Mahmoud Toulany

Summary

Country: Germany

Publications

  1. pmc Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tubingen, Roentgenweg 11, D 72076 Tubingen, Germany
    Breast Cancer Res 13:R28. 2011
  2. doi request reprint PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Roentgenweg 11, Tuebingen, Germany
    DNA Repair (Amst) 7:1746-56. 2008
  3. ncbi request reprint Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Mol Cancer Res 5:863-72. 2007
  4. doi request reprint 2-Methoxyestradiol-induced radiosensitization is independent of SOD but depends on inhibition of Akt and DNA-PKcs activities
    Urszula Florczak
    Department of Radiation Oncology, University of Tuebingen, Germany
    Radiother Oncol 92:334-8. 2009
  5. ncbi request reprint Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair
    Mahmoud Toulany
    Divison of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Tuebingen, Germany
    Clin Cancer Res 12:4119-26. 2006
  6. doi request reprint K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs
    Minjmaa Minjgee
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University, Tubingen, Germany
    Int J Radiat Oncol Biol Phys 81:1506-14. 2011
  7. doi request reprint Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Eberhard Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Mol Cancer Ther 7:1772-81. 2008
  8. doi request reprint Akt promotes post-irradiation survival of human tumor cells through initiation, progression, and termination of DNA-PKcs-dependent DNA double-strand break repair
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tubingen, Tubingen, Germany
    Mol Cancer Res 10:945-57. 2012
  9. ncbi request reprint Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany
    Radiother Oncol 76:143-50. 2005
  10. doi request reprint Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Eberhard Karls University, Tuebingen, Germany
    Radiother Oncol 101:140-6. 2011

Collaborators

Detail Information

Publications20

  1. pmc Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tubingen, Roentgenweg 11, D 72076 Tubingen, Germany
    Breast Cancer Res 13:R28. 2011
    ..These pathways can be activated by growth factors and by exposure to ionizing radiation (IR). So far, however, no studies have been conducted on IR-induced YB-1 phosphorylation...
  2. doi request reprint PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Roentgenweg 11, Tuebingen, Germany
    DNA Repair (Amst) 7:1746-56. 2008
    ..Likewise, potential of IR-induced XRCC1 expression depends on its basal expression level...
  3. ncbi request reprint Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Mol Cancer Res 5:863-72. 2007
    ..The data provide new differential insight into the importance of K-RAS mutation in the context of PI3K-AKT-mediated radioresistance of EGFR-overexpressing or EGFR-mutated tumors...
  4. doi request reprint 2-Methoxyestradiol-induced radiosensitization is independent of SOD but depends on inhibition of Akt and DNA-PKcs activities
    Urszula Florczak
    Department of Radiation Oncology, University of Tuebingen, Germany
    Radiother Oncol 92:334-8. 2009
    ....
  5. ncbi request reprint Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair
    Mahmoud Toulany
    Divison of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Tuebingen, Germany
    Clin Cancer Res 12:4119-26. 2006
    ..In the present study, we investigated whether impaired repair of DNA double-strand breaks (DSB) is responsible for the radiosensitizing effect of EGFR and PI3K inhibition in K-RAS mutated (K-RAS(mt)) cells...
  6. doi request reprint K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs
    Minjmaa Minjgee
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University, Tubingen, Germany
    Int J Radiat Oncol Biol Phys 81:1506-14. 2011
    ..In this study the molecular mechanism of radioresistance of cells overexpressing mutated K-RAS(V12) was investigated...
  7. doi request reprint Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Eberhard Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Mol Cancer Ther 7:1772-81. 2008
    ..Thus, targeting of AKT enhances radiation sensitivity of lung cancer cell lines A549 and H460 most likely through specific inhibition of DNA-PKcs-dependent DNA-dsb repair but not through enhancement of radiation-induced apoptosis...
  8. doi request reprint Akt promotes post-irradiation survival of human tumor cells through initiation, progression, and termination of DNA-PKcs-dependent DNA double-strand break repair
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tubingen, Tubingen, Germany
    Mol Cancer Res 10:945-57. 2012
    ..The data showed indicate for the first time that Akt through an immediate complex formation with DNA-PKcs can stimulate the accumulation of DNA-PKcs at DNA-DSBs and promote DNA-PKcs activity for efficient NHEJ DNA-DSB repair...
  9. ncbi request reprint Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany
    Radiother Oncol 76:143-50. 2005
    ..In the context of EGFR-targeting strategies we investigated autocrine/paracrine factors leading to in vitro radioresistance of K-Ras mutated tumor cells through activation of EGFR mediated signal transduction...
  10. doi request reprint Function of erbB receptors and DNA-PKcs on phosphorylation of cytoplasmic and nuclear Akt at S473 induced by erbB1 ligand and ionizing radiation
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Eberhard Karls University, Tuebingen, Germany
    Radiother Oncol 101:140-6. 2011
    ..In the present study effect of erbB2 as well as DNA-PKcs on ionizing radiation (IR)- and erbB1 ligand-induced phosphorylation of Akt at S473 in cytoplasmic and nuclear fractions was investigated...
  11. doi request reprint Selection of radioresistant tumor cells and presence of ALDH1 activity in vitro
    Julia Mihatsch
    Division of Radiobiology and Molecular Environmental Research, University of Tuebingen, Germany
    Radiother Oncol 99:300-6. 2011
    ..Based on the proposed function of CSCs in radioresistance, we explored the cancer stem cell properties of cells selected for radioresistance phenotype...
  12. doi request reprint Autophagy contributes to resistance of tumor cells to ionizing radiation
    Hassan Chaachouay
    Division of Radiobiology and Molecular Environmental Research, University of Tubingen, Germany
    Radiother Oncol 99:287-92. 2011
    ..To study the role of autophagy on resistance of tumor cells to ionizing radiation (IR), breast cancer cell lines differing in their intrinsic radiosensitivity were used...
  13. ncbi request reprint Radiation-induced EGFR-signaling and control of DNA-damage repair
    H Peter Rodemann
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Germany
    Int J Radiat Biol 83:781-91. 2007
    ..The following review summarizes the current knowledge on the role of EGFR and its downstream signaling pathways in the regulation of cellular radiation response and DNA repair...
  14. doi request reprint ErbB2 expression through heterodimerization with erbB1 is necessary for ionizing radiation- but not EGF-induced activation of Akt survival pathway
    Mahmoud Toulany
    Department of Radiation Oncology, University of Tuebingen, Tuebingen, Germany
    Radiother Oncol 97:338-45. 2010
    ..In the present study, we investigated the contribution of erbB2 as a heterodimerization partner of erbB1 in activation of Akt survival signaling after irradiation or EGF treatment...
  15. ncbi request reprint Cisplatin-mediated radiosensitization of non-small cell lung cancer cells is stimulated by ATM inhibition
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Germany
    Radiother Oncol 111:228-36. 2014
    ..We investigated the radiosensitizing effect of cisplatin with respect to its effect on ATM pathway activation...
  16. doi request reprint Radiocontrast media affect radiation-induced DNA damage repair in vitro and in vivo by affecting Akt signalling
    Mahmoud Toulany
    Department of Radiation Oncology, University of Tuebingen, 72076 Tuebingen, Germany
    Radiother Oncol 94:110-6. 2010
    ..The study was performed to investigate cytogenetic effects of ionic and non-ionic radiocontrast media (RCM) meglumine, iohexol alone and in combination with irradiation in mouse bone marrow cells in vivo and in vitro...
  17. ncbi request reprint Radiosensitization of Ras-mutated human tumor cells in vitro by the specific EGF receptor antagonist BIBX1382BS
    Mahmoud Toulany
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, Eberhard Karls University Tuebingen, Roentgenweg 11, 72076 Tuebingen, Germany
    Radiother Oncol 74:117-29. 2005
    ..To investigate the cellular and molecular consequences of antagonizing radiation-induced EGFR-activation in vitro...
  18. ncbi request reprint Selective radioprotection of normal tissues by Bowman-birk proteinase inhibitor (BBI) in mice
    Klaus Dittmann
    Division of Radiobiology and Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany
    Strahlenther Onkol 181:191-6. 2005
    ..The purpose of the present study was to explore the in vivo normal-tissue radioprotective potential of Bowman-Birk proteinase inhibitor (BBI), which acts as a normal-cell-specific radioprotector in vitro...
  19. doi request reprint Acquired resistance to cetuximab is associated with the overexpression of Ras family members and the loss of radiosensitization in head and neck cancer cells
    Mohammad Saki
    Division of Radiobiology and Molecular Environmental Research, Department of Radiation Oncology, University of Tuebingen, Germany Translational Radiooncology Laboratory, Department of Radiooncology and Radiotherapy, Charite Campus Mitte, Charite Universitatsmedizin, Berlin, Germany
    Radiother Oncol 108:473-8. 2013
    ..Cetuximab in combination with radiation therapy is used to treat patients with head and neck squamous cell carcinoma (HNSCC). In the present study, the mechanism of acquired resistance to cetuximab in HNSCC cells was investigated in vitro...
  20. doi request reprint Potential roles of the NFκB and glutathione pathways in mature human erythrocytes
    Mehrdad Ghashghaeinia
    Department of Physiology, Eberhard Karls University Tubingen, Germany
    Cell Mol Biol Lett 17:11-20. 2012
    ..Future studies will be aimed at discriminating between NFκB-dependent and NFκB-independent GSH-mediated effects of Bay 11-7082 and parthenolide on erythrocyte death...