T Aigner

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Chondrocyte apoptosis in osteoarthritis: comment on the letter by Kouri and Abbud-Lozoya
    Thomas Aigner
    Arthritis Rheum 48:1166-7. 2003
  2. ncbi request reprint Gene expression in chondrocytes assessed with use of microarrays
    Thomas Aigner
    Department of Pathology, University of Erlangen Nurnberg, Germany
    J Bone Joint Surg Am 85:117-23. 2003
  3. ncbi request reprint Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton
    Susanna Müller
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Mod Pathol 18:1088-94. 2005
  4. ncbi request reprint Evaluation of VEGF A expression and microvascular density as prognostic factors in extrahepatic cholangiocarcinoma
    C Möbius
    Department of Surgery II, University of Leipzig, Leipzig, Germany
    Eur J Surg Oncol 33:1025-9. 2007
  5. ncbi request reprint Achondrogenesis Type IA (Houston-Harris): a still-unresolved molecular phenotype
    Thomas Aigner
    Institute of Pathology, Liebigstrasse 26, Leipzig, Germany
    Pediatr Dev Pathol 10:328-34. 2007
  6. ncbi request reprint Osteoarthritis: pathobiology-targets and ways for therapeutic intervention
    T Aigner
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    Adv Drug Deliv Rev 58:128-49. 2006
  7. ncbi request reprint IL-1beta and BMPs--interactive players of cartilage matrix degradation and regeneration
    T Aigner
    Institute of Pathology, University of Leipzig, 04103 Leipzig, Germany
    Eur Cell Mater 12:49-56; discussion 56. 2006
  8. ncbi request reprint Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
    Thomas Aigner
    Osteoarticular and Arthritis Research, Institute of Pathology, University of Leipzig, Liebigstrasse 26, D 04103 Leipzig, Germany
    Arthritis Rheum 54:3533-44. 2006
  9. ncbi request reprint Osteoarthritis: aging of matrix and cells--going for a remedy
    T Aigner
    Institute of Pathology, University of Leipzig, Liebigstr 26, D 04301 Leipzig, FRG
    Curr Drug Targets 8:325-31. 2007
  10. ncbi request reprint Growth plate cartilage as developmental model in osteoarthritis research--potentials and limitations
    T Aigner
    Institute of Pathology, University of Leipzig, Liebigstr 26, 0341 Leipzig, FRG
    Curr Drug Targets 8:377-85. 2007

Detail Information

Publications93

  1. ncbi request reprint Chondrocyte apoptosis in osteoarthritis: comment on the letter by Kouri and Abbud-Lozoya
    Thomas Aigner
    Arthritis Rheum 48:1166-7. 2003
  2. ncbi request reprint Gene expression in chondrocytes assessed with use of microarrays
    Thomas Aigner
    Department of Pathology, University of Erlangen Nurnberg, Germany
    J Bone Joint Surg Am 85:117-23. 2003
    ..This has been shown to be true for the analysis of known genes as well as the discovery of new genes of interest...
  3. ncbi request reprint Type II collagen as specific marker for mesenchymal chondrosarcomas compared to other small cell sarcomas of the skeleton
    Susanna Müller
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Mod Pathol 18:1088-94. 2005
    ..Thus, the presence of type II collagen in the extracellular tumor matrix significantly facilitates the diagnosis of mesenchymal chondrosarcomas in the absence of histologically visible chondroid matrix formation...
  4. ncbi request reprint Evaluation of VEGF A expression and microvascular density as prognostic factors in extrahepatic cholangiocarcinoma
    C Möbius
    Department of Surgery II, University of Leipzig, Leipzig, Germany
    Eur J Surg Oncol 33:1025-9. 2007
    ..In extrahepatic cholangiocarcinoma, the VEGF expression and microvessel density have rarely been investigated...
  5. ncbi request reprint Achondrogenesis Type IA (Houston-Harris): a still-unresolved molecular phenotype
    Thomas Aigner
    Institute of Pathology, Liebigstrasse 26, Leipzig, Germany
    Pediatr Dev Pathol 10:328-34. 2007
    ..Presumably, as a consequence of this event, processes of chondrocyte maturation and differentiation and endochondral bone formation are severely affected in this case of achondrogenesis type IA...
  6. ncbi request reprint Osteoarthritis: pathobiology-targets and ways for therapeutic intervention
    T Aigner
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    Adv Drug Deliv Rev 58:128-49. 2006
    ..All the named tissues offer different directions and ways for therapeutic intervention...
  7. ncbi request reprint IL-1beta and BMPs--interactive players of cartilage matrix degradation and regeneration
    T Aigner
    Institute of Pathology, University of Leipzig, 04103 Leipzig, Germany
    Eur Cell Mater 12:49-56; discussion 56. 2006
    ..Thus, it might be neither the aim of osteoarthritis therapy to foster anabolism nor to knock down catabolism, but the balance of anabolic-catabolic activities as a total might need proper titration and balancing...
  8. ncbi request reprint Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
    Thomas Aigner
    Osteoarticular and Arthritis Research, Institute of Pathology, University of Leipzig, Liebigstrasse 26, D 04103 Leipzig, Germany
    Arthritis Rheum 54:3533-44. 2006
    ..The present study was therefore initiated in order to identify differentially expressed disease-related genes and potential therapeutic targets...
  9. ncbi request reprint Osteoarthritis: aging of matrix and cells--going for a remedy
    T Aigner
    Institute of Pathology, University of Leipzig, Liebigstr 26, D 04301 Leipzig, FRG
    Curr Drug Targets 8:325-31. 2007
    ..However, this review intends to open up the idea that age-related changes are less a fate, but rather a challenge for therapeutic intervention which can be taken...
  10. ncbi request reprint Growth plate cartilage as developmental model in osteoarthritis research--potentials and limitations
    T Aigner
    Institute of Pathology, University of Leipzig, Liebigstr 26, 0341 Leipzig, FRG
    Curr Drug Targets 8:377-85. 2007
    ....
  11. ncbi request reprint Expression of cartilage-specific markers in calcified and non-calcified atherosclerotic lesions
    Thomas Aigner
    Institute of Pathology, University of Leipzig, Liebigstr 26, D 04103 Leipzig, Germany
    Atherosclerosis 196:37-41. 2008
    ..Occasionally, however, chondrocytic differentiation markers occur within atherosclerotic lesions. This most likely represents a metaplastic event associated, but not causative for atherosclerotic vessel degeneration and calcification...
  12. ncbi request reprint Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence
    Thomas Aigner
    Institute of Pathology, University of Leipzig, Germany
    Nat Clin Pract Rheumatol 3:391-9. 2007
    ..Thus, anti-aging strategies might complement existing therapeutic targets related to anabolism, catabolism, inflammation, and apoptosis-processes that are integral to the pathogenesis of osteoarthritis...
  13. ncbi request reprint Functional genomics, evo-devo and systems biology: a chance to overcome complexity?
    Thomas Aigner
    Institute of Pathology, University of Leipzig, Leipzig, Germany
    Curr Opin Rheumatol 19:463-70. 2007
    ..This review addresses the key question of how to integrate a high complexity of processes and data to a unifying picture of disease processes and progression relevant for osteoarthritis...
  14. doi request reprint [Typing, grading and staging of osteoarthritis: histopathological assessment of joint degeneration]
    T Aigner
    Institut fur Pathologie, Universitat Leipzig, Liebigstrasse 26, 04103, Leipzig, Deutschland
    Z Rheumatol 67:32-6, 38-40. 2008
    ..Only the identification of secondary types of degenerative changes, due to as yet unknown rheumatoid diseases, gout or extensive osteonecrosis is of particular interest to clinical colleagues (i.e. typing of the joint lesion)...
  15. ncbi request reprint Chondroblastoma is an osteoid-forming, but not cartilage-forming neoplasm
    T Aigner
    Institute of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, D 91054 Erlangen, Germany
    J Pathol 189:463-9. 1999
    ..This study did not show chondroid matrix formation or chondroblastic cell differentiation in chondroblastomas, suggesting that chondroblastoma should be classified as a specific bone-forming, rather than cartilage-forming neoplasm...
  16. pmc Cell differentiation and matrix gene expression in mesenchymal chondrosarcomas
    T Aigner
    Institute of Pathology, the University of Erlangen Nürnberg, Erlangen, Germany
    Am J Pathol 156:1327-35. 2000
    ....
  17. ncbi request reprint CDRAP is expressed in adult articular cartilage, but its expression is not significantly regulated in osteoarthritic chondrocytes
    J Rose
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Germany
    Clin Exp Rheumatol 24:573-5. 2006
    ..In this study we assessed the differential in vivo mRNA expression levels of CDRAP, a potential marker of cartilage degeneration...
  18. ncbi request reprint MMP-9/gelatinase B is a gene product of human adult articular chondrocytes and increased in osteoarthritic cartilage
    S Soder
    Institute of Pathology, University of Leipzig, Germany
    Clin Exp Rheumatol 24:302-4. 2006
    ....
  19. doi request reprint A novel MSC-seeded triphasic construct for the repair of osteochondral defects
    B Marquass
    Department of Trauma and Reconstructive Surgery, University of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany
    J Orthop Res 28:1586-99. 2010
    ..Macroscopic and biomechanical analysis showed no significant differences at 12 months. Autologous MSC-seeded triphasic implants showed comparable repair quality to osteochondral autografts in terms of histology and biomechanical testing...
  20. ncbi request reprint Phenotypic characterization of chondrosarcoma-derived cell lines
    C M Schörle
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Cancer Lett 226:143-54. 2005
    ..Thus, the investigated cell lines are of limited value as substitute of primary chondrocytes but might have a much higher potential to investigate the behavior of neoplastic chondrocytes, i.e. chondrosarcoma biology...
  21. ncbi request reprint Quantification of expression levels of cellular differentiation markers does not support a general shift in the cellular phenotype of osteoarthritic chondrocytes
    Pia Margarethe Gebhard
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, FRG, Germany
    J Orthop Res 21:96-101. 2003
    ..The largely unchanged ratios of collagen subtypes investigated indicate that no general shift in the cellular phenotype does occur in osteoarthritic cartilage as suggested by previous investigations...
  22. doi request reprint DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes
    S Sesselmann
    Institute of Pathology, University Hospital Erlangen, Krankenhausstr 12, 91054 Erlangen, Germany
    Osteoarthritis Cartilage 17:507-12. 2009
    ..p21(WAF1/CIP1) was previously suggested to be down-regulated in OA chondrocytes and is known to be regulated by epigenetic modulation...
  23. ncbi request reprint Isolation of RNA from small human articular cartilage specimens allows quantification of mRNA expression levels in local articular cartilage defects
    A Gehrsitz
    Cartilage Research Group, Institute of Pathology, , Erlangen, Germany
    J Orthop Res 19:478-81. 2001
    ..We were able to analyse the expression levels of several genes in parallel including aggrecan and type II collagen...
  24. ncbi request reprint Type II collagen, but not aggrecan expression, distinguishes clear cell chondrosarcoma and chondroblastoma
    S Soder
    Department of Pathology, University of Leipzig, Leipzig, FRG
    Pathology 38:35-8. 2006
    ..Thus, it can be difficult both radiographically and histologically to distinguish these neoplasms. So far there are no immunohistochemical markers available that have been shown to be helpful in differentiating these neoplasms...
  25. ncbi request reprint Role of growth factors in rabbit articular cartilage repair by chondrocytes in agarose
    J Weisser
    Institute of Pathology, University of Jena, Germany
    Osteoarthritis Cartilage 9:S48-54. 2001
    ..Therefore, we have explored the possibility whether chondrocytes embedded into agarose gels provided better graft tissues in a repair model of full thickness defects in rabbit joint cartilage...
  26. doi request reprint Basic methods in histopathology of joint tissues
    N Schmitz
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, D 04103 Leipzig, Germany
    Osteoarthritis Cartilage 18:S113-6. 2010
    ....
  27. doi request reprint Histopathology atlas of animal model systems - overview of guiding principles
    T Aigner
    Institute of Pathology, Medical Center Coburg, Ketschendorferstr 33, 96450 Coburg, Germany
    Osteoarthritis Cartilage 18:S2-6. 2010
    ..Use of such systems, independently or in conjunction with other systems in parallel, should facilitate comparability of results across animal model studies...
  28. ncbi request reprint Targets to tackle--the pathophysiology of the disease
    N Schmitz
    Department of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    Curr Drug Targets 11:521-7. 2010
    ..It is evident that there is a great need for the development of disease modifying agents in order to improve quality of life as well as to relieve the community of the enormous socio-economic burden of the disease...
  29. doi request reprint Efficient non-viral transfection of primary human adult chondrocytes in a high-throughput format
    J Haag
    Institute of Pathology, University Hospital Leipzig, Leipzig, Germany
    Osteoarthritis Cartilage 17:813-7. 2009
    ..The development of a reliable high-throughput transfection protocol for primary human articular chondrocytes...
  30. ncbi request reprint MMP-2/gelatinase A is a gene product of human adult articular chondrocytes and is increased in osteoarthritic cartilage
    S Duerr
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Germany
    Clin Exp Rheumatol 22:603-8. 2004
    ....
  31. ncbi request reprint Molecular pathology and pathobiology of osteoarthritic cartilage
    T Aigner
    Institute of Pathology, University of Erlangen Nurnberg, Germany
    Cell Mol Life Sci 59:5-18. 2002
    ..Gene expression mapping in situ and gene expression profiling allows characterization of the osteoarthritic cellular phenotype, a key determinant for understanding and manipulating the osteoarthritic disease process...
  32. ncbi request reprint E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells
    Elke Ueberham
    Institute of Biochemistry, Medical Faculty, University of Leipzig, Johannisallee 30, 04103 Leipzig, Germany
    J Mol Histol 38:359-68. 2007
    ..In human cirrhotic liver samples E-cadherin expression was found as a common feature of both, typical and atypical reactions, and, thus, can also serve as an indication of the progenitor cell compartment activation...
  33. ncbi request reprint Outcome of patients with pre-existing portal vein thrombosis undergoing arterialization of the portal vein during liver transplantation
    Rudolf Ott
    Department of Surgery, University of Leipzig, Liebigstrasse 20a, 04103 Leipzig, Germany
    Transpl Int 16:15-20. 2003
    ..In the remaining patient, chronic rejection requiring re-transplantation developed 24 months after PVA had been performed. These unfavourable results prompt the conclusion that PVA cannot be recommended as a standard clinical procedure...
  34. ncbi request reprint Drug delivery in degenerative joint disease
    Thomas Aigner
    Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany
    Adv Drug Deliv Rev 58:123-4. 2006
  35. doi request reprint Repair of chronic osteochondral defects using predifferentiated mesenchymal stem cells in an ovine model
    Matthias Zscharnack
    Department of Cell Techniques and Applied Stem Cell Biology, Center of Biotechnology and Biomedicine, University of Leipzig, Deutscher Platz 5, D 04103 Leipzig, Germany
    Am J Sports Med 38:1857-69. 2010
    ..However, there is a lack of studies in large-animal models examining the benefits of chondrogenic predifferentiation in vitro for repair of chronic osteochondral defects...
  36. ncbi request reprint Infiltration of the pes anserinus complex by an extraarticular diffuse-type giant cell tumor (D-TGCT)
    Pierre Hepp
    Department of Trauma and Reconstructive Surgery, University of Leipzig, Liebigstr 20, 04103 Leipzig, Germany
    Arch Orthop Trauma Surg 128:155-8. 2008
    ..Regarding extraarticular D-TGCT a review of the literature showed a predominant affection of the medial region of the knee and thigh...
  37. doi request reprint Residual lymph node metastasis in stage 4 neuroblastoma--advantage of radio-guided surgery?
    Robin Wachowiak
    Department of Pediatric Surgery, University of Leipzig, Leipzig, Germany
    Pediatr Hematol Oncol 27:471-5. 2010
    ..Because study-based knowledge is missing due to the small number of affected patients, individual case reports are helpful to improve future treatment strategies...
  38. ncbi request reprint [Histogenesis of the skeleton and morphogenesis of cartilage-forming neoplasias]
    T Aigner
    Institut fur Pathologie, Universitatsklinikum, Leipzig
    Verh Dtsch Ges Pathol 91:49-56. 2007
    ..This knowledge has been used in the past years to elucidate the biology of mesenchymal neoplasias of the skeleton, in particular of the cartilage forming tumors...
  39. ncbi request reprint Bone morphogenetic protein-7 expression and activity in the human adult normal kidney is predominantly localized to the distal nephron
    P Wetzel
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Erlangen, FRG
    Kidney Int 70:717-23. 2006
    ..These findings suggest that BMP-7 plays a physiological role mostly in this part of the kidney. Still, as reported previously, PTCs are responsive to BMP-7, but presumably not in an autocrine or paracrine mode in normal adult kidneys...
  40. ncbi request reprint [Histopathological examination of joint degeneration: typing, grading and staging of osteoarthritis]
    T Aigner
    Institut fur Pathologie, Universitatsklinikum, Leipzig
    Pathologe 27:431-8. 2006
    ..Only the identification of secondary types of degenerative changes, such as those due to unknown rheumatoid disease, gout or extensive osteonecrosis, is of particular interest to the clinical colleague (i.e. typing of the joint lesion)...
  41. ncbi request reprint Jun activation domain-binding protein 1 binds Smad5 and inhibits bone morphogenetic protein signaling
    Jochen Haag
    University of Leipzig, Leipzig, Germany
    Arthritis Rheum 54:3878-84. 2006
    ..The present study was undertaken to identify binding partners of the Smad proteins, the intracellular mediators of BMP activity, which might actively modify BMP signaling in chondrocytes...
  42. ncbi request reprint Gene expression profiling of serum- and interleukin-1 beta-stimulated primary human adult articular chondrocytes--a molecular analysis based on chondrocytes isolated from one donor
    Thomas Aigner
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10, D 91054 Erlangen, FRG
    Cytokine 31:227-40. 2005
    ..In contrast, IL-1beta did not appear to be a good model for mimicking catabolic gene alterations in degenerating chondrocytes...
  43. ncbi request reprint SOX gene expression in human osteoarthritic cartilage
    Jochen Haag
    Institute of Pathology, University Hospital Leipzig, Leipzig, Germany
    Pathobiology 75:195-9. 2008
    ..Therefore, the aim of the present study was to present a thorough analysis of SOX gene expression in normal and osteoarthritic human adult cartilage...
  44. ncbi request reprint Phenotypic characterization of human chondrocyte cell line C-20/A4: a comparison between monolayer and alginate suspension culture
    Florian Finger
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Cells Tissues Organs 178:65-77. 2004
    ..These results indicate that immortalized chondrocyte cell lines, rather than substituting for primary chondrocytes, may serve as models for extending findings on chondrocyte function not achievable by the use of primary chondrocytes...
  45. ncbi request reprint Comparison of histological parameters for the diagnosis of eosinophilic oesophagitis versus gastro-oesophageal reflux disease on oesophageal biopsy material
    S Mueller
    Institute of Pathology, University of Munich, Munich, Germany
    Histopathology 53:676-84. 2008
    ..The aim was to compare histological parameters for the diagnosis of EO versus GORD on routinely taken biopsy specimens...
  46. doi request reprint [Nora's lesion. Discussion of a rare bone proliferation]
    D Adler
    Orthopädische Klinik und Poliklinik, Universitat Leipzig, Liebigstrasse 20, 04103, Leipzig
    Orthopade 39:1065-70. 2010
    ..The diagnosis of a Nora's lesion was made. The therapeutic approach, differential diagnosis and corresponding literature are presented and discussed...
  47. doi request reprint [Metastatic malignant choroidal melanoma: a case report about 18 years with palliative operative treatment]
    T Prietzel
    Orthopädische Klinik und Poliklinik, Universitat, Liebigstrasse 20, 04103, Leipzig, Deutschland
    Orthopade 38:278-82. 2009
    ..Three palliative operations made a survival of further 7 years with high quality of life possible. Therefore moderately palliative operations are recommended in case of metastatic malignant choroidal melanoma...
  48. ncbi request reprint Hgs physically interacts with Smad5 and attenuates BMP signaling
    Jochen Haag
    Osteoarticular and Arthritis Research, Department of Pathology, Friedrich Alexander University of Erlangen Nuremberg, Krankenhausstr 8 10, D 91054 Erlangen, Germany
    Exp Cell Res 312:1153-63. 2006
    ..Thus, it is tempting to speculate that both might be related to each other given the suppressive effect of BMP signaling on Hgs shown in this study...
  49. ncbi request reprint Perilesional changes of focal osteochondral defects in an ovine model and their relevance to human osteochondral injuries
    P Hepp
    Department of Trauma and Reconstructive Surgery University of Leipzig, Liebigstrasse 20, 04103 Leipzig, Germany
    J Bone Joint Surg Br 91:1110-9. 2009
    ..The perilesional cartilage in the animal model became chronic at one month and its histological appearance may be considered comparable with that seen in human osteochondral defects after trauma...
  50. doi request reprint [Osteoarthritis--histopathologic diagnosis: typing, grading, and staging]
    J Zustin
    Institut fur Pathologie, UKE Hamburg, Hamburg, Deutschland
    Orthopade 38:491-500. 2009
    ..Only the identification of previously unknown underlying conditions such as rheumatoid disease, gout, or extensive osteonecrosis is of particular clinical interest...
  51. ncbi request reprint [Painful enlargement of the 2nd toe due to an osteoid osteoma in the distal phalanx]
    T Prietzel
    Orthopädische Klinik und Poliklinik, Universitat Leipzig, Leipzig, Germany
    Z Orthop Unfall 147:362-5. 2009
    ..The tumour was excised and the oversize of the toe was corrected by exarticulation of the distal phalanx. 18 months postoperatively the patient demonstrates normal function of her forefoot without complaints or signs of inflammation...
  52. ncbi request reprint Identification of calponin 3 as a novel Smad-binding modulator of BMP signaling expressed in cartilage
    Jochen Haag
    Cartilage Research, Department of Pathology, University of Leipzig, Liebigstrasse 26, 04103, Leipzig, Germany
    Exp Cell Res 313:3386-94. 2007
    ..Furthermore, our data provide a possible explanation for the effect of the related protein calponin 1 on bone and cartilage development...
  53. ncbi request reprint Apoptosis in osteoarthritis
    Thomas Aigner
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Rheum Dis Clin North Am 30:639-53, xi. 2004
    ....
  54. ncbi request reprint Functional genomics of osteoarthritis
    Thomas Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr 8 10D 91054 Erlangen, FRG, Germany
    Pharmacogenomics 3:635-50. 2002
    ..However, care must be taken not to over or misinterpret results and some major challenges must be overcome in order to properly utilize the potential of this technology in the field of osteoarthritis...
  55. ncbi request reprint Hepatocyte growth factor/scatter factor is not a potent regulator of anabolic and catabolic gene expression in adult human articular chondrocytes
    Brigitte Bau
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Erlangen D 91054, Germany
    Biochem Biophys Res Commun 316:984-90. 2004
    ....
  56. ncbi request reprint Matrix biochemistry and cell biology of dedifferentiated chondrosarcomas
    Kerstin Dornauer
    Institute of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Pathol Int 60:365-72. 2010
    ..There was no difference in the clinical outcome of patients with differing high-grade tumor types, emphasizing that grade is a more important predictor of biological behavior than the direction of tumor differentiation...
  57. doi request reprint Evidence for a role of the amyloid precursor protein in thyroid carcinogenesis
    Kerstin Krause
    Division of Endocrinology, Department of Internal Medicine, University of Leipzig, Ph Rosenthal Str 27, D 04103 Leipzig, Germany
    J Endocrinol 198:291-9. 2008
    ..Thyroid cancers are characterized by APP upregulation, increased membrane targeting of the APP ectodomain and significantly increased mRNA levels of the APP scaffold proteins JIP1, ShcA and Fe65...
  58. ncbi request reprint Extraskeletal myxoid chondrosarcomas do not show a chondrocytic phenotype
    Thomas Aigner
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Mod Pathol 17:214-21. 2004
    ..Chondrocytic differentiation is an unusual facet in the spectrum of differentiation patterns exhibited by these lesions...
  59. ncbi request reprint Antisense inhibition of osteogenic protein 1 disturbs human articular cartilage integrity
    Stephan Soder
    Rush University Medical Center, Chicago, Illinois 60612, USA
    Arthritis Rheum 52:468-78. 2005
    ..To delineate the role of endogenous osteogenic protein 1 (OP-1) in human articular cartilage homeostasis via the inhibition of OP-1 gene expression by antisense oligonucleotides...
  60. ncbi request reprint Prognostic relevance of cell biologic and biochemical features in conventional chondrosarcomas
    Thomas Aigner
    Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Cancer 94:2273-81. 2002
    ..Currently, tumor grade is the only parameter of prognostic significance besides stage and, possibly, resection margins. Additional independent prognostic markers therefore would be highly valuable for patient management...
  61. ncbi request reprint Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta
    Zhiyong Fan
    Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, D 91054 Erlangen, Germany
    Arthritis Rheum 52:136-43. 2005
    ..Determination of whether there was a difference in reactivity between normal and osteoarthritic chondrocytes was also a goal of this study...
  62. pmc Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes
    Kosei Ijiri
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Arthritis Rheum 58:2075-87. 2008
    ..This study was undertaken, therefore, to investigate whether GADD45beta plays a role in adult articular cartilage...
  63. ncbi request reprint Matrix composition of cartilaginous anlagen in achondrogenesis type II (Langer-Saldino)
    Susanne Dertinger
    Department of Pathology, Landeskrankenhaus Feldkirch, Austria
    Front Biosci 10:446-53. 2005
    ..However, the latter are less efficient in binding aggrecan proteoglycans in the dysplastic cartilage matrix. Additionally, a delay in chondrocyte maturation appears to be important in achondrogenesis type II...
  64. ncbi request reprint Bone morphogenetic protein and transforming growth factor beta inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1beta
    Martina Kaiser
    Osteoarticular and Artheritis Research, Dept, or Pathology, University of Erlangen Nuremberg, Krankenhausstrasse 8 10, 91054 Erlangen, Germany
    Arthritis Rheum 50:3535-40. 2004
    ....
  65. ncbi request reprint IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways
    Zhiyong Fan
    Osteoarticular and Arthritis Research Group, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, D 91054 Erlangen, Germany
    Cytokine 28:17-24. 2004
    ..However, the ERK-pathway appeared to be particularly important and might be, therefore, of particular potential if one intends to block induction of these molecules by IL-1 in arthritic joint disease...
  66. ncbi request reprint Analysis of differential gene expression in healthy and osteoarthritic cartilage and isolated chondrocytes by microarray analysis
    Thomas Aigner
    Cartilege Research, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Methods Mol Med 100:109-28. 2004
    ..However, care has to be taken not to over- and misinterpret results, and some major challenges must be overcome in order to utilize the potential of this technology properly in the field of osteoarthritis...
  67. ncbi request reprint Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils
    Anja Kassner
    Institut für Physiologische Chemie und Pathobiochemie, Universitatsklinikum Munster, Waldeyerstrasse 15, 48129 Munster, Germany
    Matrix Biol 22:131-43. 2003
    ..This suprastructural versatility of a collagen is without precedent and highlights pivotal differences in the tissue-specific organization of matrix aggregate structures...
  68. ncbi request reprint SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes
    Thomas Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, Erlangen 91504, Germany
    Matrix Biol 22:363-72. 2003
    ..However, SOX9 might still be involved in maintaining the chondrocytic phenotype in normal and osteoarthritic cartilage...
  69. ncbi request reprint Quantification of mRNA expression levels in articular chondrocytes with PCR technologies
    Audrey McAlinden
    Department of Orthopaedic Surgery, School of Medicine, Washington University in St Louis, St Louis, MO, USA
    Methods Mol Med 100:79-100. 2004
    ..However, this method cannot account for factors such as efficiency of RNA isolation and reverse transcription conditions. Thus, normalization of the acquired data is required, with all its limitations as described...
  70. ncbi request reprint Genomics of osteoarthritis
    Thomas Aigner
    Cartilage Research Group, Department of Pathology, University of Erlangen Nurnberg, Erlangen Germany
    Curr Opin Rheumatol 15:634-40. 2003
    ....
  71. ncbi request reprint Down-regulation of the GTPase RhoB might be involved in the pre-apoptotic phenotype of osteoarthritic chondrocytes
    Pia M Gebhard
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, FRG
    Front Biosci 9:827-33. 2004
    ....
  72. ncbi request reprint ADAMTS-1, a gene product of articular chondrocytes in vivo and in vitro, is downregulated by interleukin 1beta
    Lydia Wachsmuth
    Cartilage Research Unit, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    J Rheumatol 31:315-20. 2004
    ....
  73. ncbi request reprint Role of mitogen-activated protein kinases and NFkappaB on IL-1beta-induced effects on collagen type II, MMP-1 and 13 mRNA expression in normal articular human chondrocytes
    Zhiyong Fan
    Osteoarticular and Arthritis Research Group, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstr, 8 10, 91054 Erlangen, Germany
    Rheumatol Int 26:900-3. 2006
    ..Our data suggest that ERK and NFkB pathways are particularly important for IL-1beta regulating collagen type II and MMP-1 and -13 expression and that p38, but not JNK is additionally involved in MMP-1 and -13 induction...
  74. ncbi request reprint Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis
    C Thomas G Appleton
    University of Western Ontario, London, Ontario, Canada
    Arthritis Rheum 56:3693-705. 2007
    ..To define the roles of transforming growth factor alpha (TGFalpha) in cartilage degradation...
  75. ncbi request reprint Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS)
    Pierre Mainil-Varlet
    Institute of Pathology, University of Bern, Switzerland
    J Bone Joint Surg Am 85:45-57. 2003
  76. pmc Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage
    Mathias Gebauer
    Aventis Pharma Deutschland, Functional Genomics, Sanofi Aventis, Frankfurt, Germany
    Arthritis Res Ther 7:R274-84. 2005
    ..Activation, the reinitiation of proliferative activity and the loss of a stable phenotype are three major changes in osteoarthritic chondrocytes that are highly significantly correlated with the repression of Tob1 expression...
  77. ncbi request reprint Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells
    Jung Park
    Department of Oro Maxillo Facial Surgery, University of Erlangen Nuernberg, Germany
    J Gene Med 8:112-25. 2006
    ..Adult primary mesenchymal cells of different origin which can be obtained with minor donor site morbidity are considered for articular cartilage repair. This study aims at a comparison of their chondrogenic potential...
  78. ncbi request reprint Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro
    Brigitte Bau
    Cartilage Research, Department of Pathology, University of Erlangen Nuremberg, Krankenhausstrasse 8 10, D 91054 Erlangen, Germany
    Arthritis Rheum 46:2648-57. 2002
    ....
  79. ncbi request reprint TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha
    Andreas R Klatt
    Institut fur Klinische Chemie, University of Cologne, Germany
    Biomed Pharmacother 60:55-61. 2006
    ....
  80. ncbi request reprint Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice
    Karoliina Pelttari
    Orthopaedic University Hospital of Heidelberg, Heidelberg, Germany
    Arthritis Rheum 54:3254-66. 2006
    ....
  81. ncbi request reprint Parosteal lipoma of the thigh with cartilaginous and osseous differentiation: an osteochondrolipoma
    Tilman Rau
    Department of Pathology, Friedrich Alexander University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    Ann Diagn Pathol 10:279-82. 2006
    ..Such a multidirectional potential was recently well established in vitro in stem cells present in adult adipocytic tissue...
  82. ncbi request reprint Cartilage in osteoarthritic joints is not automatically osteoarthritic cartilage
    Thomas Aigner
    Development 133:3497-8. 2006
  83. pmc Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels
    Claudia Grimmer
    Division of Orthopedic Rheumatology, Department of Orthopedic Surgery im Waldkrankenhaus St Marien, University of Erlangen Nuremberg, Rathsbergerstrasse 57, D 91054 Erlangen, Germany
    Am J Pathol 169:491-502. 2006
    ....
  84. ncbi request reprint Identification of markers to characterize and sort human articular chondrocytes with enhanced in vitro chondrogenic capacity
    Shawn Patrick Grogan
    University of Bern, Bern, Switzerland
    Arthritis Rheum 56:586-95. 2007
    ..To identify markers associated with the chondrogenic capacity of expanded human articular chondrocytes and to use these markers for sorting of more highly chondrogenic subpopulations...
  85. ncbi request reprint Roles of chondrocytes in the pathogenesis of osteoarthritis
    Thomas Aigner
    Cartilage Research Group, Department of Pathology, University of Erlangen Nurnberg, Erlangen, Germany
    Curr Opin Rheumatol 14:578-84. 2002
    ..Methodologically, the past year has seen the first steps of functional genomics in osteoarthritis research, providing new insights into the cell biology of this condition...
  86. ncbi request reprint Osteoarthritis
    Thomas Aigner
    Curr Opin Rheumatol 19:427-8. 2007
  87. pmc Activation of interleukin-1 signaling cascades in normal and osteoarthritic articular cartilage
    Zhiyong Fan
    Department of Pathology, University of Erlangen, Erlangen, Germany
    Am J Pathol 171:938-46. 2007
    ..Second, IL-1 seems to be involved in normal cartilage tissue homeostasis as shown by identification of baseline expression patterns and signaling cascade activation...
  88. ncbi request reprint Homeostatic effects of the metalloproteinase disintegrin ADAM15 in degenerative cartilage remodeling
    Beate B Böhm
    Friedrich Alexander University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 52:1100-9. 2005
    ..In addition, a human chondrocyte cell line overexpressing ADAM15 was used to investigate the role of ADAM15 in an in vitro model of chondrocyte-matrix interactions...
  89. ncbi request reprint The human chondrosarcoma HCS-2/8 cell line is responsive to BMP-7, but not to IL-1beta
    Joachim Saas
    Department of Thrombosis and Angiogenesis, Sanofi Aventis, Frankfurt, Germany
    Front Biosci 10:2027-35. 2005
    ..In this respect, HCS-2/8 cells are a validated tool for studying BMP-effects on chondrocytes, but not e.g. effects of interleukin-1...
  90. ncbi request reprint Bone morphogenetic protein-mediating receptor-associated Smads as well as common Smad are expressed in human articular chondrocytes but not up-regulated or down-regulated in osteoarthritic cartilage
    Brigitte Bau
    Cartilage Research, Department of Pathology, University of Erlangen Nürnberg Erlangen, Germany
    J Bone Miner Res 17:2141-50. 2002
    ....
  91. ncbi request reprint Phenotyping of chondrocytes in vivo and in vitro using cDNA array technology
    Alexander Zien
    Max Planck Institute for Biological Cybernetics, Tubingen, Germany
    Clin Orthop Relat Res 460:226-33. 2007
    ..Although it does not generate new experimental data per se, it provides valuable information regarding the biology of chondrocytes and may provide tools for diagnosing and staging the osteoarthritic disease process...
  92. ncbi request reprint Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells
    Kolja Gelse
    University of Erlangen Nuernberg, Erlangen, Germany
    Arthritis Rheum 48:430-41. 2003
    ..To investigate the repair of partial-thickness lesions in rat articular cartilage by combining cell transplantation with transfer of growth factor complementary DNA (cDNA)...
  93. ncbi request reprint Visualization of postmortem chondrocyte damage by vital staining and confocal laser scanning 3D microscopy
    Gabriele E Lasczkowski
    Institute of Legal Medicine, University of Giessen, Germany
    J Forensic Sci 47:663-6. 2002
    ..Under stable cooling conditions the use of vital dyes and confocal laser scanning 3D microscopy to measure chondrocyte loss may be a valuable tool for estimating the postmortem interval...