Thomas Thum

Summary

Country: Germany

Publications

  1. ncbi Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1
    Thomas Thum
    Universitat Wurzburg, Medizinische Klinik I Kardiologie, Wurzburg, Germany
    Circ Res 100:434-43. 2007
  2. pmc Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitat Wurzburg, Wurzburg, Germany
    Am J Pathol 171:507-12. 2007
  3. ncbi Spotlight on endothelial progenitor cell inhibitors: short review
    Thomas Thum
    Medizinische Klinik, Kardiologie, Julius Maximilians Universitat Wurzburg, Germany
    Vasc Med 10:S59-64. 2005
  4. ncbi The dying stem cell hypothesis: immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle
    Thomas Thum
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College of Medicine, London, United Kingdom
    J Am Coll Cardiol 46:1799-802. 2005
  5. ncbi Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I Kardiologie, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 92:4172-9. 2007
  6. ncbi Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells
    Thomas Thum
    Medizinische Klinik I, Kardiologie, Universitatsklinikum Wurzburg, Julius Maximilians Universitat, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 70:50-60. 2006
  7. ncbi Microarray-based gene expression profiling to elucidate cellular responses to nitric oxide--a review from an analytical and biomedical point of view
    Thomas Thum
    Bayerische Julius Maximilians Universität, Universitatsklinikum, Medizinische Klinik und Poliklinik I, Kardiologie, Wurzburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:3-11. 2007
  8. ncbi Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Diabetes 56:666-74. 2007
  9. ncbi MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure
    Thomas Thum
    University of Wurzburg, University Hospital, Department of Internal Medicine I, Cardiology, Wurzburg, Germany
    Circulation 116:258-67. 2007
  10. ncbi Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress
    Thomas Thum
    Department of Cardiology, University of Wurzburg, University Hospital, Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 27:748-54. 2007

Detail Information

Publications47

  1. ncbi Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1
    Thomas Thum
    Universitat Wurzburg, Medizinische Klinik I Kardiologie, Wurzburg, Germany
    Circ Res 100:434-43. 2007
    ..Growth hormone-mediated increase in IGF-1 reverses age-related EPC dysfunction and may be a novel therapeutic strategy against vascular disorders with impairment of EPC...
  2. pmc Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury
    Stefan Frantz
    Medizinische Klinik und Poliklinik I, Herz Kreislaufzentrum, Universitat Wurzburg, Wurzburg, Germany
    Am J Pathol 171:507-12. 2007
    ..Bone marrow transplantation experiments indicate that impaired NF-kappaB activation in p50 KO leukocytes attenuates cardiac damage...
  3. ncbi Spotlight on endothelial progenitor cell inhibitors: short review
    Thomas Thum
    Medizinische Klinik, Kardiologie, Julius Maximilians Universitat Wurzburg, Germany
    Vasc Med 10:S59-64. 2005
    ..Drug-induced mobilization and improvement of EPC function, as well as reduction of EPC inhibitors, is likely to enhance endothelial function and reduce atherosclerotic processes...
  4. ncbi The dying stem cell hypothesis: immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle
    Thomas Thum
    Department of Clinical Cardiology, National Heart and Lung Institute, Imperial College of Medicine, London, United Kingdom
    J Am Coll Cardiol 46:1799-802. 2005
    ..This leads to reduced scar formation, repressed myocardial apoptosis, and improved cardiac outcome...
  5. ncbi Growth hormone treatment improves markers of systemic nitric oxide bioavailability via insulin-like growth factor-I
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I Kardiologie, 97080 Wurzburg, Germany
    J Clin Endocrinol Metab 92:4172-9. 2007
    ..We investigated whether improved systemic NO bioavailability and increased levels of EPC after GH treatment are related and mediated by the IGF-I...
  6. ncbi Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells
    Thomas Thum
    Medizinische Klinik I, Kardiologie, Universitatsklinikum Wurzburg, Julius Maximilians Universitat, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Cardiovasc Res 70:50-60. 2006
    ..However, potential underlying mechanisms have not yet been investigated...
  7. ncbi Microarray-based gene expression profiling to elucidate cellular responses to nitric oxide--a review from an analytical and biomedical point of view
    Thomas Thum
    Bayerische Julius Maximilians Universität, Universitatsklinikum, Medizinische Klinik und Poliklinik I, Kardiologie, Wurzburg, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:3-11. 2007
    ..We also point out the limitations of general microarray-based gene expression analyses and especially when investigating the effects of NO...
  8. ncbi Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes
    Thomas Thum
    Universitatsklinikum, Medizinische Klinik I, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Diabetes 56:666-74. 2007
    ..Subsequent reduction of EPC levels and impairment of EPC function likely contributes to the pathogenesis of vascular disease in diabetes...
  9. ncbi MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure
    Thomas Thum
    University of Wurzburg, University Hospital, Department of Internal Medicine I, Cardiology, Wurzburg, Germany
    Circulation 116:258-67. 2007
    ..Here we provide evidence that cardiac microRNAs, recently discovered key regulators of gene expression, contribute to the transcriptional changes observed in heart failure...
  10. ncbi Differential effects of organic nitrates on endothelial progenitor cells are determined by oxidative stress
    Thomas Thum
    Department of Cardiology, University of Wurzburg, University Hospital, Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 27:748-54. 2007
    ..Endothelial nitric oxide synthase (eNOS)-derived NO regulates EPC mobilization and function. Organic nitrates release NO, and therefore may favorably affect EPC biology...
  11. ncbi MicroRNAs: novel regulators in cardiac development and disease
    Thomas Thum
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat, Josef Schneider Street 2, D 97080 Wurzburg, Germany
    Cardiovasc Res 79:562-70. 2008
    ..Finally, we focus on the development and use of miRNA antagonists (antagomirs) to target miRNAs in vivo, which may translate into novel therapeutic strategies for heart disease in the future...
  12. ncbi Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine
    Thomas Thum
    Bayerische Julius Maximilians Universität, Medizinische Klinik I, Wurzburg, Germany
    J Am Coll Cardiol 46:1693-701. 2005
    ..We tested the hypothesis that asymmetric dimethylarginine (ADMA) may be an endogenous inhibitor of endothelial progenitor cells (EPCs)...
  13. ncbi Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction
    Daniela Fraccarollo
    Medizinische Klinik und Poliklinik I, Universitatsklinikum, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    Circulation 118:818-27. 2008
    ..In this study, we investigated whether the transcription enhancer of endothelial NO synthase (eNOS) AVE9488 improves cardiac remodeling and heart failure after experimental myocardial infarction (MI)...
  14. doi LOX-1 receptor blockade abrogates oxLDL-induced oxidative DNA damage and prevents activation of the transcriptional repressor Oct-1 in human coronary arterial endothelium
    Thomas Thum
    Medizinische Klinik I, Kardiologie, Julius Maximilians Universitat, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    J Biol Chem 283:19456-64. 2008
    ..Taken collectively, oxLDL induced oxidative DNA damage and activation of Oct-1 to result in metabolic dysfunction of coronary arterial endothelium...
  15. ncbi Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence
    Fortunato Scalera
    Institute of Clinical Pharmacology, University Hospital, Otto von Guericke University, Magdeburg, Germany
    Arterioscler Thromb Vasc Biol 24:1816-22. 2004
    ..Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), and its accumulation has been associated with cardiovascular disease. We aimed to investigate the role of ADMA in endothelial cell senescence...
  16. doi Urinary asymmetric dimethylarginine (ADMA) is a predictor of mortality risk in patients with coronary artery disease
    Christian Wolf
    Institut für Molekulare und Translationale Therapiestrategien IMTTS, Medizinische Hochschule, Hannover, Germany
    Int J Cardiol 156:289-94. 2012
    ..Unlike circulating ADMA, very little is known about urinary ADMA and DMA concentrations and a predictive value in CAD patients...
  17. pmc The IGF-1 receptor as a therapeutic target to improve endothelial progenitor cell function
    Felix Fleissner
    Julius Maximilians Universitat, Medizinische Klinik I Kardiologie, Wurzburg, Germany
    Mol Med 14:235-7. 2008
  18. doi Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis
    Christian Werner
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    J Am Coll Cardiol 52:470-82. 2008
    ..The purpose of this study was to study the underlying molecular mechanisms of the protective cardiac effects of physical exercise...
  19. ncbi Inhibition of proteasome-mediated glucocorticoid receptor degradation restores nitric oxide bioavailability in myocardial endothelial cells in vitro
    Kinga G Blecharz
    University of Wurzburg, Department of Anaesthesia and Critical Care, Wurzburg, 97080, Germany
    Biol Cell 106:219-35. 2014
    ..One of the numerous side effects of dexamethasone therapy is hypertension arising from reduced release of the endothelium-derived vasodilator nitric oxide (NO)...
  20. ncbi TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy
    Anna Baumgarten
    Center for Cardiovascular Research, Charite Medical School, Berlin, Germany Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    Int J Cardiol 168:1447-52. 2013
    ..This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1...
  21. ncbi Recent patents on cardiovascular stem cells
    Marten Jakob
    Universitatsklinik, Medizinische Klinik I, Kardiologie, Wurzburg, Germany
    Recent Pat Cardiovasc Drug Discov 3:59-72. 2008
    ..A systematic overview on the current patent situation about use of stem cells in cardiovascular medicine should facilitate future decision making in the development of novel therapeutic strategies in regenerative medicine...
  22. pmc Prevention of liver cancer cachexia-induced cardiac wasting and heart failure
    Jochen Springer
    Applied Cachexia Research, Department of Cardiology, Charite Medical School, Campus Virchow Klinikum, Berlin, Germany
    Eur Heart J 35:932-41. 2014
    ..Herein, we evaluate the effects of drugs commonly used to treat HF (bisoprolol, imidapril, spironolactone) on development of cardiac wasting, HF, and death in the rat hepatoma CC model (AH-130)...
  23. doi Role of miR-21 in the pathogenesis of atrial fibrosis
    Oliver Adam
    Klinik fur Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitatsklinikum des Saarlandes, Homburg Saar, Germany
    Basic Res Cardiol 107:278. 2012
    ..Activation of Rac1 by angiotensin II leads to a CTGF- and lysyl oxidase-mediated increase of miR-21 expression contributing to structural remodelling of the atrial myocardium...
  24. doi No effects of human ghrelin on cardiac function despite profound effects on body composition in a rat model of heart failure
    Yoshihiro J Akashi
    Division of Applied Cachexia Research, Department of Cardiology, Charite Medical School, Berlin, Germany
    Int J Cardiol 137:267-75. 2009
    ..Ghrelin, was observed to have treatment-potential for severe chronic heart failure (CHF) and cardiac cachexia based on anti-cachectic and cardio-protective effects...
  25. doi Glucocorticoid insensitivity at the hypoxic blood-brain barrier can be reversed by inhibition of the proteasome
    Christoph Kleinschnitz
    University of Wurzburg, Department of Neurology, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Stroke 42:1081-9. 2011
    ..The reasons for this discrepancy are unresolved...
  26. doi Letter by Thum et al regarding article, "Oxidant stress impairs in vivo reendothelialization capacity of endothelial progenitor cells from patients with type 2 diabetes mellitus: restoration by the peroxisome proliferator-activated receptor-gamma ago
    Thomas Thum
    Circulation 117:e185; author reply e186. 2008
  27. ncbi Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension
    Gerhard Paul Diller
    Adult Congenital Heart Centre and Centre for Pulmonary Hypertension, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK
    Circulation 117:3020-30. 2008
    ..We speculated that PAH patients are deficient in circulating endothelial progenitor cells (EPCs), potentially contributing to endothelial dysfunction and disease progression...
  28. pmc Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus
    Philip Wenzel
    Second Medical Clinic, Department of Cardiology and Angiology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    Atherosclerosis 198:65-76. 2008
    ....
  29. ncbi GC-MS assay for hepatic DDAH activity in diabetic and non-diabetic rats by measuring dimethylamine (DMA) formed from asymmetric dimethylarginine (ADMA): evaluation of the importance of S-nitrosothiols as inhibitors of DDAH activity in vitro and in vivo in
    Kristine Chobanyan
    Institute of Clinical Pharmacology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 858:32-41. 2007
    ..The GC-MS assay reported here should be suitable to probe for DDAH activity in various disease models...
  30. ncbi Growth hormone induces eNOS expression and nitric oxide release in a cultured human endothelial cell line
    Thomas Thum
    Fraunhofer Institute of Toxicology and Experimental Medicine ITEM, Drug Research and Medical Biotechnology, 30625, Hannover, Germany
    FEBS Lett 555:567-71. 2003
    ..The enhanced eNOS gene/protein expression and enzyme activity correlate well. Our findings are suggestive for a novel role of growth hormone in endothelial biology, and particularly NO production...
  31. ncbi Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells
    Jurgen Borlak
    Center for Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Nicolai Fuchs Str 1, D 30659 Hannover, Germany
    Drug Metab Dispos 31:888-91. 2003
    ....
  32. ncbi Mobilization of bone marrow-derived stem cells after myocardial infarction and left ventricular function: simply effects of optimized drug treatment?
    Thomas Thum
    Eur Heart J 26:1685; author reply 1685-6. 2005
  33. ncbi Mechanistic role of cytochrome P450 monooxygenases in oxidized low-density lipoprotein-induced vascular injury: therapy through LOX-1 receptor antagonism?
    Thomas Thum
    Center of Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover, Germany
    Circ Res 94:e1-13. 2004
    ..Therapy of endothelial dysfunction through LOX-1 receptor antagonism will be an interesting avenue to explore. The full text of this article is available online at http://www.circresaha.org...
  34. ncbi Accurate quantification of dimethylamine (DMA) in human urine by gas chromatography-mass spectrometry as pentafluorobenzamide derivative: evaluation of the relationship between DMA and its precursor asymmetric dimethylarginine (ADMA) in health and disease
    Dimitrios Tsikas
    Institut fur Klinische Pharmakologie, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 851:229-39. 2007
    ..17+/-4.2) being insignificantly lower (P=0.46). Between urinary DMA and ADMA there was a positive correlation (R=0.6655, P<0.0001) in coronary artery disease, but no correlation (R=0.27339) was found in end-stage liver disease...
  35. ncbi Sports or statins for atheroprotection? New insight from Kruppel-like factor 2
    Thomas Thum
    Cardiovasc Res 72:193-5. 2006
  36. ncbi Tilarginine in patients with acute myocardial infarction and cardiogenic shock
    Jan T Kielstein
    JAMA 298:971; author reply 972-3. 2007
  37. ncbi Verapamil: new insight into the molecular mechanism of drug oxidation in the human heart
    Markus Walles
    Fraunhofer Institute of Toxicology and Aerosol Research, Center of Drug Research and Medical Biotechnology, Hannover, Germany
    J Chromatogr A 970:117-30. 2002
    ..A fine example of the considerable metabolic competence of human heart is the formation of M1-M4, e.g. dealkylverapamil, norverapamil and isomers of O-demethylverapamil, which were believed to be exclusively produced by the liver...
  38. ncbi Hallmarks of ion channel gene expression in end-stage heart failure
    Jurgen Borlak
    Fraunhofer Institute of Toxicology and Experimental Medicine, Center for Drug Research and Medical Biotechnology, 30625 Hannover, Germany
    FASEB J 17:1592-608. 2003
    ..Overall, the reversal of repressed ion channel gene expression in patients with implanted assist devices exemplifies the complex interactions between pressure load/stretch force and heart-specific gene expression...
  39. ncbi A rapid and simple CYP2D6 genotyping assay--case study with the analgetic tramadol
    Jurgen Borlak
    Fraunhofer Institute of Toxicology and Experimental Mecicine, Center of Drug Research and Medical Biotechnology, Hannover, Germany
    Metabolism 52:1439-43. 2003
    ..Our assay can be used reliably in clinical pharmacology studies and may be used for dose adjustment...
  40. ncbi Testosterone, cytochrome P450, and cardiac hypertrophy
    Thomas Thum
    Center of Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Aerosol Research, Hannover, Germany
    FASEB J 16:1537-49. 2002
    ..We show alpha-MHC to be significantly repressed in cardiac hypertrophy and restored to normal on testosterone supplementation. We conclude that heart-specific steroid metabolism is of critical importance in cardiac hypertrophy..
  41. doi Cardiac dissonance without conductors: how dicer depletion provokes chaos in the heart
    Thomas Thum
    Circulation 118:1524-7. 2008
  42. ncbi Detection of early signals of hepatotoxicity by gene expression profiling studies with cultures of metabolically competent human hepatocytes
    Thomas Thum
    Fraunhofer Institute of Toxicology and Experimental Medicine, Centre for Drug Research and Medical Biotechnology, Nikolai Fuchs Str 1, 30625, Hannover, Germany
    Arch Toxicol 82:89-101. 2008
    ..In conclusion, xenobiotic induced hepatotoxicity may arise via several mechanisms and gene expression profiling helps to pinpoint location and pathways perturbed by drugs and chemicals...
  43. ncbi Androgen metabolism in thymus of fetal and adult rats
    Jurgen Borlak
    Fraunhofer Institute of Toxicology and Experimental Medicine, Center for Drug Research and Medical Biotechnology, Nikolai Fuchs Str 1, D 30625 Hannover, Germany
    Drug Metab Dispos 32:675-9. 2004
    ..Changes of the underlying steroid-metabolizing enzyme systems may aid in understanding the role of androgens in altering biological functions of the thymus...
  44. ncbi Clostridium difficile toxin A induces expression of the stress-induced early gene product RhoB
    Ralf Gerhard
    Institute of Toxicology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Biol Chem 280:1499-505. 2005
    ....
  45. ncbi Obesity and risk of myocardial infarction: the INTERHEART study
    Thomas Thum
    Lancet 367:1051-2; author reply 1054. 2006
  46. pmc Expression of xenobiotic metabolizing enzymes in different lung compartments of smokers and nonsmokers
    Thomas Thum
    Drug Research and Medical Biotechnology, Fraunhofer Instituteof technology and Experimental Medicien, Hannover, Germany
    Environ Health Perspect 114:1655-61. 2006
    ..Cytochrome P450 monooxygenases (CYP) play an important role in the defense against inhaled toxicants, and expression of CYP enzymes may differ among various lung cells and tissue compartments...
  47. ncbi Aroclor 1254 modulates gene expression of nuclear transcription factors: implications for albumin gene transcription and protein synthesis in rat hepatocyte cultures
    Jurgen Borlak
    Center for Drug Research and Medical Biotechnology, Fraunhofer Institute of Toxicology and Aerosol Research, Germany
    Toxicol Appl Pharmacol 181:79-88. 2002
    ....