Stefan Scholz

Summary

Affiliation: UFZ Centre for Environmental Research
Country: Germany

Publications

  1. ncbi Induction of vitellogenin in vivo and in vitro in the model teleost medaka (Oryzias latipes): comparison of gene expression and protein levels
    Stefan Scholz
    Institute of Zoology, University of Dresden, D 01062, Germany
    Mar Environ Res 57:235-44. 2004
  2. doi The zebrafish embryo model in environmental risk assessment--applications beyond acute toxicity testing
    Stefan Scholz
    Department of Cell Toxicology, UFZ Helmholtz Centre for Environmental Research, Permoserstr 15, 04318 Leipzig, Germany
    Environ Sci Pollut Res Int 15:394-404. 2008
  3. ncbi Extensive review of fish embryo acute toxicities for the prediction of GHS acute systemic toxicity categories
    Stefan Scholz
    UFZ Helmholtz Centre for Environmental Research, Department of Bioanalytical Ecotoxicology, Permoserstr 15, 04318 Leipzig, Germany Electronic address
    Regul Toxicol Pharmacol 69:572-9. 2014
  4. doi A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
    Stefan Scholz
    UFZ Helmholtz Centre for Environmental Research, Department of Bioanalytical Ecotoxicology, 04318 Leipzig, Germany Electronic address
    Regul Toxicol Pharmacol 67:506-30. 2013
  5. doi Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians--screening for estrogen, androgen and thyroid hormone disruption
    S Scholz
    Department of Bioanalytical Ecotoxicology, UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    Crit Rev Toxicol 43:45-72. 2013
  6. doi Effects of endocrine disrupters on sexual, gonadal development in fish
    S Scholz
    UFZ Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Leipzig, Germany
    Sex Dev 3:136-51. 2009
  7. ncbi Analysis of estrogenic effects by quantification of green fluorescent protein in juvenile fish of a transgenic medaka
    Stefan Scholz
    UFZ Centre for Environmental Research Leipzig Halle in the Helmholtz Association, Department of Cell Toxicology, D 04318 Leipzig, Germany
    Environ Toxicol Chem 24:2553-61. 2005
  8. ncbi Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae
    Doris Voelker
    Helmholtz Centre for Environmental Research UFZ, Department of Cell Toxicology, Permoserstrasse 15, 04318 Leipzig, Germany
    Aquat Toxicol 81:355-64. 2007
  9. pmc Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
    Wibke Busch
    UFZ Helmholtz Centre for Environmental Research Leipzig, Department of Bioanalytical Ecotoxicology, 04318 Leipzig, Germany
    BMC Genomics 11:65. 2010
  10. ncbi The role of cyp1a and heme oxygenase 1 gene expression for the toxicity of 3,4-dichloroaniline in zebrafish (Danio rerio) embryos
    Doris Voelker
    Helmholtz Centre for Environmental Research UFZ, Department of Cell Toxicology, Permoserstrasse 15, Leipzig, Germany
    Aquat Toxicol 86:112-20. 2008

Detail Information

Publications20

  1. ncbi Induction of vitellogenin in vivo and in vitro in the model teleost medaka (Oryzias latipes): comparison of gene expression and protein levels
    Stefan Scholz
    Institute of Zoology, University of Dresden, D 01062, Germany
    Mar Environ Res 57:235-44. 2004
    ..For long term studies with the need to detect weak estrogenic chemicals and a precise quantification, immuno-chemical detection may be favoured...
  2. doi The zebrafish embryo model in environmental risk assessment--applications beyond acute toxicity testing
    Stefan Scholz
    Department of Cell Toxicology, UFZ Helmholtz Centre for Environmental Research, Permoserstr 15, 04318 Leipzig, Germany
    Environ Sci Pollut Res Int 15:394-404. 2008
    ..Fish embryos represent an attractive model for environmental risk assessment of chemicals since they offer the possibility to perform small-scale, high-throughput analyses...
  3. ncbi Extensive review of fish embryo acute toxicities for the prediction of GHS acute systemic toxicity categories
    Stefan Scholz
    UFZ Helmholtz Centre for Environmental Research, Department of Bioanalytical Ecotoxicology, Permoserstr 15, 04318 Leipzig, Germany Electronic address
    Regul Toxicol Pharmacol 69:572-9. 2014
    ..We concluded that due to fundamental exposure protocol differences (single oral dose versus water-borne exposure) a reverse dosimetry approach is needed to explore the predictive capacity of fish embryos. ..
  4. doi A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
    Stefan Scholz
    UFZ Helmholtz Centre for Environmental Research, Department of Bioanalytical Ecotoxicology, 04318 Leipzig, Germany Electronic address
    Regul Toxicol Pharmacol 67:506-30. 2013
    ..Although this article focusses on European regulations, its considerations and conclusions are of global relevance. ..
  5. doi Alternatives to in vivo tests to detect endocrine disrupting chemicals (EDCs) in fish and amphibians--screening for estrogen, androgen and thyroid hormone disruption
    S Scholz
    Department of Bioanalytical Ecotoxicology, UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    Crit Rev Toxicol 43:45-72. 2013
    ..It was concluded that there is a need for a more systematic study of the predictive capacity of alternative tests and ways to reduce inter- and intra-assay variability...
  6. doi Effects of endocrine disrupters on sexual, gonadal development in fish
    S Scholz
    UFZ Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Leipzig, Germany
    Sex Dev 3:136-51. 2009
    ..Furthermore, in combination with the analysis of molecular endpoints the processed data will be useful to deduce mechanistic information on potential endocrine disrupting compounds...
  7. ncbi Analysis of estrogenic effects by quantification of green fluorescent protein in juvenile fish of a transgenic medaka
    Stefan Scholz
    UFZ Centre for Environmental Research Leipzig Halle in the Helmholtz Association, Department of Cell Toxicology, D 04318 Leipzig, Germany
    Environ Toxicol Chem 24:2553-61. 2005
    ....
  8. ncbi Differential gene expression as a toxicant-sensitive endpoint in zebrafish embryos and larvae
    Doris Voelker
    Helmholtz Centre for Environmental Research UFZ, Department of Cell Toxicology, Permoserstrasse 15, 04318 Leipzig, Germany
    Aquat Toxicol 81:355-64. 2007
    ..This study therefore indicates that gene expression analysis in DarT is able to reveal mechanistic information and may also be exploited for the development of replacement methods for chronic fish tests...
  9. pmc Tungsten carbide cobalt nanoparticles exert hypoxia-like effects on the gene expression level in human keratinocytes
    Wibke Busch
    UFZ Helmholtz Centre for Environmental Research Leipzig, Department of Bioanalytical Ecotoxicology, 04318 Leipzig, Germany
    BMC Genomics 11:65. 2010
    ..Therefore, we investigated the impact of these particles, compared to cobalt ions applied as CoCl(2), on the global gene expression level in human keratinocytes (HaCaT) in vitro...
  10. ncbi The role of cyp1a and heme oxygenase 1 gene expression for the toxicity of 3,4-dichloroaniline in zebrafish (Danio rerio) embryos
    Doris Voelker
    Helmholtz Centre for Environmental Research UFZ, Department of Cell Toxicology, Permoserstrasse 15, Leipzig, Germany
    Aquat Toxicol 86:112-20. 2008
    ..Functional studies such as the one presented could be applied to a wide variety of genes. They would be ideally suited to study the role of genes identified from toxicogenomic studies in the zebrafish embryo model...
  11. ncbi Bacterial lipopolysaccharides induce genes involved in the innate immune response in embryos of the zebrafish (Danio rerio)
    Joerg Watzke
    UFZ Helmholtz Centre for Environmental Research, Department of Cell Toxicology, Permoserstr 15, 04318, Leipzig, Germany
    Fish Shellfish Immunol 23:901-5. 2007
    ..The gene induction required the removal of the chorion prior to lipopolysaccharide exposure...
  12. pmc Transcriptional response of zebrafish embryos exposed to neurotoxic compounds reveals a muscle activity dependent hspb11 expression
    Nils Klüver
    Department of Bioanalytical Ecotoxicology, UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    PLoS ONE 6:e29063. 2011
    ..Our findings imply that a comparative toxicogenomic approach and functional analysis can lead to the identification of molecular mechanisms and specific marker genes for potential neurotoxic compounds...
  13. ncbi Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems
    Oliver Zierau
    Institute of Zoology, Dresden University of Technology, 01062 Dresden, Germany
    Biochem Biophys Res Commun 326:909-16. 2005
    ..In the medaka sex reversal/vtg gene expression assay no estrogenic effects of the naringenin-type flavonoids were observed, while mammalian in vitro systems showed a similar and graded response to the test compounds...
  14. ncbi The zebrafish embryo model in toxicology and teratology, September 2–3, 2010, Karlsruhe, Germany
    Wibke Busch
    UFZ Helmholtz Centre for Environmental Research, Department of Bioanalytical Ecotoxicology, Permoserstr 15, 04318 Leipzig, Germany
    Reprod Toxicol 31:585-8. 2011
    ..Furthermore, the constraints and possibilities of the model as discussed at the workshop are described. A follow up-meeting was appreciated by the about 120 participants and is planned for 2012...
  15. pmc Transient overexpression of adh8a increases allyl alcohol toxicity in zebrafish embryos
    Nils Klüver
    Department of Bioanalytical Ecotoxicology, UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    PLoS ONE 9:e90619. 2014
    ..These results underline the necessity to critically consider metabolic activation in the zebrafish embryo. As demonstrated here, mRNA injection is one useful approach to study the role of candidate enzymes involved in metabolization. ..
  16. ncbi Hormonal induction and stability of monosex populations in the medaka (Oryzias latipes): expression of sex-specific marker genes
    Stefan Scholz
    Junior Research Group of Molecular Animal Cell Toxicology, UFZ Centre for Environmental Research, D 04318 Leipzig, Germany
    Biol Reprod 69:673-8. 2003
    ..This process is apparently hormone insensitive, and the expression of further downstream acting genes can be regulated (directly or indirectly) by sex steroids...
  17. doi Agglomeration of tungsten carbide nanoparticles in exposure medium does not prevent uptake and toxicity toward a rainbow trout gill cell line
    Dana Kühnel
    Department of Bioanalytical Ecotoxicology, Helmholtz Centre for Environmental Research Leipzig, Germany
    Aquat Toxicol 93:91-9. 2009
    ..Taken together, our findings indicate that minimal exposure media can lead to rapid agglomeration of nanoparticles but that agglomeration does not prevent uptake into cells and the expression of toxicity...
  18. doi Mixture toxicity revisited from a toxicogenomic perspective
    Rolf Altenburger
    Department Bioanalytical Ecotoxicology, UFZ Helmholtz Centre for Environmental Research, Permoser Street 15, 04318 Leipzig, Germany
    Environ Sci Technol 46:2508-22. 2012
    ....
  19. ncbi [Erosive verrucous skin lesion on the umbilicus of a 83 year old woman]
    Stefan Scholz
    Hautklinik, Klinikum Kassel
    J Dtsch Dermatol Ges 3:67-9. 2005
  20. ncbi Germ cell-less expression in medaka (Oryzias latipes)
    Stefan Scholz
    Institut fur Zoologie, Technische Universitat Dresden, Dresden, Germany
    Mol Reprod Dev 67:15-8. 2004
    ..By in situ hybridisation (ISH), gcl could not be detected in embryos. In contrast to vasa, ISH revealed expression of gcl in the ovary but not in the testis. Mol. Reprod. Dev. 67: 15-18, 2004...