V Alt

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. ncbi request reprint Bone ingrowth in bFGF-coated hydroxyapatite ceramic implants
    Reinhard Schnettler
    Department of Trauma Surgery, Justus Liebig University Giessen, Rudolf Buchheim Street 7, 35385 Giessen, Germany
    Biomaterials 24:4603-8. 2003
  2. doi request reprint A new metaphyseal bone defect model in osteoporotic rats to study biomaterials for the enhancement of bone healing in osteoporotic fractures
    Volker Alt
    Department of Trauma Surgery, University Hospital Giessen Marburg GmbH, Campus Giessen, Giessen, Germany
    Acta Biomater 9:7035-42. 2013
  3. ncbi request reprint Treatment of a double nonunion of the femur by rhBMP-2
    Volker Alt
    Department of Trauma Surgery, University Hospital Giessen Marburg, Site Giessen, Giessen, Germany
    J Orthop Trauma 21:734-7. 2007
  4. ncbi request reprint Economic considerations for the use of recombinant human bone morphogenetic protein-2 in open tibial fractures in Europe: the German model
    V Alt
    Department of Trauma Surgery, University Hospital Giessen Marburg, Rudolf Buchheim Strasse 7, D 35385 Giessen, Germany
    Curr Med Res Opin 22:S19-22. 2006
  5. ncbi request reprint A health economic analysis of the use of rhBMP-2 in Gustilo-Anderson grade III open tibial fractures for the UK, Germany, and France
    Volker Alt
    Department of Trauma Surgery Giessen University Hospital Giessen Marburg, Site Giessen, Rudolf Buchheim Str 7, 35385 Giessen, Germany
    Injury 40:1269-75. 2009
  6. pmc An economic analysis of using rhBMP-2 for lumbar fusion in Germany, France and UK from a societal perspective
    Volker Alt
    Department of Trauma Surgery, University Hospital Giessen Marburg GmbH, Site Giessen, Rudolf Buchheim Str 7, 35385, Giessen, Germany
    Eur Spine J 18:800-6. 2009
  7. ncbi request reprint The effects of combined gentamicin-hydroxyapatite coating for cementless joint prostheses on the reduction of infection rates in a rabbit infection prophylaxis model
    Volker Alt
    Department of Trauma Surgery Giessen, University Hospital Giessen Marburg, Rudolf Buchheim Strasse 7, 35385 Giessen, Germany
    Biomaterials 27:4627-34. 2006
  8. ncbi request reprint [Cost-benefit analysis of the use of rhBMP-2 in open tibial fractures: savings from a health insurer's perspective]
    V Alt
    Klinik und Poliklinik für Unfallchirurgie Giessen, Universitätsklinikum Giessen Marburg, Rudolf Buchheim Strasse 7, 35385 Giessen
    Unfallchirurg 109:463-70. 2006
  9. doi request reprint Effects of gentamicin and gentamicin-RGD coatings on bone ingrowth and biocompatibility of cementless joint prostheses: an experimental study in rabbits
    Volker Alt
    Department of Trauma Surgery, University Hospital of Giessen Marburg GmbH, and Laboratory of Experimental Trauma Surgery, Institute of Medical Computer Sciences, Justus Liebig University Giessen, Campus Giessen, 35385 Giessen, Germany
    Acta Biomater 7:1274-80. 2011
  10. doi request reprint A new animal model for implant-related infected non-unions after intramedullary fixation of the tibia in rats with fluorescent in situ hybridization of bacteria in bone infection
    Volker Alt
    Department of Trauma Surgery Giessen, University Hospital of Giessen Marburg, Giessen, Germany
    Bone 48:1146-53. 2011

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Bone ingrowth in bFGF-coated hydroxyapatite ceramic implants
    Reinhard Schnettler
    Department of Trauma Surgery, Justus Liebig University Giessen, Rudolf Buchheim Street 7, 35385 Giessen, Germany
    Biomaterials 24:4603-8. 2003
    ..The current experimental study revealed comparable results of bFGF-coated HA implants and autogenous grafts regarding angiogenesis, bone synthesis and bone ingrowth...
  2. doi request reprint A new metaphyseal bone defect model in osteoporotic rats to study biomaterials for the enhancement of bone healing in osteoporotic fractures
    Volker Alt
    Department of Trauma Surgery, University Hospital Giessen Marburg GmbH, Campus Giessen, Giessen, Germany
    Acta Biomater 9:7035-42. 2013
    ..68±0.34mm(2)), in which no bridging of the initial defect was found. These results were confirmed by histology. In conclusion, the 5mm defect can be considered as a critical size defect model in which biomaterials can be tested...
  3. ncbi request reprint Treatment of a double nonunion of the femur by rhBMP-2
    Volker Alt
    Department of Trauma Surgery, University Hospital Giessen Marburg, Site Giessen, Giessen, Germany
    J Orthop Trauma 21:734-7. 2007
    ..We believe this is the first study to report the successful use of 2 kits of rhBMP-2 in a double nonunion of the femur...
  4. ncbi request reprint Economic considerations for the use of recombinant human bone morphogenetic protein-2 in open tibial fractures in Europe: the German model
    V Alt
    Department of Trauma Surgery, University Hospital Giessen Marburg, Rudolf Buchheim Strasse 7, D 35385 Giessen, Germany
    Curr Med Res Opin 22:S19-22. 2006
    ..It is anticipated that the overall savings that can be achieved by rhBMP-2 treatment in open tibia fractures, offset the upfront price of rhBMP-2 and lead to net savings for health insurance companies...
  5. ncbi request reprint A health economic analysis of the use of rhBMP-2 in Gustilo-Anderson grade III open tibial fractures for the UK, Germany, and France
    Volker Alt
    Department of Trauma Surgery Giessen University Hospital Giessen Marburg, Site Giessen, Rudolf Buchheim Str 7, 35385 Giessen, Germany
    Injury 40:1269-75. 2009
    ..In summary, despite the apparent high direct cost of rhBMP-2 in grade III A and B open tibial fractures, at a national level there are net cost savings from a societal perspective for all three countries...
  6. pmc An economic analysis of using rhBMP-2 for lumbar fusion in Germany, France and UK from a societal perspective
    Volker Alt
    Department of Trauma Surgery, University Hospital Giessen Marburg GmbH, Site Giessen, Rudolf Buchheim Str 7, 35385, Giessen, Germany
    Eur Spine J 18:800-6. 2009
    ..Improved clinical outcome for the patient combined with better health-economic outcome for the society support rhBMP-2 as a valuable alternative compared with autograft...
  7. ncbi request reprint The effects of combined gentamicin-hydroxyapatite coating for cementless joint prostheses on the reduction of infection rates in a rabbit infection prophylaxis model
    Volker Alt
    Department of Trauma Surgery Giessen, University Hospital Giessen Marburg, Rudolf Buchheim Strasse 7, 35385 Giessen, Germany
    Biomaterials 27:4627-34. 2006
    ..In further studies biocompatibility of the coatings has to be assessed...
  8. ncbi request reprint [Cost-benefit analysis of the use of rhBMP-2 in open tibial fractures: savings from a health insurer's perspective]
    V Alt
    Klinik und Poliklinik für Unfallchirurgie Giessen, Universitätsklinikum Giessen Marburg, Rudolf Buchheim Strasse 7, 35385 Giessen
    Unfallchirurg 109:463-70. 2006
    ....
  9. doi request reprint Effects of gentamicin and gentamicin-RGD coatings on bone ingrowth and biocompatibility of cementless joint prostheses: an experimental study in rabbits
    Volker Alt
    Department of Trauma Surgery, University Hospital of Giessen Marburg GmbH, and Laboratory of Experimental Trauma Surgery, Institute of Medical Computer Sciences, Justus Liebig University Giessen, Campus Giessen, 35385 Giessen, Germany
    Acta Biomater 7:1274-80. 2011
    ..Limitations of the study are the high standard deviation of the results and the limited number of animals per time point...
  10. doi request reprint A new animal model for implant-related infected non-unions after intramedullary fixation of the tibia in rats with fluorescent in situ hybridization of bacteria in bone infection
    Volker Alt
    Department of Trauma Surgery Giessen, University Hospital of Giessen Marburg, Giessen, Germany
    Bone 48:1146-53. 2011
    ..This work presents the first animal model for the induction of intramedullary device-related infected non-union in the tibia and detection of bacteria by FISH technique in infected bone...
  11. ncbi request reprint [Health-economic considerations for the use of BMP-2 for spinal surgery in Germany]
    V Alt
    Klinik für Unfallchirurgie, Universitätsklinikum Giessen Marburg, Standort Giessen, Germany
    Z Orthop Ihre Grenzgeb 144:577-82. 2006
    ....
  12. doi request reprint Assessment of angiogenesis in osseointegration of a silica-collagen biomaterial using 3D-nano-CT
    Volker Alt
    Department of Trauma Surgery, Justus Liebig University Giessen, Germany
    Acta Biomater 7:3773-9. 2011
    ..8) but not with the dimension of the fracture zone (r=0.3). Nano-CT imaging is feasible for quantitative analysis of angiogenesis during bony integration of biomaterials and a promising tool in this context for the future...
  13. pmc In vitro testing of antimicrobial activity of bone cement
    Volker Alt
    Department of Trauma Surgery, University Hospital Giessen, Rudolf Buchheim Str 7, 35385 Giessen, Germany
    Antimicrob Agents Chemother 48:4084-8. 2004
    ....
  14. ncbi request reprint Health-economic evaluation in implant trials: design considerations
    Volker Alt
    Department of Trauma Surgery, University Hospital Giessen Marburg GmbH, Giessen, Germany
    J Long Term Eff Med Implants 19:279-85. 2009
    ..Furthermore, close cooperation between researchers, clinicians, and health economists is essential...
  15. ncbi request reprint Effect of glycerol-L-lactide coating polymer on bone ingrowth of bFGF-coated hydroxyapatite implants
    Volker Alt
    Department of Trauma Surgery, Justus Liebig University Giessen, Rudolf Buchheim Str 7, 35385 Giessen, Germany
    J Control Release 99:103-11. 2004
    ..Only after 84 days starting resorption of the polymer accompanied by bone ingrowth was found. The current study showed that glycerol-L-lactide is not suitable for coating of HA implants due to polymer induced "locking" of HA pores...
  16. ncbi request reprint [Nanoparticulate silver. A new antimicrobial substance for bone cement]
    V Alt
    Klinik und Poliklinik für Unfallchirurgie der Justus Liebig Universität Giessen
    Orthopade 33:885-92. 2004
    ..Multiresistant bacteria have become an important problem in prosthetic joint infections. Their frequent resistance against gentamicin, which is commonly used in antibiotic-loaded bone cements, makes a new prophylaxis necessary...
  17. ncbi request reprint An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement
    Volker Alt
    Department of Trauma Surgery, Justus Liebig University Giessen, Rudolf Buchheim Str 7, 35385 Giessen, Germany
    Biomaterials 25:4383-91. 2004
    ..This new form of silver called NanoSilver was free of in vitro cytotoxicity and showed high effectiveness against multiresistant bacteria. If the results can be confirmed in vivo NanoSilver may have a high interest in joint arthroplasty...
  18. ncbi request reprint mRNA expression and protein distribution of fibronectin splice variants and high-molecular weight tenascin-C in different phases of human fracture healing
    O Kilian
    Department of Trauma Surgery, University of Giessen, Giessen, Germany
    Calcif Tissue Int 83:101-11. 2008
    ..The possibility of stimulating fracture healing by EDB + fibronectin-cytokine complexes should be tested in further investigations...
  19. doi request reprint Comparison of new bone formation, implant integration, and biocompatibility between RGD-hydroxyapatite and pure hydroxyapatite coating for cementless joint prostheses--an experimental study in rabbits
    Achim Bitschnau
    Department of Trauma Surgery, University Hospital Giessen Marburg GmbH, Giessen, Germany
    J Biomed Mater Res B Appl Biomater 88:66-74. 2009
    ..Overall, no significant effects of an additional RGD coating on HA surfaces were detected in this model after 12 weeks...
  20. ncbi request reprint [The arteries of the humerus and their relevance in fracture treatment]
    C Meyer
    Klinik und Poliklinik fur Unfallchirurgie, Universitätsklinikum Giessen, Rudolf Buchheim Strasse 7, 35385 Giessen, Germany
    Zentralbl Chir 130:562-7. 2005
    ..The purpose of the current work was to study the arterial blood supply of the humerus to evaluate impairments of the blood supply after humeral fractures and different methods of fracture treatment...
  21. ncbi request reprint Glycerol-l-lactide coating polymer leads to delay in bone ingrowth in hydroxyapatite implants
    Reinhard Schnettler
    Department of Trauma Surgery, University Hospital Giessen, Rudolf Buchheim Str 7, 35385 Giessen, Germany
    J Control Release 106:154-61. 2005
    ..Also electron microscopy showed filling of the HA pores by the polymer. Therefore, it can be concluded that glycerol-l-lactide should not be used to coat HA ceramic implants due to significant delay in bone ingrowth...
  22. doi request reprint Diagnosis of osteoporosis with vitamin k as a new biochemical marker
    C Heiss
    Department of Trauma Surgery, University Hospital of Giessen Marburg, Giessen, Germany
    Vitam Horm 78:417-34. 2008
    ..Beyond this, aspects on the current and prospective use of vitamin K as well as other newly developed biochemical bone markers will be discussed...
  23. ncbi request reprint [School accidents--an epidemiological assessment of injury types and treatment effort]
    R Kraus
    Klinik und Poliklinik fur Unfallchirurgie, Universitätsklinikum Giessen und Marburg, Standort Giessen, Giessen
    Zentralbl Chir 131:411-6. 2006
    ..Traffic education may reduce severe injuries. For diagnosis and treatment of school accidents specific knowledge of the growing longbones of the upper extremity and the hand is important...
  24. ncbi request reprint Plasma transglutaminase factor XIII induces microvessel ingrowth into biodegradable hydroxyapatite implants in rats
    Olaf Kilian
    Department of Trauma Surgery, University of Giessen, Rudolf Buchheim Str 7, 35392 Giessen, Germany
    Biomaterials 26:1819-27. 2005
    ..In contrast, addition of plasma factor XIII to hydroxyapatite (group III) stimulated formation of vessels within the biomaterial. The current study reveals that factor XIII can improve angiogenesis in hydroxyapatite...
  25. ncbi request reprint [Covering of soft tissue defects of the lower leg with adipo-facial flaps]
    C Meyer
    Klinik und Poliklinik fur Unfallchirurgie, Universitätsklinikum Giessen
    Zentralbl Chir 130:26-31. 2005
    ..Soft tissue covering on the lower leg is a difficult challenge. A plastic surgical method for covering of these soft tissue defects is presented...
  26. ncbi request reprint [Difficulties involved in the Hoffa fractures]
    C Meyer
    Klinik und Poliklinik fur Unfallchirurgie, Universitatsklinikum, Giessen
    Unfallchirurg 107:15-21. 2004
    ..They can be expected to ensure the arterial blood supply. Hoffa fracture is a very rare injury. In our patients, careful surgical treatment with open reduction and safe screw fixation yielded good to very good results...
  27. doi request reprint [Operative treatment of osseous pull out of the extensor tendon using a hook plate]
    G Szalay
    Klinik und Poliklinik fur Unfallchirurgie, Universitätsklinikum Gießen und Marburg GmbH, Standort Gießen, Deutschland
    Oper Orthop Traumatol 23:151-7. 2011
    ..Anatomical reposition and stabilization of dorsal distal phalanx fractures with a hook plate...
  28. ncbi request reprint Bond strength of an alkylene bis(dilactoyl)-methacrylate bone adhesive: a biomechanical evaluation in sheep
    Christian Heiss
    Department of Trauma Surgery, University Hospital of Giessen Marburg, Rudolf Buchheim Strasse 7, D 35385 Giessen, Germany
    J Biomater Sci Polym Ed 21:1345-58. 2010
    ..This bone adhesive exhibited good in vivo and in vitro bond strength and mechanical efficiency in both the short and long term without impairment of physiological fracture healing...
  29. ncbi request reprint The tissue response to an alkylene bis(dilactoyl)-methacrylate bone adhesive
    Christian Heiss
    Department of Trauma Surgery, Justus Liebig University of Giessen, Rudolf Buchheim Strasse 7, D 35385 Giessen, Germany
    Biomaterials 26:1389-96. 2005
    ..Complete remodelling of the former osteotomy gap was found in all rabbits after 84 days. This bioresorbable bone adhesive exhibited good biocompatibility and its degradation did not interfere with physiological fracture healing...
  30. doi request reprint Enhancement of bone formation in hydroxyapatite implants by rhBMP-2 coating
    Reinhard Schnettler
    Department of Trauma Surgery Giessen, University Hospital of Giessen Marburg, Giessen 35385, Germany
    J Biomed Mater Res B Appl Biomater 90:75-81. 2009
    ..This study showed that the coating of HA ceramic implants with rhBMP-2 can significantly enhance new bone formation attributable to its osteoinductive effects...
  31. ncbi request reprint Effects of platelet factors on biodegradation and osteogenesis in metaphyseal defects filled with nanoparticular hydroxyapatite--an experimental study in minipigs
    Olaf Kilian
    Department of Trauma Surgery, University of Giessen, Germany
    Growth Factors 25:191-201. 2007
    ..Furthermore, there was a higher number of CD44 and cathepsin-K positive cells by PLF-loading. In summary, PLF led to stimulation of the cellular process of the biodegradation of HA...
  32. ncbi request reprint Connexin 43 expression of foreign body giant cells after implantation of nanoparticulate hydroxyapatite
    Katja Herde
    Institute of Veterinary Anatomy, University of Giessen, Frankfurter Str 98, 35392, Giessen, Germany
    Biomaterials 28:4912-21. 2007
    ....
  33. ncbi request reprint Frequency and effects of intratendinous and peritendinous calcifications after open Achilles tendon repair
    Ralf Kraus
    Trauma Surgery, Justus Liebig University, Rudolf Buchheim Strasse 7, Giessen D 35385, Germany
    Foot Ankle Int 25:827-32. 2004
    ..The purposes of this work were to determine the frequency of calcifications in the Achilles tendon after open repair and their effects on clinical outcomes and to identify possible risk factors for postoperative calcification...
  34. ncbi request reprint Human reaming debris: a source of multipotent stem cells
    Sabine Wenisch
    Experimental Trauma Surgery, University of Giessen, 35394 Giessen, Germany
    Bone 36:74-83. 2005
    ..These findings have prompted interest in the use of reaming debris-derived stem cells in cell and bone replacement therapies...
  35. ncbi request reprint New blood vessel formation and expression of VEGF receptors after implantation of platelet growth factor-enriched biodegradable nanocrystalline hydroxyapatite
    Olaf Kilian
    Department of Trauma Surgery, University of Giessen, Giessen, Germany
    Growth Factors 23:125-33. 2005
    ..These observation are most likely attributable to a stimulating effect of TGF-ss from the platelet factor on VEGF expression in osteoblasts...
  36. ncbi request reprint Immunochemical, ultrastructural and electrophysiological investigations of bone-derived stem cells in the course of neuronal differentiation
    Sabine Wenisch
    Experimental Trauma Surgery, Justus Liebig University, Kerkrader Strasse 9, 35394 Giessen, Germany
    Bone 38:911-21. 2006
    ..Based upon the results, it can be concluded that neuronal induction had initiated the early steps of neuronal differentiation, while exposure of the cells to non-neurological stressors had caused necrotic alterations...
  37. ncbi request reprint Derotation of post-traumatic femoral deformities by closed intramedullary sawing
    Jens Peter Stahl
    University Hospital Giessen, Department of Trauma Surgery, Rudolf Buchheim Str 7, Giessen 35385, Germany
    Injury 37:145-51. 2006
    ..No device-related complications were observed. Therefore, we conclude that "closed" osteotomy with an intramedullary saw is a minimal-invasive, safe and reliable option for derotation procedures in the femur...
  38. ncbi request reprint Treatment of periprosthetic femoral fractures by effective lengthening of the prosthesis
    Christof Meyer
    Department of Trauma Surgery Giessen, University Hospital of Giessen and Marburg, Rudolf Buchheim Strasse 7, 35835 Giessen, Germany
    Clin Orthop Relat Res 463:120-7. 2007
    ..The major complication rate was 6% (one of 18). We believe effective lengthening of the indwelling prosthesis by a custom-made slotted hollow intramedullary nail is a reasonable option for treating periprosthetic femoral fractures...
  39. ncbi request reprint Expression of EDA+ and EDB+ fibronectin splice variants in bone
    O Kilian
    Department of Trauma Surgery, University of Giessen, Germany
    Bone 35:1334-45. 2004
    ..In conclusion, EDA+ and EDB+ fibronectin splice variants are strong markers for active fibrogenetic and osteoid-forming processes in human bones...
  40. doi request reprint [Operative treatment of rhizarthritis: comparison of ligament reconstruction according to Epping with trapezectomy and interposition of pyrocarbon spacers as replacement of the trapezium]
    G Szalay
    Klinik und Poliklinik fur Unfallchirurgie, Universitätsklinikum Giessen und Marburg, Standort Giessen, Rudolf Buchheim Str 7, D 35385, Giessen, Deutschland
    Orthopade 40:237-46. 2011
    ..The aim of this study was to compare the results of resection suspension arthroplasty according to Epping with trapezium replacement using pyrocarbon spacers...
  41. ncbi request reprint The arteries of the humeral head and their relevance in fracture treatment
    C Meyer
    Department of Trauma Surgery, University Hospital Giessen, Rudolf Buchheim Strasse 7, 35385 Giessen, Germany
    Surg Radiol Anat 27:232-7. 2005
    ..Therefore, necessary repositioning manoeuvres during open reduction of the fracture should be conducted with care in order to preserve these arteries...
  42. pmc Vascular endothelial growth factor (VEGF)-induced up-regulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing
    Athanasios N Athanasopoulos
    Department of Internal Medicine I, University Heidelberg, D 69120 Heidelberg, Germany
    J Biol Chem 282:26746-53. 2007
    ..Such a loop could be operative during fracture healing...
  43. ncbi request reprint Nanocrystalline hydroxyapatite and calcium sulphate as biodegradable composite carrier material for local delivery of antibiotics in bone infections
    Michael A Rauschmann
    Department of Orthopaedic Surgery, University Hospital, Johann Wolfgang Goethe University, Marienburgstrasse 2, 60528 Frankfurt am Main, Germany
    Biomaterials 26:2677-84. 2005
    ..Calcium sulphate showed cytotoxic effects in two out of four tests. PerOssal exhibits excellent properties regarding resorption, biocompatibility, and antibiotic release...
  44. ncbi request reprint Injuries of the scapholunate ligament in children
    Volker Alt
    Department of Orthopaedic Surgery, C H G Sarrebourg, Sarrebourg, France
    J Pediatr Orthop B 13:326-9. 2004
    ..4 years all patients were pain free and resumed all sports activities. This study shows that different kind of injuries can occur to the scapholunate ligament in the skeletally immature carpus. Surgical repair leads to good results...