Hakan Alakus


Affiliation: University of Cologne
Country: Germany


  1. Alakus H, Afriani N, Warnecke Eberz U, Bollschweiler E, Fetzner U, Drebber U, et al. Clinical impact of MMP and TIMP gene polymorphisms in gastric cancer. World J Surg. 2010;34:2853-9 pubmed publisher
    ..766) and TIMP-2 (p = 0.684). The TIMP-2(303C>T) CC genotype is associated with higher pN and pM categories and, in contrast to previous studies, with worse survival in gastric cancer. ..
  2. Pasternack H, Fassunke J, Plum P, Chon S, Hescheler D, Gassa A, et al. Somatic alterations in circulating cell-free DNA of oesophageal carcinoma patients during primary staging are indicative for post-surgical tumour recurrence. Sci Rep. 2018;8:14941 pubmed publisher
    ..Taken together, we showed a higher sensitivity for ddPCR compared to NGS in detecting mutated ccfDNA in OC. Detection of somatically altered ccfDNA during primary staging seems to be indicative for post-surgical tumour recurrence. ..
  3. Alakus H, Yost S, Woo B, French R, Lin G, Jepsen K, et al. BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma. J Transl Med. 2015;13:122 pubmed publisher
    ..Our findings suggest a major role for BAP1 in peritoneal MM susceptibility and oncogenesis and indicate important molecular differences to pleural MM as well as potential strategies for therapy and prevention. ..
  4. Berlth F, Messerle K, Plum P, Chon S, von Ambüren J, Hohn A, et al. Impact of the Weekday of Surgery on Outcome in Gastric Cancer Patients who Underwent D2-Gastrectomy. World J Surg. 2018;42:1811-1818 pubmed publisher
    ..948). The present study does not show any evidence for a significant impact of weekday of surgery on short- and long-term outcome of patients undergoing gastrectomy for gastric adenocarcinoma. ..
  5. Maus M, Leers J, Herbold T, Bludau M, Chon S, Kleinert R, et al. Gastric Outlet Obstruction After Esophagectomy: Retrospective Analysis of the Effectiveness and Safety of Postoperative Endoscopic Pyloric Dilatation. World J Surg. 2016;40:2405-11 pubmed publisher
    ..The use of a 30-mm balloon has the same safety profile but a 2.5 lower redilatation rate compared to the 20-mm balloon. Thus, the use of 20-mm balloons has been abandoned in our clinic. ..
  6. Berlth F, Mönig S, Pinther B, Grimminger P, Maus M, Schlösser H, et al. Both GLUT-1 and GLUT-14 are Independent Prognostic Factors in Gastric Adenocarcinoma. Ann Surg Oncol. 2015;22 Suppl 3:S822-31 pubmed publisher
    ..It gives additional information to UICC stages and identifies patients with inferior prognosis. If confirmed in prospective studies, these markers need to be considered for future classification systems. ..