Velavan Tp


Country: Germany


  1. Peko S, Gueye N, Vouvoungui C, Koukouikila Koussounda F, Kobawila S, Nderu D, et al. Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection. Int J Infect Dis. 2019;82:111-116 pubmed publisher
    ..This study contributes to increasing understanding on population pharmacogenetics and may help policy makers regulate treatment guidelines in the Congolese population with a high burden of HIV, Malaria and TB. ..
  2. Nderu D, Kimani F, Thiong o K, Karanja E, Akinyi M, Too E, et al. Plasmodium falciparum histidine-rich protein (PfHRP2 and 3) diversity in Western and Coastal Kenya. Sci Rep. 2019;9:1709 pubmed publisher
    ..This study shows the variability of PfHRP2, PfHRP3 and PfHRP2 concentration among uncomplicated malaria cases. These findings will be useful to understand the performance of PfHRP2-based RDTs in Kenya. ..
  3. Binh M, Hoan N, Van Tong H, Sy B, Trung N, Bock C, et al. NTCP S267F variant associates with decreased susceptibility to HBV and HDV infection and decelerated progression of related liver diseases. Int J Infect Dis. 2019;80:147-152 pubmed publisher
    ..The NTCP S267F variant of the SLC10A1 gene exhibits protective effects against HBV and HDV infection and is associated with a reduced risk of developing to advanced stages of LC and HCC. ..
  4. Boldt A, Van Tong H, Grobusch M, Kalmbach Y, Dzeing Ella A, Kombila M, et al. The blood transcriptome of childhood malaria. EBioMedicine. 2019;40:614-625 pubmed publisher
    ..B. W. Boldt. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. ..
  5. Van Tong H, Van Ba N, Hoan N, Binh M, Quyen D, Son H, et al. Soluble fibrinogen-like protein 2 levels in patients with hepatitis B virus-related liver diseases. BMC Infect Dis. 2018;18:553 pubmed publisher
    ..014, 0.033, respectively). sFGL2 levels are induced by HBV infection and correlated with the progression and clinical outcome of HBV-related liver diseases. Thus, sFGL2 may serve as a potential indicator for HBV-related liver diseases. ..
  6. Nderu D, Kimani F, Thiong o K, Akinyi M, Karanja E, Meyer C, et al. PfHRP2-PfHRP3 diversity among Kenyan isolates and comparative evaluation of PfHRP2/pLDH malaria RDT with microscopy and nested PCR methodologies. Parasitol Int. 2018;67:793-799 pubmed publisher
    ..False positivity by microscopy and under reporting of infections may thus be a barrier in malaria control and elimination programs. The HRP2/pLDH(Pf) based RDT yet demonstrate to be an effective tool for malaria surveillance program. ..
  7. Mishra A, Antony J, Gai P, Sundaravadivel P, Van T, Jha A, et al. Mannose-binding Lectin (MBL) as a susceptible host factor influencing Indian Visceral Leishmaniasis. Parasitol Int. 2015;64:591-6 pubmed publisher
    ..69, 95% CI=0.5-0.97, adjusted P=0.034). MBL recognizes Leishmania and plays a relative role in establishing L. donovani infection and subsequent disease progression. In conclusion, MBL2 functional variants were associated with VL. ..
  8. Tong H, Song L, Hoan N, Cuong B, Sy B, Son H, et al. Soluble MICB protein levels and platelet counts during hepatitis B virus infection and response to hepatocellular carcinoma treatment. BMC Infect Dis. 2015;15:25 pubmed publisher
    ..22, P = 0.025, respectively). Our results demonstrate a potential role of sMICB serum levels and platelet counts during immune response to the HBV infection, liver disease progression and response to the HCC treatment. ..
  9. Antony J, Ojurongbe O, Meyer C, Thangaraj K, Mishra A, Kremsner P, et al. Correlation of Interleukin-6 levels and lectins during Schistosoma haematobium infection. Cytokine. 2015;76:152-155 pubmed publisher
    ..IL-6 was also found to be correlated with the production of lectins in S. haematobium infection. A similar correlation between IL-6 and MBL was observed during visceral leishmaniasis. ..

More Information


  1. Binh M, Hoan N, Van Tong H, Giang D, Sy B, Toan N, et al. HDV infection rates in northern Vietnam. Sci Rep. 2018;8:8047 pubmed publisher
    ..HDV nucleic acid testing to minimize the associated risk should be considered. ..
  2. Mishra A, Jha A, Van Tong H, Singh V, Gomes C, Singh L, et al. Analysis of genetic variants in the IL4 promoter and VNTR loci in Indian patients with Visceral Leishmaniasis. Hum Immunol. 2014;75:1177-81 pubmed publisher
  3. Port J, Nguetse C, Adukpo S, Velavan T. A reliable and rapid method for molecular detection of malarial parasites using microwave irradiation and loop mediated isothermal amplification. Malar J. 2014;13:454 pubmed publisher
    ..The methodology has been validated as a proof of concept and has specifically be developed for use at low-resource settings. Such RmDTs may aid health providers to make timely therapeutic interventions in malaria endemic regions. ..
  4. Trung N, Hien T, Huyen T, Quyen D, Van Son T, Hoan P, et al. Enrichment of bacterial DNA for the diagnosis of blood stream infections. BMC Infect Dis. 2016;16:235 pubmed publisher
    ..With the detection increase of our in-house DNA removal approach, subsequent PCR assays can reach detection limits of 10 E. coli CFUs/ml and significantly improve the diagnostic rate in blood sepsis cases. ..
  5. Nguetse C, Meyer C, Adegnika A, Agbenyega T, Ogutu B, Kremsner P, et al. Glucose-6-phosphate dehydrogenase deficiency and reduced haemoglobin levels in African children with severe malaria. Malar J. 2016;15:346 pubmed publisher
    ..In addition, there was no association of G6PD variant types with parasite densities on admission. ..
  6. Van Tong H, Brindley P, Meyer C, Velavan T. Parasite Infection, Carcinogenesis and Human Malignancy. EBioMedicine. 2017;15:12-23 pubmed publisher
    ..Observations suggest that Strongyloides stercoralis may be a relevant co-factor in HTLV-1-related T cell lymphomas. This review provides an overview of the mechanisms of parasitic infection-induced carcinogenicity. ..
  7. Hoan N, Tong H, Song L, Meyer C, Velavan T. Vitamin D deficiency and hepatitis viruses-associated liver diseases: A literature review. World J Gastroenterol. 2018;24:445-460 pubmed publisher
    ..Furthermore, current literature was reviewed in order to understand the effects of vitamin D supplementation in combination with IFN-based therapy on the virological response in HBV and HCV infected patients. ..
  8. Sandri T, Lidani K, Andrade F, Meyer C, Kremsner P, de Messias Reason I, et al. Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease. Sci Rep. 2018;8:526 pubmed publisher
    ..15) whereas CR1*AGGGTG was related to the risk of chagasic cardiomyopathy (p = 0.028, OR 12.15, CI 1.13-113). This is the first study that provides insights on the role of CR1 in development and clinical presentation of chronic CD. ..
  9. Sy B, Hoan N, Tong H, Meyer C, Toan N, Song L, et al. Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection. World J Gastroenterol. 2018;24:248-256 pubmed publisher
    ..The IRF5*TCAT haplotype was also associated with increased levels of ALT, AST and bilirubin. Our study shows that IFR5 variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. ..
  10. Koukouikila Koussounda F, Jeyaraj S, Nguetse C, Nkonganyi C, Kokou K, Etoka Beka M, et al. Molecular surveillance of Plasmodium falciparum drug resistance in the Republic of Congo: four and nine years after the introduction of artemisinin-based combination therapy. Malar J. 2017;16:155 pubmed publisher
    ..Taken together, this study could serve as the basis for epidemiological studies monitoring the distribution of molecular markers of artemisinin resistance in the Republic of Congo. ..
  11. Amorim L, Van Tong H, Hoan N, Vargas L, Ribeiro E, Petzl Erler M, et al. KIR-HLA distribution in a Vietnamese population from Hanoi. Hum Immunol. 2018;79:93-100 pubmed publisher
    ..05). Studies regarding KIR-HLA in populations are of prime importance to understand their evolution, function and role in diseases. ..
  12. request reprint
    Velavan T, Bechlars S, Tomiuk J, Kremsner P, Kun J. Molecular characterization of regulatory polymorphisms in the promoter region of the STAT6 gene in a Gabonese population. Mem Inst Oswaldo Cruz. 2011;106:65-9 pubmed
    ..One promoter variant, rs3024944 (G/C), revealed an altered expression of the marker gene. The identification of function-altering SNPs in the promoter may facilitate studying parasite susceptibility in association studies...
  13. Trung N, Hien T, Huyen T, Quyen D, Binh M, Hoan P, et al. Simple multiplex PCR assays to detect common pathogens and associated genes encoding for acquired extended spectrum betalactamases (ESBL) or carbapenemases from surgical site specimens in Vietnam. Ann Clin Microbiol Antimicrob. 2015;14:23 pubmed publisher
    ..This is the first report of Turkey-specific ESBL gene (PER-1) and two Oxacilinase families (Oxa23 and Oxa 58) in Vietnam. ..
  14. Velavan T, Bechlars S, Huang X, Kremsner P, Kun J. Novel regulatory SNPs in the promoter region of the TNFRSF18 gene in a Gabonese population. Braz J Med Biol Res. 2011;44:418-20 pubmed publisher
    ..The detection and analysis of these human immune gene polymorphisms contribute to a better understanding of the interaction between host-parasite and expression of Treg activity. ..
  15. Hoan N, Tong H, Hecht N, Sy B, Marcinek P, Meyer C, et al. Hepatitis E Virus Superinfection and Clinical Progression in Hepatitis B Patients. EBioMedicine. 2015;2:2080-2086 pubmed publisher
    ..This study indicates high prevalences of HEV infection in Vietnamese HBV patients and among healthy individuals and shows that HEV superinfection may influence the outcome and progression of HBV-related liver disease. ..
  16. Nguetse C, Adegnika A, Agbenyega T, Ogutu B, Krishna S, Kremsner P, et al. Molecular markers of anti-malarial drug resistance in Central, West and East African children with severe malaria. Malar J. 2017;16:217 pubmed publisher
    ..This study indicates a need to constantly monitor drug resistance to artemisinin in field isolates from malaria-endemic countries. ..
  17. Velavan T, Ojurongbe O. Regulatory T cells and parasites. J Biomed Biotechnol. 2011;2011:520940 pubmed publisher
    ..This review discusses the several mechanism of Treg-mediated immunosuppression in the human host and focuses on the functional role of Tregs and regulatory gene polymorphisms in infectious diseases...
  18. Velavan T, Büyükyazici B, Kremsner P, Kun J. Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children. Immunogenetics. 2012;64:87-95 pubmed publisher
    ..73 (95% CI 0.56-0.94) P?=?0.01]. This study may provide a better understanding on the role of IL10R promoter allelic variants contribution to a protective effect on the development of severe malaria. ..