Peter Achenbach

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. doi request reprint A simplified method to assess affinity of insulin autoantibodies
    Peter Achenbach
    Institut fuer Diabetesforschung, Helmholtz Zentrum Muenchen, Ingolstaedter Landstr 1, 85764 Neuherberg, Germany
    Clin Immunol 137:415-21. 2010
  2. ncbi request reprint Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, Munich 80804, Germany
    Curr Diab Rep 8:87-93. 2008
  3. ncbi request reprint Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization Program
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, 80804 Munich, Germany
    Clin Immunol 122:85-90. 2007
  4. ncbi request reprint Identification of insulin autoantibodies of IgA isotype that preferentially target non-human insulin
    Kerstin Koczwara
    Diabetes Research Institute, Munich, Germany
    Clin Immunol 124:77-82. 2007
  5. ncbi request reprint GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetes
    Anja Mayr
    Diabetes Research Institute, Munich, Germany
    Diabetes 56:1527-33. 2007
  6. ncbi request reprint Translating mucosal antigen based prevention of autoimmune diabetes to human
    Ezio Bonifacio
    Diabetes Research Institute, Munich, Germany
    Novartis Found Symp 292:187-99; discussion 199-201, 202-3. 2008
  7. pmc Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
    Peter Achenbach
    Institut fur Diabetesforschung, Kolner Platz 1, 80804 Munich, Germany
    J Clin Invest 114:589-97. 2004
  8. ncbi request reprint Natural history of type 1 diabetes
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, 80804 Munich, Germany
    Diabetes 54:S25-31. 2005
  9. ncbi request reprint Predicting type 1 diabetes
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, Munich 80804, Germany
    Curr Diab Rep 5:98-103. 2005
  10. ncbi request reprint Diabetes-related antibodies in euglycemic subjects
    Peter Achenbach
    Diabetes Research Institute and 3rd Medical Department Academic, Hospital München Schwabing, Koelner Platz 1, 80804 Munich, Germany
    Best Pract Res Clin Endocrinol Metab 19:101-17. 2005

Detail Information

Publications13

  1. doi request reprint A simplified method to assess affinity of insulin autoantibodies
    Peter Achenbach
    Institut fuer Diabetesforschung, Helmholtz Zentrum Muenchen, Ingolstaedter Landstr 1, 85764 Neuherberg, Germany
    Clin Immunol 137:415-21. 2010
    ..0 nM competitor including 89 (94%) of 95 sera with multiple islet autoantibodies (P<0.0001). Thus, increased IAA specificity can be achieved with simple modification to existing assays...
  2. ncbi request reprint Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, Munich 80804, Germany
    Curr Diab Rep 8:87-93. 2008
    ....
  3. ncbi request reprint Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization Program
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, 80804 Munich, Germany
    Clin Immunol 122:85-90. 2007
    ..This workshop has demonstrated that different laboratories are able to reproduce IAA affinity results and that considering IAA affinity is likely to improve the diagnostic performance of IAA assays...
  4. ncbi request reprint Identification of insulin autoantibodies of IgA isotype that preferentially target non-human insulin
    Kerstin Koczwara
    Diabetes Research Institute, Munich, Germany
    Clin Immunol 124:77-82. 2007
    ..The findings suggest that some IAA can result from immunization against molecules other than human insulin at mucosal sites...
  5. ncbi request reprint GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetes
    Anja Mayr
    Diabetes Research Institute, Munich, Germany
    Diabetes 56:1527-33. 2007
    ..We asked whether autoantibodies to GAD (GADAs) are heterogeneous in affinity and epitope recognition and whether diabetes-related GADA are restricted to high-affinity responses...
  6. ncbi request reprint Translating mucosal antigen based prevention of autoimmune diabetes to human
    Ezio Bonifacio
    Diabetes Research Institute, Munich, Germany
    Novartis Found Symp 292:187-99; discussion 199-201, 202-3. 2008
    ..The efficacy of increasing doses of mucosal insulin to induce protective immunity will be assessed as the primary end point of the trial. The rationale for primary vaccination and the trial strategy are discussed...
  7. pmc Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes
    Peter Achenbach
    Institut fur Diabetesforschung, Kolner Platz 1, 80804 Munich, Germany
    J Clin Invest 114:589-97. 2004
    ....
  8. ncbi request reprint Natural history of type 1 diabetes
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, 80804 Munich, Germany
    Diabetes 54:S25-31. 2005
    ..Characteristics that describe the magnitude of the autoimmunity can stage progression to type 1 diabetes in islet autoantibody-positive subjects regardless of genetic background or age...
  9. ncbi request reprint Predicting type 1 diabetes
    Peter Achenbach
    Diabetes Research Institute, Koelner Platz 1, Munich 80804, Germany
    Curr Diab Rep 5:98-103. 2005
    ..Further stratification of diabetes risk in autoantibody-positive subjects can be made on the basis of autoantibody characteristics that correspond to the magnitude of the autoantibody response...
  10. ncbi request reprint Diabetes-related antibodies in euglycemic subjects
    Peter Achenbach
    Diabetes Research Institute and 3rd Medical Department Academic, Hospital München Schwabing, Koelner Platz 1, 80804 Munich, Germany
    Best Pract Res Clin Endocrinol Metab 19:101-17. 2005
    ....
  11. pmc Tracing the Pathogenesis of Type 1 Diabetes: A Report on the 44th Annual Meeting of the European Association for the Study of Diabetes (EASD)
    Liang Hao Guo
    Diabetes Research Institute, Munich, Germany
    Rev Diabet Stud 5:171-4. 2008
    ..This report highlights some of the recent studies on diabetes biomarkers, with a particular focus on zinc transporter ZnT8, presented at the EASD meeting in September 2008 in Rome, Italy...
  12. ncbi request reprint Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics
    Peter Achenbach
    Diabetes Research Institute and 3rd Medical Department, Hospital München Schwabing, Munich, Germany
    Diabetes 53:384-92. 2004
    ..Using models based on these antibody characteristics, autoantibody-positive relatives can be classified into groups with risks of diabetes ranging from 7 to 89% within 5 years...
  13. ncbi request reprint Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic mice
    Peter Achenbach
    Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
    J Autoimmun 19:111-6. 2002
    ..The results show that the phogrin molecule is targeted early in the course of disease in NOD animals at a time when circulating autoantibodies are absent and insulitis is minimal...