Research Topics
Species | Peter AchenbachSummaryAffiliation: University of Munich Country: Germany Publications
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Detail Information
Publications
A simplified method to assess affinity of insulin autoantibodiesPeter Achenbach
Institut fuer Diabetesforschung, Helmholtz Zentrum Muenchen, Ingolstaedter Landstr 1, 85764 Neuherberg, Germany
Clin Immunol 137:415-21. 2010..0 nM competitor including 89 (94%) of 95 sera with multiple islet autoantibodies (P<0.0001). Thus, increased IAA specificity can be achieved with simple modification to existing assays...
Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunizationPeter Achenbach
Diabetes Research Institute, Koelner Platz 1, Munich 80804, Germany
Curr Diab Rep 8:87-93. 2008....- Combined testing of antibody titer and affinity improves insulin autoantibody measurement: Diabetes Antibody Standardization ProgramPeter Achenbach
Diabetes Research Institute, Koelner Platz 1, 80804 Munich, Germany
Clin Immunol 122:85-90. 2007..This workshop has demonstrated that different laboratories are able to reproduce IAA affinity results and that considering IAA affinity is likely to improve the diagnostic performance of IAA assays... - Identification of insulin autoantibodies of IgA isotype that preferentially target non-human insulinKerstin Koczwara
Diabetes Research Institute, Munich, Germany
Clin Immunol 124:77-82. 2007..The findings suggest that some IAA can result from immunization against molecules other than human insulin at mucosal sites... - GAD autoantibody affinity and epitope specificity identify distinct immunization profiles in children at risk for type 1 diabetesAnja Mayr
Diabetes Research Institute, Munich, Germany
Diabetes 56:1527-33. 2007..We asked whether autoantibodies to GAD (GADAs) are heterogeneous in affinity and epitope recognition and whether diabetes-related GADA are restricted to high-affinity responses... - Translating mucosal antigen based prevention of autoimmune diabetes to humanEzio Bonifacio
Diabetes Research Institute, Munich, Germany
Novartis Found Symp 292:187-99; discussion 199-201, 202-3. 2008..The efficacy of increasing doses of mucosal insulin to induce protective immunity will be assessed as the primary end point of the trial. The rationale for primary vaccination and the trial strategy are discussed... - Natural history of type 1 diabetesPeter Achenbach
Diabetes Research Institute, Koelner Platz 1, 80804 Munich, Germany
Diabetes 54:S25-31. 2005..Characteristics that describe the magnitude of the autoimmunity can stage progression to type 1 diabetes in islet autoantibody-positive subjects regardless of genetic background or age... 
Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetesPeter Achenbach
, , 80804 Munich, Germany
J Clin Invest 114:589-97. 2004....- Predicting type 1 diabetesPeter Achenbach
Diabetes Research Institute, Koelner Platz 1, Munich 80804, Germany
Curr Diab Rep 5:98-103. 2005..Further stratification of diabetes risk in autoantibody-positive subjects can be made on the basis of autoantibody characteristics that correspond to the magnitude of the autoantibody response... - Diabetes-related antibodies in euglycemic subjectsPeter Achenbach
Diabetes Research Institute and 3rd Medical Department Academic, , Koelner Platz 1, 80804 Munich, Germany
Best Pract Res Clin Endocrinol Metab 19:101-17. 2005.... - Tracing the Pathogenesis of Type 1 Diabetes: A Report on the 44th Annual Meeting of the European Association for the Study of Diabetes (EASD)Liang Hao Guo
Diabetes Research Institute, Munich, Germany
Rev Diabet Stud 5:171-4. 2008..This report highlights some of the recent studies on diabetes biomarkers, with a particular focus on zinc transporter ZnT8, presented at the EASD meeting in September 2008 in Rome, Italy... - Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristicsPeter Achenbach
Diabetes Research Institute and 3rd Medical Department, , Munich, Germany
Diabetes 53:384-92. 2004..Using models based on these antibody characteristics, autoantibody-positive relatives can be classified into groups with risks of diabetes ranging from 7 to 89% within 5 years... - Spontaneous peripheral T-cell responses to the IA-2beta (phogrin) autoantigen in young nonobese diabetic micePeter Achenbach
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 4200 E 9th Avenue, Denver, CO 80262, USA
J Autoimmun 19:111-6. 2002..The results show that the phogrin molecule is targeted early in the course of disease in NOD animals at a time when circulating autoantibodies are absent and insulitis is minimal...