C Trenkwalder

Summary

Country: Germany

Publications

  1. ncbi request reprint Efficacy of pergolide in treatment of restless legs syndrome: the PEARLS Study
    C Trenkwalder
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Neurology 62:1391-7. 2004
  2. ncbi request reprint Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia
    Brit Mollenhauer
    Department of Neurology, Georg August University, Kassel, Germany
    Dement Geriatr Cogn Disord 22:200-8. 2006
  3. ncbi request reprint [Restless legs syndrome and periodic limb movements in sleep]
    C Trenkwalder
    Georg August Universitat Gottingen, Abteilung Klinische Neurophysiologie, Robert Koch Str 40, 37075 Gottingen
    Nervenarzt 72:425-36. 2001
  4. pmc Ropinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries
    C Trenkwalder
    Department of Clinical Neurophysiology, Paracelsus Elena Klinik, University of Gottingen, Gottingen, Germany
    J Neurol Neurosurg Psychiatry 75:92-7. 2004
  5. ncbi request reprint Restless-legs syndrome in primary care: counting patients in Idaho
    Claudia Trenkwalder
    Department of Clinical Neurophysiology, University of Goettingen, Paracelsus Elena Klinik, Klinikstr 16, D 34128 Kassel, Germany
    Lancet Neurol 3:83. 2004
  6. ncbi request reprint Why do restless legs occur at rest?--pathophysiology of neuronal structures in RLS. Neurophysiology of RLS (part 2)
    C Trenkwalder
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Clin Neurophysiol 115:1975-88. 2004
  7. ncbi request reprint One-year treatment with standard and sustained-release levodopa: appropriate long-term treatment of restless legs syndrome?
    Claudia Trenkwalder
    Max Planck Institute of Psychiatry, Munich, Germany
    Mov Disord 18:1184-9. 2003
  8. ncbi request reprint Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    Mol Psychiatry 12:671-80. 2007
  9. ncbi request reprint Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients
    J Winkelmann
    Max Planck Institute of Psychiatry, Section of Neurology, Munich, Germany
    Sleep 23:597-602. 2000
  10. ncbi request reprint Sleep and periodic leg movement patterns in drug-free patients with Parkinson's disease and multiple system atrophy
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Sleep 23:361-7. 2000

Detail Information

Publications92

  1. ncbi request reprint Efficacy of pergolide in treatment of restless legs syndrome: the PEARLS Study
    C Trenkwalder
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Neurology 62:1391-7. 2004
    ..To evaluate the short- and long-term safety and efficacy of pergolide therapy for restless legs syndrome (RLS) in a double-blind, placebo-controlled, randomized trial (Pergolide European Australian RLS [PEARLS] study)...
  2. ncbi request reprint Beta-amlyoid 1-42 and tau-protein in cerebrospinal fluid of patients with Parkinson's disease dementia
    Brit Mollenhauer
    Department of Neurology, Georg August University, Kassel, Germany
    Dement Geriatr Cogn Disord 22:200-8. 2006
    ..These findings suggest that such protein CSF changes may help to support the clinical diagnosis of cognitive decline in PD and that there may be apolipoprotein-E-isoform-specific differences in CSF protein regulation in advanced PDD...
  3. ncbi request reprint [Restless legs syndrome and periodic limb movements in sleep]
    C Trenkwalder
    Georg August Universitat Gottingen, Abteilung Klinische Neurophysiologie, Robert Koch Str 40, 37075 Gottingen
    Nervenarzt 72:425-36. 2001
    ....
  4. pmc Ropinirole in the treatment of restless legs syndrome: results from the TREAT RLS 1 study, a 12 week, randomised, placebo controlled study in 10 European countries
    C Trenkwalder
    Department of Clinical Neurophysiology, Paracelsus Elena Klinik, University of Gottingen, Gottingen, Germany
    J Neurol Neurosurg Psychiatry 75:92-7. 2004
    ..To assess the efficacy, safety, and tolerability of ropinirole in the treatment of patients with restless legs syndrome...
  5. ncbi request reprint Restless-legs syndrome in primary care: counting patients in Idaho
    Claudia Trenkwalder
    Department of Clinical Neurophysiology, University of Goettingen, Paracelsus Elena Klinik, Klinikstr 16, D 34128 Kassel, Germany
    Lancet Neurol 3:83. 2004
  6. ncbi request reprint Why do restless legs occur at rest?--pathophysiology of neuronal structures in RLS. Neurophysiology of RLS (part 2)
    C Trenkwalder
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Clin Neurophysiol 115:1975-88. 2004
    ..A diversity of hypothetical affections of different neuronal levels might lead to various combinations of RLS symptomatology. No single pathophysiological explanation has yet been developed that covers all clinical features...
  7. ncbi request reprint One-year treatment with standard and sustained-release levodopa: appropriate long-term treatment of restless legs syndrome?
    Claudia Trenkwalder
    Max Planck Institute of Psychiatry, Munich, Germany
    Mov Disord 18:1184-9. 2003
    ....
  8. ncbi request reprint Validation of amyloid-beta peptides in CSF diagnosis of neurodegenerative dementias
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    Mol Psychiatry 12:671-80. 2007
    ..CSF Abeta peptides may reflect disease-specific impact of distinct neurodegenerative processes on Abeta peptide metabolism and represent a potential diagnostic biomarker for AD, FTD and DLB...
  9. ncbi request reprint Clinical characteristics and frequency of the hereditary restless legs syndrome in a population of 300 patients
    J Winkelmann
    Max Planck Institute of Psychiatry, Section of Neurology, Munich, Germany
    Sleep 23:597-602. 2000
    ..1% vs. 2.6%, p < 0.05). Our study shows that patients with hereditary RLS may experience an earlier onset of the disease. Hereditary and non-hereditary RLS present with similiar clinical signs and symptoms...
  10. ncbi request reprint Sleep and periodic leg movement patterns in drug-free patients with Parkinson's disease and multiple system atrophy
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Sleep 23:361-7. 2000
    ..To assess and compare polygraphic sleep measures and periodic leg movement (PLM) patterns in untreated patients with mild to moderate Parkinson's disease (PD), multiple system atrophy (MSA) and healthy age-matched controls...
  11. ncbi request reprint Increased growth hormone response to apomorphine in Parkinson disease compared with multiple system atrophy
    E Friess
    Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
    Arch Neurol 58:241-6. 2001
    ..In search of a suitable endocrinologic challenge test, we investigated dopaminergic sensitivity in patients with de novo parkinsonian syndromes...
  12. ncbi request reprint CSF diagnosis of Alzheimer's disease and dementia with Lewy bodies
    M Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    J Neural Transm 113:1771-8. 2006
    ..Combined evaluation of these biomarkers provides a reasonable accuracy for differential diagnosis of AD and DLB...
  13. ncbi request reprint Dehydroepiandrosterone response to the adrenocorticotropin test and the combined dexamethasone and corticotropin-releasing hormone test in patients with multiple sclerosis
    T Kümpfel
    Max Planck Institute of Psychiatry, Munich, Germany
    Neuroendocrinology 70:431-8. 1999
    ..45; p = 0.031). As with the hypothalamic-pituitary-adrenal axis system, our results suggest a dysfunction in the DHEA secretion in patients with MS...
  14. ncbi request reprint Polysomnographic measures in Parkinson's disease: a comparison between patients with and without REM sleep disturbances
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Federal Republic of Germany
    Wien Klin Wochenschr 113:249-53. 2001
    ..To assess the frequency of rapid eye movement (REM) sleep abnormalities in Parkinson's disease (PD) patients and compare polygraphic sleep measures in those with and without REM sleep disturbances...
  15. ncbi request reprint Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome
    I Eisensehr
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Neurology 57:1307-9. 2001
    ..The authors conclude that striatal dopamine transporter and receptor density is normal in drug-naive and levodopa-treated patients with RLS...
  16. ncbi request reprint Improvement of motor fluctuations in patients with Parkinson's disease following treatment with high doses of pergolide and cessation of levodopa
    J Schwarz
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Eur Neurol 37:236-8. 1997
    ..These data show that in some patients oral treatment with high doses of a dopamine agonist may improve the severity of motor fluctuations and achieve a good control of parkinsonian signs without concomitant levodopa treatment...
  17. ncbi request reprint Increased alpha activity in REM sleep in de novo patients with Parkinson's disease
    T C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    Mov Disord 16:928-33. 2001
    ..The analysis of the temporal dynamics of the observed changes suggests a dysregulation of the REM sleep homeostasis in the patients with PD...
  18. ncbi request reprint Effect of sleep deprivation on motor performance in patients with Parkinson's disease
    B Hogl
    Max Planck Institute of Psychiatry, Neurology Department, Munich, Germany
    Mov Disord 16:616-21. 2001
    ..However, the results indicate that different response types to sleep deprivation may exist and that a subgroup of patients could benefit from partial sleep deprivation...
  19. ncbi request reprint [When L-Dopa preparations, dopamine agonists or opioids? Therapy of restless legs syndrome]
    T Tings
    Abteilung Klinische Neurophysiologie, Georg August Universitat, Gottingen
    MMW Fortschr Med 145:48-9. 2003
  20. ncbi request reprint Growth hormone response in low-dose apomorphine test correlates with nigrostriatal dopamine transporter binding in patients with Parkinson's disease
    S Happe
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    J Neural Transm 114:589-94. 2007
    ..490 and -0.587; p between 0.04 and 0.01). Challenge with low-dose apomorphine may therefore be used as an indirect tool to measure the extent of nigrostriatal neurodegeneration in early PD...
  21. doi request reprint Differentiation of typical and atypical Parkinson syndromes by quantitative MR imaging
    N K Focke
    Department of Clinical Neurophysiology, Georg August University Gottingen, Gottingen, Germany
    AJNR Am J Neuroradiol 32:2087-92. 2011
    ..We, therefore, conducted a head-to-head study with different quantitative MR imaging measurements in patients with IPS, MSA-type Parkinson, PSP, and healthy elderly controls...
  22. ncbi request reprint Acute effects of interferon beta-1a on plasma cytokine levels in patients with MS
    T Kümpfel
    Max Planck Institute of Psychiatry, Section of Neurology, Munich, Germany
    Neurology 55:1231-3. 2000
    ..After interferon beta injection we found an acute rise in plasma cytokine levels and an increase in plasma hormone concentrations, both of which were modulated by indomethacin comedication...
  23. doi request reprint Dopaminergic treatment is associated with decreased body weight in patients with Parkinson's disease and dyskinesias
    C G Bachmann
    Department of Clinical Neurophysiology, Georg August University, Gottingen, Germany
    Eur J Neurol 16:895-901. 2009
    ..We aimed to investigate whether PD patients with dyskinesias display body weight alterations and to observe any correlations between medication and other putative determinants...
  24. ncbi request reprint Movement disorders in sleep: Parkinson's disease and restless legs syndrome
    S Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Biomed Tech (Berl) 48:62-7. 2003
    ..The present review focuses on nocturnal motor activity and sleep in Parkinson's disease and RLS...
  25. ncbi request reprint Clinical and biochemical findings in uremic patients with and without restless legs syndrome
    V Collado-Seidel
    Max Planck Institute of Psychiatry, Clinical Institute, Neurology, Munich, Germany
    Am J Kidney Dis 31:324-8. 1998
    ..The significantly higher number of psychopharmacological drugs prescribed to uremic patients with RLS may be related to the symptoms of RLS...
  26. ncbi request reprint Magnetic resonance proton spectroscopy of the brain in Wilson's disease
    E Kraft
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neurol 246:693-9. 1999
    ..Additionally, there was no evidence of increased lactate concentration, indicating that cerebral energy metabolism was not grossly impaired...
  27. ncbi request reprint Combined treatment with corticosteroids and moclobemide favors normalization of hypothalamo-pituitary-adrenal axis dysregulation in relapsing-remitting multiple sclerosis: a randomized, double blind trial
    F Then Bergh
    Department of Neurology, Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Clin Endocrinol Metab 86:1610-5. 2001
    ..Although corticosteroids alone had no effect on the HPA response using the dexamethasone-CRH test, treatment with moclobemide combined with corticosteroids favors normalization of the HPA response in relapsing-remitting MS...
  28. ncbi request reprint RLS3: fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity
    K M Liebetanz
    Department of Clinical Neurophysiology, Georg August University, Goettingen, Germany
    Neurology 67:320-1. 2006
    ..P values were 0.0054 for marker D9S1810 for TDT and 0.0009 for the affecteds-only linkage analysis, providing a confirmation of RLS3. This study narrows the region containing the autosomal dominant RLS3 locus to 11.1 cM (16.6 Mbp)...
  29. ncbi request reprint Circadian variation in restless legs syndrome
    P C Baier
    Department of Clinical Neurophysiology, Georg August University of Gottingen, Gottingen, Germany
    Sleep Med 8:645-50. 2007
    ..This contribution reviews the current literature on circadian variation in RLS and discusses potential intrinsic and extrinsic causes...
  30. ncbi request reprint [Diagnosis and clinical therapy for Parkinson's disease]
    S Wenzel
    Paracelsus Elena Klinik, Klinikstrasse 16, 34128 Kassel, Germany
    Nervenarzt 77:1439-43. 2006
    ..The difficulties and related problems affect prognosis more than do the motor symptoms. There is a need for standardized diagnostic and specific therapeutic intervention, but appropriate studies are still lacking...
  31. ncbi request reprint "Anxietas tibiarum". Depression and anxiety disorders in patients with restless legs syndrome
    J Winkelmann
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neurol 252:67-71. 2005
    ..However, it is unclear whether rates of threshold depression and anxiety disorders according to DSM-IV criteria in such patients are also elevated...
  32. ncbi request reprint Imaging of nonmotor symptoms in Parkinson syndromes
    W Paulus
    Department of Clinical Neurophysiology, University Hospital, Gottingen, Germany
    Clin Neurosci 5:115-20. 1998
    ..To investigate the pathophysiology of hallucinations with functional imaging may be a promising field of future research...
  33. ncbi request reprint Involuntary vocalisations and a complex hyperkinetic movement disorder following left side thalamic haemorrhage
    T Dietl
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Behav Neurol 14:99-102. 2003
    ..In addition, the patient developed a complex hyperkinetic movement disorder with right-sided painful hemidystonia and bilateral clonic jerks and a right-sided postural tremor...
  34. ncbi request reprint Follow-up investigations in cerebrospinal fluid of patients with dementia with Lewy bodies and Alzheimer's disease
    B Mollenhauer
    Department of Neurology, Georg August University, Goettingen, Germany
    J Neural Transm 112:933-48. 2005
    ..Follow-up CSF analyses are of limited value for the differentiation of AD and DLB. We conclude that more specific markers have to be established for the differentiation and follow-up of these diseases...
  35. ncbi request reprint Unimpaired negative but enhanced positive priming in Parkinson's disease: evidence from an identity and a location priming task
    S J Troche
    Georg Elias Müller Institute for Psychology, University of Goettingen, Goettingen, Germany
    Neuropsychologia 44:1811-21. 2006
    ..These findings suggest that disturbed selective attention associated with PD is due to changed mechanisms mediating attention to relevant information rather than due to mechanisms involved in inhibition of irrelevant information...
  36. ncbi request reprint Retention of dopamine 2 receptor mRNA and absence of the protein in craniospinal and extracranial metastasis of a malignant prolactinoma: a case report
    J Winkelmann
    Department of Neurology, Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
    Eur J Endocrinol 146:81-8. 2002
    ..In this case, the presence of dopamine 2 receptor (D2R) was studied at the mRNA and protein level, in order to understand the pathological background of the resistance to treatment with different dopamine agonists...
  37. ncbi request reprint T2*-weighted MRI in diagnosis of multiple system atrophy. A practical approach for clinicians
    Friederike von Lewinski
    Paracelsus Elena Klinik, Klinikstr 16, 34128 Kassel, Germany
    J Neurol 254:1184-8. 2007
    ..T2*-weighted magnetic resonance imaging (MRI) gradient echo (GE) sequences are sensitive for paramagnetic susceptibility changes and therefore may support the clinical differential diagnosis between MSA and PD...
  38. ncbi request reprint Mapping the effects of three dopamine agonists with different dyskinetogenic potential and receptor selectivity using pharmacological functional magnetic resonance imaging
    Marina Delfino
    Laboratorio de Parkinsonismo Experimental, Instituto de Investigaciones Farmacologicas, CONICET, Buenos Aires, Argentina
    Neuropsychopharmacology 32:1911-21. 2007
    ..Our results suggest that striatal and cortical activation induced by stimulation of D1/D5 receptors has a primary role in the induction of peak dose dyskinesia in parkinsonism...
  39. ncbi request reprint Cabergoline compared to levodopa in the treatment of patients with severe restless legs syndrome: results from a multi-center, randomized, active controlled trial
    Claudia Trenkwalder
    Paracelsus Elena Hospital, University of Gottingen, Kassel, Germany
    Mov Disord 22:696-703. 2007
    ..0001). This first large-scale active controlled study in RLS showed superior efficacy of cabergoline versus levodopa after a 30-week long-term therapy. Tolerability was found more favorable with levodopa than with cabergoline...
  40. ncbi request reprint Acute and chronic neuroendocrine effects of interferon-beta 1a in multiple sclerosis
    Florian Then Bergh
    Max Planck Institute of Psychiatry, Section of Neurology, Kraepelinstrasse 10, 80804 München, Germany
    Clin Endocrinol (Oxf) 66:295-303. 2007
    ..Since hyperactivity of the hypothalamo-pituitary-adrenal (HPA) axis and other neuroendorine disturbances occur in multiple sclerosis, we determined the detailed neuroendocrine response of patients with multiple sclerosis to IFN-beta...
  41. ncbi request reprint Endocrine rhythms in patients with restless legs syndrome
    Thomas C Wetter
    Max Planck Institute of Psychiatry, Munich, Germany
    J Neurol 249:146-51. 2002
    ..9 +/- 17.1) compared with the controls (12.0 +/- 9.2; p < 0.05). It is suggested that a possible dysfunction of the dopaminergic system in RLS does not affect the release of prolactin and hGH from the pituitary gland...
  42. ncbi request reprint Less is more: pathophysiology of dopaminergic-therapy-related augmentation in restless legs syndrome
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Lancet Neurol 5:878-86. 2006
    ....
  43. ncbi request reprint Microstructure of the non-rapid eye movement sleep electroencephalogram in patients with newly diagnosed Parkinson's disease: effects of dopaminergic treatment
    Hans Brunner
    Max Planck Institute of Psychiatry, Munich, Germany
    Mov Disord 17:928-33. 2002
    ..It is suggested that Parkinson's disease as well as the application of dopaminergic drugs exerts a desynchronizing effect on the sleep EEG that is reflected in a disruption of sleep continuity...
  44. ncbi request reprint Relation of cerebral small-vessel disease and brain atrophy to mild Parkinsonism in the elderly
    Christiane Reitz
    Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany
    Mov Disord 21:1914-9. 2006
    ..Determining the presence of these brain changes using brain imaging might contribute to identify persons at risk for MPS...
  45. ncbi request reprint Treatment of drug-induced psychosis in Parkinson's disease with ziprasidone can induce severe dose-dependent off-periods and pathological laughing
    Jan Schindehütte
    Paracelsus Elena Klinik Kassel, Klinikstrasse 16, 34128 Kassel, Germany
    Clin Neurol Neurosurg 109:188-91. 2007
    ..Ziprasidone may serve as an additional "atypical anti-psychotic" for the treatment of DP in PD but can also induce deterioration of motor function...
  46. ncbi request reprint Assessment of spontaneously occurring periodic limb movements in sleep in the rat
    Paul Christian Baier
    Sleep Pharmacology, Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    J Neurol Sci 198:71-7. 2002
    ..The objective of this study is to explore whether a PLMS-like phenomenon can be observed in rodents in order to elucidate the underlying mechanisms...
  47. ncbi request reprint Growth hormone response to low-dose apomorphine in restless legs syndrome
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Growth Horm IGF Res 17:323-7. 2007
    ..It is therefore the aim of this study to determine whether the GH response to subcutaneously applied low-dose apomorphine is generally altered in patients with RLS as compared to healthy controls...
  48. ncbi request reprint Relationship of periodic leg movements and severity of restless legs syndrome: a study in unmedicated and medicated patients
    Magdolna Hornyak
    Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany
    Clin Neurophysiol 118:1532-7. 2007
    ....
  49. pmc The tumorigenicity of mouse embryonic stem cells and in vitro differentiated neuronal cells is controlled by the recipients' immune response
    Ralf Dressel
    Department of Cellular and Molecular Immunology, University of Gottingen, Gottingen, Germany
    PLoS ONE 3:e2622. 2008
    ..Interestingly, the differentiated cells must contain a tumorigenic cell population that is not present among ES cells and which might be resistant to NK cell-mediated killing...
  50. doi request reprint Efficacy of rotigotine for treatment of moderate-to-severe restless legs syndrome: a randomised, double-blind, placebo-controlled trial
    Claudia Trenkwalder
    Paracelsus Elena Hospital, Kassel, Germany
    Lancet Neurol 7:595-604. 2008
    ..Continuous administration of a dopamine agonist could be used to treat patients with restless legs syndrome. Our aim was to investigate the efficacy of transdermal rotigotine in the treatment of idiopathic restless legs syndrome...
  51. doi request reprint Cognitive impairment in 873 patients with idiopathic Parkinson's disease. Results from the German Study on Epidemiology of Parkinson's Disease with Dementia (GEPAD)
    Oliver Riedel
    Institute of Clinical Psychology and Psychotherapy, Technical University of Dresden, Chemnitzer Strasse 46, Dresden, Germany
    J Neurol 255:255-64. 2008
    ..Prevalence estimates of these complications are quite variable and are lacking for the outpatient care sector...
  52. ncbi request reprint Blood-based neurochemical diagnosis of vascular dementia: a pilot study
    Mirko Bibl
    Department of Psychiatry University of Goettingen, von Siebold Str, Goettingen, Germany
    J Neurochem 103:467-74. 2007
    ..From the presented results, we consider the ratio of plasma Abeta1-38/Abeta1-40 peptides to be a blood-based biomarker candidate for VAD...
  53. ncbi request reprint Serum heart-type fatty acid-binding protein and cerebrospinal fluid tau: marker candidates for dementia with Lewy bodies
    Brit Mollenhauer
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neurodegener Dis 4:366-75. 2007
    ..Heart-type fatty acid-binding protein (H-FABP) was recently discovered in CSF and serum of patients with neurodegenerative diseases...
  54. ncbi request reprint Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in Europe
    Wolfgang H Oertel
    Department of Neurology, Philipps University, Rudolf Bultmann Strasse 8, D 35039 Marburg, Germany
    Sleep Med 9:228-39. 2008
    ..In a pilot placebo-controlled study, low dosages of 0.5-2mg/24h rotigotine showed a dose-dependent beneficial effect in restless legs syndrome (RLS) patients...
  55. ncbi request reprint Diagnostic standards for dopaminergic augmentation of restless legs syndrome: report from a World Association of Sleep Medicine-International Restless Legs Syndrome Study Group consensus conference at the Max Planck Institute
    Diego Garcia-Borreguero
    Sleep Research Institute, Alberto Alcocer 19, 28036 Madrid, Spain
    Sleep Med 8:520-30. 2007
    ..The Consensus Conference sought to develop a better understanding of augmentation and generate a better operational definition for its clinical identification...
  56. ncbi request reprint Validation of the Augmentation Severity Rating Scale (ASRS): a multicentric, prospective study with levodopa on restless legs syndrome
    Diego Garcia-Borreguero
    Fundacion Jimenez Diaz, Madrid, Spain
    Sleep Med 8:455-63. 2007
    ..The changes in each dimension are summed to give an ASRS total score...
  57. ncbi request reprint Sex and the risk of restless legs syndrome in the general population
    Klaus Berger
    Institute of Epidemiology and Social Medicine, University of Munster, Germany
    Arch Intern Med 164:196-202. 2004
    ..Population-based studies are rare, and risk factors in the general population are not known...
  58. ncbi request reprint Pathophysiological concepts of restless legs syndrome
    Walter Paulus
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    Mov Disord 22:1451-6. 2007
    ..Neurophysiologically excitability alterations can be measured by a variety of methods such as determination of pain thresholds, H-reflex testing, and quantitative sensory testing...
  59. ncbi request reprint Controlled withdrawal of pramipexole after 6 months of open-label treatment in patients with restless legs syndrome
    Claudia Trenkwalder
    Paracelsus Elena Klinik, Kassel, Germany
    Mov Disord 21:1404-10. 2006
    ..The great majority of adverse events (AEs) were mild or moderate, and of expected types. Augmentation was considered an AE, but in this population of responders it did not occur...
  60. pmc Monthly intravenous methylprednisolone in relapsing-remitting multiple sclerosis - reduction of enhancing lesions, T2 lesion volume and plasma prolactin concentrations
    Florian Then Bergh
    Section of Neurology, Max Planck Institut fur Psychiatrie, Munchen, Germany
    BMC Neurol 6:19. 2006
    ..Intermittent IV-MP, alone or with immunomodulators, has been suggested but insufficiently studied as a strategy to prevent relapses...
  61. ncbi request reprint Validation of the "L-DOPA test" for diagnosis of restless legs syndrome
    Karin Stiasny-Kolster
    Department of Neurology, Center of Nervous Diseases, Philipps University, Marburg, Germany
    Mov Disord 21:1333-9. 2006
    ..We recommend the L-DOPA test for diagnostic decision making in all patients with an unclear RLS diagnosis according to the essential diagnostic criteria of the International RLS Study Group...
  62. ncbi request reprint T2*-weighted MRI differentiates multiple system atrophy from Parkinson's disease
    Eduard Kraft
    Max Planck Institute of Psychiatry, Munich, Germany
    Neurology 59:1265-7. 2002
    ..Hypointense putaminal signal changes were more often observed in MSA than in PD using T2* but not T2-weighted images, indicating that T2*-weighted GE sequences are of diagnostic value for patients with parkinsonism...
  63. ncbi request reprint Presynaptic dopaminergic function in patients with restless legs syndrome: are there common features with early Parkinson's disease?
    Rainer Linke
    Department of Nuclear Medicine, University of Munich, Munich, Germany
    Mov Disord 19:1158-62. 2004
    ..Our results do not strengthen an identical pathophysiologic pathway between RLS and PD on the level of nigrostriatal presynaptic terminal function...
  64. ncbi request reprint Dyskinesias due to intravenous apomorphine abuse in a patient without basal ganglia disorder
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Mov Disord 20:105-8. 2005
    ..We describe a patient with psychogenic parkinsonism and intravenous apomorphine abuse leading to subsequent choreatiform dyskinesias...
  65. ncbi request reprint Clinical symptomatology and treatment of restless legs syndrome and periodic limb movement disorder
    Karin Stiasny
    Department of Neurology, Center of Nervous Diseases, Philipps University of Marburg, Germany
    Sleep Med Rev 6:253-65. 2002
    ..This article gives an overview of the epidemiology, pathophysiology, clinical symptomatology and diagnosis of RLS and PLMD and focuses on treatment strategies in both disorders...
  66. ncbi request reprint Restless legs syndrome and periodic limb movement disorder in the elderly
    Magdolna Hornyak
    Department of Psychiatry and Psychotherapy, University of Freiburg, Hauptstrasse 5, D 79104 Freiburg, Germany
    J Psychosom Res 56:543-8. 2004
    ..However, interaction with other medications and the possibility of severe sedation due to slower metabolism in the elderly should be considered...
  67. ncbi request reprint Behavioral changes in unilaterally 6-hydroxy-dopamine lesioned rats after transplantation of differentiated mouse embryonic stem cells without morphological integration
    Paul Christian Baier
    Department of Clinical Neurophysiology, Georg August University Gottingen, Gottingen, Germany
    Stem Cells 22:396-404. 2004
    ..In this study, we aimed to investigate differentiated mouse ES cells regarding their in vivo development and fate after transplantation in the striatum in the 6-OHDA rat model and the behavioral changes induced after transplantation...
  68. ncbi request reprint Levodopa treatment does not affect low-dose apomorphine test in patients with Parkinson's disease
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Germany
    Mov Disord 19:1511-5. 2004
    ..Thus, the low-dose apomorphine test may also be a useful biological marker in the early differential diagnosis of PD patients who have already received levodopa treatment...
  69. ncbi request reprint Role of dopamine receptor agonists in the treatment of restless legs syndrome
    Svenja Happe
    Department of Clinical Neurophysiology, University of Gottingen, Gottingen, Germany
    CNS Drugs 18:27-36. 2004
    ..Further research should focus on long-term observations and comparisons of different dopamine receptor agonists in RLS...
  70. ncbi request reprint The effect of cabergoline on sleep, periodic leg movements in sleep, and early morning motor function in patients with Parkinson's disease
    Birgit Hogl
    Max Planck Institute of Psychiatry, Department of Neurology, Munich, Germany
    Neuropsychopharmacology 28:1866-70. 2003
    ..Cabergoline slightly fragmented sleep, without altering its total amount. The functional significance of this finding is uncertain. The subjective quality of sleep improved, and periodic limb movements in sleep decreased...
  71. ncbi request reprint Tau protein, Abeta42 and S-100B protein in cerebrospinal fluid of patients with dementia with Lewy bodies
    Brit Mollenhauer
    Department of Neurology, Georg August University Gottingen, Gottingen, Germany
    Dement Geriatr Cogn Disord 19:164-70. 2005
    ..We conclude that more specific markers have to be established for the differentiation of these diseases...
  72. ncbi request reprint Circadian distribution of motor-activity in unilaterally 6-hydroxy-dopamine lesioned rats
    Paul Christian Baier
    Department of Clinical Neurophysiology, Georg August University Gottingen, Robert Koch Str 40, 37075, Gottingen, Germany
    Exp Brain Res 169:283-8. 2006
    ..In order to further elucidate the described phenomena, it will be necessary to perform studies combining sleep recordings with locomotor activity measurements...
  73. ncbi request reprint CSF amyloid-beta-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia
    Mirko Bibl
    Department of Psychiatry, University of Goettingen, Goettingen, Germany
    Brain 129:1177-87. 2006
    ..Their distinct molecular phenotypes support the view of different pathophysiological pathways for each of these neurodegenerative diseases...
  74. ncbi request reprint High-dose treatment with pergolide in Parkinson's disease patients with motor fluctuations and dyskinesias
    Alexander Storch
    Department of Neurology, University of Ulm, Ulm, Germany
    Parkinsonism Relat Disord 11:393-8. 2005
    ..Controlled trials are needed to further substantiate the efficacy and safety of this treatment strategy...
  75. ncbi request reprint Fate of pre-differentiated mouse embryonic stem cells transplanted in unilaterally 6-hydroxydopamine lesioned rats: histological characterization of the grafted cells
    Keneuoe Thinyane
    Department of Clinical Neurophysiology, University Göttingen, 37075 Gottingen, Germany
    Brain Res 1045:80-7. 2005
    ..After 5 weeks, two out of fifteen graft recipients had tumors indicating that pre-differentiation of mouse embryonic stem cells using this differentiation protocol is not sufficient to prevent tumor formation...
  76. ncbi request reprint Total tau protein, phosphorylated tau (181p) protein, beta-amyloid(1-42), and beta-amyloid(1-40) in cerebrospinal fluid of patients with dementia with Lewy bodies
    Brit Mollenhauer
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Chem Lab Med 44:192-5. 2006
    ..We conclude that more specific markers have to be established to differentiate between these diseases...
  77. ncbi request reprint Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases
    Petra Steinacker
    Department of Neurology, University Hospital, Robert Koch Str 40, 37075 Goettingen, Germany
    Neurosci Lett 370:36-9. 2004
    ..Our results suggest that H-FABP might be a useful biomarker for the differentiation between the dementias examined if levels in CSF and serum are determined in parallel...
  78. ncbi request reprint Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome
    Arthur S Walters
    New Jersey Neuroscience Institute, JFK Medical Center, Edison, NJ 08818, USA
    Sleep Med 4:121-32. 2003
    ..Moreover, RLS is primarily a subjective disorder. Therefore, a subjective scale is at present the optimal instrument to meet this need...
  79. ncbi request reprint Point mutations in exon 1 of the NR4A2 gene are not a major cause of familial Parkinson's disease
    Alexander Zimprich
    Neurogenetics 4:219-20. 2003
  80. ncbi request reprint [Can relaxation exercises calm the legs?]
    Claudia Trenkwalder
    MMW Fortschr Med 148:16. 2006
  81. ncbi request reprint Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
    Juliane Winkelmann
    Institute of Human Genetics, GSF National Research Center of Environment and Health, D 85764 Neuherberg, Munich, Germany
    Nat Genet 39:1000-6. 2007
    ..MEIS1 has been implicated in limb development, raising the possibility that RLS has components of a developmental disorder...
  82. ncbi request reprint Restless Legs Syndrome induced by impairment of sensory spinal pathways
    Tobias Tings
    J Neurol 250:499-500. 2003
  83. ncbi request reprint Iron metabolism and the risk of restless legs syndrome in an elderly general population--the MEMO-Study
    Klaus Berger
    Institute of Epidemiology and Social Medicine, University of Muenster, Domagkstr 3, 48149 Muenster, Germany
    J Neurol 249:1195-9. 2002
    ..All reports are based on single cases or case series of hospitalized patients or those from outpatient clinics. No data from population studies are available...
  84. ncbi request reprint The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study
    Sarah von Spiczak
    Division of Neuroscience and MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK
    Brain 128:906-17. 2005
    ..We therefore discuss a possible role for opioids in the pathophysiology of RLS with respect to sensory and motor symptoms...
  85. ncbi request reprint Impact of regular LDL apheresis on the development of restless legs syndrome
    Tobias Tings
    Department of Clinical Neurophysiology, University of Goettingen, Robert Koch Str 40, 37075 Goettingen, Germany
    Mov Disord 19:1072-5. 2004
    ..Substitution of iron therefore may be a promising line of treatment for LA-induced RLS...
  86. ncbi request reprint The restless legs syndrome
    Claudia Trenkwalder
    Paracelsus Elena Klinik, Centre of Parkinsonism and Movement Disorders, Kassel, Germany
    Lancet Neurol 4:465-75. 2005
    ..Various other drugs, such as opioids, gabapentin, and benzodiazepines, provide alternative treatment possibilities...
  87. ncbi request reprint State of the art in restless legs syndrome therapy: practice recommendations for treating restless legs syndrome
    Wolfgang H Oertel
    Department of Neurology, Philipps University, Marburg, Germany
    Mov Disord 22:S466-75. 2007
    ..Opioids and anticonvulsants such as gabapentine are second-line options in individual patients. Iron substitution is justified in people with iron deficiency related RLS (ferritin concentration lower than 50 microg/L)...
  88. ncbi request reprint Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in subclinical and clinically manifest idiopathic REM sleep behavior disorder, Parkinson's disease
    Ilonka Eisensehr
    Department of Neurology, University of Munich, Germany
    Sleep 26:507-12. 2003
    ....
  89. ncbi request reprint Paroxetine treatment improves motor symptoms in patients with multiple system atrophy
    Elisabeth Friess
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Parkinsonism Relat Disord 12:432-7. 2006
    ..In addition, we assessed the effects on the psychopathological status of the patients...
  90. ncbi request reprint Restless legs syndrome and periodic limb movements
    Claudia Trenkwalder
    Department of Clinical Neurophysiology, University of Goettingen, Goettingen, Germany
    Adv Neurol 89:145-51. 2002
  91. ncbi request reprint Long-term course of restless legs syndrome in dialysis patients after kidney transplantation
    Juliane Winkelmann
    Max Planck Institute of Psychiatry, Munich, Germany
    Mov Disord 17:1072-6. 2002
    ..Kidney transplantation has a strong and positive influence on RLS symptoms in hemodialysis patients. Hemodialysis patients can expect a substantial improvement of RLS symptoms after a successful kidney transplant...
  92. ncbi request reprint Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health
    Richard P Allen
    Department of Neurology, Sleep Medicine, Johns Hopkins Bayview Medical Center, Asthma and Allergy Building 1B46b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 4:101-19. 2003
    ..Modification of the criteria is now necessary to better reflect that increased body of knowledge, as well as to clarify slight confusion with the wording of the original criteria...