Hans Peter Tony

Summary

Country: Germany

Publications

  1. ncbi request reprint Combination of B cell biomarkers as independent predictors of response in patients with rheumatoid arthritis treated with rituximab
    H P Tony
    Department of Rheumatology and Immunology, University of Wurzburg, Germany
    Clin Exp Rheumatol 33:887-94. 2015
  2. pmc Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)
    Hans Peter Tony
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Wurzburg, Klinikstr 6 8, 97070 Wurzburg, Germany
    Arthritis Res Ther 13:R75. 2011
  3. doi request reprint Rituximab therapy leads to reduced imprints of receptor revision in immunoglobulin κ and λ light chains
    Arumugam Palanichamy
    Department of Rheumatology and Clinical Immunology, Medizinische Klinik und Poliklinik II, Oberdürrbacherstr 6, 97080 Wurzburg, Germany
    J Rheumatol 39:1130-8. 2012
  4. pmc Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients
    Stefan Bittner
    Department of Neurology, University of Wuerzburg, Josef Schneider Str 11, Wuerzburg 97080, Germany
    Arthritis Res Ther 13:R21. 2011
  5. pmc Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody
    Anne Sophie Rouzière
    Department of Medicine II, Rheumatology and Clinical Immunology, University of Wuerzburg, Germany
    Arthritis Res Ther 7:R714-24. 2005
  6. ncbi request reprint Regeneration of B cell subsets after transient B cell depletion using anti-CD20 antibodies in rheumatoid arthritis
    Petra Roll
    University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 54:2377-86. 2006
  7. doi request reprint Impact of IL-6 receptor inhibition on human memory B cells in vivo: impaired somatic hypermutation in preswitch memory B cells and modulation of mutational targeting in memory B cells
    Khalid Muhammad
    Medizinische Klinik und Poliklinik II, Division of Rheumatology Clinical Immunology, University of Wurzburg, Wurzburg, Germany
    Ann Rheum Dis 70:1507-10. 2011
  8. doi request reprint In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment
    Petra Roll
    University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 63:1255-64. 2011
  9. doi request reprint Modulation of molecular imprints in the antigen-experienced B cell repertoire by rituximab
    Arumugam Palanichamy
    University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 58:3665-74. 2008
  10. ncbi request reprint Semiquantitative and qualitative assessment of B-lymphocyte V H repertoire by a fluorescent multiplex PCR
    Martin Feuchtenberger
    Medizinische Poliklinik, University of Wurzburg, Wurzburg, Germany
    J Immunol Methods 276:121-7. 2003

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Combination of B cell biomarkers as independent predictors of response in patients with rheumatoid arthritis treated with rituximab
    H P Tony
    Department of Rheumatology and Immunology, University of Wurzburg, Germany
    Clin Exp Rheumatol 33:887-94. 2015
    ..Identification of B cell biomarkers predictive of response prior to therapy with rituximab (RTX) and evaluation of the efficacy of long-term treatment in patients with rheumatoid arthritis (RA)...
  2. pmc Safety and clinical outcomes of rituximab therapy in patients with different autoimmune diseases: experience from a national registry (GRAID)
    Hans Peter Tony
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Wurzburg, Klinikstr 6 8, 97070 Wurzburg, Germany
    Arthritis Res Ther 13:R75. 2011
    ....
  3. doi request reprint Rituximab therapy leads to reduced imprints of receptor revision in immunoglobulin κ and λ light chains
    Arumugam Palanichamy
    Department of Rheumatology and Clinical Immunology, Medizinische Klinik und Poliklinik II, Oberdürrbacherstr 6, 97080 Wurzburg, Germany
    J Rheumatol 39:1130-8. 2012
    ..Although phenotypic repopulation kinetics of B cell subsets are well documented, precise molecular analyses of the reconstituting immunoglobulin (Ig) genes encoding the B cell receptor in RA are sparse...
  4. pmc Expression of K2P5.1 potassium channels on CD4+ T lymphocytes correlates with disease activity in rheumatoid arthritis patients
    Stefan Bittner
    Department of Neurology, University of Wuerzburg, Josef Schneider Str 11, Wuerzburg 97080, Germany
    Arthritis Res Ther 13:R21. 2011
    ..1 is upregulated upon (autoimmune) T cell stimulation. The aim of this study was to correlate expression levels of K(2P)5.1 on T cells from patients with rheumatoid arthritis (RA) to disease activity in these patients...
  5. pmc Regeneration of the immunoglobulin heavy-chain repertoire after transient B-cell depletion with an anti-CD20 antibody
    Anne Sophie Rouzière
    Department of Medicine II, Rheumatology and Clinical Immunology, University of Wuerzburg, Germany
    Arthritis Res Ther 7:R714-24. 2005
    ..The longitudinal observation of a single patient up to 27 months shows subtle intraindividual changes, which may indicate repertoire modulation...
  6. ncbi request reprint Regeneration of B cell subsets after transient B cell depletion using anti-CD20 antibodies in rheumatoid arthritis
    Petra Roll
    University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 54:2377-86. 2006
    ..The aim of this study was to delineate the regeneration profile of different B cell subsets in the peripheral blood after selective anti-CD20-mediated B cell depletion...
  7. doi request reprint Impact of IL-6 receptor inhibition on human memory B cells in vivo: impaired somatic hypermutation in preswitch memory B cells and modulation of mutational targeting in memory B cells
    Khalid Muhammad
    Medizinische Klinik und Poliklinik II, Division of Rheumatology Clinical Immunology, University of Wurzburg, Wurzburg, Germany
    Ann Rheum Dis 70:1507-10. 2011
    ..As IL-6 is a late differentiation factor of B cells the authors asked if IL-6R inhibition impacts on the mutational differentiation of human memory B-cell antigen receptors in vivo...
  8. doi request reprint In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment
    Petra Roll
    University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 63:1255-64. 2011
    ..IL-6 induces in vitro differentiation of B cells into antibody-forming cells; however, the in vivo effects of IL-6 inhibition on the B cell compartment are currently not known. The purpose of this study was to examine this feature...
  9. doi request reprint Modulation of molecular imprints in the antigen-experienced B cell repertoire by rituximab
    Arumugam Palanichamy
    University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 58:3665-74. 2008
    ..Nevertheless, little is known about the reemerging B cells. We analyzed dynamic changes in the repopulating B cells, particularly the postswitch B cells, and studied the mutational patterns of Ig genes in antigen-experienced B cells...
  10. ncbi request reprint Semiquantitative and qualitative assessment of B-lymphocyte V H repertoire by a fluorescent multiplex PCR
    Martin Feuchtenberger
    Medizinische Poliklinik, University of Wurzburg, Wurzburg, Germany
    J Immunol Methods 276:121-7. 2003
    ....
  11. pmc CD27-IgD- memory B cells are modulated by in vivo interleukin-6 receptor (IL-6R) blockade in rheumatoid arthritis
    Zafar Mahmood
    Department of Medicine II, Rheumatology and Clinical Immunology, University of Wurzburg, Oberdürrbacher Str 6, D 97080, Wurzburg, Germany
    Arthritis Res Ther 17:61. 2015
    ..We therefore focused on DN B cells in RA, studied their isotypes and modulation during interleukin-6 receptor (IL-6R) inhibition by tocilizumab (TCZ)...
  12. ncbi request reprint Long-term repopulation of peripheral B-cell subsets after single and repeated rituximab infusions in patients with rheumatoid arthritis
    Petra Roll
    Department of Medicine II, Rheumatology and Clinical Immunology, University of Wurzburg, Wurzburg, Germany
    Clin Exp Rheumatol 33:347-53. 2015
    ..Long-term effects on the B-cell system after single and repeated treatments are sparse. Our aim was to study the effect of multiple courses of rituximab to evaluate its impact on repeated B-cell re-population capacity...
  13. doi request reprint Anti-CD20 therapy in patients with rheumatoid arthritis: predictors of response and B cell subset regeneration after repeated treatment
    Petra Roll
    University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 58:1566-75. 2008
    ..The effects on B cell homeostasis after repeated treatments and the relationship of certain B cell subsets to clinical response or relapse are currently not known...
  14. ncbi request reprint Effective B cell depletion with rituximab in the treatment of autoimmune diseases
    Christian Kneitz
    Medizinische Poliklinik der Universität Würzburg, Germany
    Immunobiology 206:519-27. 2002
    ..Further studies are needed to assess the clinical benefit of B cell depletion in the treatment of autoimmune diseases...
  15. ncbi request reprint Micronodular thymoma: an epithelial tumour with abnormal chemokine expression setting the stage for lymphoma development
    Philipp Strobel
    Institute of Pathology, University of Wurzburg, Germany
    J Pathol 207:72-82. 2005
    ....
  16. ncbi request reprint Psoriatic arthritis: clinical spectrum and diagnostic procedures
    Stefan Kleinert
    Medizinische Klinik and Poliklinik II, Department of Rheumatology and Clinical Immunology, University of Wuerzburg, Klinikstrasse 6, D 97070 Wurzburg, Germany
    Clin Dermatol 25:519-23. 2007
    ..This article reviews the clinical spectrum and diagnostic procedures that can lead to the diagnosis of psoriatic arthritis...
  17. pmc Frequency of Regulatory T Cells is Not Affected by Transient B Cell Depletion Using Anti-CD20 Antibodies in Rheumatoid Arthritis
    Martin Feuchtenberger
    University of Wurzburg, Department of Medicine II, Rheumatology and Clinical Immunology, Germany
    Open Rheumatol J 2:81-8. 2008
    ..Recently a characteristic regeneration pattern of B cell subpopulations has been reported. However, little is known about the impact of B-cell depletion on peripheral T cells in particular regulatory T cells...
  18. doi request reprint Psoriatic arthritis: therapeutic principles
    Martin Feuchtenberger
    Medizinische Klinik and Poliklinik II, Department of Rheumatology and Clinical Immunology, University of Wurzburg, Klinikstrasse 6, D 97070 Wurzburg, Germany
    Clin Dermatol 26:460-3. 2008
    ..Substantial improvement in understanding immunopathology of PsA has led to a variety of new therapeutic options. This article reviews the current therapeutic principles for PsA...
  19. doi request reprint CD27-IgD- memory B cells are modulated by in vivo interleukin-6 receptor (IL-6R) blockade in rheumatoid arthritis
    Zafar Mahmood
    Department of Medicine II, Rheumatology and Clinical Immunology, University of Wurzburg, Wurzburg, Germany
    Arthritis Res Ther 17:580. 2015
    ..We therefore focused on DN B cells in RA, studied their isotypes and modulation during interleukin-6 receptor (IL-6R) inhibition by tocilizumab (TCZ)...
  20. doi request reprint Effect of ATG-F on B-cell reconstitution after hematopoietic stem cell transplantation
    Petra Roll
    Department of Medicine II, University of Wurzburg, Wurzburg, Germany
    Eur J Haematol 95:514-23. 2015
    ..Thus, ATG seems also to negatively influence B-cell immune reconstitution. ..
  21. doi request reprint Vaccination survey in patients with rheumatoid arthritis: a cross-sectional study
    Martin Feuchtenberger
    Medizinische Klinik, Universität Wuerzburg, Schwerpunkt Rheumatologie Klinische Immunologie, Oberdürrbacherstrasse 6, 97080, Wuerzburg, Germany
    Rheumatol Int 32:1533-9. 2012
    ..Nevertheless, there was a discrepancy between vaccination awareness and actual vaccination rates for all cohorts...
  22. doi request reprint Human regulatory T cells are selectively activated by low-dose application of the CD28 superagonist TGN1412/TAB08
    Paula Tabares
    Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    Eur J Immunol 44:1225-36. 2014
    ..These results demonstrate the potential of appropriately dosed CD28SA and corticosteroid comedication to mobilize human Treg cells for the treatment of autoimmune and inflammatory conditions. ..
  23. ncbi request reprint Pax-5 is a key regulator of the B cell-restricted expression of the CD23a isoform
    Ioana Visan
    Medizinische Poliklinik, University of Wurzburg, Wurzburg, Germany
    Eur J Immunol 33:1163-73. 2003
    ..Our results suggest that Pax-5 is a key regulator of the B-cell-restricted expression of the CD23a isoform...
  24. ncbi request reprint Assessment of a case-based training system (d3web.Train) in rheumatology
    Stanislaus Reimer
    Medizinische Klinik und Poliklinik II, Department of Rheumatology and Clinical Immunology, University of Wurzburg, Klinikstr 6 8, 97070 Wurzburg, Germany
    Rheumatol Int 26:942-8. 2006
    ..Train offers a new tool for medical education in rheumatology. The main advantage of the system is the relatively low effort needed to create a case-based program starting from the available dismissal records...
  25. pmc Impact of patient and disease characteristics on therapeutic success during adalimumab treatment of patients with rheumatoid arthritis: data from a German noninterventional observational study
    Stefan Kleinert
    Rheumatologie Klinische Immunologie, Universitatsklinikum Wurzburg, Medizinische Klinik und Poliklinik II, Oberdürrbacherstr 6, 97080 Wurzburg, Germany
    Rheumatol Int 32:2759-67. 2012
    ..Patients with high disease activity and low functional capacity are particularly benefitted by adalimumab therapy...
  26. pmc Nucleoporin p62 antibodies in a case of mixed connective tissue disease
    Doris M Kraemer
    Medizinische Poliklinik, University of Wurzburg, 97070 Wurzburg, Germany
    Clin Diagn Lab Immunol 10:329-31. 2003
    ..Thus far, p62 antibodies have mainly been described in cases of primary biliary cirrhosis. We speculate that the presence of p62 antibodies is an indication of a poor prognosis in connective tissue disorders...
  27. doi request reprint Efficacy and safety of rituximab treatment in patients with antineutrophil cytoplasmic antibody-associated vasculitides: results from a German registry (GRAID)
    Petra Roll
    Department of Rheumatology and Clinical Immunology, University of Wurzburg, Wurzburg, Germany
    J Rheumatol 39:2153-6. 2012
    ..We investigated the tolerability and clinical efficacy of RTX in a cohort of patients with refractory AAV...
  28. ncbi request reprint Sun-induced life-threatening lupus nephritis
    Enno Schmidt
    Department of Dermatology, University of Wurzburg, Wurzburg, Germany
    Ann N Y Acad Sci 1108:35-40. 2007
    ..The patient highlights the impact of UV light not only on skin but also on internal organ involvement in LE...
  29. pmc Sustained Remission After Combination Therapy with Rituximab and Etanercept in Two Patients with Rheumatoid Arthritis After TNF Failure: Case Report
    Martin Feuchtenberger
    University of Wurzburg, Dept of Medicine II, Rheumatology and Clinical Immunology, Germany Department of Medicine II, Klinikum Südstadt Rostock, Germany
    Open Rheumatol J 3:9-13. 2009
    ..MATERIALS AND METHODOLOGY: We report two female patients suffering from active, refractory rheumatoid arthritis despite TNF blocking agents who have been treated with rituximab added to ongoing therapy with etanercept...
  30. doi request reprint Delayed acquisition of somatic hypermutations in repopulated IGD+CD27+ memory B cell receptors after rituximab treatment
    Khalid Muhammad
    Medizinische Klinik II, Department of Rheumatology and Clinical Immunology, University of Wurzburg, Wurzburg, Germany
    Arthritis Rheum 60:2284-93. 2009
    ..This study was undertaken to determine whether mutational acquisition in individual B cell receptors in repopulating class-switched and non-class-switched memory B cells is affected by rituximab...