Bettina Tudzynski

Summary

Country: Germany

Publications

  1. ncbi request reprint Identification of Botrytis cinerea genes up-regulated during infection and controlled by the Galpha subunit BCG1 using suppression subtractive hybridization (SSH)
    Christian Schulze Gronover
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Schlossgarten 3, D 48149 Munster, Germany
    Mol Plant Microbe Interact 17:537-46. 2004
  2. doi request reprint The Galpha subunit BCG1, the phospholipase C (BcPLC1) and the calcineurin phosphatase co-ordinately regulate gene expression in the grey mould fungus Botrytis cinerea
    Julia Schumacher
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Schlossgarten 3, D 48149 Munster, Germany
    Mol Microbiol 67:1027-50. 2008
  3. ncbi request reprint Gibberellin biosynthesis in fungi: genes, enzymes, evolution, and impact on biotechnology
    Bettina Tudzynski
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Schlossgarten 3, 48149, Munster, Germany
    Appl Microbiol Biotechnol 66:597-611. 2005
  4. doi request reprint Cpc1 mediates cross-pathway control independently of Mbf1 in Fusarium fujikuroi
    Birgit Schönig
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Schlossgarten 3, 48149 Munster, Germany
    Fungal Genet Biol 46:898-908. 2009
  5. pmc Isolation and characterization of the gibberellin biosynthetic gene cluster in Sphaceloma manihoticola
    Christiane Bömke
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlossgarten 3, 48149 Munster, Germany
    Appl Environ Microbiol 74:5325-39. 2008
  6. pmc Loss of gibberellin production in Fusarium verticillioides (Gibberella fujikuroi MP-A) is due to a deletion in the gibberellic acid gene cluster
    Christiane Bömke
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlossgarten 3, 48149 Munster, Germany
    Appl Environ Microbiol 74:7790-801. 2008
  7. doi request reprint Biosynthesis of the red pigment bikaverin in Fusarium fujikuroi: genes, their function and regulation
    Philipp Wiemann
    Institut fur Botanik, Schlossgarten 3, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    Mol Microbiol 72:931-46. 2009
  8. pmc Impact of ammonium permeases mepA, mepB, and mepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi
    Sabine Teichert
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlossgarten 3, D 48149 Munster, Germany
    Eukaryot Cell 7:187-201. 2008
  9. pmc Cross-species hybridization with Fusarium verticillioides microarrays reveals new insights into Fusarium fujikuroi nitrogen regulation and the role of AreA and NMR
    Birgit Schönig
    Institut für Botanik der Westfälische Wilhelms Universität Münster, Munster, Germany
    Eukaryot Cell 7:1831-46. 2008
  10. pmc Natural variation in the VELVET gene bcvel1 affects virulence and light-dependent differentiation in Botrytis cinerea
    Julia Schumacher
    Institut für Biologie und Biotechnologie der Pflanzen, Westfalische Wilhelms Universitat Munster, Munster, Germany
    PLoS ONE 7:e47840. 2012

Collaborators

  • P Tudzynski
  • Hans Ulrich Humpf
  • Julia Schumacher
  • P Hedden
  • Muriel Viaud
  • Daren W Brown
  • Ron Ophir
  • Caroline B Michielse
  • Michael Freitag
  • Pierre Leroux
  • Sabine Fillinger
  • Jeroen S Dickschat
  • Erich Bornberg-Bauer
  • Robert H Proctor
  • Adeline Simon
  • JOSEPH B HEITMAN
  • M Cecilia Rojas
  • Philipp Wiemann
  • Sabine Albermann
  • Karin Harren
  • Lena Studt
  • Christiane Bömke
  • Dominik Wagner
  • Birgit Schönig
  • Sabine Teichert
  • Karin Kleigrewe
  • Stefan Malonek
  • Pia Linnemannstons
  • Verena Siewers
  • Kathleen Huß
  • Katharina W von Bargen
  • Eva Maria Niehaus
  • Christian Schulze Gronover
  • Claudia Troncoso
  • Nadja Segmüller
  • Marieke Wottawa
  • Veronique Chague
  • Paul Hopkins
  • Martina Mihlan
  • Gunter Reuter
  • Wolfgang Krischke
  • André Fleißner
  • Martin Munsterkotter
  • Andreas Fischer
  • Till Bald
  • Ulrich Guldener
  • Michael Knodler
  • Stanley Freeman
  • Tino Elter
  • Sonja V Bergner
  • Lanelle R Connolly
  • Beate Brandhoff
  • Thomas Hirth
  • Ulrike Brandt
  • Christian M K Sieber
  • José J Espino
  • Kristina M Smith
  • Michael Hippler
  • Andreas Teubner
  • Brenda D Wingfield
  • Nelson L Brock
  • Magdalena Mos
  • Anne Schmeinck
  • Mark X Caddick
  • Igor Y Morozov
  • Marita Beyer
  • Sabine Vogel
  • Marcus Straeten
  • Anita Willmann
  • Julian C Rutherford
  • Fan Gong
  • Birgitt Oeser
  • José Cárcamo
  • Ursula Ellendorf
  • Christian Schulze-Gronover
  • Levanoni Visel Danit
  • Amir Sharon
  • Jean Marc Pradier
  • Daniel Jimenez-Teja
  • Isidro G Collado
  • Corinna Schorn
  • Paul Gaskin
  • Ta Wei D Liu
  • Veronika Homann
  • Jessica Schulte
  • Javier Avalos
  • Maria del Mar Prado

Detail Information

Publications36

  1. ncbi request reprint Identification of Botrytis cinerea genes up-regulated during infection and controlled by the Galpha subunit BCG1 using suppression subtractive hybridization (SSH)
    Christian Schulze Gronover
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Schlossgarten 3, D 48149 Munster, Germany
    Mol Plant Microbe Interact 17:537-46. 2004
    ..Of the 22 BCG1-controlled genes, 11 also were found in the in planta SSH library. Therefore, SSH technology can be successfully applied to identify target genes of signaling pathways and differentially expressed genes in planta...
  2. doi request reprint The Galpha subunit BCG1, the phospholipase C (BcPLC1) and the calcineurin phosphatase co-ordinately regulate gene expression in the grey mould fungus Botrytis cinerea
    Julia Schumacher
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Schlossgarten 3, D 48149 Munster, Germany
    Mol Microbiol 67:1027-50. 2008
    ....
  3. ncbi request reprint Gibberellin biosynthesis in fungi: genes, enzymes, evolution, and impact on biotechnology
    Bettina Tudzynski
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Schlossgarten 3, 48149, Munster, Germany
    Appl Microbiol Biotechnol 66:597-611. 2005
    ..This review concentrates mainly on the fungal biosynthetic pathway, the genes and enzymes involved, the regulation network, the biotechnological relevance of recent studies, and on evolutionary aspects of GA biosynthetic genes...
  4. doi request reprint Cpc1 mediates cross-pathway control independently of Mbf1 in Fusarium fujikuroi
    Birgit Schönig
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Schlossgarten 3, 48149 Munster, Germany
    Fungal Genet Biol 46:898-908. 2009
    ..Surprisingly, cross-pathway control is repressed by nitrogen limitation in an AreA-dependent manner...
  5. pmc Isolation and characterization of the gibberellin biosynthetic gene cluster in Sphaceloma manihoticola
    Christiane Bömke
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlossgarten 3, 48149 Munster, Germany
    Appl Environ Microbiol 74:5325-39. 2008
    ..The close similarity between the two GA gene clusters, the identical gene functions, and the conserved intron positions suggest a common evolutionary origin despite the distant relatedness of the two fungi...
  6. pmc Loss of gibberellin production in Fusarium verticillioides (Gibberella fujikuroi MP-A) is due to a deletion in the gibberellic acid gene cluster
    Christiane Bömke
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlossgarten 3, 48149 Munster, Germany
    Appl Environ Microbiol 74:7790-801. 2008
    ..verticillioides. Furthermore, the GA(4) desaturase gene des from F. verticillioides encodes an active enzyme which was able to restore the GA production in a corresponding des deletion mutant of F. fujikuroi...
  7. doi request reprint Biosynthesis of the red pigment bikaverin in Fusarium fujikuroi: genes, their function and regulation
    Philipp Wiemann
    Institut fur Botanik, Schlossgarten 3, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    Mol Microbiol 72:931-46. 2009
    ..Thus, bikaverin synthesis is regulated by a complex regulatory network. Understanding how different factors influence the synthesis of this model secondary metabolite will aid understanding secondary metabolism in general...
  8. pmc Impact of ammonium permeases mepA, mepB, and mepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi
    Sabine Teichert
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlossgarten 3, D 48149 Munster, Germany
    Eukaryot Cell 7:187-201. 2008
    ..fujikuroi yet does not provide the sensor activity of Mep2 in yeast, indicating differences in the mechanisms by which nitrogen is sensed in S. cerevisiae and F. fujikuroi...
  9. pmc Cross-species hybridization with Fusarium verticillioides microarrays reveals new insights into Fusarium fujikuroi nitrogen regulation and the role of AreA and NMR
    Birgit Schönig
    Institut für Botanik der Westfälische Wilhelms Universität Münster, Munster, Germany
    Eukaryot Cell 7:1831-46. 2008
    ..This is the first report on genome-wide expression studies examining the influence of AreA on nitrogen-responsive gene expression in a genome-wide manner in filamentous fungi...
  10. pmc Natural variation in the VELVET gene bcvel1 affects virulence and light-dependent differentiation in Botrytis cinerea
    Julia Schumacher
    Institut für Biologie und Biotechnologie der Pflanzen, Westfalische Wilhelms Universitat Munster, Munster, Germany
    PLoS ONE 7:e47840. 2012
    ....
  11. pmc A functional bikaverin biosynthesis gene cluster in rare strains of Botrytis cinerea is positively controlled by VELVET
    Julia Schumacher
    Institute for Biology and Biotechnology of Plants, Westfalische Wilhelms University, Munster, Germany
    PLoS ONE 8:e53729. 2013
    ..Finally, a genetic cross between strain 1750 and a bikaverin-nonproducing strain sensitive to fenhexamid revealed that the functional bikaverin cluster is genetically linked to the HydR2 locus...
  12. pmc Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites
    Philipp Wiemann
    Institut für Biologie und Biotechnologie der Pflanzen, Molecular Biology and Biotechnology of Fungi, Westfalische Wilhelms Universitat Munster, Munster, Germany
    PLoS Pathog 9:e1003475. 2013
    ..Thus, our results indicate that combined comparative genomics and genome-wide experimental analyses identified novel genes and secondary metabolites that contribute to the evolutionary success of F. fujikuroi as a rice pathogen. ..
  13. doi request reprint The cAMP-dependent signaling pathway and its role in conidial germination, growth, and virulence of the gray mold Botrytis cinerea
    Julia Schumacher
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Schlossgarten 3, D 48149 Munster, Germany
    Mol Plant Microbe Interact 21:1443-59. 2008
    ..Both effects could be partially restored by exogenous cAMP, suggesting that BcRAS2 activates the adenylate cyclase in addition to the Galpha subunits BCG1 and BCG3, thus influencing cAMP-dependent signal transduction...
  14. ncbi request reprint Distribution of gibberellin biosynthetic genes and gibberellin production in the Gibberella fujikuroi species complex
    Stefan Malonek
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlossgarten 3, D 48149 Munster, Germany
    Phytochemistry 66:1296-311. 2005
    ..The molecular phylogenetic studies for both genes have revealed good agreement with phylogenetic trees inferred from other genes. Furthermore, we discuss the role and evolutionary origin of the GA biosynthetic gene cluster...
  15. pmc The Sfp-type 4'-phosphopantetheinyl transferase Ppt1 of Fusarium fujikuroi controls development, secondary metabolism and pathogenicity
    Philipp Wiemann
    Institut für Biologie und Biotechnologie der Pflanzen, Westfalische Wilhelms Universitat Munster, Hindenburgplatz 55, Munster, Germany
    PLoS ONE 7:e37519. 2012
    ..Targeted deletion of the first Fusarium homolog of this GATA-type transcription factor-encoding gene, Ffsre1, strongly indicates its involvement in regulation of iron homeostasis and oxidative stress resistance...
  16. pmc The bZIP transcription factor MeaB mediates nitrogen metabolite repression at specific loci
    Dominik Wagner
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Germany
    Eukaryot Cell 9:1588-601. 2010
    ..These data demonstrate that MeaB and AreA coordinately mediate nitrogen metabolite repression and, importantly, that independently of AreA, MeaB can mediate nitrogen metabolite repression at specific loci in F. fujikuroi...
  17. pmc Role of the Fusarium fujikuroi TOR kinase in nitrogen regulation and secondary metabolism
    Sabine Teichert
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlossgarten 3, D 48149 Munster, Germany
    Eukaryot Cell 5:1807-19. 2006
    ....
  18. pmc BcSAK1, a stress-activated mitogen-activated protein kinase, is involved in vegetative differentiation and pathogenicity in Botrytis cinerea
    Nadja Segmüller
    Institut fur Botanik, Westf Wilhelms Universität, Schlossgarten 3, D 48149 Munster, Germany
    Eukaryot Cell 6:211-21. 2007
    ..These data indicate that in B. cinerea the stress-activated MAPK cascade is involved in essential differentiation programs...
  19. doi request reprint Strategies for strain improvement in Fusarium fujikuroi: overexpression and localization of key enzymes of the isoprenoid pathway and their impact on gibberellin biosynthesis
    Sabine Albermann
    Institut für Biologie und Biotechnologie der Pflanzen, Westfalische Wilhelms Universitat Munster, Schlossplatz 8, 48143, Munster, Germany
    Appl Microbiol Biotechnol 97:2979-95. 2013
    ..5-fold). Fluorescence microscopy revealed localization of the key enzymes in different compartments...
  20. pmc Cch1 and Mid1 are functionally required for vegetative growth under low-calcium conditions in the phytopathogenic ascomycete Botrytis cinerea
    Karin Harren
    Westfalische Wilhelms Universitat Munster, Institute of Biology and Biotechnology of Plants, Munster, Germany
    Eukaryot Cell 12:712-24. 2013
    ..cinerea...
  21. pmc Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi perithecia
    Lena Studt
    Institute for Biology and Biotechnology of Plants, Westfalische Wilhelms University, Munster, Germany
    Appl Environ Microbiol 78:4468-80. 2012
    ....
  22. ncbi request reprint The NADPH-cytochrome P450 reductase gene from Gibberella fujikuroi is essential for gibberellin biosynthesis
    Stefan Malonek
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Schlossgarten 3, D 48149 Munster, Germany
    J Biol Chem 279:25075-84. 2004
    ..In addition, expression of cpr-Gf is induced by benzoate. These results indicate that CPR-Gf is the main but not the only electron donor for several P450 monooxygenases from primary and secondary metabolism...
  23. ncbi request reprint Functional analysis of the cytochrome P450 monooxygenase gene bcbot1 of Botrytis cinerea indicates that botrydial is a strain-specific virulence factor
    Verena Siewers
    Institut fur Botanik, Westf Wilhelms Universität Münster, Schlossgarten 3, D 48149 Munster, Germany
    Mol Plant Microbe Interact 18:602-12. 2005
    ..Deletion of bcbot1 in three standard strains of B. cinerea shows that the effect on virulence (on several host plants) is strain-dependent; only deletion in one of the strains (T4) led to reduced virulence...
  24. doi request reprint Diversity, regulation, and evolution of the gibberellin biosynthetic pathway in fungi compared to plants and bacteria
    Christiane Bömke
    Institut für Botanik der Westfälischen Wilhelms Universität Münster, Munster, Germany
    Phytochemistry 70:1876-93. 2009
    ....
  25. pmc Signaling governed by G proteins and cAMP is crucial for growth, secondary metabolism and sexual development in Fusarium fujikuroi
    Lena Studt
    Institut fur Lebensmittelchemie, Westfalische Wilhelms Universitat, Munster, Germany
    PLoS ONE 8:e58185. 2013
    ..Finally, sexual crosses of ffg1 mutants showed the importance of a functional FfG1 protein for development of perithecia in the mating strain that carries the MAT1-1 idiomorph...
  26. ncbi request reprint The polyketide synthase gene pks4 from Gibberella fujikuroi encodes a key enzyme in the biosynthesis of the red pigment bikaverin
    Pia Linnemannstons
    Institut fur Botanik, Westfalische Wilhelms Universitat Munster, Schlossgarten 3, D 48149, Munster, Germany
    Fungal Genet Biol 37:134-48. 2002
    ..Three additional polyketide synthase genes have been cloned from G. fujikuroi MP-C by heterologous hybridization. The presence of these four PKS genes demonstrates the diversity of polyketide biosynthetic pathways in this fungus...
  27. ncbi request reprint Characterization of the final two genes of the gibberellin biosynthesis gene cluster of Gibberella fujikuroi: des and P450-3 encode GA4 desaturase and the 13-hydroxylase, respectively
    Bettina Tudzynski
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlobetagarten 3, D 48149 Munster, Germany
    J Biol Chem 278:28635-43. 2003
    ..In common with the other five GA biosynthesis genes, expression of the desaturase gene is repressed by high amounts of nitrogen in the culture medium, whereas P450-3 is the only gene in the cluster not repressed by nitrogen...
  28. pmc A sensing role of the glutamine synthetase in the nitrogen regulation network in Fusarium fujikuroi
    Dominik Wagner
    Institut für Biologie und Biotechnologie der Pflanzen, Westfalische Wilhelms Universitat Munster, Munster, Germany
    PLoS ONE 8:e80740. 2013
    ..These novel insights into the regulatory role of the GS provide fascinating perspectives for elucidating regulatory roles of GS proteins of different organism in general. ..
  29. pmc The Ca2+/calcineurin-dependent signaling pathway in the gray mold Botrytis cinerea: the role of calcipressin in modulating calcineurin activity
    Karin Harren
    Westfalische Wilhelms Universitat Munster, Institute of Biology and Biotechnology of Plants, Munster, Germany
    PLoS ONE 7:e41761. 2012
    ..Based on the observed phenotypes we conclude that BcRcn1 acts as a positive modulator of BcCnA and the Ca(2+)/calcineurin-mediated signal transduction in B. cinerea, and that both proteins regulate fungal development and virulence...
  30. pmc The high-affinity phosphodiesterase BcPde2 has impact on growth, differentiation and virulence of the phytopathogenic ascomycete Botrytis cinerea
    Karin Harren
    Westfalische Wilhelms Universitat Munster, Institute of Biology and Biotechnology of Plants, Munster, Germany
    PLoS ONE 8:e78525. 2013
    ....
  31. doi request reprint Characterization of novel mutants with an altered gibberellin spectrum in comparison to different wild-type strains of Fusarium fujikuroi
    Sabine Albermann
    Institute of Plant Biology and Biotechnology, Westfälische Wilhelms Universiät Münster, Schlossplatz 8, 48143, Munster, Germany
    Appl Microbiol Biotechnol 97:7779-90. 2013
    ....
  32. ncbi request reprint AREA directly mediates nitrogen regulation of gibberellin biosynthesis in Gibberella fujikuroi, but its activity is not affected by NMR
    Martina Mihlan
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlossgarten 3, D 48149, Munster, Germany
    Mol Microbiol 47:975-91. 2003
    ..nidulans and N. crassa nmr mutants. Therefore, we postulate that, in contrast to A. nidulans and N. crassa, NMR does not function independently as the main modulator of AREA in G. fujikuroi...
  33. ncbi request reprint Influence of electron transport proteins on the reactions catalyzed by Fusarium fujikuroi gibberellin monooxygenases
    Claudia Troncoso
    Laboratorio de Bioorgánica, Departamento de Quimica, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Phytochemistry 69:672-83. 2008
    ..Thus these partially oxidized GAs correspond to intermediates of the sequential oxidation of C-20 catalyzed by P450-2...
  34. ncbi request reprint Kaurenolides and fujenoic acids are side products of the gibberellin P450-1 monooxygenase in Gibberella fujikuroi
    M Cecilia Rojas
    Departamento de Quimica, Laboratorio de Bioorgánica, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Phytochemistry 65:821-30. 2004
    ..fujikuroi and are thus side products that probably result from stabilization of radical intermediates involved in GA14 synthesis...
  35. ncbi request reprint The gibberellin 20-oxidase of Gibberella fujikuroi is a multifunctional monooxygenase
    Bettina Tudzynski
    Westfalische Wilhelms Universitat Munster, Institut fur Botanik, Schlobetagarten 3, D 48149 Munster, Germany
    J Biol Chem 277:21246-53. 2002
    ....
  36. ncbi request reprint Ethylene sensing and gene activation in Botrytis cinerea: a missing link in ethylene regulation of fungus-plant interactions?
    Veronique Chague
    Department of Plant Sciences, Tel Aviv University, Tel Aviv, 69978, Israel
    Mol Plant Microbe Interact 19:33-42. 2006
    ..Our results show that the responses of B. cinerea to ethylene are partly mediated by a G protein signaling pathway, and that ethylene-induced plant resistance might involve effects of plant ethylene on both the plant and the fungus...