Werner Brack

Summary

Affiliation: UFZ Centre for Environmental Research
Country: Germany

Publications

  1. ncbi request reprint Effect-directed analysis of key toxicants in European river basins a review
    Werner Brack
    UFZ Centre for Environmental Research, Department of Effect Directed Analysis, Leipzig, Germany
    Environ Sci Pollut Res Int 14:30-8. 2007
  2. ncbi request reprint Effect-directed analysis of mutagens and ethoxyresorufin-o-deethylase inducers in aquatic sediments
    Werner Brack
    Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, Permoserstrasse 15, D 04318 Leipzig, Germany
    Environ Toxicol Chem 24:2445-58. 2005
  3. ncbi request reprint MODELKEY. Models for assessing and forecasting the impact of environmental key pollutants on freshwater and marine ecosystems and biodiversity
    Werner Brack
    UFZ Centre for Environmental Research, Permoserstrasse 15, 04318 Leipzig, Germany
    Environ Sci Pollut Res Int 12:252-6. 2005
  4. doi request reprint Toward a holistic and risk-based management of European river basins
    Werner Brack
    UFZ Helmholtz Centre for Environmental Research, Department Effect Directed Analysis, Permoserstrasse 15, D 04318 Leipzig, Germany
    Integr Environ Assess Manag 5:5-10. 2009
  5. doi request reprint How to confirm identified toxicants in effect-directed analysis
    Werner Brack
    Department Effect Directed Analysis, UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    Anal Bioanal Chem 390:1959-73. 2008
  6. ncbi request reprint Polychlorinated naphthalenes and other dioxin-like compounds in Elbe River sediments
    Werner Brack
    UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    Environ Toxicol Chem 27:519-28. 2008
  7. doi request reprint Toward an integrated assessment of the ecological and chemical status of European river basins
    Peter C von der Ohe
    UFZ, Department of Effect Directed Analysis Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany
    Integr Environ Assess Manag 5:50-61. 2009
  8. doi request reprint Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments
    Urte Lübcke-von Varel
    UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    Environ Int 44:31-9. 2012
  9. ncbi request reprint Identification of toxicants from marine sediment using effect-directed analysis
    Matthias Grote
    UFZ Centre for Environmental Research Leipzig Halle, Permoserstrasse 15, 04318 Leipzig, Germany
    Environ Toxicol 20:475-86. 2005
  10. doi request reprint Effect-directed analysis of sediment-associated algal toxicants at selected hot spots in the river Elbe basin with a special focus on bioaccessibility
    Katrin Schwab
    Department of Effect Directed Analysis, UFZ Helmholtz Centre for Environmental Research, Permoser Str 15, D 04318 Leipzig, Germany
    Environ Toxicol Chem 28:1506-17. 2009

Detail Information

Publications48

  1. ncbi request reprint Effect-directed analysis of key toxicants in European river basins a review
    Werner Brack
    UFZ Centre for Environmental Research, Department of Effect Directed Analysis, Leipzig, Germany
    Environ Sci Pollut Res Int 14:30-8. 2007
    ..Thus, one focus of present European research is on toxicant identification in European river basins in order to allow for a reduction of toxic pressure on aquatic ecosystems according to the WFD...
  2. ncbi request reprint Effect-directed analysis of mutagens and ethoxyresorufin-o-deethylase inducers in aquatic sediments
    Werner Brack
    Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, Permoserstrasse 15, D 04318 Leipzig, Germany
    Environ Toxicol Chem 24:2445-58. 2005
    ..This suggests that hazard and risk assessment of complex environmental mixtures should make increasing attempts to identify and consider hazardous key pollutants rather than focusing on a priori-selected key pollutants alone...
  3. ncbi request reprint MODELKEY. Models for assessing and forecasting the impact of environmental key pollutants on freshwater and marine ecosystems and biodiversity
    Werner Brack
    UFZ Centre for Environmental Research, Permoserstrasse 15, 04318 Leipzig, Germany
    Environ Sci Pollut Res Int 12:252-6. 2005
    ..The project is funded by the European Commission within the Sixth Framework Programme...
  4. doi request reprint Toward a holistic and risk-based management of European river basins
    Werner Brack
    UFZ Helmholtz Centre for Environmental Research, Department Effect Directed Analysis, Permoserstrasse 15, D 04318 Leipzig, Germany
    Integr Environ Assess Manag 5:5-10. 2009
    ..Extending this holistic approach beyond a consideration of existing pressures by anticipating on future ones to use and protect the aquatic environment in a sustainable way is one of the big challenges...
  5. doi request reprint How to confirm identified toxicants in effect-directed analysis
    Werner Brack
    Department Effect Directed Analysis, UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    Anal Bioanal Chem 390:1959-73. 2008
    ..Promising tools include bioavailability-directed extraction and dosing techniques, biomarker approaches and the concept of pollution-induced community tolerance (PICT). [figure: see text]..
  6. ncbi request reprint Polychlorinated naphthalenes and other dioxin-like compounds in Elbe River sediments
    Werner Brack
    UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    Environ Toxicol Chem 27:519-28. 2008
    ..The contribution of PCBs was less significant (maximum, 0.2%). Thus, in Elbe River sediments, PCNs should be considered as relevant contaminants and be included in future monitoring and risk assessment programs...
  7. doi request reprint Toward an integrated assessment of the ecological and chemical status of European river basins
    Peter C von der Ohe
    UFZ, Department of Effect Directed Analysis Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany
    Integr Environ Assess Manag 5:50-61. 2009
    ....
  8. doi request reprint Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments
    Urte Lübcke-von Varel
    UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    Environ Int 44:31-9. 2012
    ..We suggest the inclusion of dinitropyrenes and 3-nitrobenzanthrone into sediment monitoring in order to minimize the mutagenic risk to aquatic organisms and to human health...
  9. ncbi request reprint Identification of toxicants from marine sediment using effect-directed analysis
    Matthias Grote
    UFZ Centre for Environmental Research Leipzig Halle, Permoserstrasse 15, 04318 Leipzig, Germany
    Environ Toxicol 20:475-86. 2005
    ....
  10. doi request reprint Effect-directed analysis of sediment-associated algal toxicants at selected hot spots in the river Elbe basin with a special focus on bioaccessibility
    Katrin Schwab
    Department of Effect Directed Analysis, UFZ Helmholtz Centre for Environmental Research, Permoser Str 15, D 04318 Leipzig, Germany
    Environ Toxicol Chem 28:1506-17. 2009
    ..The extraction with TENAX with a subsequent EDA proved to be a powerful tool for prioritizing contaminants and contaminated sites with respect to the hazard of sediment-associated toxicants to green algae...
  11. doi request reprint Use of factorial design for the multivariate optimization of polypropylene membranes for the cleanup of environmental samples using the accelerated membrane-assisted cleanup approach
    Tobias Schulze
    UFZ Helmholtz Center for Environmental Research, Department of Effect Directed Analysis, 04318 Leipzig, Germany
    J Chromatogr A 1225:26-36. 2012
    ..We concluded that the permeation of the molecules was related to molecular shapes and the availability of free solvent cavities in the membranes...
  12. doi request reprint Application of preparative capillary gas chromatography (pcGC), automated structure generation and mutagenicity prediction to improve effect-directed analysis of genotoxicants in a contaminated groundwater
    Cornelia Meinert
    Department of Effect Directed Analysis, UFZ, Helmholtz Centre for Environmental Research, Permoserstrasse 15, 04318, Leipzig, Germany
    Environ Sci Pollut Res Int 17:885-97. 2010
    ..A major focus was put on the added value of these tools compared to conventional EDA combining reversed-phase liquid chromatography (RP-LC) followed by GC/MS analysis and MS library search...
  13. ncbi request reprint Polychlorinated naphthalenes in sediments from the industrial region of Bitterfeld
    Werner Brack
    Department of Chemical Ecotoxicology, UFZ Center for Environmental Research Leipzig Halle, Germany
    Environ Pollut 121:81-5. 2003
    ..Because of their toxicological relevance we suggest to include PCNs into monitoring and risk assessment programs of the rivers Mulde and Elbe downstream of Bitterfeld...
  14. ncbi request reprint Effect-directed fractionation and identification of cytochrome p4501A-inducing halogenated aromatic hydrocarbons in a contaminated sediment
    Werner Brack
    Department of Chemical Ecotoxicology, UFZ Center for Environmental Research Leipzig Halle, Permoserstrasse 15, 04318 Leipzig, Germany
    Environ Toxicol Chem 21:2654-62. 2002
    ..This approach was designed to minimize methodological limitations due to superimposing inhibitory effects...
  15. ncbi request reprint Light as a confounding factor for toxicity assessment of complex contaminated sediments
    Matthias Grote
    UFZ Centre for Environmental Research Leipzig Halle, Department of Chemical Ecotoxicology, Leipzig, Germany
    Environ Toxicol Chem 24:3143-52. 2005
    ..Finally, the relevance of light conditions in the toxicity assessment is demonstrated for eight out of 13 transect samples of sediment extracts from river Elbe, Germany...
  16. ncbi request reprint Determination of 10 particle-associated multiclass polar and semi-polar pesticides from small streams using accelerated solvent extraction
    Ralf Bernhard Schäfer
    UFZ Helmholtz Centre for Environmental Research, Department of System Ecotoxicology, Permoser Strasse 15, 04318 Leipzig, Germany
    Chemosphere 70:1952-60. 2008
    ..We suggest that the method presented here be used for the extraction and quantitation of particle-associated polar pesticides...
  17. doi request reprint Polar compounds dominate in vitro effects of sediment extracts
    Urte Lübcke-von Varel
    Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany
    Environ Sci Technol 45:2384-90. 2011
    ....
  18. doi request reprint A new risk assessment approach for the prioritization of 500 classical and emerging organic microcontaminants as potential river basin specific pollutants under the European Water Framework Directive
    Peter Carsten Von Der Ohe
    UFZ, Department of Effect Directed Analysis, Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany
    Sci Total Environ 409:2064-77. 2011
    ....
  19. doi request reprint Identification of a phytotoxic photo-transformation product of diclofenac using effect-directed analysis
    Tobias Schulze
    UFZ Helmholtz Centre for Environmental Research, Department of Effect Directed Analysis, Permoserstrasse 15, 04318 Leipzig, Germany
    Environ Pollut 158:1461-6. 2010
    ..The EC(50) of CPAB (4.8 mg/L) was a factor of 10 lower than that for DCF (48.1 mg/L), due to the higher hydrophobicity of CPAB (log K(ow) = 3.62) compared with DCF (log D(ow) = 2.04) at pH 7.0...
  20. ncbi request reprint Partitioning-based dosing: an approach to include bioavailability in the effect-directed analysis of contaminated sediment samples
    Nicole Bandow
    Department of Effect Directed Analysis, UFZ Helmholtz Centre for Environmental Research, Permoserstrasse 15, 04315 Leipzig, Germany
    Environ Sci Technol 43:3891-6. 2009
    ..We suggestthat partitioning-based dosing better reflects exposure in sediments and thus provides a more realistic identification of key toxicants...
  21. ncbi request reprint Confirmation of cause-effect relationships using effect-directed analysis for complex environmental samples
    Matthias Grote
    UFZ Centre for Environmental Research Leipzig Halle, Department of Chemical Ecotoxicology, Permoserstrasse 15, 04318 Leipzig, Germany
    Environ Toxicol Chem 24:1420-7. 2005
    ....
  22. doi request reprint Triclosan--the forgotten priority substance?
    Peter Carsten Von Der Ohe
    Department of Effect Directed Analysis, Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany
    Environ Sci Pollut Res Int 19:585-91. 2012
    ....
  23. doi request reprint HPLC/APCI-FTICR-MS as a tool for identification of partial polar mutagenic compounds in effect-directed analysis
    Mahmoud Bataineh
    Department of Effect Directed Analysis, UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    J Am Soc Mass Spectrom 21:1016-27. 2010
    ..The applicability of the method was demonstrated by positive and tentative identification of constituents of mutagenic sediment fractions similar to selected model compounds...
  24. ncbi request reprint Effect-directed analysis of contaminated sediments with partition-based dosing using green algae cell multiplication inhibition
    Nicole Bandow
    Department of Effect Directed Analysis, UFZ Helmholtz Centre for Environmental Research, Permoserstrasse 15, 04315 Leipzig, Germany
    Environ Sci Technol 43:7343-9. 2009
    ....
  25. ncbi request reprint Organic chemicals jeopardize the health of freshwater ecosystems on the continental scale
    Egina Malaj
    Department of Effect Directed Analysis, Helmholtz Centre for Environmental Research UFZ, 04318 Leipzig, Germany Institute for Environmental Sciences, University of Koblenz Landau, 76829 Landau, Germany
    Proc Natl Acad Sci U S A 111:9549-54. 2014
    ..Our results clearly indicate that chemical pollution is a large-scale environmental problem and requires far-reaching, holistic mitigation measures to preserve and restore ecosystem health. ..
  26. doi request reprint Prediction of gas chromatographic retention indices as classifier in non-target analysis of environmental samples
    Nadin Ulrich
    UFZ Department of Effect directed Analysis, Helmholtz Centre for Environmental Research, Permoserstr 15, 04318 Leipzig, Germany
    J Chromatogr A 1285:139-47. 2013
    ..The models help to reduce the number of potential candidates, and seem to be a useful addition to already existing classifiers...
  27. doi request reprint Physiological sensitivity of freshwater macroinvertebrates to heavy metals
    Egina Malaj
    Department of Effect Directed Analysis, Helmholtz Centre for Environmental Research UFZ, Leipzig, Germany
    Environ Toxicol Chem 31:1754-64. 2012
    ....
  28. doi request reprint Application of nd-SPME to determine freely dissolved concentrations in the presence of green algae and algae-water partition coefficients
    Nicole Bandow
    UFZ Helmholtz Centre for Environmental Research, Department of Effect Directed Analysis, Permoser Strasse 15, Leipzig, Germany
    Chemosphere 79:1070-6. 2010
    ..The nd-SPME-method was applied to determine partitioning coefficients between algae and the surrounding aqueous phase and can be used to determine real exposure concentrations in a cell multiplication inhibition test with green algae...
  29. doi request reprint Optimisation of trapping parameters in preparative capillary gas chromatography for the application in effect-directed analysis
    Cornelia Meinert
    UFZ Helmholtz Centre for Environmental Research, Department of Effect Directed Analysis, Permoserstrasse 15, D 04318 Leipzig, Germany
    Chemosphere 78:416-22. 2010
    ....
  30. ncbi request reprint Water quality indices across Europe--a comparison of the good ecological status of five river basins
    Peter Carsten Von Der Ohe
    Department of Effect Directed Analysis, UFZ Helmholtz Centre for Environmental Research, Leipzig, Germany
    J Environ Monit 9:970-8. 2007
    ....
  31. doi request reprint Identification of novel micropollutants in wastewater by a combination of suspect and nontarget screening
    Christine Hug
    UFZ Helmholtz Centre for Environmental Research, Department Effect Directed Analysis, Permoserstr 15, 04318 Leipzig, Germany RWTH Aachen University, Department of Ecosystem Analyses, Institute for Environmental Research, Worringerweg 1, 52074 Aachen, Germany Electronic address
    Environ Pollut 184:25-32. 2014
    ..Six suspected and five nontarget chemicals were identified, of which two have not been previously reported as environmental pollutants. ..
  32. ncbi request reprint Fractionation of technical p-nonylphenol with preparative capillary gas chromatography
    Cornelia Meinert
    UFZ, Helmholtz Centre for Environmental Research, Department of Effect Directed Analysis, Permoserstrasse 15, D 04318 Leipzig, Germany
    Chemosphere 70:215-23. 2007
    ..This provides the fractionation of nonylphenol isomers into 11 fractions containing 77-552microg of isomers collected after 600 single injections. This yield is sufficient to allow subsequent biotesting in the E-screen assay...
  33. doi request reprint Linear Solvation Energy Relationships as classifiers in non-target analysis--a capillary liquid chromatography approach
    Nadin Ulrich
    UFZ Department of Effect directed Analysis, Helmholtz Centre for Environmental Research, Permoserstr 15, 04318 Leipzig, Germany
    J Chromatogr A 1218:8192-6. 2011
    ..The example of several isomers, with the empirical formula C₁₂H₁₀O₂, demonstrates the application as classifier and indicates limits of this prognosis...
  34. ncbi request reprint Matching structures to mass spectra using fragmentation patterns: are the results as good as they look?
    Emma L Schymanski
    Helmholtz Centre for Environmental Research UFZ, Department of Effect Directed Analysis, Permoserstrasse 15, D 04318 Leipzig, Germany
    Anal Chem 81:3608-17. 2009
    ....
  35. ncbi request reprint On the mode of action of N-phenyl-2-naphthylamine in plants
    Rolf Altenburger
    UFZ Centre for Environmental Research Leipzig Halle, Germany
    Environ Sci Technol 40:6163-9. 2006
    ..The effects may become first apparent in membrane-rich compartments such as the algal chloroplast...
  36. ncbi request reprint Automated Strategies To Identify Compounds on the Basis of GC/EI-MS and Calculated Properties
    Emma L Schymanski
    Department of Effect Directed Analysis, UFZ Helmholtz Centre for Environmental Research, Permoser Strasse 15, D 04103 Leipzig, Germany
    Anal Chem 83:903-12. 2011
    ..This method can be used in the absence of matching database spectra and brings unknown identification based on MS interpretation and structure generation techniques a step closer to practical reality...
  37. doi request reprint Consensus structure elucidation combining GC/EI-MS, structure generation, and calculated properties
    Emma L Schymanski
    UFZ Helmholtz Centre for Environmental Research, Department of Effect Directed Analysis, Permoserstrasse 15, D 04318 Leipzig, Germany
    Anal Chem 84:3287-95. 2012
    ....
  38. doi request reprint Automated fractionation procedure for polycyclic aromatic compounds in sediment extracts on three coupled normal-phase high-performance liquid chromatography columns
    Urte Lübcke-von Varel
    UFZ Helmholtz Centre for Environmental Research, Permoserstrasse 15, Leipzig, Germany
    J Chromatogr A 1185:31-42. 2008
    ..Excellent group-specific resolution, high reproducibility and good recoveries suggest that this method is suitable for the fractionation of a multitude of major sediment contaminants in one HPLC-run...
  39. ncbi request reprint Effect-directed analysis: a promising tool for the identification of organic toxicants in complex mixtures?
    Werner Brack
    Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research, Permoserstrasse 15, 04318, Leipzig, Germany
    Anal Bioanal Chem 377:397-407. 2003
    ..Sophisticated chemical tools are required to identify individual toxicants in mixtures of thousands of compounds, which are typical for contaminated environments...
  40. ncbi request reprint Identification of toxic products of anthracene photomodification in simulated sunlight
    Werner Brack
    Department of Chemical Ecotoxicology, UFZ Centre for Environmental Research Leipzig Halle, Permoserstrasse 15, 04318 Leipzig, Germany
    Environ Toxicol Chem 22:2228-37. 2003
    ..The results stress the potential of effect-directed analysis approaches in contrast to mere chemical analysis in studies aiming at toxicologically relevant photomodified substances...
  41. ncbi request reprint Accelerated membrane-assisted clean-up as a tool for the clean-up of extracts from biological tissues
    H Georg Streck
    UFZ Helmholtz Centre for Environmental Research, Permoserstrasse 15, Leipzig, Germany
    J Chromatogr A 1196:33-40. 2008
    ..AMAC is especially applicable for processing large amounts of sample as a result of the high matrix removal capacity...
  42. doi request reprint Linear solvation energy relationships as classifiers in non-target analysis - a gas chromatographic approach
    Nadin Ulrich
    UFZ Department of Effect directed Analysis, Helmholtz Centre for Environmental Research, Permoserstr 15, 04318 Leipzig, Germany
    J Chromatogr A 1264:95-103. 2012
    ....
  43. doi request reprint Passive dosing: an approach to control mutagen exposure in the Ames fluctuation test
    Cynthia Bougeard
    UFZ Helmholtz Centre for Environmental Research, Department of Effect Directed Analysis, Permoserstrasse 15, 04315 Leipzig, Germany
    Chemosphere 83:409-14. 2011
    ..Partition coefficients and NEC(50)/DEC(50) ratios were well correlated with lipophilicity...
  44. ncbi request reprint Carbamazepine and its metabolites in wastewater: Analytical pitfalls and occurrence in Germany and Portugal
    Arnold Bahlmann
    Helmholtz Centre for Environmental Research UFZ, Department for Effect Directed Analysis, Permoserstrasse 15, D 04318 Leipzig, Germany Electronic address
    Water Res 57:104-14. 2014
    ..In combination with high resolution mass spectrometry and hydrogen-deuterium exchange, this LC column enabled us to identify 1-OH-CBZ and 4-OH-CBZ in wastewater for the first time. ..
  45. ncbi request reprint Biological and chemical determination of dioxin-like compounds in sediments by means of a sediment triad approach in the catchment area of the river Neckar
    Ner Hollert
    Department of Zoology, University of Heidelberg, Germany
    Ecotoxicology 11:323-36. 2002
    ....
  46. ncbi request reprint Endocrine disruption of water and sediment extracts in a non-radioactive dot blot/RNAse protection-assay using isolated hepatocytes of rainbow trout
    Henner Hollert
    Department of Zoology, University of Heidelberg, Germany
    Environ Sci Pollut Res Int 12:347-60. 2005
    ....
  47. ncbi request reprint Chemical and ecotoxicological assessment of polycyclic aromatic hydrocarbon--contaminated sediments of the Niger Delta, Southern Nigeria
    Abass A Olajire
    Department of Pure and Applied Chemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria
    Sci Total Environ 340:123-36. 2005
    ..6% and 33.67%, respectively, after 7 days of exposure. The total PAH concentrations showed no correlation with toxicity bioassays, and thereby implied that chemical analysis of PAHs cannot be an indicator of sediment toxicity...
  48. ncbi request reprint Induction of aryl hydrocarbon receptor-mediated and estrogen receptor-mediated activities, and modulation of cell proliferation by dinaphthofurans
    Jan Vondracek
    Veterinary Research Institute, 62132 Brno, Czech Republic
    Environ Toxicol Chem 23:2214-20. 2004
    ..In summary, the present study indicated that DNFs can exert multiple biological effects in vitro, including induction of the AhR-mediated activity, release of cells from contact inhibition, and induction of ER-mediated activity...