Research Topics
Genomes and GenesSpecies | Eva TolosaSummaryCountry: Germany Publications
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Publications
Temporal and spatial dynamics of cerebral immune cell accumulation in strokeMathias Gelderblom
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Stroke 40:1849-57. 2009..The objectives of this study were to define the temporal and spatial infiltration of immune cell populations and their activation patterns in a murine cerebral ischemia-reperfusion injury model...
Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravisEva Tolosa
Neuroimmunology, Department of Neurology, Tubingen University Hospital, Auf der Morgenstelle 15, 72076 Tubingen, Germany
J Clin Invest 112:517-26. 2003....- The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in miceMathias Gelderblom
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
J Cereb Blood Flow Metab 32:835-43. 2012..Our findings strongly suggest that the fisetin-mediated inhibition of the inflammatory response after stroke is part of the mechanism through which fisetin is neuroprotective in cerebral ischemia... 
Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathiesHeinz Wiendl
Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, D 72076 Tubingen, Germany
J Neuroimmunol 138:132-43. 2003..We therefore conclude that CatS is involved in the regulation of class II expression in human myoblasts independently from Ii processing...- Expression of the B7-related molecule ICOSL by human glioma cells in vitro and in vivoBettina Schreiner
Department of Neurology, University of Tubingen, Medical School, Tubingen, Germany
Glia 44:296-301. 2003..However, ICOSL gene transfer into glioma cells does not alter their immunogenicity under primary or secondary alloreactive coculture assays... - The CD28 related molecule ICOS: T cell modulation in the presence and absence of B7.1/2 and regulational expression in multiple sclerosisHeinz Wiendl
Department of Neurology, University of Tubingen, Hoppe Seyler Strasse 3, Tubingen, D 72076, Germany
J Neuroimmunol 140:177-87. 2003..In MS patients we demonstrate the functionality of the ICOS costimulatory pathway. Potential implications of ICOSL/ICOS interactions for MS immunopathogenesis are discussed... - Prednisolone treatment induces tolerogenic dendritic cells and a regulatory milieu in myasthenia gravis patientsClaudia Luther
Department of General Neurology and Neurodegenerative Disorders, Hertie Institute for Clinical Brain Research, Tubingen University Hospital, Germany
J Immunol 183:841-8. 2009..The results shown in this study indicate that prednisolone treatment promotes an environment that favors immune regulation rather than inflammation... - Different patterns of nicotinic acetylcholine receptor subunit transcription in human thymusRoxana Bruno
Reference Health Services-Center for Transfusion and Tissue Bank, Department of Cell Biology, Physiology and Immunology, , Hospital Universitari Germans Trias i Pujol, Spain
J Neuroimmunol 149:147-59. 2004..The different patterns of subunit expression may influence decisively the level of central tolerance to the subunits and explain the focusing of the T cell response to the alpha and gamma subunits... - Polymorphisms in the cathepsin L2 (CTSL2) gene show association with type 1 diabetes and early-onset myasthenia gravisMarte K Viken
Institute of Immunology, Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
Hum Immunol 68:748-55. 2007..No association was observed in rheumatoid arthritis or juvenile idiopathic arthritis. Our findings suggest that the CTSL2 gene is associated with T1D and with early-onset MG... - Interferon-gamma regulates cathepsin G activity in microglia-derived lysosomes and controls the proteolytic processing of myelin basic protein in vitroTimo Burster
Department of Medicine II, University of Tubingen, Germany
Immunology 121:82-93. 2007..Thus, the cytokine environment modulates lysosomal proteases in microglia by a selective down-regulation of CatG, leading to decreased MBP-processing by microglia-derived lysosomal proteases in vitro... - Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytesTimo Burster
Department of Medicine II, University of Tubingen, Tubingen, Germany
J Immunol 172:5495-503. 2004..Internalization of exogenous CatG represents a novel mechanism of professional APC to acquire functionally dominant proteolytic activity that complements the panel of endogenous lysosomal enzymes... - HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammationUte Feger
Department of General Neurology, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tuebingen, Tuebingen, Germany
Blood 110:568-77. 2007.... - Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegenerationDaniela Rosenkranz
Department of Cellular Neurology, Tubingen, Germany
J Neuroimmunol 188:117-27. 2007..The analysis of Treg from AD and PD patients as well as non-affected individuals, revealed that the frequency of Treg (CD4(+)Foxp3(+)) increases with age and is accompanied by intensified suppressive activity for Treg in patients... - Characterization of a conduit system containing laminin-5 in the human thymus: a potential transport system for small moleculesMihaela Drumea-Mirancea
Section for Transplantation Immunology and Immunohematology, Center for Medical Research, , , Germany
J Cell Sci 119:1396-405. 2006.... - Human cytomegalovirus infection interferes with major histocompatibility complex type II maturation and endocytic proteases in dendritic cells at multiple levelsTobias Kessler
Department of Virology, University of Tubingen, Tubingen, Germany
J Gen Virol 89:2427-36. 2008..Thus, HCMV infection interferes with MHC II biosynthesis and maturation, as well as with the expression and function of endocytic proteases in infected DCs... - Differential processing of autoantigens in lysosomes from human monocyte-derived and peripheral blood dendritic cellsTimo Burster
Department of Medicine II, , , Germany
J Immunol 175:5940-9. 2005..Thus, human MO-DC and PB-DC significantly differ with respect to their repertoire of active endocytic proteases, so that both proteolytic machineries process a given autoantigen via different proteolytic pathways... - Human CD4+ T cells displaying viral epitopes elicit a functional virus-specific memory CD8+ T cell responseEleni Adamopoulou
Medical Clinic and Polyclinic II, Julius Maximilian University of Würzburg, Röntgernring 11, D 97070 Wurzburg, Germany
J Immunol 178:5465-72. 2007..These results indicate that viral epitope presentation by Ag-specific CD4+ T cells may contribute to the rapid recruitment of virus-specific memory CD8+ T cells during a viral recall response...