Christoph Thorns

Summary

Country: Germany

Publications

  1. ncbi EMMPRIN (CD 147) is expressed in Hodgkin's lymphoma and anaplastic large cell lymphoma. An immunohistochemical study of 60 cases
    Christoph Thorns
    Institute of Pathology, Medical University of Luebeck, Germany
    Anticancer Res 22:1983-6. 2002
  2. ncbi cDNA arrays: gene expression profiles of Hodgkin's disease and anaplastic large cell lymphoma cell lines
    Christoph Thorns
    Department of Pathology, German Consultation and Reference Center for Lymphomas, Medical University of Luebeck, Luebeck, Germany
    Pathol Int 52:578-85. 2002
  3. ncbi Matrix-metalloproteinases in Hodgkin lymphoma
    C Thorns
    Institute of Pathology, University of Luebeck, German Consultation and Reference Centre for Lymphomas, Germany
    Anticancer Res 23:1555-8. 2003
  4. doi Prevalence of targetable oncogenic mutations and genomic alterations in Epstein-Barr virus-associated diffuse large B-cell lymphoma of the elderly
    Niklas Gebauer
    Department of Internal Medicine I, University Hospital of Schleswig Holstein, Luebeck, Germany
    Leuk Lymphoma 56:1100-6. 2015
  5. doi Immunoblastic morphology but not the immunohistochemical GCB/nonGCB classifier predicts outcome in diffuse large B-cell lymphoma in the RICOVER-60 trial of the DSHNHL
    German Ott
    Institute of Pathology, University of Wurzburg, Wurzburg, Germany
    Blood 116:4916-25. 2010
  6. doi MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas
    Anja Roehle
    Institute for Pathology, University Clinic Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Br J Haematol 142:732-44. 2008
  7. doi miRNA expression profiling in formalin-fixed and paraffin-embedded placental tissue samples from pregnancies with severe preeclampsia
    Frank Noack
    Institute of Pathology, University of Lubeck, Germany
    J Perinat Med 39:267-71. 2011
  8. doi TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and BCL6 translocations
    Niklas Gebauer
    Department of Pathology, Reference Center for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig Holstein, Luebeck, Germany
    Leuk Lymphoma 56:179-85. 2015
  9. ncbi Dysregulation of microRNAs in angioimmunoblastic T-cell lymphoma
    Katharina Reddemann
    Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Anticancer Res 35:2055-61. 2015
  10. doi Oncogenic mutations and chromosomal aberrations in primary extranodal diffuse large B-cell lymphomas of the thyroid--a study of 21 cases
    Juliana Knief
    Department of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology J K, V B, J S, K R, A C F, C T, Department of Internal Medicine I N G, J G, G B, H L, and Department of Radiation Oncology D R, University Hospital of Schleswig Holstein, Campus Luebeck, 23538 Luebeck, Germany
    J Clin Endocrinol Metab 100:754-62. 2015

Collaborators

Detail Information

Publications24

  1. ncbi EMMPRIN (CD 147) is expressed in Hodgkin's lymphoma and anaplastic large cell lymphoma. An immunohistochemical study of 60 cases
    Christoph Thorns
    Institute of Pathology, Medical University of Luebeck, Germany
    Anticancer Res 22:1983-6. 2002
    ..Whereas TIMP-1 expression is described for high-grade malignant lymphomas and seems to be correlated with unfavourable prognosis, there are no data on the expression of EMMPRIN in malignant lymphoma...
  2. ncbi cDNA arrays: gene expression profiles of Hodgkin's disease and anaplastic large cell lymphoma cell lines
    Christoph Thorns
    Department of Pathology, German Consultation and Reference Center for Lymphomas, Medical University of Luebeck, Luebeck, Germany
    Pathol Int 52:578-85. 2002
    ..Because the expression profiling was performed on cell lines, further studies are needed to clarify the biological significance of the differentially expressed genes...
  3. ncbi Matrix-metalloproteinases in Hodgkin lymphoma
    C Thorns
    Institute of Pathology, University of Luebeck, German Consultation and Reference Centre for Lymphomas, Germany
    Anticancer Res 23:1555-8. 2003
    ..These morphological peculiarities led to the idea that the interaction between tumour cells and bystander cells as well as the extracellular matrix may be important in Hodgkin lymphomas...
  4. doi Prevalence of targetable oncogenic mutations and genomic alterations in Epstein-Barr virus-associated diffuse large B-cell lymphoma of the elderly
    Niklas Gebauer
    Department of Internal Medicine I, University Hospital of Schleswig Holstein, Luebeck, Germany
    Leuk Lymphoma 56:1100-6. 2015
    ..Few mutations affecting CD79B and CARD11 and no MYD88 mutations were detectable, hinting at EBV-mediated activation of NF-κB as an alternative to pathologically enforced B-cell receptor signaling in this rare entity. ..
  5. doi Immunoblastic morphology but not the immunohistochemical GCB/nonGCB classifier predicts outcome in diffuse large B-cell lymphoma in the RICOVER-60 trial of the DSHNHL
    German Ott
    Institute of Pathology, University of Wurzburg, Wurzburg, Germany
    Blood 116:4916-25. 2010
    ....
  6. doi MicroRNA signatures characterize diffuse large B-cell lymphomas and follicular lymphomas
    Anja Roehle
    Institute for Pathology, University Clinic Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Br J Haematol 142:732-44. 2008
    ..Finally, eight miRNAs were found to correlate with event-free and overall survival in DLBCL including known tumour suppressors (MIRN21, MIRN127 and MIRN34a) and oncogenes (MIRN195 and MIRNLET7G)...
  7. doi miRNA expression profiling in formalin-fixed and paraffin-embedded placental tissue samples from pregnancies with severe preeclampsia
    Frank Noack
    Institute of Pathology, University of Lubeck, Germany
    J Perinat Med 39:267-71. 2011
    ..The placenta is considered to play a key role in pathogenesis of preeclampsia. The purpose of this study was to demonstrate deregulation of miRNAs in placentas with preeclampsia using formalin-fixed and paraffin-embedded (FFPE) tissues...
  8. doi TP53 mutations are frequent events in double-hit B-cell lymphomas with MYC and BCL2 but not MYC and BCL6 translocations
    Niklas Gebauer
    Department of Pathology, Reference Center for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig Holstein, Luebeck, Germany
    Leuk Lymphoma 56:179-85. 2015
    ..Immunohistochemical staining appears to be a sensitive surrogate of TP53 mutation status with moderate specificity...
  9. ncbi Dysregulation of microRNAs in angioimmunoblastic T-cell lymphoma
    Katharina Reddemann
    Institute of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Medical Center Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Anticancer Res 35:2055-61. 2015
    ..MicroRNAs are a group of small non-coding RNAs that can negatively regulate gene expression on a posttranscriptional level. Their dysregulation has been shown to be of importance in numerous tumour entities...
  10. doi Oncogenic mutations and chromosomal aberrations in primary extranodal diffuse large B-cell lymphomas of the thyroid--a study of 21 cases
    Juliana Knief
    Department of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology J K, V B, J S, K R, A C F, C T, Department of Internal Medicine I N G, J G, G B, H L, and Department of Radiation Oncology D R, University Hospital of Schleswig Holstein, Campus Luebeck, 23538 Luebeck, Germany
    J Clin Endocrinol Metab 100:754-62. 2015
    ..Primary extranodal diffuse large B-cell lymphomas of the thyroid (ptDLBCL) constitute a rare entity, which until now was not fully explored...
  11. doi Sarcoma of follicular dendritic cells with features of sinus lining cells--a new subtype of reticulum cell sarcoma?
    Manuela Krokowski
    Department of Pathology, Reference Center for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Virchows Arch 452:565-70. 2008
    ..Due to the assumed specificity of this antibody, we propose designation of this reticulum cell sarcoma as lymphatic sinus lining cell sarcoma which might finally represent another subtype of reticulum cell sarcomas...
  12. ncbi BCL6-translocations affect the phenotype of follicular lymphomas only in the absence of t(14;18)IgH/BCL2
    Wiebke Gollub
    Department of Pathology, University Clinic Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Anticancer Res 29:4649-55. 2009
    ..This study aimed to determine the frequency of BCL2- and BCL6-translocations in FL and to identify morphological and immuno-histochemical features with respect to the presence of BCL2- and BCL6-translocations...
  13. doi MicroRNA profiling of low-grade and transformed nodal marginal zone lymphoma reveals a similar signature pattern distinct from diffuse large B cell lymphoma
    Niklas Gebauer
    Department of Pathology, Reference Centre for Lymph Node Pathology and Hematopathology, University Hospital of Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Acta Haematol 133:214-20. 2015
    ..Many hematologic malignancies exhibit distinct microRNA signatures. MicroRNA implication in the pathogenesis of nodal marginal zone lymphoma (NMZL), however, remains widely elusive...
  14. pmc Genomic landscape of pancreatic neuroendocrine tumors
    Niklas Gebauer
    Niklas Gebauer, Christian Schmidt Werthern, Veronica Bernard, Alfred C Feller, Christoph Thorns, Department of Pathology, University Hospital of Schleswig Holstein, 23538 Luebeck, Germany
    World J Gastroenterol 20:17498-506. 2014
    ..To investigate the prognostic role of genomic stability and copy number alterations (CNAs) pancreatic neuroendocrine tumors (PanNETs)...
  15. ncbi Gene profiling in anaplastic large-cell lymphoma-derived cell lines with cDNA expression arrays
    Timo Gaiser
    Department of Pathology, Medical University of Luebeck, 23538 Luebeck, Germany
    J Hematother Stem Cell Res 11:423-8. 2002
    ....
  16. pmc Loss of HLA-DR expression and immunoblastic morphology predict adverse outcome in diffuse large B-cell lymphoma - analyses of cases from two prospective randomized clinical trials
    Heinz Wolfram Bernd
    Institute of Pathology, Universitatsklinikum Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160 D 23538 Lübeck, Germany
    Haematologica 94:1569-80. 2009
    ....
  17. ncbi Prognostic value of MCM2 immunoreactivity in stage T1 transitional cell carcinoma of the bladder
    Stefan Kruger
    Institute of Pathology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    Eur Urol 43:138-45. 2003
    ..To our knowledge, there are no reports on studies investigating minichromosome maintenance protein 2 (MCM2) expression in bladder carcinomas. Thus, we investigated the prognostic value of MCM2 immunoreactivity in stage T1 bladder tumors...
  18. ncbi Application of novel tissue microarrays to investigate expression of tryptase, chymase and KIT protein in placental mast cells
    Frank Noack
    Department of Pathology, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Arch Gynecol Obstet 272:223-8. 2005
    ..Because little is known about the role of mast cells in the placenta, we investigated the number and expression of chymase, tryptase, and KIT protein in placental mast cells using newly developed tissue microarrays...
  19. ncbi Basal cell carcinoma with neuroendocrine differentiation arising in a scar: A case report
    Manuela Krokowski
    Department of Pathology, University Hospital of Schleswig Holstein, Campus Luebeck, Germany
    Dermatol Online J 15:4. 2009
    ..Neuroendocrine differentiation was proven by immunohistochemistry and electron microscopy. The simultaneous occurrence of BCC development in a scar and neuroendocrine differentiation is quite rare...
  20. ncbi Unlocking pathology archives for microRNA-profiling
    Kai P Hoefig
    Institute for Pathology, UKSH Campus Luebeck, Luebeck, Germany
    Anticancer Res 28:119-23. 2008
    ..A variety of high-throughput screening methods has been developed to identify dysregulated miRNA species in tumours. For retrospective clinical studies formalin-fixed, paraffin-embedded (FFPE) tissue is the most widely used material...
  21. ncbi Activating mutations affecting the NF-kappa B pathway and EZH2-mediated epigenetic regulation are rare events in primary mediastinal large B-cell lymphoma
    Niklas Gebauer
    Department of Internal Medicine I, University Hospital of Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Anticancer Res 34:5503-7. 2014
    ..Several promising targeted-therapy approaches, derived from these findings, are currently under development...
  22. ncbi Chromosomal aberrations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma unspecified: A matrix-based CGH approach
    Christoph Thorns
    Department of Pathology, German Consultation and Reference Center for Lymphomas, University Clinic Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Genes Chromosomes Cancer 46:37-44. 2007
    ..In conclusion, CGH revealed common genetic events in peripheral T-cell lymphomas as well as peculiar differences between AILT and PTCL-u...
  23. ncbi Immunohistochemical prognostic markers in diffuse large B-cell lymphoma: validation of tissue microarray as a prerequisite for broad clinical applications--a study from the Lunenburg Lymphoma Biomarker Consortium
    Daphne de Jong
    Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Oncol 25:805-12. 2007
    ....
  24. doi Preservation of follicle mantle in follicular lymphoma
    Christoph Thorns
    Leuk Lymphoma 49:166-7. 2008