Matthias Unger

Summary

Country: Germany

Publications

  1. ncbi request reprint Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction
    Matthias Unger
    Institute of Pharmacy and Food Chemistry, Julius Maximilians University Würzburg, 97074 Wurzburg, Germany
    Rapid Commun Mass Spectrom 18:2273-81. 2004
  2. ncbi request reprint Capillary zone electrophoresis as a tool for the quality control of goldenseal extracts
    Matthias Unger
    Institute of Pharmacy and Food Chemistry, Julius Maximilians University, Wurzburg, Germany
    Electrophoresis 26:2430-6. 2005
  3. ncbi request reprint Analysis of the glucosinolate pattern of Arabidopsis thaliana seeds by capillary zone electrophoresis coupled to electrospray ionization-mass spectrometry
    Gerhard Bringmann
    Institute of Organic Chemistry, University of Wurzburg, Wurzburg, Germany
    Electrophoresis 26:1513-22. 2005
  4. ncbi request reprint Analytical characterisation of crude extracts from an African Ancistrocladus species using high-performance liquid chromatography and capillary electrophoresis coupled to ion trap mass spectrometry
    Matthias Unger
    Institute of Pharmacy and Food Chemistry, Julius Maximilians University Würzburg, D 97074 Wurzburg, Germany
    Phytochem Anal 15:21-6. 2004
  5. pmc Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidis and human cells
    Alexander Cecil
    University of Wurzburg, Theodor Boveri Institute, Department of Bioinformatics, Am Hubland, 97074 Wurzburg, Germany
    Genome Biol 12:R24. 2011
  6. ncbi request reprint Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction
    Andreas Frank
    Institute of Pharmacy and Food Chemistry, Julius Maximilians University Würzburg, 97074 Wurzburg, Germany
    J Chromatogr A 1112:255-62. 2006
  7. ncbi request reprint Formation of the indigo precursor indican in genetically engineered tobacco plants and cell cultures
    Heribert Warzecha
    Lehrstuhl fur Pharmazeutische Biologie, Julius von Sachs Institut fur Biowissenschaften, Julius Maximilians Universitat, 97080 Wurzburg, Germany
    Plant Biotechnol J 5:185-91. 2007
  8. ncbi request reprint [Botanical sedatives]
    Matthias Unger
    Institut für Pharmazie und LMC, Universitat Wurzburg
    Pharm Unserer Zeit 36:206-12. 2007
  9. doi request reprint Pharmacokinetic drug interactions involving Ginkgo biloba
    Matthias Unger
    Department of Pharmaceutical Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilians University Würzburg, Am Hubland, 97074 Wurzburg, Germany
    Drug Metab Rev 45:353-85. 2013
  10. doi request reprint [Pharmacokinetic drug interactions by herbal drugs: Critical evaluation and clinical relevance]
    Matthias Unger
    Institut für Pharmazie und Lebensmittelchemie, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Wien Med Wochenschr 160:571-7. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction
    Matthias Unger
    Institute of Pharmacy and Food Chemistry, Julius Maximilians University Würzburg, 97074 Wurzburg, Germany
    Rapid Commun Mass Spectrom 18:2273-81. 2004
    ....
  2. ncbi request reprint Capillary zone electrophoresis as a tool for the quality control of goldenseal extracts
    Matthias Unger
    Institute of Pharmacy and Food Chemistry, Julius Maximilians University, Wurzburg, Germany
    Electrophoresis 26:2430-6. 2005
    ..0 microg/mL and the linearity was obtained between 2.5 and 500 microg/mL. Using our newly developed method, both the alkaloids could be analysed in herbal remedies containing goldenseal root extracts within 8 min...
  3. ncbi request reprint Analysis of the glucosinolate pattern of Arabidopsis thaliana seeds by capillary zone electrophoresis coupled to electrospray ionization-mass spectrometry
    Gerhard Bringmann
    Institute of Organic Chemistry, University of Wurzburg, Wurzburg, Germany
    Electrophoresis 26:1513-22. 2005
    ..The sensitivity together with mass accuracy and true isotopic pattern of the TOF-MS allowed identification of a broad series of glucosinolates in Arabidopsis thaliana seeds...
  4. ncbi request reprint Analytical characterisation of crude extracts from an African Ancistrocladus species using high-performance liquid chromatography and capillary electrophoresis coupled to ion trap mass spectrometry
    Matthias Unger
    Institute of Pharmacy and Food Chemistry, Julius Maximilians University Würzburg, D 97074 Wurzburg, Germany
    Phytochem Anal 15:21-6. 2004
    ..By performing additional CE-MS/MS experiments, in combination with parallel isolation studies and structural elucidation using conventional methods, six alkaloidal substances present in the plant could be identified...
  5. pmc Modeling antibiotic and cytotoxic effects of the dimeric isoquinoline IQ-143 on metabolism and its regulation in Staphylococcus aureus, Staphylococcus epidermidis and human cells
    Alexander Cecil
    University of Wurzburg, Theodor Boveri Institute, Department of Bioinformatics, Am Hubland, 97074 Wurzburg, Germany
    Genome Biol 12:R24. 2011
    ..Here, we demonstrate the utility of complementary analysis of both host and pathogen datasets in assessing bacterial adaptation to IQ-143, a synthetic analog of the novel type N,C-coupled naphthyl-isoquinoline alkaloid ancisheynine...
  6. ncbi request reprint Analysis of frankincense from various Boswellia species with inhibitory activity on human drug metabolising cytochrome P450 enzymes using liquid chromatography mass spectrometry after automated on-line extraction
    Andreas Frank
    Institute of Pharmacy and Food Chemistry, Julius Maximilians University Würzburg, 97074 Wurzburg, Germany
    J Chromatogr A 1112:255-62. 2006
    ..Although the boswellic acids could be identified as moderate to potent inhibitors of the applied CYP enzymes, they are not the major CYP inhibitory principle of frankincense...
  7. ncbi request reprint Formation of the indigo precursor indican in genetically engineered tobacco plants and cell cultures
    Heribert Warzecha
    Lehrstuhl fur Pharmazeutische Biologie, Julius von Sachs Institut fur Biowissenschaften, Julius Maximilians Universitat, 97080 Wurzburg, Germany
    Plant Biotechnol J 5:185-91. 2007
    ..Although the de novo formation of indican in transgenic tobacco plants hampered indigo formation, it supports the contention that biosynthetic pathways can be efficiently mimicked by metabolic engineering...
  8. ncbi request reprint [Botanical sedatives]
    Matthias Unger
    Institut für Pharmazie und LMC, Universitat Wurzburg
    Pharm Unserer Zeit 36:206-12. 2007
  9. doi request reprint Pharmacokinetic drug interactions involving Ginkgo biloba
    Matthias Unger
    Department of Pharmaceutical Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilians University Würzburg, Am Hubland, 97074 Wurzburg, Germany
    Drug Metab Rev 45:353-85. 2013
    ..If this applies to other extracts prepared according to the European Pharmacopoeia remains uncertain. Also, a relevant potential for drug interactions cannot be excluded for poorly standardized GLEs used in many food supplements...
  10. doi request reprint [Pharmacokinetic drug interactions by herbal drugs: Critical evaluation and clinical relevance]
    Matthias Unger
    Institut für Pharmazie und Lebensmittelchemie, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Wien Med Wochenschr 160:571-7. 2010
    ..Since for herbal extracts a positive in vitro - in vivo correlation regarding the impact on drug bioavailability is rare, results from in vitro studies should be carefully interpreted...
  11. ncbi request reprint Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNA
    Katharina Dueckershoff
    Lehrstuhl fur Pharmazeutische Biologie, Julius von Sachs Institut fur Biowissenschaften, Julius Maximilians Universitat, Wurzburg, Germany
    FEBS Lett 579:2480-4. 2005
    ..This result substantiates that metabolic engineering of the plant secondary metabolism via mammalian P450 enzymes is possible in vivo...
  12. ncbi request reprint Random chemistry as a new tool for the generation of small compound libraries: development of a new acetylcholinesterase inhibitor
    Petra Kapkova
    Institute of Pharmacy and Food Chemistry, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    J Med Chem 48:7496-9. 2005
    ..The structure of the new highly potent AChE inhibitor, 9-amino-5,6,7,8-tetrahydroacridin-4yl)methanol (1), was elucidated by NMR spectroscopy and ESI (tandem) mass spectrometry...
  13. ncbi request reprint Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava)
    Matthias Unger
    Institute of Pharmacy and Food Chemistry, Julius Maximilians University, Wurzburg, Germany
    Planta Med 68:1055-8. 2002
    ..Positive fractions were analysed with LC/MS using electrospray ionisation and kavapyrones could be identified as the main CYP3A4 inhibitory components of Piper methysticum...
  14. doi request reprint Capillary electrophoresis of natural products: current applications and recent advances
    Matthias Unger
    Institute of Pharmacy and Food Chemistry, Department of Pharmaceutical Chemistry, University of Wurzburg, Wurzburg, Germany
    Planta Med 75:735-45. 2009
    ..Therefore, the focus of this mini-review will be on the advances and new aspects of recently published CE methods in natural products analysis...
  15. ncbi request reprint Structure-based engineering of strictosidine synthase: auxiliary for alkaloid libraries
    Elke A Loris
    Department of Pharmaceutical Biology, Institute of Pharmacy, Johannes Gutenberg University Mainz, Staudingerweg 5, D 55099 Mainz, Germany
    Chem Biol 14:979-85. 2007
    ....
  16. ncbi request reprint Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro
    Johanna Weiss
    Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany
    Drug Metab Dispos 33:1580-3. 2005
    ..The f2 value of yangonin could not be determined due to its higher lipophilicity. In conclusion, our results for the first time demonstrate P-gp-inhibitory activity of kava-kava and its components in vitro...
  17. ncbi request reprint Pharmacokinetic herb-drug interactions: are preventive screenings necessary and appropriate?
    Veronika Butterweck
    Department of Pharmaceutics, University of Florida, Gainesville, FL, USA
    Planta Med 70:784-91. 2004
    ..Efforts to identify all possible interactions will lead to limitless investigations and to inconsistent decisions...
  18. ncbi request reprint High-performance liquid chromatographic, capillary electrophoretic and capillary electrophoretic-electrospray ionisation mass spectrometric analysis of selected alkaloid groups
    Joachim Stockigt
    Department of Pharmaceutical Biology, Institute of Pharmacy, Johannes Gutenberg University, Mainz, Germany
    J Chromatogr A 967:85-113. 2002
    ..serpentina roots, R. serpentina cell suspension cultures and cortex of Aspidosperma quebracho-blanco. The influence of buffer composition and analyte structures on separation is discussed...
  19. ncbi request reprint Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors
    Wolfgang Egge-Jacobsen
    Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
    Ther Drug Monit 26:546-62. 2004
    ..The assay allows fast analysis of patient samples for therapeutic drug monitoring (TDM) and has successfully been used for TDM and pharmacokinetic drug-drug interactions studies...
  20. ncbi request reprint Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction
    Matthias Unger
    Department of Biopharmaceutical Sciences, University of California, San Francisco 94143 0446, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 767:245-53. 2002
    ..The assay was linear from 5 to 5000 ng/ml (r2>0.99) and analytical recovery was >80%. Inter-assay precision for the quality control samples was less than 3% and inter-assay accuracy was within +/- 5%...