Hendrik Ungefroren

Summary

Country: Germany

Publications

  1. pmc Interaction of tumor cells with the microenvironment
    Hendrik Ungefroren
    First Department of Medicine, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Cell Commun Signal 9:18. 2011
  2. pmc Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
    Hendrik Ungefroren
    Clinic for Applied Cellular Medicine, University Hospital Schleswig Holstein UKSH Campus Kiel, 24105 Kiel, Germany
    Mol Cancer 10:67. 2011
  3. ncbi request reprint The Src family kinase inhibitors PP2 and PP1 block TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors
    Hendrik Ungefroren
    Clinic for Applied Cellular Medicine at the UKSH, Campus Kiel, 24105 Kiel, Germany
    Curr Cancer Drug Targets 11:524-35. 2011
  4. doi request reprint Differential roles of Src in transforming growth factor-ß regulation of growth arrest, epithelial-to-mesenchymal transition and cell migration in pancreatic ductal adenocarcinoma cells
    Hendrik Ungefroren
    First Department of Medicine, UKSH, Lubeck, Germany
    Int J Oncol 38:797-805. 2011
  5. doi request reprint The programmable cell of monocytic origin (PCMO): a potential adult stem/progenitor cell source for the generation of islet cells
    Hendrik Ungefroren
    Clinic for Applied Cellular Medicine, UKS H, Campus Kiel, 24105 Kiel, Germany
    Adv Exp Med Biol 654:667-82. 2010
  6. ncbi request reprint Antitumor activity of ALK1 in pancreatic carcinoma cells
    Hendrik Ungefroren
    Department of General Surgery and Thoracic Surgery, UKSH, Campus Kiel, Arnold Heller Str 7, 24105 Kiel, Germany
    Int J Cancer 120:1641-51. 2007
  7. ncbi request reprint Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta
    Hendrik Ungefroren
    Department of General Surgery and Thoracic Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    J Biol Chem 280:2644-52. 2005
  8. ncbi request reprint Adhesion and Rac1-dependent regulation of biglycan gene expression by transforming growth factor-beta. Evidence for oxidative signaling through NADPH oxidase
    Stephanie Groth
    Department of General Surgery and Thoracic Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 7, Kiel 24105, Germany
    J Biol Chem 280:33190-9. 2005
  9. ncbi request reprint Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells
    Maren Ruhnke
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Kiel, Germany
    Gastroenterology 128:1774-86. 2005
  10. ncbi request reprint Stable expression of temperature-sensitive p53: a suitable model to study wild-type p53 function in pancreatic carcinoma cells
    Dieter Nuevemann
    Department of General and Thoracic Surgery, Research Unit Molecular Oncology, University Hospital Schleswig Holstein, D 24105 Kiel, Germany
    Oncol Rep 16:575-9. 2006

Collaborators

Detail Information

Publications31

  1. pmc Interaction of tumor cells with the microenvironment
    Hendrik Ungefroren
    First Department of Medicine, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Cell Commun Signal 9:18. 2011
    ..e. migration through connective tissue), metastasis formation, neovascularisation, apoptosis and chemotherapeutic drug resistance. In this mini-review we will focus on these issues that were recently raised by two review articles in CCS...
  2. pmc Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
    Hendrik Ungefroren
    Clinic for Applied Cellular Medicine, University Hospital Schleswig Holstein UKSH Campus Kiel, 24105 Kiel, Germany
    Mol Cancer 10:67. 2011
    ....
  3. ncbi request reprint The Src family kinase inhibitors PP2 and PP1 block TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors
    Hendrik Ungefroren
    Clinic for Applied Cellular Medicine at the UKSH, Campus Kiel, 24105 Kiel, Germany
    Curr Cancer Drug Targets 11:524-35. 2011
    ..Both agents may be useful as dual TGF-β/Src inhibitors in experimental therapeutics of late stage metastatic disease...
  4. doi request reprint Differential roles of Src in transforming growth factor-ß regulation of growth arrest, epithelial-to-mesenchymal transition and cell migration in pancreatic ductal adenocarcinoma cells
    Hendrik Ungefroren
    First Department of Medicine, UKSH, Lubeck, Germany
    Int J Oncol 38:797-805. 2011
    ..Together, the data provide evidence for a role of Src in the regulation of basal proliferation as well as in basal and TGF-ß1-mediated cell motility but not EMT in TGF-ß-responsive pancreatic (tumor) cells...
  5. doi request reprint The programmable cell of monocytic origin (PCMO): a potential adult stem/progenitor cell source for the generation of islet cells
    Hendrik Ungefroren
    Clinic for Applied Cellular Medicine, UKS H, Campus Kiel, 24105 Kiel, Germany
    Adv Exp Med Biol 654:667-82. 2010
    ..Combining these two strategies has great potential in generating large amounts of blood-derived cells suitable for both autologous and allogeneic therapy of type 1 diabetes...
  6. ncbi request reprint Antitumor activity of ALK1 in pancreatic carcinoma cells
    Hendrik Ungefroren
    Department of General Surgery and Thoracic Surgery, UKSH, Campus Kiel, Arnold Heller Str 7, 24105 Kiel, Germany
    Int J Cancer 120:1641-51. 2007
    ....
  7. ncbi request reprint Transforming growth factor-beta (TGF-beta) type I receptor/ALK5-dependent activation of the GADD45beta gene mediates the induction of biglycan expression by TGF-beta
    Hendrik Ungefroren
    Department of General Surgery and Thoracic Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 7, 24105 Kiel, Germany
    J Biol Chem 280:2644-52. 2005
    ....
  8. ncbi request reprint Adhesion and Rac1-dependent regulation of biglycan gene expression by transforming growth factor-beta. Evidence for oxidative signaling through NADPH oxidase
    Stephanie Groth
    Department of General Surgery and Thoracic Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Strasse 7, Kiel 24105, Germany
    J Biol Chem 280:33190-9. 2005
    ..These results show that the TGF-beta effect on BGN is dependent on cell adhesion and that activated Rac1, presumably acting through NADPH oxidase(s), is necessary but not sufficient for TGF-beta-induced BGN expression...
  9. ncbi request reprint Differentiation of in vitro-modified human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells
    Maren Ruhnke
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Kiel, Germany
    Gastroenterology 128:1774-86. 2005
    ..We evaluated the differentiation potential of human peripheral blood monocytes into hepatocyte-like and pancreatic islet-like cells...
  10. ncbi request reprint Stable expression of temperature-sensitive p53: a suitable model to study wild-type p53 function in pancreatic carcinoma cells
    Dieter Nuevemann
    Department of General and Thoracic Surgery, Research Unit Molecular Oncology, University Hospital Schleswig Holstein, D 24105 Kiel, Germany
    Oncol Rep 16:575-9. 2006
    ..These results demonstrate that the ts p53/AsPC-1 model is suitable to investigate the effect of wt p53 restoration in pancreatic carcinoma cells...
  11. ncbi request reprint Gemcitabine-mediated apoptosis is associated with increased CD95 surface expression but is not inhibited by DN-FADD in Colo357 pancreatic cancer cells
    Matthias Christgen
    Clinic for General and Thoracic Surgery, Molecular Oncology Research Group, University of Kiel, Arnold Heller Str 7, 24105 Kiel, Germany
    Cancer Lett 227:193-200. 2005
    ..These observations argue against a role of CD95 in gemcitabine-induced caspase-8 activation and reveal that the anti-apoptotic function of DN-FADD differs from caspase-8 inhibition in Colo357 cells...
  12. doi request reprint The generation of programmable cells of monocytic origin involves partial repression of monocyte/macrophage markers and reactivation of pluripotency genes
    Hendrik Ungefroren
    Clinic for Applied Cellular Medicine, Department of Neurosurgery, Kiel, Germany
    Stem Cells Dev 19:1769-80. 2010
    ..These results show that peripheral blood monocytes can be induced in vitro to transiently acquire stem cell-like properties and concomitantly a state of increased differentiation potential toward the hepatocytic phenotype...
  13. pmc Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β
    Hendrik Ungefroren
    Clinic for Applied Cellular Medicine, UKSH, Kiel, Germany
    PLoS ONE 10:e0118097. 2015
    ....
  14. ncbi request reprint TGF-β Signal Transduction in Pancreatic Carcinoma Cells is Sensitive to Inhibition by the Src Tyrosine Kinase Inhibitor AZM475271
    Tobias Bartscht
    First Department of Medicine, University of Lubeck, 23538 Lubeck, Germany
    Anticancer Agents Med Chem . 2016
    ....
  15. pmc Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling
    Hendrik Ungefroren
    First Department of Medicine, University Hospital Schleswig Holstein UKSH, Campus Lubeck, Lubeck, Germany
    Oncotarget 5:277-90. 2014
    ..Hence, it could be exploited for diagnostic/prognostic purposes or even therapeutically in late-stage PDAC as an antimetastatic agent. ..
  16. ncbi request reprint Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer
    Sebastian Hinz
    Division Molecular Oncology, Department for General Surgery, Institute of Immunology, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cancer Res 67:8344-50. 2007
    ..These findings indicate that pancreatic carcinoma cells share growth-suppressive effects with Treg and suggest that mimicking Treg function may represent a new mechanism of immune evasion in pancreatic cancer...
  17. pmc Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5
    Franziska Zeeh
    First Department of Medicine, University of Lubeck, Lubeck, Germany
    Oncotarget 7:41095-41109. 2016
    ..Therapeutically targeting PAR2 may thus be a promising approach in preventing TGF-β-dependent driven metastatic dissemination in PDAC and possibly other stroma-rich tumour types...
  18. ncbi request reprint Inhibition of TGF-β signaling in tumor cells by small molecule Src family kinase inhibitors
    Tobias Bartscht
    First Department of Medicine, UKSH, Campus Lubeck, D 23538 Lubeck, Germany Germany
    Anticancer Agents Med Chem . 2017
    ..If AZM475271 and dasatinib can indeed act as dual Src / TGF-β inhibitors in vivo, this may be beneficial for prevention of metastatic disease in more advanced tumor stages...
  19. pmc Peripheral Blood Monocytes as Adult Stem Cells: Molecular Characterization and Improvements in Culture Conditions to Enhance Stem Cell Features and Proliferative Potential
    Hendrik Ungefroren
    First Department of Medicine, UKSH, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Stem Cells Int 2016:7132751. 2016
    ....
  20. doi request reprint The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells
    Tobias Bartscht
    Division of Hematology and Oncology, First Department of Medicine, UKSH, Campus Lubeck, 23538 Lubeck, Germany
    Cancer Chemother Pharmacol 70:221-30. 2012
    ....
  21. ncbi request reprint Detection of tumor stem cell markers in pancreatic carcinoma cell lines
    Monika Olempska
    Department of General and Thoracic Surgery, University Hospital Schleswig Holstein, Campus Kiel, Arnold Heller Str 7, 24 105 Kiel, Germany
    Hepatobiliary Pancreat Dis Int 6:92-7. 2007
    ..Because previous data implicated ABCG2 and CD133 as stem cell markers in hematopoietic and neural stem/progenitor cells, we analyzed the expression of these two proteins in pancreatic carcinoma cell lines...
  22. ncbi request reprint Human monocyte-derived neohepatocytes: a promising alternative to primary human hepatocytes for autologous cell therapy
    Maren Ruhnke
    Department of General and Thoracic Surgery, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transplantation 79:1097-103. 2005
    ..We have generated hepatocyte-like (NeoHep) cells from terminally differentiated peripheral blood monocytes and, in this study, have evaluated these cells as a possible tool for autologous cell therapy...
  23. doi request reprint Can anthocyanins improve maintenance therapy of Ph(+) acute lymphoblastic leukaemia?
    Joachim Köchling
    Department of Paediatrics, UKSH, Campus Lubeck, Universitat zu Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Eur J Haematol 90:291-300. 2013
    ..Furthermore, this approach may serve as strategy for maintenance therapy of other malignancies...
  24. pmc EGF and HB-EGF enhance the proliferation of programmable cells of monocytic origin (PCMO) through activation of MEK/ERK signaling and improve differentiation of PCMO-derived hepatocyte-like cells
    Ayman Hyder
    Clinic for Applied Cellular Medicine, UKSH, Campus Kiel, Arnold Heller Strasse 3, HS, 18, 24105, Kiel, Germany
    Cell Commun Signal 10:23. 2012
    ....
  25. pmc Proteinase-Activated Receptor 2 Is a Novel Regulator of TGF-β Signaling in Pancreatic Cancer
    David Witte
    First Department of Medicine, University Hospital Schleswig Holstein UKSH, and University of Lübeck, D 23538 Lubeck, Germany
    J Clin Med 5:. 2016
    ..If so, PAR2 could represent a molecular linker between PDAC development and cancer-related cachexia...
  26. doi request reprint Ionizing radiation induces a motile phenotype in human carcinoma cells in vitro through hyperactivation of the TGF-beta signaling pathway
    Cedric Carl
    Department of Internal Medicine I, UKSH, Campus Lubeck, 23538, Lubeck, Germany
    Cell Mol Life Sci 73:427-43. 2016
    ..Our data raise the possibility that hyperactivation of TGF-β signaling during radiotherapy contributes to EMT-associated changes like metastasis, cancer stem cell formation and chemoresistance of tumor cells. ..
  27. pmc Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action
    Tobias Bartscht
    First Department of Medicine, UKSH, Campus Lubeck, 23538, Lubeck, Germany
    Mol Cancer 14:199. 2015
    ..Here, we investigated the ability of the clinically utilised SRC/ABL inhibitor dasatinib to mimic the PP2/PP1 effect...
  28. doi request reprint Customized cell-based treatment options to combat autoimmunity and restore beta-cell function in type 1 diabetes mellitus: current protocols and future perspectives
    Fred Fandrich
    Clinic for Applied Cellular Therapy CACT, University of Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany
    Adv Exp Med Biol 654:641-65. 2010
    ..These tolerogenic monocytes provide a feasible option to be used as autologous cellular transplants to halt autoimmunity and to protect still viable beta-cells within Langerhans islets...
  29. doi request reprint Using annexin V-coated magnetic beads to capture active tissue factor-bearing microparticles from body fluids
    Frank Gieseler
    First Department of Medicine, University Hospital Schleswig Holstein UKSH, Campus Lubeck, 23538, Lubeck, Germany
    Cell Biol Int 38:277-81. 2014
    ..This should help gain a deeper insight into various disease situations, which in turn should pave the way for the development of novel drugs and specific therapy strategies. ..
  30. ncbi request reprint WOFIE stimulates regulatory T cells: a 2-year follow-up of renal transplant recipients
    Bettina Dresske
    Department of General and Thoracic Surgery, University of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Transplantation 81:1549-57. 2006
    ..Initial interruption of immunosuppression for 72 hr was analyzed in renal transplant recipients according to Calne et al.'s "window of opportunity for immunologic engagement" (WOFIE) concept...
  31. ncbi request reprint Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling
    Hendrik Ungefroren
    Research Unit Molecular Oncology, Clinic for General Surgery and Thoracic Surgery, Christian Albrechts University, 24105 Kiel, Germany
    J Biol Chem 278:11041-9. 2003
    ....