Research Topics
Species | Jan ThoneSummaryCountry: Germany Publications
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Publications
Anti-inflammatory effects of levetiracetam in experimental autoimmune encephalomyelitisJan Thone
Department of Neurology at St Josef Hospital, Ruhr University Bochum, Germany
Int Immunopharmacol 14:9-12. 2012..In summary, LEV showed only minor anti-inflammatory effects not sufficient to ameliorate disease course in an autoimmune inflammatory disease of CNS...
Components of acquisition-to-acquisition variance in continuous arterial spin labelling (CASL) imagingRoberto Viviani
Department of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12, Ulm, Germany
BMC Neurosci 11:30. 2010..Little is known about the spatial determinants of this variation during the acquisition process and their impact on voxel-by-voxel estimates of effects...- Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factorJan Thone
Department of Neurology at St Josef Hospital, Group for Molecular Cell Biology, Ruhr University Bochum, Bochum, Germany
Am J Pathol 180:267-74. 2012..Consistent with immunomodulatory properties, laquinimod skewed monocytes toward a regulatory phenotype and also acted via modulation of BDNF, which may contribute to neuroprotection in MS patients... - Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosisJan Thone
Ruhr University Bochum, Department of Neurology at St Josef Hospital Bochum, Gudrunstr 56, 44791 Bochum, Germany
Expert Opin Drug Metab Toxicol 7:365-70. 2011..Hopefully, the two current pivotal Phase III trials currently underway will shed some light on laquinimod confirming its clinical potential and add to the current armamentarium for the treatment of RRMS... 
Severe spinal cord ischemia subsequent to fibrocartilaginous embolismJan Thone
Department of Neurology, Clinical Center Nuernberg South, Breslauerstr 201, 90471 Nuernberg, Germany
J Neurol Sci 263:211-3. 2007..Altogether, clinical presentation, neuroimaging and lack of evidence of other plausible diagnosis suggest fibrocartilaginous embolism as the most probable diagnosis...- Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibitionJan Thone
Institute of Physiology, University of Duisburg Essen, Essen, Germany
Epilepsy Res 79:105-11. 2008..Clinically relevant concentrations of ZNS strongly inhibit 4-AP induced epileptiform activity of hippocampal CA3 neurons in vitro, but this effect was unlikely based on carbonic anhydrase inhibition or changes of neuronal pHi... - Effective immunosuppressant therapy with cyclophosphamide and corticosteroids in paraneoplastic cerebellar degenerationJan Thone
Department of Neurology, Clinical Center Nuernberg South, Breslauerstr 201, 90471 Nuernberg, Germany
J Neurol Sci 272:171-3. 2008..This case demonstrates the benefit of immunosuppressive therapy in an anti-Yo positive patient with severe PCD secondary to an ovarian cancer... - Guillain-Barré syndrome as leading manifestation of graft-versus-host disease in an allogeneic bone marrow transplanted patientJan Thone
Department of Neurology, Clinical Center Nuernberg South, Breslauerstr 201, 90471 Nuernberg, Germany
J Neurol Sci 292:114-6. 2010..In contrast to former case reports both IVIg and plasma exchange failed while resumption of immunosuppressive medication improved the condition of the patient clearly... - Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behaviorIsabella Peruga
Department of Neurology, St Josef Hospital, Ruhr University Bochum, Universitatsstr 150, Bochum, Germany
Behav Brain Res 229:325-32. 2012..These data imply that endogenous CNTF plays a pivotal role for the structural maintenance of hippocampal functions and thus has an important impact on the modulation of affective behavior in rodent models of anxiety and depression... - Levetiracetam inhibits Na+-dependent Cl-/HCO3- exchange of adult hippocampal CA3 neurons from guinea-pigsTobias Leniger
Department of Neurology, University of Essen, Hufelandstr 55, Essen 45122, Germany
Br J Pharmacol 142:1073-80. 2004..These data show that LEV at clinically relevant concentrations inhibits Na+-dependent Cl-/HCO3- exchange, lowers neuronal pHi, and thereby may contribute to its anticonvulsive activity... - Topiramate modulates pH of hippocampal CA3 neurons by combined effects on carbonic anhydrase and Cl-/HCO3- exchangeTobias Leniger
Department of Neurology, University of Essen, Hufelandstr 55, 45122 Essen, Germany
Br J Pharmacol 142:831-42. 2004..The apparent decrease of steady-state pHi may contribute to the anticonvulsive property of TPM... - Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neuronsJan Thone
Institute of Physiology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
Epilepsy Res 76:73-6. 2007..In contrast, ZNS failed to alter epileptiform bursting. We conclude that 5-HT augmenting effects of ZNS are missing or are not sufficient to inhibit epileptiform activity in hippocampal slice preparations... - Inflammation modulates anxiety in an animal model of multiple sclerosisIsabella Peruga
Department of Neurology, St Josef Hospital, Ruhr University Bochum, 44791 Bochum, Germany
Behav Brain Res 220:20-9. 2011..These data imply that chronic inflammation in the CNS may impact on emotional responses in rodent models of anxiety... - Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammationGisa Ellrichmann
Department of Neurology, St Josef Hospital Bochum, Ruhr University Bochum, Germany
J Neuroinflammation 9:15. 2012..In summary, myeloid cell derived NF-κB plays a crucial role in autoimmune inflammation of the CNS and drives a pathogenic role of monocytes and macrophages independently from T-cells... - Anti-inflammatory effects of the anticonvulsant drug levetiracetam on electrophysiological properties of astroglia are mediated via TGFβ1 regulationMartin N Stienen
Institute of Neuroanatomy, Ruhr University, Bochum, Germany
Br J Pharmacol 162:491-507. 2011..Evidence so far suggests a mode of action different from that of classical AEDs. We have shown that LEV restored functional gap junction coupling and basic membrane properties in an astrocytic inflammatory model in vitro... - Natalizumab-associated reversible encephalopathy syndrome mimicking progressive multifocal leukoencephalopathyBernhard F Décard
Department of Neurology at St Josef Hospital, Ruhr University Bochum, Germany
Mult Scler 19:249-51. 2013..To our knowledge, this is the first case of its kind. Our case suggests that awareness ought to be sharpened for reversible leukoencephalopathy syndrome in the follow-up of natalizumab treated multiple sclerosis patients... - Oral available agents in the treatment of relapsing remitting multiple sclerosis: an overview of merits and culpritsJan Thone
Department of Neurology, St JosefHospital Bochum, Ruhr University Bochum, Bochum, Germany
Drug Healthc Patient Saf 5:37-47. 2013..In this article, we review the pharmaceutical properties of fingolimod, laquinimod, teriflunomide, cladribine, and BG-12; and their suggested mechanisms of action, clinical efficacy, and side-effect profiles...