Research Topics
Species | A AgaimySummaryAffiliation: University of Erlangen-Nuremberg Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Loss of DOG-1 expression associated with shift from spindled to epithelioid morphology in gastric gastrointestinal stromal tumors with KIT and platelet-derived growth factor receptor α mutationsAbbas Agaimy
Institute of Pathology, University Hospital, Erlangen, Germany
Ann Diagn Pathol 17:187-91. 2013..These cases confirm the immunophenotypic heterogeneity as secondary events in GIST. Loss of DOG-1 in KIT-negative PDGFRA mutants should not preclude diagnosis...
Lipomatous salivary gland tumors: a series of 31 cases spanning their morphologic spectrum with emphasis on sialolipoma and oncocytic lipoadenomaAbbas Agaimy
Pathologisches Institut, Universitatsklinikum Erlangen, Krankenhausstrae 8 10, 91054 Erlangen, Germany
Am J Surg Pathol 37:128-37. 2013..Oncocytic lipoadenoma is an epithelial-predominant tumor that is distinct from the fat-dominated nononcocytic sialolipoma, but the 2 types seem to merge in some cases...
Gastrointestinal manifestations of neurofibromatosis type 1 (Recklinghausen's disease): clinicopathological spectrum with pathogenetic considerationsAbbas Agaimy
Institute of Pathology, University Hospital, Erlangen, Germany
Int J Clin Exp Pathol 5:852-62. 2012..In addition, this review underlines the great value of specific gastrointestinal findings in uncovering undiagnosed or missed NF-1 cases...
Primary and metastatic cardiac sarcomas: a 12-year experience at a German heart centerAbbas Agaimy
Institute of Pathology, Friedrich Alexander University, Erlangen, Germany
Int J Clin Exp Pathol 5:928-38. 2012..To date, there exist no uniform guidelines for their surgical and/or oncological treatment...
Hepatic angiomyolipoma: a series of six cases with emphasis on pathological-radiological correlations and unusual variants diagnosed by core needle biopsyAbbas Agaimy
Institute of Pathology, University Hospital, Erlangen, Germany
Int J Clin Exp Pathol 5:512-21. 2012..Awareness of their diverse morphological spectrum in liver biopsy is necessary to avoid misdiagnosis as hepatocellular carcinoma, metastatic melanoma or other malignant neoplasms...
[Intraoperative frozen section diagnosis of head and neck tumors: possibilities, limitations, pitfalls and tips for the daily practice]A Agaimy
Pathologisches Institut, Universitatsklinikum Erlangen, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstr 8 10, 91054, Erlangen, Deutschland
Pathologe 33:389-96. 2012..Sticking to this approach would result in a high positive impact on the surgical treatment of a variety of neoplastic diseases and help to minimize or even eliminate the rate of medicolegal consequences...
Cytokeratin-positive epithelioid angiosarcoma presenting in the tonsil: a diagnostic challengeAbbas Agaimy
Institute of Pathology, University Hospital, 91054 Erlangen, Germany
Hum Pathol 43:1142-7. 2012..Thus, awareness of this rare and highly aggressive neoplasm is necessary for distinguishing it from poorly differentiated and acantholytic squamous cell carcinoma and diffuse large cell lymphoma...
Follicular thyroid adenoma dominated by spindle cells: report of two unusual cases and literature reviewAbbas Agaimy
Institute of Pathology, University Hospital, 91054 Erlangen, Germany
Int J Clin Exp Pathol 5:143-51. 2012....
Impact of serosal involvement/extramural growth on the risk of synchronous and metachronous peritoneal spread in gastrointestinal stromal tumors: proposal for a macroscopic classification of GISTAbbas Agaimy
Institute of Pathology, University Hospital, Erlangen, Germany
Int J Clin Exp Pathol 5:12-22. 2012..Peritoneal and hepatic metastases are the main routes of spread of gastrointestinal stromal tumors (GIST). However, criteria to predict the site and pattern of recurrence in individual cases are still lacking...
Multifocal gastric gastrointestinal stromal tumors (GISTs) with lymph node metastases in children and young adults: a comparative clinical and histomorphological study of three cases including a new case of Carney triadClaudia Otto
Institute of Pathology, University Hospital Freiburg, Germany
Diagn Pathol 6:52. 2011..Thus, these patients need to be regularly examined for the development of extraadrenal paraganglioma or pulmonary chondroma...
Distinct biphasic histomorphological pattern in gastrointestinal stromal tumours (GISTs) with common primary mutations but divergent molecular cytogenetic progressionAbbas Agaimy
Institute of Pathology, Nürnberg Clinic Centre, Nurnberg, Germany
Histopathology 54:295-302. 2009..The aim of this study was to shed light on the molecular pathogenesis of GISTs displaying a distinct biphasic histomorphological pattern, which is poorly understood...
V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumoursA Agaimy
Institute of Pathology, Friedrich Alexander University, Erlangen, Germany
J Clin Pathol 62:613-6. 2009..However, the frequency and distribution of BRAF mutations within the spectrum of GISTs, and whether they might represent secondary events acquired during tumour progression, remain unknown...
Multiple sporadic gastrointestinal stromal tumours arising at different gastrointestinal sites: pattern of involvement of the muscularis propria as a clue to independent primary GISTsAbbas Agaimy
Institute of Pathology, University Hospital, 91054 Erlangen, Germany
Virchows Arch 455:101-8. 2009....
Sporadic segmental Interstitial cell of cajal hyperplasia (microscopic GIST) with unusual diffuse longitudinal growth replacing the muscularis propria: differential diagnosis to hereditary GIST syndromesAbbas Agaimy
Institute of Pathology, University Hospital, Erlangen, Germany
Int J Clin Exp Pathol 3:549-56. 2010..This peculiar diffuse form of sporadic ICC hyperplasia results from somatic c-KIT mutations and must be distinguished from syndromic ICC hyperplasia associated with hereditary GIST syndromes...
[Gastrointestinal stromal tumors: evolution of a tumor concept from unclassifiable neoplasms to targeted molecular therapy]A Agaimy
Pathologisches Institut, Universitatsklinikum Erlangen, Krankenhausstr 12, 91054, Erlangen, Deutschland
Pathologe 31:115-22. 2010..This article gives an overview on current developments in the histopathological and molecular diagnostics of GIST and the role of kinase mutation analysis for optimizing patient treatment...
Calcifying fibrous tumor of the stomach: clinicopathologic and molecular study of seven cases with literature review and reappraisal of histogenesisAbbas Agaimy
Institute of Pathology, University Hospital, Erlangen, Germany
Am J Surg Pathol 34:271-8. 2010..They differ from soft tissue CFTs by smaller size, older age at presentation and lack of recurrence, and from peritoneal CFTs by equal gender distribution, older age, and absent multifocal occurrence...
Gastrointestinal stromal tumors (GIST) from risk stratification systems to the new TNM proposal: more questions than answers? A review emphasizing the need for a standardized GIST reportingAbbas Agaimy
Institute of Pathology, Friedrich Alexander University Erlangen, 91054 Erlangen, Germany
Int J Clin Exp Pathol 3:461-71. 2010....
Hyaline globules in paucicellular leiomyomas of the gastrointestinal tract are distinct from skeinoid fibers and represent degenerating smooth muscle cellsAbbas Agaimy
Institute of Pathology, University Hospital of Erlangen, Krankenhausstrasse 12, 91054 Erlagen, Germany
Pathol Res Pract 205:417-22. 2009..Awareness of this finding would prevent misinterpretation as GIST, particularly in small biopsies...
Lymph node metastasis in gastrointestinal stromal tumours (GIST) occurs preferentially in young patients < or = 40 years: an overview based on our case material and the literatureAbbas Agaimy
Institut fur Pathologie, Universitatsklinikum Erlangen, Erlangen, Germany
Langenbecks Arch Surg 394:375-81. 2009..Data on the clinicopathological and biological profiles of gastrointestinal stromal tumours (GISTs) at higher risk for nodal metastasis are lacking...
[Hereditary and non-hereditary syndromic gastointestinal stromal tumours]A Agaimy
Institut fur Pathologie, Universitatsklinikum Erlangen, Krankenhausstr 12, 91054, Erlangen
Pathologe 31:430-7. 2010..This review summarizes the pertinent clinicopathological and molecular features of the main GIST syndromes to facilitate their diagnosis and distinction from their non-syndromic mimics...
Benign serrated colorectal fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF mutationsAbbas Agaimy
Institute of Pathology, University Hospital, Erlangen Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany
Am J Surg Pathol 34:1663-71. 2010..The perineurial stromal component might be derived from modified pericryptic fibroblasts as a consequence of a yet poorly understood epithelial-stromal interaction...
Perineurioma of the parotid gland: first case reportAbbas Agaimy
Institute of Pathology, University Hospital of Erlangen, 91054 Erlangen, Germany
Hum Pathol 42:904-8. 2011..To our knowledge, this case represents the first report of soft tissue perineurioma in the salivary gland. Lack of previous reports suggests underrecognition of this tumor entity at this unusual anatomical site...
Hybrid schwannoma-perineurioma of the gastrointestinal tract: a clinicopathologic study of 2 cases and reappraisal of perineurial cells in gastrointestinal schwannomasAbbas Agaimy
Institute of Pathology, University Hospital, Erlangen, Germany
Appl Immunohistochem Mol Morphol 19:454-9. 2011..We conclude that hybrid schwannoma-perineuriomas are distinct from gastrointestinal schwannoma, both histologically and immunohistochemically...
Left atrial myxoma with papillary fibroelastoma-like featuresAbbas Agaimy
Institute of Pathology, Friedrich Alexander University Erlangen Nuremberg, Germany
Int J Clin Exp Pathol 4:307-11. 2011..This unusual case may shed light on the pathogenesis of the PFE pattern...
Morphological heterogeneity of oral salivary gland carcinomas: a clinicopathologic study of 41 cases with long term follow-up emphasizing the overlapping spectrum of adenoid cystic carcinoma and polymorphous low-grade adenocarcinomaStephan Schwarz
Department of Pathology, University of Erlangen, Germany
Int J Clin Exp Pathol 4:336-48. 2011..Our results emphasize the diversity of oral salivary gland carcinomas and the overlapping clinicopathological features of ACC and PLGA...
Cytomegalovirus infection presenting as isolated inflammatory polyps of the gastrointestinal tractAbbas Agaimy
Institute of Pathology, University Hospital, Erlangen, Germany
Pathology 43:440-6. 2011..Rarely, CMV may affect immunocompetent healthy individuals. However, CMV infection presenting as isolated inflammatory polyps is unusual...
Peripheral nerve sheath tumors of the gastrointestinal tract: a multicenter study of 58 patients including NF1-associated gastric schwannoma and unusual morphologic variantsAbbas Agaimy
Pathologisches Institut, Universitatsklinikum Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany
Virchows Arch 456:411-22. 2010..Gastrointestinal PNSTs are still underrecognized by general pathologists. Awareness of their diverse morphology will help to avoid confusing them with smooth muscle neoplasms and GIST that they may closely mimic...
Lymphatics and D2-40/podoplanin expression in gastrointestinal stromal tumours of the stomach with and without lymph node metastasis: an immunohistochemical study with special reference to the Carney triadAbbas Agaimy
Pathologisches Institut, Universitatsklinikum Erlangen, 91054 Erlangen, Germany
J Clin Pathol 63:229-34. 2010..In previous studies, expression of the lymphatic endothelial marker D2-40/podoplanin in carcinoma cells and the presence of intratumoural/peritumoural lymphatics have been correlated with tumour invasiveness and nodal metastasis...
Pancreatic-type acinar cell carcinoma of the liver: a clinicopathologic study of four patientsAbbas Agaimy
Institutes of Pathology, University of Erlangen, Erlangen, Germany
Mod Pathol 24:1620-6. 2011..Because our cases were observed within a rather short period, it is likely that this tumor type is so far underrecognized and has been mistaken as a variant of hepatocellular carcinoma, cholangiocarcinoma or any other liver tumor...
Low-grade abdominopelvic sarcoma with myofibroblastic features (low-grade myofibroblastic sarcoma): clinicopathological, immunohistochemical, molecular genetic and ultrastructural study of two cases with literature reviewA Agaimy
Institute of Pathology, Nuremberg Clinic Centre, Nuremberg, Germany
J Clin Pathol 61:301-6. 2008..Intra-abdominal LGMS are rare with only four unequivocal examples reported so far. Two further cases in females in their 60s and 70s are analysed here...
[Salivary gland mucoepidermoid carcinoma: unusual variants with detection of the t(11,19)(q21;p13) translocation]S Schwarz
Pathologisches Institut, Universitatsklinikum Erlangen, Krankenhausstr 12, 91054 Erlangen
Pathologe 30:472-7. 2009..The differential diagnosis includes squamous cell carcinoma, clear cell carcinoma and oncocytic neoplasms, as well as highly malignant adenocarcinomas which cannot be further classified...
Distribution of neural cell adhesion molecule (NCAM/CD56) in gastrointestinal stromal tumours and their intra-abdominal mesenchymal mimicsA Agaimy
Institute of Pathology, Klinikum Nürnberg, Nurnberg, Germany
J Clin Pathol 61:499-503. 2008..The distribution and reactivity pattern of neural cell adhesion molecule (NCAM/CD56) in gastrointestinal stromal tumours (GISTs) and their mesenchymal mimics have not been investigated in the KIT era...
Epithelioid gastric stromal tumours of the antrum in young females with the Carney triad: a report of three new cases with mutational analysis and comparative genomic hybridizationAbbas Agaimy
Institute of Pathology, Klinikum Nürnberg, 90419 Nurnberg, Germany
Oncol Rep 18:9-15. 2007....
Perineurioma of the stomach. A rare spindle cell neoplasm that should be distinguished from gastrointestinal stromal tumorAbbas Agaimy
Institute of Pathology, Clinic Centre Nuremberg, Prof Ernst Nathan Strasse 1, 90419 Nurnberg, Germany
Pathol Res Pract 201:463-7. 2005..Gastrointestinal perineuriomas might be under-recognized, as our case was initially diagnosed as a benign GIST...
Primary and metastatic high-grade pleomorphic sarcoma/malignant fibrous histiocytoma of the gastrointestinal tract: an approach to the differential diagnosis in a series of five cases with emphasis on myofibroblastic differentiationAbbas Agaimy
Institute of Pathology, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, 90419 Nurnberg, Germany
Virchows Arch 451:949-57. 2007..They should be distinguished from a variety of primary and metastatic pleomorphic neoplasms, in particular high-grade sarcomatous GI stromal tumours (GIST), pleomorphic leiomyosarcoma, sarcomatoid carcinoma and other mimics...
Perivascular epithelioid cell sarcoma (malignant PEComa) of the ileumA Agaimy
Institut fur Pathologie, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, 90419 Nurnberg, Germany
Pathol Res Pract 202:37-41. 2006..The differential diagnosis and malignancy criteria of GI PEComas will be discussed...
[Plexiform angiomyxoid myofibroblastic tumour of the stomach]T Schulz
Institut fur Pathologie, Klinikum Bayreuth, Preuschwitzer Str 101, 95445, Bayreuth, Deutschland
Pathologe 33:65-9. 2012..Worthy of note is that PAMTs can be diagnosed safely in sufficient biopsy material which enables adequate therapeutic steps to be initiated without delay, because PMATs although considered to be benign, can cause serious complications...
Giant metastatic alveolar soft part sarcoma in the left ventricle: appearance in echocardiography, magnetic resonance imaging, and histopathologyThomas Strecker
Center of Cardiac Surgery, Friedrich Alexander University, Erlangen Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
Clin Cardiol 34:E6-8. 2011..Here we present the diagnostic evaluation and successful surgical resection of such a cardiac tumor in a patient aged 50 years with a histology-confirmed diagnosis of metastatic alveolar soft part sarcoma...
Gastrointestinal stromal tumours: a regular origin in the muscularis propria, but an extremely diverse gross presentation. A review of 200 cases to critically re-evaluate the concept of so-called extra-gastrointestinal stromal tumoursAbbas Agaimy
Institut fur Pathologie, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, 90419, Nurnberg, Germany
Langenbecks Arch Surg 391:322-9. 2006..ICCs form a network surrounding the myenteric plexus and between-muscle fibres of the muscularis propria of the tubular GI tract. The cell of origin of so-called extra-gastrointestinal stromal tumours (EGISTs) is not known...
Sustained treatment response of metastatic hepatocellular carcinoma with bevacizumab and sorafenibChristina Wich
Department of Medicine I, University Hospital Erlangen, Ulmenweg 18, 91054 Erlangen, Germany
World J Gastroenterol 16:3592-6. 2010..We here report a patient with metastasized HCC who shows a sustained response for more than 30 mo to sorafenib therapy after failure of a first line therapy with gemcitabine, oxaliplatin and bevacizumab...
Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutationsAbbas Agaimy
Institute of Pathology, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, 90419 Nuremberg, Germany
Am J Surg Pathol 31:113-20. 2007..GIST tumorlets likely represent preclinical (preneoplastic) lesions that need additional stimuli to evolve into clinical GISTs, raising the possibility of a hyperplasia-neoplasia sequence in the development of sporadic GISTs...
Follicular dendritic cell tumor of the gastrointestinal tract: Report of a rare neoplasm and literature reviewAbbas Agaimy
Institut fur Pathologie, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, 90419 Nurnberg, Germany
Pathol Res Pract 202:541-8. 2006....
Malignant peritoneal mesothelioma in a 16-year-old girl: presentation of a rare diseaseI B Brecht
Pediatric Hematology and Oncology, University Hospital Erlangen, Loschgestrasse 15, Erlangen, Germany
Klin Padiatr 224:170-3. 2012..International and interdisciplinary cooperation is necessary in order to provide evidence based guidelines for diagnosis and treatment in the future...
Leiomyoma of the gallbladder: a case report with review of the literature and discussion of the differential diagnosisD L Wachter
Institute of Pathology, Erlangen University Hospital, Erlangen, Germany
J Clin Pathol 63:177-9. 2010....
Multiple sporadic gastrointestinal stromal tumors (GISTs) of the proximal stomach are caused by different somatic KIT mutations suggesting a field effectAbbas Agaimy
Institute of Pathology, Nürnberg Clinic Center, Nurnberg, Germany daggerInstitute of Pathology, University of Basel, Basel, Switzerland
Am J Surg Pathol 32:1553-9. 2008....
Outcomes following surgery for colorectal cancer with synchronous peritoneal metastasesJ Mulsow
Department of Surgery, University of Erlangen Nuremberg, Erlangen, Germany
Br J Surg 98:1785-91. 2011..The aim of this study was to assess the feasibility of, and outcomes following, surgical treatment and systemic chemotherapy alone...
Gastrointestinal stromal tumours in patients with other-type cancer: a mere coincidence or an etiological association? A study of 97 GIST casesA Agaimy
Institut fur Pathologie, Klinikum Nürnberg, Nurnberg, Germany
Z Gastroenterol 43:1025-30. 2005....
True smooth muscle neoplasms of the gastrointestinal tract: morphological spectrum and classification in a series of 85 cases from a single instituteAbbas Agaimy
Institut fur Pathologie, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, 90419 Nurnberg, Germany
Langenbecks Arch Surg 392:75-81. 2007..True smooth-muscle neoplasms of the GI tract have been only rarely studied in the KIT era. Their incidence among other GI mesenchymal tumours and their clinicopathological spectrum have not been sufficiently analysed...
Severe cytological atypia (large cell change) in focal nodular hyperplasia with numerous mallory bodies. A benign (adaptive) change?Abbas Agaimy
Institute of Pathology, Clinical Center of Nuremberg, Germany
Pathol Res Pract 199:509-11. 2003..This rare variant of FNH should be differentiated from other neoplastic lesions, in particular from the fibrolamellar variant of hepatocellular carcinoma...
Sporadic Cajal cell hyperplasia is common in resection specimens for distal oesophageal carcinoma. A retrospective review of 77 consecutive surgical resection specimensAbbas Agaimy
Institute of Pathology, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, Nurnberg, Germany
Virchows Arch 448:288-94. 2006..The possible mechanisms leading to the development of these putative precursor lesions will be discussed...
Gastrointestinal stromal tumors of the vermiform appendix: clinicopathologic, immunohistochemical, and molecular study of 2 cases with literature reviewAbbas Agaimy
Institute of Pathology, Klinikum Nürnberg, 90419 Nurnberg, Germany
Hum Pathol 39:1252-7. 2008....
Microscopic gastrointestinal stromal tumors in esophageal and intestinal surgical resection specimens: a clinicopathologic, immunohistochemical, and molecular study of 19 lesionsAbbas Agaimy
Institute of Pathology, Nürnberg Clinic Center, Nurnberg, Germany
Am J Surg Pathol 32:867-73. 2008..The remarkable variation in the incidence of microscopic GISTs at different GI sites suggests an origin from heterogeneous subsets of interstitial cells of Cajal with varying potentials for neoplastic transformation...
Epithelioid and sarcomatoid malignant pleural mesothelioma in endoscopic gastric biopsies: a diagnostic pitfallAbbas Agaimy
Institut fur Pathologie, Klinikum Nürnberg, Prof Ernst Nathan Strasse 1, 90419 Nurnberg, Germany
Pathol Res Pract 202:617-22. 2006..The major differential diagnoses encompass primary or metastatic adenocarcinoma in case one and cytokeratin-positive (KIT negative!) GI stromal tumors (GISTs) and sarcomatoid carcinoma in case two, as well as other rare entities...
Occurrence of other malignancies in patients with gastrointestinal stromal tumorsAbbas Agaimy
Institute of Pathology, Nuremberg Clinic Center, Nuremberg, Germany
Semin Diagn Pathol 23:120-9. 2006..The potential nonrandom association and causal relationship between GIST and other neoplasms remain to be investigated...
