University of Bonn

Summary

Organization: University of Bonn
Country: Germany

Top Publications

  1. ncbi Molecular pathology in forensic medicine--Introduction
    Burkhard Madea
    Institute of Forensic Medicine, University of Bonn, Bonn, Germany
    Forensic Sci Int 203:3-14. 2010
  2. ncbi Power comparison of generalizations of the mean test for affected sib pairs in case of incompletely informative markers
    Michael Knapp
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
    Genet Epidemiol 30:314-9. 2006
  3. ncbi [Non-ionic iodinated dimeric versus monomeric X-ray contrast media: effects on complement factors in vivo]
    I Böhm
    Radiologische Universitatsklinik, Rheinische Friedrich Wilhelms Universitat
    Rofo 178:306-12. 2006
  4. ncbi Temporal analysis of moving DC electric fields in aquatic media
    Michael H Hofmann
    Institute of Zoology, University of Bonn, Poppelsdorfer Schloss, 53115 Bonn, Germany
    Phys Biol 2:23-8. 2005
  5. ncbi AgCl precipitates in isolated cuticular membranes reduce rates of cuticular transpiration
    Lukas Schreiber
    Institute of Cellular and Molecular Botany IZMB, University of Bonn, Kirschallee 1, 53115 Bonn, Germany
    Planta 223:283-90. 2006
  6. ncbi [Accidental urban hypothermia. Severe hypothermia of 20.7 degrees C]
    J C Schewe
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Bonn
    Anaesthesist 54:1005-11. 2005
  7. ncbi Platelet activation markers in patients with heart assist device
    Oliver Dewald
    Department of Cardiac Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Artif Organs 29:292-9. 2005
  8. ncbi Results after replantation of avulsed permanent teeth. II. Periodontal healing and the role of physiologic storage and antiresorptive-regenerative therapy
    Yango Pohl
    Department of Oral Surgery, University of Bonn, Bonn, Germany
    Dent Traumatol 21:93-101. 2005
  9. ncbi Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
    Julia Reichelt
    Institut fur Physiologische Chemie, Universitat Bonn, Bonn, Germany
    Eur J Cell Biol 83:747-59. 2004
  10. ncbi Arrested germ cell divisions in the ageing human testis
    A Miething
    Institute of Anatomy, University of Bonn, Bonn, Germany
    Andrologia 37:10-6. 2005

Detail Information

Publications62

  1. ncbi Molecular pathology in forensic medicine--Introduction
    Burkhard Madea
    Institute of Forensic Medicine, University of Bonn, Bonn, Germany
    Forensic Sci Int 203:3-14. 2010
    ....
  2. ncbi Power comparison of generalizations of the mean test for affected sib pairs in case of incompletely informative markers
    Michael Knapp
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Germany
    Genet Epidemiol 30:314-9. 2006
    ..Most importantly, the new test is less powerful than its competitors, especially in case of low marker informativity it was designed for...
  3. ncbi [Non-ionic iodinated dimeric versus monomeric X-ray contrast media: effects on complement factors in vivo]
    I Böhm
    Radiologische Universitatsklinik, Rheinische Friedrich Wilhelms Universitat
    Rofo 178:306-12. 2006
    ..To survey contrast media (CM)-induced alterations of complement factors...
  4. ncbi Temporal analysis of moving DC electric fields in aquatic media
    Michael H Hofmann
    Institute of Zoology, University of Bonn, Poppelsdorfer Schloss, 53115 Bonn, Germany
    Phys Biol 2:23-8. 2005
    ....
  5. ncbi AgCl precipitates in isolated cuticular membranes reduce rates of cuticular transpiration
    Lukas Schreiber
    Institute of Cellular and Molecular Botany IZMB, University of Bonn, Kirschallee 1, 53115 Bonn, Germany
    Planta 223:283-90. 2006
    ....
  6. ncbi [Accidental urban hypothermia. Severe hypothermia of 20.7 degrees C]
    J C Schewe
    Klinik und Poliklinik für Anästhesiologie und operative Intensivmedizin, Universitatsklinikum Bonn
    Anaesthesist 54:1005-11. 2005
    ....
  7. ncbi Platelet activation markers in patients with heart assist device
    Oliver Dewald
    Department of Cardiac Surgery, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Artif Organs 29:292-9. 2005
    ..Future studies in larger patient populations are necessary to identify new and specific markers of platelet activation in this clinical setting...
  8. ncbi Results after replantation of avulsed permanent teeth. II. Periodontal healing and the role of physiologic storage and antiresorptive-regenerative therapy
    Yango Pohl
    Department of Oral Surgery, University of Bonn, Bonn, Germany
    Dent Traumatol 21:93-101. 2005
    ..Extraoral endodontic treatment reduces infection-related complications; this item was discussed in the first part of the publication...
  9. ncbi Loss of keratin 10 is accompanied by increased sebocyte proliferation and differentiation
    Julia Reichelt
    Institut fur Physiologische Chemie, Universitat Bonn, Bonn, Germany
    Eur J Cell Biol 83:747-59. 2004
    ....
  10. ncbi Arrested germ cell divisions in the ageing human testis
    A Miething
    Institute of Anatomy, University of Bonn, Bonn, Germany
    Andrologia 37:10-6. 2005
    ..The presence of arrested germ cell divisions in ageing men might be connected with local dysfunctions of the Sertoli cell barrier, which are known to appear focally in the ageing human seminiferous epithelium as well...
  11. ncbi Intramers and aptamers: applications in protein-function analyses and potential for drug screening
    Michael Famulok
    , , Gerhard-Domagk-Strasse 1, 53121 Bonn, Germany
    Chembiochem 6:19-26. 2005
  12. ncbi Development of mental health dysfunction in childhood epilepsy
    Meinolf Noeker
    Department of Pediatrics, University of Bonn, Adenauerallee 119, D 53113, Bonn, Germany
    Brain Dev 27:5-16. 2005
    ..On the scientific level, it provides an appropriate tool to approach childhood epilepsy in general, whereas on the clinical level, it facilitates the assessment and management of individual patients...
  13. ncbi Diagnostic accuracy of atypical p-ANCA in autoimmune hepatitis using ROC- and multivariate regression analysis
    B Terjung
    Department of Internal Medicine I, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Eur J Med Res 9:439-48. 2004
    ..Antineutrophil cytoplasmic antibodies (atypical p-ANCA) are detected at high prevalence in sera from patients with autoimmune hepatitis (AIH), but their diagnostic relevance for AIH has not been systematically evaluated so far...
  14. ncbi Significant influence of scaler tip design on root substance loss resulting from ultrasonic scaling: a laserprofilometric in vitro study
    Søren Jepsen
    Department of Periodontology, Operative and Preventive Dentistry, University of Bonn, Germany
    J Clin Periodontol 31:1003-6. 2004
    ..The aim of the present study was to investigate the influence of different working tip designs (narrow versus wide) on root substance loss caused by either magnetostrictive or piezoelectric ultrasonic devices...
  15. ncbi Long-term follow-up of patients with frontalis sling operation in the treatment of essential blepharospasm unresponsive to botulinum toxin therapy
    Bettina Wabbels
    Department of Ophthalmology, University of Bonn, Klinikum, Abbestrasse 2, 53127 Bonn, Germany
    Graefes Arch Clin Exp Ophthalmol 245:45-50. 2007
    ..This led to the idea of performing frontalis suspension, normally used for certain types of ptosis. We set out to evaluate the long-term results, complication rates and patient acceptance of this intervention...
  16. ncbi [Control of infection in gastrointestinal endoscopy]
    E Biecker
    Medizinische Klinik und Poliklinik I, , Bonn
    Dtsch Med Wochenschr 131:2726-32. 2006
  17. ncbi [Orbital aneurysmal bone cyst in a 2-year-old child]
    A Glien
    Klinik und Poliklinik für Hals Nasen Ohrenheilkunde Chirurgie, Universitatsklinikum Bonn
    HNO 55:281-6. 2007
    ..It is not possible to confirm diagnosis from clinical or radiological data. Early biopsy is essential for a reliable diagnosis even if histological assessment is challenging...
  18. ncbi Prenatal diagnosis of tricuspid atresia: intrauterine course and outcome
    C Berg
    Department of Obstetrics and Prenatal Medicine University of Bonn, Bonn, Germany
    Ultrasound Obstet Gynecol 35:183-90. 2010
    ..To evaluate the intrauterine course and outcome of tricuspid atresia detected in the fetus...
  19. ncbi A novel microdeletion syndrome involving 5q14.3-q15: clinical and molecular cytogenetic characterization of three patients
    Hartmut Engels
    Institute of Human Genetics, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Eur J Hum Genet 17:1592-9. 2009
    ..3 microdeletion syndrome...
  20. ncbi Three new spongian diterpenes from the Fijian marine sponge Spongia sp
    Harald Gross
    Institute for Pharmaceutical Biology, University ofBonn, 53115 Bonn, Germany
    Nat Prod Commun 4:315-22. 2009
    ..Despite their labile nature the structures could be established through a combined strategy including complete analysis of spectroscopic data (NMR, MS), molecular modeling and quantum-mechanical calculations...
  21. ncbi [Medical treatment of epilepsy: hidden dimensions]
    J Bauer
    Klinik für Epileptologie, Universitatsklinikum Bonn, Bonn, Germany
    Nervenarzt 80:386-98. 2009
    ..Of all patients with epilepsy, 30-50% suffer from depression, but about 50% of these are not willing to start antidepressant drug therapy...
  22. ncbi Complex climate controls on 20th century oak growth in Central-West Germany
    Dagmar A Friedrichs
    Department of Geography, University of Bonn, Meckenheimer Allee 166, 53115 Bonn, Germany
    Tree Physiol 29:39-51. 2009
    ..Our results indicate uncertainty in estimates of future growth trends of Central European oak forests in a warming and drying world...
  23. ncbi 2-Amino- and 2-alkylthio-4H-3,1-benzothiazin-4-ones: synthesis, interconversion and enzyme inhibitory activities
    Hans Georg Häcker
    Pharmaceutical Institute, Pharmaceutical Chemistry I, University of Bonn, An der Immenburg 4, D 53121 Bonn, Germany
    Molecules 14:378-402. 2009
    ..Twelve benzothiazinones were evaluated as inhibitors against a panel of eight proteases and esterases to identify one selective inhibitor of human cathepsin L, 2b, and one selective inhibitor of human leukocyte elastase, 5i...
  24. ncbi Genetic association analysis with FAMHAP: a major program update
    Christine Herold
    Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Bioinformatics 25:134-6. 2009
    ..As an example, we describe application to HapMap data. AVAILABILITY: The software is available at http://famhap.meb.uni-bonn.de..
  25. ncbi Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export
    Cornelius F H Mueller
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Circulation 117:2912-8. 2008
    ..To test this hypothesis, we investigated the effects of MRP1 inhibition and LTC(4) receptor blockade (Cys-LT1 receptor) in vitro and in vivo...
  26. ncbi Temporal lobe epilepsy surgery and the quest for optimal extent of resection: a review
    Johannes Schramm
    Department of Neurosurgery, Bonn University Medical Center, University of Bonn, Bonn, Germany
    Epilepsia 49:1296-307. 2008
    ..SAH appears to have similar seizure outcome and a better cognitive outcome than TLR. It remains unclear whether a larger mesial resection extent leads to better seizure outcome...
  27. ncbi Oral valganciclovir for symptomatic congenital cytomegalovirus infection in an extremely low birth weight infant
    A Muller
    Department of Neonatology, Children s Hospital, University of Bonn, Bonn, Germany
    J Perinatol 28:74-6. 2008
    ....
  28. ncbi Global diversity of island floras from a macroecological perspective
    Holger Kreft
    Nees Institute for Biodiversity of Plants, University of Bonn, Meckenheimer Allee 170, D 53115 Bonn, Germany
    Ecol Lett 11:116-27. 2008
    ..Elevation and island geology show relatively weak yet significant effects. Together these variables account for 85% of the global variation in species richness...
  29. ncbi Pre-operative staging of breast cancer with breast MRI: one step forward, two steps back?
    C Kuhl
    Department of Radiology, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Breast 16:S34-44. 2007
    ..Using the same guidelines to manage MR-detected multicentric cancer foci may be inappropriate because some small MRI detected additional multicentric breast cancer foci will be sufficiently treated by radiation therapy...
  30. ncbi MRI for diagnosis of pure ductal carcinoma in situ: a prospective observational study
    Christiane K Kuhl
    Department of Radiology, University of Bonn, Bonn, Germany
    Lancet 370:485-92. 2007
    ..Our aim was to investigate the sensitivity with which ductal carcinoma in situ (DCIS) is diagnosed by mammography and by breast MRI...
  31. ncbi [Design and testing of a novel measuring system for use in dental biomechanics--principles and examples of measurements with the hexapod measuring system]
    L Keilig
    Abteilung für Zahnärztliche Propädeutik Experimentelle Zahnheilkunde der Rheinischen Friedrich Wilhelms Universität Bonn
    Biomed Tech (Berl) 49:208-15. 2004
    ..Using the setup, the deflection behaviour of these devices under high and low loading was measured at a resolution of approximately one micrometer or one angular second...
  32. ncbi Molecular biology. RNAs turn on in tandem
    Michael Famulok
    , D-53121 Bonn, Germany
    Science 306:233-4. 2004
  33. ncbi Functional screening of G protein-coupled receptors by measuring intracellular calcium with a fluorescence microplate reader
    Matthias U Kassack
    Pharmaceutical Institute, University of Bonn, Bonn, Germany
    J Biomol Screen 7:233-46. 2002
    ....
  34. ncbi Nerve fibers in tumors of the human urinary bladder
    Peter Seifert
    Alfried Krupp Laboratory for Electron Microscopy, Department of Ophthalmology, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Virchows Arch 440:291-7. 2002
    ..Thus, a morphological basis for neuronal influence on the behavior of such tumors has been demonstrated...
  35. ncbi Gene therapy of hemophilia
    R Schwaab
    Institute for Experimental Hematology and Transfusion Medicine, University Clinics, Sigmund Freud Str 25, 53105 Bonn, Germany
    Semin Thromb Hemost 27:417-24. 2001
    ..Encouraged by the results of preliminary experiments using preponderant mouse and canine models, three clinical phase I studies on hemophilia A and B patients have been initiated, one of which has been preliminarily reported successful...
  36. ncbi Gravistimulated asymmetries in the outer epidermal cell walls of graviresponding coleoptiles
    H G Edelmann
    Botanisches Institut, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    Planta 203:S123-9. 1997
    ..In addition, recent results obtained by the author in experiments with rye coleoptiles will be presented and discussed in the context of a tentative model of gravistimulated wall asymmetries temporarily causing differential growth...
  37. ncbi Tissue expansion using osmotically active hydrogel systems for direct closure of the donor defect of the radial forearm flap
    S J Berge
    Department of Oral and Maxillofacial Surgery, Friedrich Wilhelm University, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Plast Reconstr Surg 108:1-5, discussion 6-7. 2001
    ..By using osmotically active hydrogel tissue expanders, there is no postoperative filling and no risk of complications arising from defective balloon expanders, filling valves, or missing ports...
  38. ncbi Mitochondrial gene fragments suggest paraphyly of the genus Panorpa (Mecoptera, Panorpidae)
    B Misof
    Institute for Evolutionary Biology and Ecology, An der Immenburg 1, Bonn, D 53121, Germany
    Mol Phylogenet Evol 17:76-84. 2000
    ..We conclude that the sequenced mitochondrial gene fragments appear to be well suited for future more comprehensive phylogenetic investigations of panorpid scorpionflies...
  39. ncbi Early intracellular signalling pathway of ethanol in vascular smooth muscle cells
    A Sachinidis
    Medizinische Universitäts Poliklinik, Wilhelmstr 35 37, 53111 Bonn, Germany
    Br J Pharmacol 128:1761-71. 1999
    ..4. We may postulate that the activation of these mitogenic signals including the elevation of DNA synthesis reflects a cell effort to protect itself against the toxic effects of ethanol...
  40. ncbi Alpha-1-antichymotrypsin gene polymorphism and risk for sporadic Alzheimer's disease in a German population
    S G Schwab
    Department of Psychiatry, University of Bonn, Germany
    Dement Geriatr Cogn Disord 10:469-72. 1999
    ..When we analyzed the polymorphism in APOE epsilon4 carriers, no overrepresentation in our AD group could be shown for the ACT*AA genotype carriers. Copyrightz1999S.KargerAG,Basel..
  41. ncbi Calycopterones and calyflorenones, novel biflavonoids from Calycopteris floribunda
    R Mayer
    Pharmazeutisches Institut, Universitat Bonn, Kreuzbergweg 26, D 53115 Bonn, Germany
    J Nat Prod 62:1274-8. 1999
    ..Cytotoxicity test results of 1 and 2 are reported. The monoflavonoid penduletin was isolated as a minor component from C. floribunda for the first time...
  42. ncbi Gene defects in idiopathic epilepsy
    O K Steinlein
    Institute of Human Genetics, Bonn, Germany
    Rev Neurol (Paris) 155:450-3. 1999
    ..The genetic basis of two monogenic epilepsies have recently been identified: autosomal dominant nocturnal frontal lobe epilepsy and benign familial neonatal convulsions...
  43. ncbi Comparative pharmacodynamic modeling of the electroencephalography-slowing effect of isoflurane, sevoflurane, and desflurane
    B Rehberg
    Klinik und Poliklinik für Anaesthesiologie und spezielle Intensivmedizin, University of Bonn, Germany
    Anesthesiology 91:397-405. 1999
    ....
  44. ncbi Simulation of orthodontic tooth movements. A comparison of numerical models
    C Bourauel
    Poliklinik für Kieferorthopädie, Rheinische Friedrich Wilhelms Universitat Bonn, Germany
    J Orofac Orthop 60:136-51. 1999
    ..The results show that the first model allows reliable simulation of orthodontic tooth movements, whereas the second is to be rejected...
  45. ncbi Distribution and dynamics of the cytoskeleton in graviresponding protonemata and rhizoids of characean algae: exclusion of microtubules and a convergence of actin filaments in the apex suggest an actin-mediated gravitropism
    M Braun
    Botanisches Institut, Universitat Bonn, Germany
    Planta 205:39-50. 1998
    ....
  46. ncbi SNP detection and linkage mapping of the porcine ferritin heavy-chain gene
    S Ponsuksili
    Institute of Animal Breeding Science, University of Bonn, Germany
    Anim Genet 33:325-6. 2002
  47. ncbi [Intracellular signal transduction of angiotensin II and possible interventions in the renin-angiotensin system]
    U Schmitz
    Medizinische Poliklinik, , Germany
    Dtsch Med Wochenschr 127:2400-3. 2002
  48. ncbi Bispectral index (BIS) and burst suppression: revealing a part of the BIS algorithm
    J Bruhn
    Department of Anesthesiology, Stanford University School of Medicine, Stanford, CA, USA
    J Clin Monit Comput 16:593-6. 2000
    ..The exact algorithm used to synthetize the information to the BIS value is unpublished and still unknown. This study provides insight into the integration of the suppression ratio into the BIS algorithm...
  49. ncbi Ninetis russellsmithi n. sp., an unusual new pholcid spider species from Malawi (Araneae: Pholcidae)
    Bernhard A Huber
    Zoological Research Institute and Museum Alexander Koenig, Adenauerallee 160, 53113 Bonn, Germany
    J Insect Sci 2:4. 2002
    ..Biogeographically this species marks the first record for the genus in a 3000 km gap between its African congeners in Namibia and Tanzania...
  50. ncbi The mitochondrial DNA of land plants: peculiarities in phylogenetic perspective
    Volker Knoop
    IZMB Institut für Zelluläre und Molekulare Botanik, Universitat Bonn, Kirschallee 1, Bonn, Germany
    Curr Genet 46:123-39. 2004
    ..This review attempts to summarize the unique aspects of land plant mitochondrial evolution from a phylogenetic perspective...
  51. ncbi [Development of a database system for multicentric ENT tumor documentation]
    S Langenberg
    Klinik und Poliklinik für Hals Nasen Ohrenheilkunde Chirurgie der Universität Bonn
    Laryngorhinootologie 83:433-7. 2004
    ..Multicentric clinical studies have a great impact on progress in diagnostics and therapy in oncology. However, multicentric retrospective clinical trials require a common documentation standard...
  52. ncbi Genes and mutations in human idiopathic epilepsy
    Ortrud K Steinlein
    Institute of Human Genetics, University Hospital Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
    Brain Dev 26:213-8. 2004
    ..It can therefore be suspected that more than one pathogenetic concept exists in epileptogenesis...
  53. ncbi The diagnostic utility of human papillomavirus-testing in combination with immunohistochemistry in advanced gynaecologic pelvic tumours: a new diagnostic approach
    Tjoung Won Park
    Departmetn of Obstetrics and Gynaecology, University of Bonn, D 53105 Bonn, Germany
    Int J Oncol 24:829-36. 2004
    ..The proposed diagnostic approach is helpful in the identification and management of pelvic tumours of unknown primary origin...
  54. ncbi Fluid intake and epidemiology of urolithiasis
    R Siener
    Division of Experimental Urology, Department of Urology, University of Bonn, Germany
    Eur J Clin Nutr 57:S47-51. 2003
    ..The type of fluids should be carefully selected to achieve the appropriate change of urine composition depending on stone composition. A sufficient intake of fluid is one of the most important preventive measures for stone recurrence...
  55. ncbi Sticky proteins for stem cells
    Thomas Kolter
    , , Gerhard-Domagk Strasse 1, 53121 Bonn, Germany
    Chembiochem 4:1303-5. 2003
  56. ncbi Acute haemodynamic effects of losartan in anaesthetized cirrhotic rats
    J Heller
    Department of Internal Medicine I, University of Bonn, Bonn, Germany
    Eur J Clin Invest 33:1006-12. 2003
    ..The angiotensin II type 1 receptor antagonist losartan has been suggested as a portal pressure-lowering drug in patients with cirrhosis...
  57. ncbi How to model a complex trait. 1. General considerations and suggestions
    Konstantin Strauch
    Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, Bonn, Germany
    Hum Hered 55:202-10. 2003
    ..Our considerations and suggestions aim at guiding researchers to genotyping individuals at a trait locus as accurately as possible...
  58. ncbi Pneumocystis carinii pneumonia
    S Tasci
    Department of Internal Medicine II, University of Bonn, Germany
    Lancet 362:124. 2003
  59. ncbi Xenin plasma concentrations during modified sham feeding and during meals of different composition demonstrated by radioimmunoassay and chromatography
    Gerhard E Feurle
    DRK Krankenhaus Neuwied, Markstr 104, 56564 Neuwied, Germany
    Regul Pept 111:153-9. 2003
    ..CONCLUSION: Cephalic factors, investigated by modified sham feeding, stimulate release of xenin into the circulation. Xenin may participate in the central nervous regulation of gastrointestinal function...
  60. ncbi Subjective intensity of pain during the treatment of periodontal lesions with the Vector-system
    Andreas Braun
    Department of Operative Dentistry and Periodontology, University of Bonn, Germany
    J Periodontal Res 38:135-40. 2003
    ..Using cleaning methods that cause less discomfort and pain, it might be possible to increase the patient's compliance during non-surgical periodontal therapy and recall...
  61. ncbi Tolerability of tiagabine: a prospective open-label study
    Jurgen Bauer
    Department of Epileptology, University of Bonn, Germany
    Epileptic Disord 4:257-60. 2002
    ..Median total seizure frequency decreased from 4.5 to 2.0 seizures/4 weeks. Adverse events occurred in 78 patients (13.6%). Tiagabine proved to be a well-tolerated AED...
  62. ncbi An insertion mutation of the CHRNA4 gene in a family with autosomal dominant nocturnal frontal lobe epilepsy
    O K Steinlein
    Institute for Human Genetics, University of Bonn, Germany
    Hum Mol Genet 6:943-7. 1997
    ..Comparison of the two mutations identified so far in families with ADNFLE illustrates that different mutations can result in similar phenotypes...