier creams
    Gintautas Korinth
    Institute and Out Patient Clinic of Occupational, Social and Environmental Medicine, University Erlangen Nuremberg, Schillerstrasse 25 29, D 91054 Erlangen, Germany
    Toxicol In Vitro 22:812-8. 2008
    ..The efficacy of skin creams to protect the percutaneous penetration of aromatic amines is not confirmed by our own experiments...
  57. ncbi request reprint Quantification of two urinary metabolites of organophosphorus flame retardants by solid-phase extraction and gas chromatography-tandem mass spectrometry
    Birgit Karin Schindler
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25 29, 91054 Erlangen, Germany
    Anal Bioanal Chem 395:1167-71. 2009
    ..Twelve percent of the urine samples analysed tested positive for BCPP at concentrations from below the limit of detection to 0.85 microg/l; one sample contained 0.26 microg/l DBP...
  58. ncbi request reprint Determination of DMF modified DNA base N4-methylcarbamoylcytosine in human urine using off-line sample clean-up, two-dimensional LC and ESI-MS/MS detection
    Kristina Hennebrüder
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 822:124-32. 2005
    ..In 10 out of 32 urine samples of occupationally to DMF exposed subjects NMC-C could be detected. The concentrations ranged up to 172 ng/L (1023 pmol/L) with a 95th percentile of 121 ng/L (720 pmol/L)...