Research Topics
Species | Matthias UngerSummaryCountry: Germany Publications
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Publications
Capillary zone electrophoresis as a tool for the quality control of goldenseal extractsMatthias Unger
Institute of Pharmacy and Food Chemistry, Julius Maximilians University, Wurzburg, Germany
Electrophoresis 26:2430-6. 2005..0 microg/mL and the linearity was obtained between 2.5 and 500 microg/mL. Using our newly developed method, both the alkaloids could be analysed in herbal remedies containing goldenseal root extracts within 8 min...- Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extractionMatthias Unger
Institute of Pharmacy and Food Chemistry, Julius Maximilians University Würzburg, 97074 Wurzburg, Germany
Rapid Commun Mass Spectrom 18:2273-81. 2004.... - Analytical characterisation of crude extracts from an African Ancistrocladus species using high-performance liquid chromatography and capillary electrophoresis coupled to ion trap mass spectrometryMatthias Unger
Institute of Pharmacy and Food Chemistry, Julius Maximilians University Würzburg, D 97074 Wurzburg, Germany
Phytochem Anal 15:21-6. 2004..By performing additional CE-MS/MS experiments, in combination with parallel isolation studies and structural elucidation using conventional methods, six alkaloidal substances present in the plant could be identified... - Analysis of the glucosinolate pattern of Arabidopsis thaliana seeds by capillary zone electrophoresis coupled to electrospray ionization-mass spectrometryGerhard Bringmann
Institute of Organic Chemistry, University of Wurzburg, Wurzburg, Germany
Electrophoresis 26:1513-22. 2005..The sensitivity together with mass accuracy and true isotopic pattern of the TOF-MS allowed identification of a broad series of glucosinolates in Arabidopsis thaliana seeds... - Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extractionAndreas Frank
Institute of Pharmacy and Food Chemistry, , , Germany
J Chromatogr A 1112:255-62. 2006..Although the boswellic acids could be identified as moderate to potent inhibitors of the applied CYP enzymes, they are not the major CYP inhibitory principle of frankincense... 
Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidis and human cellsAlexander Cecil
University of Wurzburg, Theodor Boveri Institute, Department of Bioinformatics, Am Hubland, 97074 Wurzburg, Germany
Genome Biol 12:R24. 2011..Here, we demonstrate the utility of complementary analysis of both host and pathogen datasets in assessing bacterial adaptation to IQ-143, a synthetic analog of the novel type N,C-coupled naphthyl-isoquinoline alkaloid ancisheynine...- Formation of the indigo precursor indican in genetically engineered tobacco plants and cell culturesHeribert Warzecha
Lehrstuhl fur Pharmazeutische Biologie, Julius von Sachs Institut fur Biowissenschaften, Julius Maximilians Universitat, 97080 Wurzburg, Germany
Plant Biotechnol J 5:185-91. 2007..Although the de novo formation of indican in transgenic tobacco plants hampered indigo formation, it supports the contention that biosynthetic pathways can be efficiently mimicked by metabolic engineering... - [Botanical sedatives]Matthias Unger
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Pharm Unserer Zeit 36:206-12. 2007 
[Pharmacokinetic drug interactions by herbal drugs: Critical evaluation and clinical relevance]Matthias Unger
Institut für Pharmazie und Lebensmittelchemie, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
Wien Med Wochenschr 160:571-7. 2010..Since for herbal extracts a positive in vitro - in vivo correlation regarding the impact on drug bioavailability is rare, results from in vitro studies should be carefully interpreted...- Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNAKatharina Dueckershoff
Lehrstuhl fur Pharmazeutische Biologie, Julius von Sachs Institut fur Biowissenschaften, Julius Maximilians Universitat, Wurzburg, Germany
FEBS Lett 579:2480-4. 2005..This result substantiates that metabolic engineering of the plant secondary metabolism via mammalian P450 enzymes is possible in vivo... - Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava)Matthias Unger
Institute of Pharmacy and Food Chemistry, Julius Maximilians University, Wurzburg, Germany
Planta Med 68:1055-8. 2002..Positive fractions were analysed with LC/MS using electrospray ionisation and kavapyrones could be identified as the main CYP3A4 inhibitory components of Piper methysticum... - Random chemistry as a new tool for the generation of small compound libraries: development of a new acetylcholinesterase inhibitorPetra Kapkova
Institute of Pharmacy and Food Chemistry, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
J Med Chem 48:7496-9. 2005..The structure of the new highly potent AChE inhibitor, 9-amino-5,6,7,8-tetrahydroacridin-4yl)methanol (1), was elucidated by NMR spectroscopy and ESI (tandem) mass spectrometry... - Capillary electrophoresis of natural products: current applications and recent advancesMatthias Unger
Institute of Pharmacy and Food Chemistry, Department of Pharmaceutical Chemistry, University of Wurzburg, Wurzburg, Germany
Planta Med 75:735-45. 2009..Therefore, the focus of this mini-review will be on the advances and new aspects of recently published CE methods in natural products analysis... - Pharmacokinetic herb-drug interactions: are preventive screenings necessary and appropriate?Veronika Butterweck
Department of Pharmaceutics, University of Florida, Gainesville, FL, USA
Planta Med 70:784-91. 2004..Efforts to identify all possible interactions will lead to limitless investigations and to inconsistent decisions... - Structure-based engineering of strictosidine synthase: auxiliary for alkaloid librariesElke A Loris
Department of Pharmaceutical Biology, Institute of Pharmacy, Johannes Gutenberg University Mainz, Staudingerweg 5, D 55099 Mainz, Germany
Chem Biol 14:979-85. 2007.... - High-performance liquid chromatographic, capillary electrophoretic and capillary electrophoretic-electrospray ionisation mass spectrometric analysis of selected alkaloid groupsJoachim Stockigt
Department of Pharmaceutical Biology, Institute of Pharmacy, Johannes Gutenberg University, Mainz, Germany
J Chromatogr A 967:85-113. 2002..serpentina roots, R. serpentina cell suspension cultures and cortex of Aspidosperma quebracho-blanco. The influence of buffer composition and analyte structures on separation is discussed... - Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitroJohanna Weiss
Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany
Drug Metab Dispos 33:1580-3. 2005..The f2 value of yangonin could not be determined due to its higher lipophilicity. In conclusion, our results for the first time demonstrate P-gp-inhibitory activity of kava-kava and its components in vitro... - Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitorsWolfgang Egge-Jacobsen
Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
Ther Drug Monit 26:546-62. 2004..The assay allows fast analysis of patient samples for therapeutic drug monitoring (TDM) and has successfully been used for TDM and pharmacokinetic drug-drug interactions studies... - Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extractionMatthias Unger
Department of Biopharmaceutical Sciences, University of California, San Francisco 94143-0446, USA
J Chromatogr B Analyt Technol Biomed Life Sci 767:245-53. 2002..The assay was linear from 5 to 5000 ng/ml (r2>0.99) and analytical recovery was >80%. Inter-assay precision for the quality control samples was less than 3% and inter-assay accuracy was within +/- 5%...