Hans Joachim Anders

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi The role of innate immunity in autoimmune tissue injury
    Ramanjaneyulu Allam
    Medical Policlinic, University of Munich, Munich, Germany
    Curr Opin Rheumatol 20:538-44. 2008
  2. ncbi [Microbial nucleic acids in the pathogenesis of glomerulonephritis]
    Hans-Joachim Anders
    , , , Allemagne
    Nephrol Ther 2:422-31. 2006
  3. ncbi Nucleic acids modulate autoimmunity through nucleic-acid-specific toll-like receptors
    Prashant S Patole
    Medical Policlinic, University of Munich, Germany
    Curr Med Chem 13:3061-7. 2006
  4. ncbi Ligands to nucleic acid-specific toll-like receptors and the onset of lupus nephritis
    Rahul D Pawar
    Medical Poliklinik, University of Munich, Munich, Germany
    J Am Soc Nephrol 17:3365-73. 2006
  5. ncbi Beyond the LUNAR trial. Efficacy of rituximab in refractory lupus nephritis
    Marc Weidenbusch
    Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Munich, Germany
    Nephrol Dial Transplant 28:106-11. 2013
  6. ncbi Uromodulin triggers IL-1β-dependent innate immunity via the NLRP3 inflammasome
    Murthy Narayana Darisipudi
    Nephrologisches Zentrum, Medizinische Klinik, Klinikum der Universitat Munchen, Ziemssenstr 1, Munich D 80336, Germany
    J Am Soc Nephrol 23:1783-9. 2012
  7. ncbi Four danger response programs determine glomerular and tubulointerstitial kidney pathology: clotting, inflammation, epithelial and mesenchymal healing
    Hans Joachim Anders
    Nephrologisches Zentrum Medizinische Klinik und Poliklinik IV Klinikum der Universität München, Germany
    Organogenesis 8:29-40. 2012
  8. ncbi Lupus nephritis: Implications of the new ACR lupus nephritis guidelines
    Hans Joachim Anders
    Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Ziemssenstrasse 1, 80336 Munich, Germany
    Nat Rev Nephrol 8:500-1. 2012
  9. ncbi Recombinant chaperonin 10 suppresses cutaneous lupus and lupus nephritis in MRL-(Fas)lpr mice
    Onkar P Kulkarni
    Medizinische Poliklinik Innenstadt, Department of Dermatology and Allergology, University of Munich, Munich, Germany
    Nephrol Dial Transplant 27:1358-67. 2012
  10. ncbi Innate pathogen recognition in the kidney: toll-like receptors, NOD-like receptors, and RIG-like helicases
    H J Anders
    Department of Nephrology, Medical Policlinic, University of Munich, Munich, Germany
    Kidney Int 72:1051-6. 2007

Collaborators

Detail Information

Publications97

  1. ncbi The role of innate immunity in autoimmune tissue injury
    Ramanjaneyulu Allam
    Medical Policlinic, University of Munich, Munich, Germany
    Curr Opin Rheumatol 20:538-44. 2008
    ..To discriminate the pathomechanims of autoimmunity from that of autoimmune tissue injury, for example, in systemic lupus erythematosus, with a special focus on the role of innate pathogen recognition receptors in lupus nephritis...
  2. ncbi [Microbial nucleic acids in the pathogenesis of glomerulonephritis]
    Hans-Joachim Anders
    , , , Allemagne
    Nephrol Ther 2:422-31. 2006
    ..In this review we summarize the arising evidence in this field and discuss new hypotheses for the pathogenesis of kidney diseases that are triggered by infectious organisms...
  3. ncbi Nucleic acids modulate autoimmunity through nucleic-acid-specific toll-like receptors
    Prashant S Patole
    Medical Policlinic, University of Munich, Germany
    Curr Med Chem 13:3061-7. 2006
    ..Rapidly accumulating data on the role of nucleic acid-specific TLRs has not only provided insights about their pathogenic potential of endogenous nucleic acid molecules, but is also fuelling the development of novel immunotherapies...
  4. ncbi Ligands to nucleic acid-specific toll-like receptors and the onset of lupus nephritis
    Rahul D Pawar
    Medical Poliklinik, University of Munich, Munich, Germany
    J Am Soc Nephrol 17:3365-73. 2006
    ..In summary, among the ligands tested, CpG-DNA triggers lupus nephritis in genetically predisposed hosts. These data support the concept that systemic lupus erythematosus is triggered by pathogens that release CG-rich DNA...
  5. ncbi Beyond the LUNAR trial. Efficacy of rituximab in refractory lupus nephritis
    Marc Weidenbusch
    Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Munich, Germany
    Nephrol Dial Transplant 28:106-11. 2013
    ..At present, no such trial is available for the use of RTX in refractory LN...
  6. ncbi Uromodulin triggers IL-1β-dependent innate immunity via the NLRP3 inflammasome
    Murthy Narayana Darisipudi
    Nephrologisches Zentrum, Medizinische Klinik, Klinikum der Universitat Munchen, Ziemssenstr 1, Munich D 80336, Germany
    J Am Soc Nephrol 23:1783-9. 2012
    ..The inability of renal parenchymal cells to secrete IL-1β may explain why uromodulin remains immunologically inert inside the luminal compartment of the urinary tract...
  7. ncbi Four danger response programs determine glomerular and tubulointerstitial kidney pathology: clotting, inflammation, epithelial and mesenchymal healing
    Hans Joachim Anders
    Nephrologisches Zentrum Medizinische Klinik und Poliklinik IV Klinikum der Universität München, Germany
    Organogenesis 8:29-40. 2012
    ..Thus, renal pathology results from ancient danger responses that evolved because of their evolutional benefits upon trauma. Understanding these causalities may help to shape the search for novel treatments for kidney disease patients...
  8. ncbi Lupus nephritis: Implications of the new ACR lupus nephritis guidelines
    Hans Joachim Anders
    Nephrologisches Zentrum, Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Ziemssenstrasse 1, 80336 Munich, Germany
    Nat Rev Nephrol 8:500-1. 2012
    ..The American College of Rheumatology recently published guidelines for the screening, treatment, and management of lupus nephritis. How will or should these guidelines impact our current daily practice?..
  9. ncbi Recombinant chaperonin 10 suppresses cutaneous lupus and lupus nephritis in MRL-(Fas)lpr mice
    Onkar P Kulkarni
    Medizinische Poliklinik Innenstadt, Department of Dermatology and Allergology, University of Munich, Munich, Germany
    Nephrol Dial Transplant 27:1358-67. 2012
    ..Heat shock protein 10, or chaperonin 10 (Cpn10), is a secretory molecule that can suppress innate and adaptive immunity...
  10. ncbi Innate pathogen recognition in the kidney: toll-like receptors, NOD-like receptors, and RIG-like helicases
    H J Anders
    Department of Nephrology, Medical Policlinic, University of Munich, Munich, Germany
    Kidney Int 72:1051-6. 2007
    ..This article summarizes ligand-receptor interactions and their known or potential significance in kidney diseases...
  11. ncbi Molecular mechanisms of autoimmunity triggered by microbial infection
    Hans Joachim Anders
    Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    Arthritis Res Ther 7:215-24. 2005
    ..This review summarizes important facts about TLR biology, available data on their role in autoimmunity, and potential consequences for the management of patients with autoimmune disease...
  12. ncbi Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis
    Hans Joachim Anders
    Department of Nephrology, Medizinische Poliklinik der LMU, University of Munich, Munich, Germany
    Kidney Int 80:915-25. 2011
    ....
  13. ncbi Renal co-morbidity in patients with rheumatic diseases
    Hans Joachim Anders
    Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstraße 8a, 80336 Munchen, Germany
    Arthritis Res Ther 13:222. 2011
    ....
  14. ncbi Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonists
    H J Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Munich, Germany
    Kidney Int 69:29-32. 2006
    ..In fact, blocking CCR-1 with specific small-molecule antagonists was shown to retard progression in various types of rodent CKD models. Here we discuss the perspective of CCR-1 as a new potential target for the treatment of CKD...
  15. ncbi [Chloroquine-induced cutaneous hyperpigmentation]
    Hans-Joachim Anders
    Lupus-Ambulanz, Medizinische Poliklinik, , Pettenkoferstrasse 8a,
    Med Klin (Munich) 101:421. 2006
  16. ncbi The inflammasomes in kidney disease
    Hans Joachim Anders
    Department of Medicine, University of Calgary, Calgary, AB, T2N 4N1 Canada
    J Am Soc Nephrol 22:1007-18. 2011
    ..We further provide a perspective on the potential roles of the inflammasomes in the pathogenesis of acute and chronic kidney diseases...
  17. ncbi Predicting thrombosis in systemic lupus erythematosus
    Hans Joachim Anders
    Medizinische Poliklinik, University of Munich, Munich, Germany
    Nat Clin Pract Nephrol 5:68-9. 2009
    ....
  18. ncbi Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus
    Hans Joachim Anders
    Medizinische Poliklinik, Ludwig Maximilians University Munich, Pettenkoferstrasse 8a, Munich, Germany
    Eur J Immunol 38:1795-9. 2008
    ..This finding highlights the need to address the significance of TLR7 in human lupus in terms of both genetic risk and as a therapeutic option...
  19. ncbi Interferon-alpha and -beta in kidney inflammation
    Hans Joachim Anders
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munich, Germany
    Kidney Int 77:848-54. 2010
    ..Finally, we propose areas of research that may help unravel the roles of type I interferons and interferon-related genes in the renal field...
  20. ncbi Pseudoviral immunity - a novel concept for lupus
    Hans Joachim Anders
    Medizinische Poliklinik, University of Munich, Pettenkoferstr 8a, 80336 Munich, Germany
    Trends Mol Med 15:553-61. 2009
    ..Therefore, self nucleic acid-driven 'pseudoviral' immunity is evolving as another concept in understanding the pathogenesis of lupus and may offer novel targets for therapy...
  21. ncbi Identifying and validating novel targets with in vivo disease models: guidelines for study design
    Hans Joachim Anders
    Medizinische Poliklinik, Universitat Munchen, Pettenkoferstrasse 8a, 80336 Munchen, Germany
    Drug Discov Today 12:446-51. 2007
    ..Altogether, the presentation of target validation studies should meet defined criteria similar to those used in human trials...
  22. ncbi Toll-like receptors and danger signaling in kidney injury
    Hans Joachim Anders
    Department of Nephrology, University of Munich, Munich, Germany
    J Am Soc Nephrol 21:1270-4. 2010
    ..The evolving concept of danger signaling provides a general mechanism for kidney injury...
  23. ncbi Pigmented villonodular synovitis of the hip in systemic lupus erythematosus: a case report
    Hans Joachim Anders
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munich, Germany
    J Med Case Reports 5:443. 2011
    ..abstract:..
  24. ncbi Signaling danger: toll-like receptors and their potential roles in kidney disease
    Hans Joachim Anders
    Nephrological Center, Medizinische Poliklinik, Klinikum der Universität München Junenstadt, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 15:854-67. 2004
    ..Here the authors provide an overview on the biology of TLR, summarize the present data on their expression in the kidney, and provide an outlook for the potential roles of TLR in kidney disease...
  25. ncbi Current paradigms about chemokines as therapeutic targets
    Hans-Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig-Maximilians-University, Munich, Germany
    Nephrol Dial Transplant 19:2948-51. 2004
  26. ncbi Late onset of treatment with a chemokine receptor CCR1 antagonist prevents progression of lupus nephritis in MRL-Fas(lpr) mice
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 15:1504-13. 2004
    ..This is the first evidence that, in advanced chronic renal injury, blockade of CCR1 can halt disease progression and improve renal function by selective inhibition of interstitial leukocyte recruitment and fibrosis...
  27. ncbi [Chronic kidney disease]
    Hans Joachim Anders
    Nephrologisches Zentrum, Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Munchen
    Med Klin (Munich) 100:714-21. 2005
    ..New data from multiple multicenter trials have changed existing treatment guidelines. New drugs have become available. This update provides an overview about new treatment guidelines for patients with chronic kidney disease...
  28. ncbi Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Germany
    FASEB J 18:534-6. 2004
    ..We conclude that TLR9 activation triggers disease activity of systemic autoimmunity, for example, lupus nephritis, and that adaptive and innate immune mechanisms contribute to the CpG-DNA-induced progression of lupus nephritis...
  29. ncbi A Toll for lupus
    H J Anders
    Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    Lupus 14:417-22. 2005
    ..interaction involved in infection-induced disease activity of lupus? 2) What are the risks of CpG motifs in vaccine adjuvants for lupus patients? 3) Is TLR9 signalling involved in the pathogenesis of lupus by recognizing self DNA?..
  30. ncbi Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease
    Volha Ninichuk
    Nephrological Center, Medical Policlinic, University of Munich, Germany
    J Am Soc Nephrol 16:977-85. 2005
    ..These data identify CCR1 as a potential therapeutic target for Alport disease or other progressive nephropathies associated with interstitial macrophage infiltrates...
  31. ncbi Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens
    Maciej Lech
    Medical Policlinic, University of Munich, 80336 Munich, Germany
    J Exp Med 205:1879-88. 2008
    ..These data identify Sigirr as a novel SLE susceptibility gene in mice...
  32. ncbi Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 14:317-26. 2003
    ..This mechanism may be relevant during infection-triggered exacerbation of human immune-complex GN and other immune-mediated diseases in general...
  33. ncbi Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4
    Ramanjaneyulu Allam
    Medizinische Klinik und Poliklinik IV, Klinikum der Universitat Munchen, Pettenkoferstr 8a, D 80336 Munich, Germany
    J Am Soc Nephrol 23:1375-88. 2012
    ..Because the induction of proinflammatory cytokines in dendritic cells requires TLR2 and TLR4, these results support the concept that renal damage triggers an innate immune response, which contributes to the pathogenesis of AKI...
  34. ncbi Viral double-stranded RNA aggravates lupus nephritis through Toll-like receptor 3 on glomerular mesangial cells and antigen-presenting cells
    Prashant S Patole
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Am Soc Nephrol 16:1326-38. 2005
    ..g., glomerular mesangial cells, to produce cytokines and chemokines, factors that can aggravate autoimmune tissue injury, e.g., lupus nephritis...
  35. ncbi CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome
    Volker Vielhauer
    Nephrologisches Zentrum, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Kidney Int 66:2264-78. 2004
    ..We therefore studied the effect of the small-molecule CCR1 antagonist BX471 in a murine model of adriamycin-induced focal segmental glomerulosclerosis (FSGS) with nephrotic syndrome and progressive interstitial inflammation and fibrosis...
  36. ncbi Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis
    Maciej Lech
    Medizinische Poliklinik, University of Munich, Germany
    J Pathol 220:596-607. 2010
    ..Thus, TIR8/SIGIRR protects from hydrocarbon oil-induced lupus by suppressing the TLR7-mediated activation of dendritic cells, via its intracellular BB loop...
  37. ncbi Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses
    Ramanjaneyulu Allam
    Medical Policlinic, University of Munich, Germany
    Eur J Immunol 38:3487-98. 2008
    ..We conclude, 3P-RNA or non-CpG DNA both trigger autoimmune disease in MRL(lpr/lpr) mice by specifically activating adaptive immunity but similarly enhance inflammation on the tissue level...
  38. ncbi A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation
    Hans Joachim Anders
    Nephrological Center, Medizinische Poliklinik, Innenstadt, Universitat Munchen, Munchen, Germany
    J Clin Invest 109:251-9. 2002
    ..We therefore conclude that CCR1 blockade may represent a new therapeutic strategy for reducing cellular infiltration and renal fibrosis as major factors in the progression to end-stage renal failure...
  39. ncbi Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus
    Rahul D Pawar
    Medizinische Poliklinik, University of Munich, Pettenkoferstrasse 8a, 80336 Munich, Germany
    J Am Soc Nephrol 18:1721-31. 2007
    ..Hence, TLR-7 is proposed as a novel and potential therapeutic target in systemic lupus erythematosus...
  40. ncbi Phenotyping renal leukocyte subsets by four-color flow cytometry: characterization of chemokine receptor expression
    Volker Vielhauer
    Nephrologisches Zentrum, Medizinische Poliklinik, Ludwig Maximilian University, Munich, Germany
    Nephron Exp Nephrol 93:e63. 2003
    ..They demonstrate that flow cytometric analysis of single cell suspensions prepared from inflamed kidneys is a rapid and reliable technique to characterize and quantify surface receptor expression on infiltrating renal leukocyte subsets...
  41. ncbi Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10
    Sufyan G Sayyed
    Nephrological Center, Medizinische Poliklinik, Ludwig Maximilians University, Munich, Germany
    Nephrol Dial Transplant 25:1811-7. 2010
    ..The current study examined the role of histone epigenetics in development and progression of nephropathy in db/db mice...
  42. ncbi Toll-like receptor signaling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction
    Veronika Skuginna
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munich, Germany
    PLoS ONE 6:e19204. 2011
    ..Together, postobstructive renal interstitial fibrosis and tubular atrophy develop independent of SIGIRR, TLR2, TLR9, and MyD88. These data argue against a significant role of these molecules in renal fibrosis...
  43. ncbi Coactivation of Toll-like receptor-3 and -7 in immune complex glomerulonephritis
    Prashant S Patole
    Medical Policlinic, Ludwig Maximilians University Munich, Pettenkoferstr 8a, 80336 Munich, Germany
    J Autoimmun 29:52-9. 2007
    ..We conclude that a number of mechanisms protect the host from additive effects of TLR3-TLR7 coactivation on renal pathology in vivo...
  44. ncbi Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating Toll-like receptor 2 at the glomerular filtration barrier
    Rahul D Pawar
    Medical Policlinic, University of Munich, Munich, Germany
    Immunology 128:e206-21. 2009
    ..LPS also induced moderate albuminuria. In summary, bacterial lipopeptide and LPS can aggravate glomerulonephritis but only lipopeptide potently induces severe albuminuria in MRL(lpr/lpr) mice...
  45. ncbi Anti-GBM glomerulonephritis involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1
    Julia Lichtnekert
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    PLoS ONE 6:e26778. 2011
    ..Together, the NLRP3-ASC-caspase-1 axis does not contribute to intrinsic glomerular inflammation via glomerular parenchymal cells as these cannot produce IL-1β during sterile inflammation...
  46. ncbi CC chemokine ligand 5/RANTES chemokine antagonists aggravate glomerulonephritis despite reduction of glomerular leukocyte infiltration
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Immunol 170:5658-66. 2003
    ....
  47. ncbi Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5: Implications for viral infection-associated glomerulonephritis
    Katharina Flür
    Medical Policlinic, University of Munich, Germany
    Am J Pathol 175:2014-22. 2009
    ..Thus, TLR-independent recognition of viral RNA is a potent inducer of type I interferon in mesangial cells, which can be an important mediator of virally induced glomerulonephritis...
  48. ncbi Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus
    Maciej Lech
    Medizinische Poliklinik, Campus Innenstadt, Klinikum der Universität München LMU, Germany
    Ann Rheum Dis 70:2207-17. 2011
    ..Interleukin-1 receptor-associated kinase (IRAK)-M suppresses Toll-like receptor (TLR)-mediated activation of innate immunity during infection. A similar role was hypothesised for IRAK-M in autoimmunity...
  49. ncbi Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus
    Maciej Lech
    Medizinische Poliklinik, University of Munich, Munich, Germany
    PLoS ONE 6:e20118. 2011
    ..Vice versa, loss-of-function mutations in the Ptx3 gene might represent a genetic risk factor for pulmonary (but not renal) manifestations of systemic lupus or other autoimmune diseases...
  50. ncbi Double-stranded DNA activates glomerular endothelial cells and enhances albumin permeability via a toll-like receptor-independent cytosolic DNA recognition pathway
    Holger Hägele
    Department of Nephrology, University of Munich, Germany
    Am J Pathol 175:1896-904. 2009
    ..This innate antiviral response program suggests a novel pathomechanism regulating DNA virus-mediated induction or aggravation of glomerulonephritis...
  51. ncbi Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease
    Murthy N Darisipudi
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    Am J Pathol 179:116-24. 2011
    ....
  52. ncbi Efficient renal recruitment of macrophages and T cells in mice lacking the duffy antigen/receptor for chemokines
    Volker Vielhauer
    Medizinische Poliklinik, Campus Innenstadt, Ludwig Maximilians University Munich, Munich, Germany
    Am J Pathol 175:119-31. 2009
    ....
  53. ncbi Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice
    Volha Ninichuk
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    Am J Pathol 172:628-37. 2008
    ....
  54. ncbi Spiegelmer inhibition of CCL2/MCP-1 ameliorates lupus nephritis in MRL-(Fas)lpr mice
    Onkar Kulkarni
    Nephrological Center, Ludwig Maximilians University, 80336 Munich, Germany
    J Am Soc Nephrol 18:2350-8. 2007
    ..Thus, mNOX-E36-based inhibition of CCL2 represents a novel strategy for the treatment of autoimmune tissue injury, such as lupus nephritis...
  55. ncbi IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production
    Maciej Lech
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munich, Germany
    J Am Soc Nephrol 22:1443-52. 2011
    ..Because these adaptive immune effectors are essential for the evolution of lupus nephritis, we conclude that IRF4 promotes the development of lupus nephritis despite suppressing antigen-presenting cells...
  56. ncbi Mdm2 promotes systemic lupus erythematosus and lupus nephritis
    Ramanjaneyulu Allam
    Medizinische Poliklinik, Universitat Munchen, Pettenkoferstraße 8a, D 80336 MUnchen, Germany
    J Am Soc Nephrol 22:2016-27. 2011
    ..Antagonizing Mdm2 may have therapeutic potential in lupus nephritis...
  57. ncbi Activated protein C attenuates systemic lupus erythematosus and lupus nephritis in MRL-Fas(lpr) mice
    Julia Lichtnekert
    Nephrologisches Zentrum, Medizinische Poliklinik, Campus Innenstadt, Klinikum der Universität München LMU, 80336 Munchen, Germany
    J Immunol 187:3413-21. 2011
    ..These results implicate that recombinant activated protein C might be useful for the treatment of human SLE...
  58. ncbi Chemokine receptor CCR1: a new target for progressive kidney disease
    Volha Ninichuk
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University of Munich, Germany
    Am J Nephrol 25:365-72. 2005
    ..Identification of new targets may add to the therapeutic options in chronic kidney disease...
  59. ncbi The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice
    Volha Ninichuk
    Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Pettenkoferstr 8a, 80336 Munchen, Germany
    Am J Pathol 170:1267-76. 2007
    ..These data identify oral treatment with the CCR1 antagonist BL5923 as a potential therapy for late-stage diabetic nephropathy...
  60. ncbi The contribution of B cells to renal interstitial inflammation
    Florian Heller
    Medizinische Poliklinik Innenstadt, University of Munich, Germany
    Am J Pathol 170:457-68. 2007
    ..CXCR5-positive B cells might be recruited via the chemokine CXCL13 and seem to contribute to the formation of intrarenal lymphoid follicle-like structures. These might represent an intrarenal immune system...
  61. ncbi Toll-like receptor-4: renal cells and bone marrow cells signal for neutrophil recruitment during pyelonephritis
    Prashant S Patole
    Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
    Kidney Int 68:2582-7. 2005
    ..Toll-like receptor-4 (TLR4) mutant mice infected with uropathogenic Escherichia coli lack renal CXCL2 mRNA expression, subsequent neutrophil recruitment, and renal abscess formation...
  62. ncbi Chemokine receptors Ccr1, Ccr2, and Ccr5 mediate neutrophil migration to postischemic tissue
    Christoph A Reichel
    Institute for Surgical Research, Arbeitsgruppe Klinische Biochemie, University of Munich, Germany
    J Leukoc Biol 79:114-22. 2006
    ..In conclusion, these in vivo data demonstrate that Ccr1, Ccr2, and Ccr5 mediate the postischemic recruitment of neutrophils through effects on intravascular adherence and subsequent transmigration...
  63. ncbi Anti-Ccl2 Spiegelmer permits 75% dose reduction of cyclophosphamide to control diffuse proliferative lupus nephritis and pneumonitis in MRL-Fas(lpr) mice
    Onkar Kulkarni
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University, Munich, Germany
    J Pharmacol Exp Ther 328:371-7. 2009
    ..We propose anti-Ccl2 Spiegelmer therapy as a novel strategy to reduce CYC toxicity in the treatment of severe lupus...
  64. ncbi Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif
    Julia Lichtnekert
    Medizinische Poliklinik, Klinikum der Universität Innenstadt, Pettenkoferstr 8a, 80336 Munich, Germany
    Am J Physiol Renal Physiol 296:F867-74. 2009
    ..We therefore conclude that apoptotic cell RNA is a poor activator of Trif signaling in mesangial cells and that necrotic cells' releases rather activate mesangial cells via the Tlr2/Myd88 signaling pathway...
  65. ncbi Bacterial CpG-DNA accelerates Alport glomerulosclerosis by inducing an M1 macrophage phenotype and tumor necrosis factor-α-mediated podocyte loss
    Mi Ryu
    Nephrologisches Zentrum, Medizinische Poliklinik der LMU, University of München, Munchen, Germany
    Kidney Int 79:189-98. 2011
    ..Hence, factors that modulate the phenotype of renal macrophages can affect the progression of Alport nephropathy and, potentially, other types of chronic kidney diseases...
  66. ncbi 4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice
    Onkar P Kulkarni
    Medizinische Poliklinik Innenstadt, University of Munich, Munich, Germany
    Am J Pathol 176:2840-7. 2010
    ..Hence, DHODH inhibition with 4SC-101 might be suitable to treat active SLE with fewer side effects than CYC...
  67. ncbi Double-stranded RNA activates type I interferon secretion in glomerular endothelial cells via retinoic acid-inducible gene (RIG)-1
    Holger Hägele
    Department of Nephrology, Medical Policlinic, University of Munich, Munich, Germany
    Nephrol Dial Transplant 24:3312-8. 2009
    ....
  68. ncbi Toll-like receptors: emerging concepts in kidney disease
    Hans Joachim Anders
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    Curr Opin Nephrol Hypertens 16:177-83. 2007
    ..To summarize the recent advances in the role of Toll-like receptors (TLRs) in innate immunity, with a special focus on recent studies addressing the expression and function of TLRs in kidney disease...
  69. ncbi Expression of the chemokine receptor CCR1 in human renal allografts
    Verena Mayer
    Medizinische Poliklinik Innenstadt, Pettenkoferstrasse 8a, 80336 Munich, Germany
    Nephrol Dial Transplant 22:1720-9. 2007
    ..CCR1 is a receptor for various proinflammatory chemokines and CCR1 blockade reduces renal allograft injury in rabbits. The purpose of the study was to characterize CCR1-positive cells in human renal allografts...
  70. ncbi Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis
    Emina Savarese
    Department of Internal Medicine II, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
    Arthritis Rheum 58:1107-15. 2008
    ....
  71. ncbi Chemokines and chemokine receptors as therapeutic targets in lupus nephritis
    Volker Vielhauer
    Medizinische Poliklinik Innenstadt, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany
    Semin Nephrol 27:81-97. 2007
    ....
  72. ncbi An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes
    Sufyan G Sayyed
    Nephrologisches Zentrum, Medizinische Poliklinik, University of Munich, Germany
    Kidney Int 80:68-78. 2011
    ..This successful pre-clinical trial suggests that this antagonist may now be ready for testing in humans with the nephropathy of diabetes mellitus...
  73. ncbi Interstitial inflammation in Alport syndrome
    Jan Jedlicka
    Medizinische Poliklinik Campus Innenstadt, University of Munich, 80336 Munich, Germany
    Hum Pathol 41:582-93. 2010
    ..The degree of infiltration correlated with renal function. We speculate that targeting T lymphocytes, for example, by CXCR3 blocking agents, might be a novel approach to inhibit disease progression in patients with Alport syndrome...
  74. ncbi Targeting the recruitment of monocytes and macrophages in renal disease
    Volker Vielhauer
    Klinikum der Universitat, Ludwig Maximilians University, Munich, Germany
    Semin Nephrol 30:318-33. 2010
    ....
  75. ncbi Targeting the chemokine network in renal inflammation
    Vaclav Eis
    Nephrological Center, Medical Policlinic, Ludwig Maximilians University Munich, Germany
    Arch Immunol Ther Exp (Warsz) 52:164-72. 2004
    ....
  76. ncbi Identifying chemokines as therapeutic targets in renal disease: lessons from antagonist studies and knockout mice
    Volker Vielhauer
    Medizinische Poliklinik Innenstadt, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany
    Kidney Blood Press Res 27:226-38. 2004
    ....
  77. ncbi Ischemia reperfusion induces IFN regulatory factor 4 in renal dendritic cells, which suppresses postischemic inflammation and prevents acute renal failure
    Saraswati Lassen
    Medizinische Poliklinik, Universitat Munchen, Munchen, Germany
    J Immunol 185:1976-83. 2010
    ....
  78. ncbi Viral RNA and DNA trigger common antiviral responses in mesangial cells
    Ramanjaneyulu Allam
    Medizinische Poliklinik, University of Munich, Munich, Germany
    J Am Soc Nephrol 20:1986-96. 2009
    ..We conclude that 3P-RNA and double-stranded DNA trigger a common, TLR-independent, antiviral response in glomerular mesangial cells, which may promote glomerulonephritis in the setting of viral infection...
  79. ncbi Chemokine receptor CCR1 but not CCR5 mediates leukocyte recruitment and subsequent renal fibrosis after unilateral ureteral obstruction
    Vaclav Eis
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 15:337-47. 2004
    ..Therefore, CCR1 is a promising target for therapeutic intervention in leukocyte-mediated fibrotic tissue injury, e.g. progressive renal fibrosis...
  80. ncbi Questions about chemokine and chemokine receptor antagonism in renal inflammation
    Hans Joachim Anders
    Medizinische Poliklinik, Ludwig Maximilians University of Munich, Munich, Germany hjanders med uni muenchen de
    Nephron Exp Nephrol 114:e33-8. 2010
    ..What are the functional roles of homeostatic chemokines and atypical, nonsignaling chemokine receptors in renal inflammation? And finally, what classes of chemokine antagonists are available to address these questions experimentally?..
  81. ncbi Postischemic vascular permeability requires both TLR-2 and TLR-4, but only TLR-2 mediates the transendothelial migration of leukocytes
    Alexander Georg Khandoga
    Walter Brendel Centre of Experimental Medicine, Ludwig Maximilians Universitat Munchen, Munich, Germany
    Shock 31:592-8. 2009
    ..We conclude that both TLR-2 signaling and TLR-4 signaling enhance postischemic vascular permeability and that TLR-2 has additional effects on the transendothelial migration of leukocytes at the postischemic vascular wall...
  82. ncbi Chemokines and chemokine receptors as therapeutic targets in chronic kidney disease
    Volker Vielhauer
    Medizinische Poliklinik, Klinikum der Universitat Munchen, Campus Innenstadt, Ludwig Maximilians University, Pettenkoferstr 8a, 80336 Munich, Germany
    Front Biosci (Schol Ed) 1:1-12. 2009
    ....
  83. ncbi G-rich DNA suppresses systemic lupus
    Prashant S Patole
    Medical Policlinic, Ludwig-Maximilians-University Munich, Germany
    J Am Soc Nephrol 16:3273-80. 2005
    ..It is concluded that adjuvant activity of self-DNA contributes to the pathogenesis of lupus nephritis. Modulating the CpG-DNA-TLR-9 pathway may offer new opportunities for the understanding and treatment of lupus...
  84. ncbi Toll-like receptor-7 modulates immune complex glomerulonephritis
    Rahul D Pawar
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    J Am Soc Nephrol 17:141-9. 2006
    ....
  85. ncbi Chemokines and chemokine receptors are involved in the resolution or progression of renal disease
    Hans-Joachim Anders
    Medizinische Poliklinik - Innenstadt, , Munich, Germany
    Kidney Int 63:401-15. 2003
    ....
  86. ncbi Resident dendritic cells prevent postischemic acute renal failure by help of single Ig IL-1 receptor-related protein
    Maciej Lech
    Medizinische Poliklinik University of Munich, Munich, Germany
    J Immunol 183:4109-18. 2009
    ..Thus, loss of function mutations in the SIGIRR gene predispose to acute renal failure because SIGIRR prevents overshooting tissue injury by suppressing the postischemic activation of intrarenal myeloid cells...
  87. ncbi Bone marrow-derived progenitor cells and renal fibrosis
    Volha Ninichuk
    Medical Policlinic, University of Munich, Germany
    Front Biosci 13:5163-73. 2008
    ..However, in the process of tissue fibrosis the contribution of either cell type is less clear. Here we discuss current concepts on how different bone marrow-derived progenitor cell populations may contribute to renal fibrosis...
  88. ncbi Ccl2/Mcp-1 blockade reduces glomerular and interstitial macrophages but does not ameliorate renal pathology in collagen4A3-deficient mice with autosomal recessive Alport nephropathy
    Sebastian Clauss
    Nephrological Center, Medical Policlinic, University of München, Germany
    J Pathol 218:40-7. 2009
    ..We conclude that Ccl2 mediates the recruitment of glomerular and interstitial macrophages but this mechanism does not contribute to the progression of Alport nephropathy in Col4a3-deficient mice...
  89. ncbi Innate immune receptors and autophagy: implications for autoimmune kidney injury
    Hans Joachim Anders
    Department of Nephrology, University of Munich, Munich, Germany
    Kidney Int 78:29-37. 2010
    ..A better understanding of danger signaling should enable us to unravel yet unknown triggers for renal immunopathology and progressive kidney disease...
  90. ncbi Chemokines in lupus nephritis
    Onkar Kulkarni
    Department of Nephrology, Medizinische Poliklinik, Klinikum der Universitat Munchen Innenstadt, Munich, Germany
    Front Biosci 13:3312-20. 2008
    ..In this review we summarise the available experimental and human data on the expression and functional role of chemokines and chemokine receptors in lupus nephritis...
  91. ncbi Microbial nucleic acids pay a Toll in kidney disease
    Rahul D Pawar
    Nephrological Center, Medical Policlinic, University of Munich, Munich, Germany
    Am J Physiol Renal Physiol 291:F509-16. 2006
    ..In this review, we summarize recent advances in this field and discuss new hypotheses for the pathogenesis of kidney diseases that are triggered by infectious organisms...
  92. ncbi Blockade of chemokine-mediated tissue injury in lupus nephritis
    Volker Vielhauer
    Department of Nephrology, Medizinische Poliklinik Innenstadt, Ludwig-Maximilians-University, Pettenkoferstr. 8a, 80336 Munich, Germany
    Endocr Metab Immune Disord Drug Targets 6:313-21. 2006
    ....
  93. ncbi Functional consequences of integrin-linked kinase activation in podocyte damage
    Vicente de Paulo Castro Teixeira
    Medizinische Poliklinik, , Munich, Germany
    Kidney Int 67:514-23. 2005
    ..As this pathway is amendable to pharmacologic intervention, further detailed studies of in vivo ILK function in glomerular disease appear justified...
  94. ncbi Renal failure increases cardiac histone h3 acetylation, dimethylation, and phosphorylation and the induction of cardiomyopathy-related genes in type 2 diabetes
    Anil Bhanudas Gaikwad
    Department of Nephrology, Medizinische Poliklinik, University of Munich, Munchen, Germany
    Am J Pathol 176:1079-83. 2010
    ..These data suggest that renal failure alters cardiac histone H3 epigenetics, which foster cardiomyocyte hypertrophy in type 2 diabetes...
  95. ncbi B-cell-attracting chemokine CXCL13 as a marker of disease activity and renal involvement in systemic lupus erythematosus (SLE)
    Lena Schiffer
    Department of Medicine Nephrology, Hannover Medical School, Munchen, Germany
    Nephrol Dial Transplant 24:3708-12. 2009
    ..Here, we ask whether serum levels of CXCL13 correlate with disease activity and renal involvement in SLE patients...
  96. ncbi Expression and regulation of Toll-like receptors in lupus-like immune complex glomerulonephritis of MRL-Fas(lpr) mice
    Prashant S Patole
    Nephrological Center, Medizinische Poliklinik, , , Germany
    Nephrol Dial Transplant 21:3062-73. 2006
    ..CONCLUSION: Thus, cell-type-specific expression and regulation of TLRs may be involved in infection-associated exacerbation of immune complex glomerulonephritis of MRLlpr/lpr mice...
  97. ncbi Toll-like receptors recognize uropathogenic Escherichia coli and trigger inflammation in the urinary tract
    Hans-Joachim Anders
    Nephrol Dial Transplant 20:1529-32. 2005