Christoph Thorns

Summary

Country: Germany

Publications

  1. ncbi request reprint Significant high expression of CD23 in follicular lymphoma of the inguinal region
    C Thorns
    Institute of Pathology and German Reference and Consultation Centre for Haematopathy and Lymphoproliferative Diseases, University Clinic Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Histopathology 50:716-9. 2007
  2. doi request reprint Hibernoma-like brown fat in the bone marrow: report of a unique case
    C Thorns
    Institut für Pathologie und Konsultations und Referenzzentrum für Lymphknotendiagnostik und Hämatopathologie, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Virchows Arch 452:343-5. 2008
  3. ncbi request reprint Chromosomal aberrations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma unspecified: A matrix-based CGH approach
    Christoph Thorns
    Department of Pathology, German Consultation and Reference Center for Lymphomas, University Clinic Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Genes Chromosomes Cancer 46:37-44. 2007
  4. doi request reprint MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas
    Anja Roehle
    Institute for Pathology, University Clinic Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Br J Haematol 142:732-44. 2008
  5. doi request reprint Prevalence of targetable oncogenic mutations and genomic alterations in Epstein-Barr virus-associated diffuse large B-cell lymphoma of the elderly
    Niklas Gebauer
    Department of Internal Medicine I, University Hospital of Schleswig Holstein, Luebeck, Germany
    Leuk Lymphoma 56:1100-6. 2015
  6. ncbi request reprint cDNA arrays: gene expression profiles of Hodgkin's disease and anaplastic large cell lymphoma cell lines
    Christoph Thorns
    Department of Pathology, German Consultation and Reference Center for Lymphomas, Medical University of Luebeck, Luebeck, Germany
    Pathol Int 52:578-85. 2002
  7. doi request reprint Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 15:1107. 2015
  8. doi request reprint MicroRNA profiling of low-grade and transformed nodal marginal zone lymphoma reveals a similar signature pattern distinct from diffuse large B cell lymphoma
    Niklas Gebauer
    Department of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Acta Haematol 133:214-20. 2015
  9. ncbi request reprint BCL6-translocations affect the phenotype of follicular lymphomas only in the absence of t(14;18)IgH/BCL2
    Wiebke Gollub
    Department of Pathology, University Clinic Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Anticancer Res 29:4649-55. 2009
  10. doi request reprint TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and BCL6 translocations
    Niklas Gebauer
    Department of Pathology, Reference Center for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig Holstein, Luebeck, Germany
    Leuk Lymphoma 56:179-85. 2015

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Significant high expression of CD23 in follicular lymphoma of the inguinal region
    C Thorns
    Institute of Pathology and German Reference and Consultation Centre for Haematopathy and Lymphoproliferative Diseases, University Clinic Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Histopathology 50:716-9. 2007
    ..The aim was to investigate the morphology and immunophenotype of follicular lymphomas (FL) in order to clarify whether FL presenting in inguinal nodes differs from FL biopsies from other sites...
  2. doi request reprint Hibernoma-like brown fat in the bone marrow: report of a unique case
    C Thorns
    Institut für Pathologie und Konsultations und Referenzzentrum für Lymphknotendiagnostik und Hämatopathologie, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Virchows Arch 452:343-5. 2008
    ..To the best of our knowledge, this is the first report on brown adipose tissue in the bone marrow...
  3. ncbi request reprint Chromosomal aberrations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma unspecified: A matrix-based CGH approach
    Christoph Thorns
    Department of Pathology, German Consultation and Reference Center for Lymphomas, University Clinic Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Genes Chromosomes Cancer 46:37-44. 2007
    ..In conclusion, CGH revealed common genetic events in peripheral T-cell lymphomas as well as peculiar differences between AILT and PTCL-u...
  4. doi request reprint MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas
    Anja Roehle
    Institute for Pathology, University Clinic Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Br J Haematol 142:732-44. 2008
    ..Finally, eight miRNAs were found to correlate with event-free and overall survival in DLBCL including known tumour suppressors (MIRN21, MIRN127 and MIRN34a) and oncogenes (MIRN195 and MIRNLET7G)...
  5. doi request reprint Prevalence of targetable oncogenic mutations and genomic alterations in Epstein-Barr virus-associated diffuse large B-cell lymphoma of the elderly
    Niklas Gebauer
    Department of Internal Medicine I, University Hospital of Schleswig Holstein, Luebeck, Germany
    Leuk Lymphoma 56:1100-6. 2015
    ..Few mutations affecting CD79B and CARD11 and no MYD88 mutations were detectable, hinting at EBV-mediated activation of NF-κB as an alternative to pathologically enforced B-cell receptor signaling in this rare entity. ..
  6. ncbi request reprint cDNA arrays: gene expression profiles of Hodgkin's disease and anaplastic large cell lymphoma cell lines
    Christoph Thorns
    Department of Pathology, German Consultation and Reference Center for Lymphomas, Medical University of Luebeck, Luebeck, Germany
    Pathol Int 52:578-85. 2002
    ..Because the expression profiling was performed on cell lines, further studies are needed to clarify the biological significance of the differentially expressed genes...
  7. doi request reprint Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 15:1107. 2015
    ..This study investigated the prognostic role of nuclear expression of p65 in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) receiving post-operative radio(chemo)therapy...
  8. doi request reprint MicroRNA profiling of low-grade and transformed nodal marginal zone lymphoma reveals a similar signature pattern distinct from diffuse large B cell lymphoma
    Niklas Gebauer
    Department of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Acta Haematol 133:214-20. 2015
    ..Many hematologic malignancies exhibit distinct microRNA signatures. MicroRNA implication in the pathogenesis of nodal marginal zone lymphoma (NMZL), however, remains widely elusive...
  9. ncbi request reprint BCL6-translocations affect the phenotype of follicular lymphomas only in the absence of t(14;18)IgH/BCL2
    Wiebke Gollub
    Department of Pathology, University Clinic Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Anticancer Res 29:4649-55. 2009
    ..This study aimed to determine the frequency of BCL2- and BCL6-translocations in FL and to identify morphological and immuno-histochemical features with respect to the presence of BCL2- and BCL6-translocations...
  10. doi request reprint TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and BCL6 translocations
    Niklas Gebauer
    Department of Pathology, Reference Center for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig Holstein, Luebeck, Germany
    Leuk Lymphoma 56:179-85. 2015
    ..Immunohistochemical staining appears to be a sensitive surrogate of TP53 mutation status with moderate specificity...
  11. doi request reprint Oncogenic mutations and chromosomal aberrations in primary extranodal diffuse large B-cell lymphomas of the thyroid--a study of 21 cases
    Juliana Knief
    Department of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology J K, V B, J S, K R, A C F, C T, Department of Internal Medicine I N G, J G, G B, H L, and Department of Radiation Oncology D R, University Hospital of Schleswig Holstein, Campus Luebeck, 23538 Luebeck, Germany
    J Clin Endocrinol Metab 100:754-62. 2015
    ..Primary extranodal diffuse large B-cell lymphomas of the thyroid (ptDLBCL) constitute a rare entity, which until now was not fully explored...
  12. doi request reprint Sarcoma of follicular dendritic cells with features of sinus lining cells--a new subtype of reticulum cell sarcoma?
    Manuela Krokowski
    Department of Pathology, Reference Center for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Virchows Arch 452:565-70. 2008
    ..Due to the assumed specificity of this antibody, we propose designation of this reticulum cell sarcoma as lymphatic sinus lining cell sarcoma which might finally represent another subtype of reticulum cell sarcomas...
  13. ncbi request reprint Dysregulation of microRNAs in angioimmunoblastic T-cell lymphoma
    Katharina Reddemann
    Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Anticancer Res 35:2055-61. 2015
    ..MicroRNAs are a group of small non-coding RNAs that can negatively regulate gene expression on a posttranscriptional level. Their dysregulation has been shown to be of importance in numerous tumour entities...
  14. pmc Genomic landscape of pancreatic neuroendocrine tumors
    Niklas Gebauer
    Niklas Gebauer, Christian Schmidt Werthern, Veronica Bernard, Alfred C Feller, Christoph Thorns, Department of Pathology, University Hospital of Schleswig Holstein, 23538 Luebeck, Germany
    World J Gastroenterol 20:17498-506. 2014
    ..To investigate the prognostic role of genomic stability and copy number alterations (CNAs) pancreatic neuroendocrine tumors (PanNETs)...
  15. ncbi request reprint Activating mutations affecting the NF-kappa B pathway and EZH2-mediated epigenetic regulation are rare events in primary mediastinal large B-cell lymphoma
    Niklas Gebauer
    Department of Internal Medicine I, University Hospital of Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Anticancer Res 34:5503-7. 2014
    ..Several promising targeted-therapy approaches, derived from these findings, are currently under development...
  16. pmc Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - analyses of cases from two prospective randomized clinical trials
    Heinz Wolfram Bernd
    Institute of Pathology, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160 D 23538 Lübeck, Germany
    Haematologica 94:1569-80. 2009
    ....
  17. ncbi request reprint MicroRNA-150 Is up-regulated in extranodal marginal zone lymphoma of MALT type
    Niklas Gebauer
    Institut fur Pathologie, Universitat zu Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Deutschland
    Cancer Genomics Proteomics 11:51-6. 2014
    ..This follow-up study aimed to validate candidate microRNAs (miRs) in the process of neoplastic transformation...
  18. doi request reprint Deregulation of a distinct set of microRNAs is associated with transformation of gastritis into MALT lymphoma
    Christoph Thorns
    Institut für Pathologie und Referenzzentrum für Hämatopathologie und Lymphknotendiagnostik, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Universitat zu Lubeck, Lubeck, Germany
    Virchows Arch 460:371-7. 2012
    ..This differential expression might therefore indicate a central role of these microRNAs in the process of malignant transformation...
  19. ncbi request reprint Basal cell carcinoma with neuroendocrine differentiation arising in a scar: A case report
    Manuela Krokowski
    Department of Pathology, University Hospital of Schleswig Holstein, Campus Luebeck, Germany
    Dermatol Online J 15:4. 2009
    ..Neuroendocrine differentiation was proven by immunohistochemistry and electron microscopy. The simultaneous occurrence of BCC development in a scar and neuroendocrine differentiation is quite rare...
  20. ncbi request reprint Unlocking pathology archives for microRNA-profiling
    Kai P Hoefig
    Institute for Pathology, UKSH Campus Luebeck, Luebeck, Germany
    Anticancer Res 28:119-23. 2008
    ..A variety of high-throughput screening methods has been developed to identify dysregulated miRNA species in tumours. For retrospective clinical studies formalin-fixed, paraffin-embedded (FFPE) tissue is the most widely used material...
  21. ncbi request reprint Application of novel tissue microarrays to investigate expression of tryptase, chymase and KIT protein in placental mast cells
    Frank Noack
    Department of Pathology, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Arch Gynecol Obstet 272:223-8. 2005
    ..Because little is known about the role of mast cells in the placenta, we investigated the number and expression of chymase, tryptase, and KIT protein in placental mast cells using newly developed tissue microarrays...
  22. ncbi request reprint Prognostic value of MCM2 immunoreactivity in stage T1 transitional cell carcinoma of the bladder
    Stefan Kruger
    Institute of Pathology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    Eur Urol 43:138-45. 2003
    ..To our knowledge, there are no reports on studies investigating minichromosome maintenance protein 2 (MCM2) expression in bladder carcinomas. Thus, we investigated the prognostic value of MCM2 immunoreactivity in stage T1 bladder tumors...
  23. doi request reprint Evaluation of the prognostic role of tumor cell podoplanin expression in locally advanced squamous cell carcinoma of the head and neck
    Stefan Huttenlocher
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:1021-7. 2014
    ..To investigate the potential prognostic role of tumor cell podoplanin expression in patients treated with resection followed by irradiation or chemoradiotherapy for locally advanced squamous cell carcinoma of the head and neck (SCCHN)...
  24. ncbi request reprint Gene profiling in anaplastic large-cell lymphoma-derived cell lines with cDNA expression arrays
    Timo Gaiser
    Department of Pathology, Medical University of Luebeck, 23538 Luebeck, Germany
    J Hematother Stem Cell Res 11:423-8. 2002
    ....
  25. ncbi request reprint Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: validation of tissue microarray as a prerequisite for broad clinical applications--a study from the Lunenburg Lymphoma Biomarker Consortium
    Daphne de Jong
    Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 25:805-12. 2007
    ....
  26. doi request reprint Preservation of follicle mantle in follicular lymphoma
    Christoph Thorns
    Leuk Lymphoma 49:166-7. 2008