Jan Thone

Summary

Country: Germany

Publications

  1. doi request reprint Anti-inflammatory effects of levetiracetam in experimental autoimmune encephalomyelitis
    Jan Thone
    Department of Neurology at St Josef Hospital, Ruhr University Bochum, Germany
    Int Immunopharmacol 14:9-12. 2012
  2. pmc Components of acquisition-to-acquisition variance in continuous arterial spin labelling (CASL) imaging
    Roberto Viviani
    Department of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12, Ulm, Germany
    BMC Neurosci 11:30. 2010
  3. doi request reprint Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor
    Jan Thone
    Department of Neurology at St Josef Hospital, Group for Molecular Cell Biology, Ruhr University Bochum, Bochum, Germany
    Am J Pathol 180:267-74. 2012
  4. doi request reprint Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis
    Jan Thone
    Ruhr University Bochum, Department of Neurology at St Josef Hospital Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Expert Opin Drug Metab Toxicol 7:365-70. 2011
  5. ncbi request reprint Severe spinal cord ischemia subsequent to fibrocartilaginous embolism
    Jan Thone
    Department of Neurology, Clinical Center Nuernberg South, Breslauerstr 201, 90471 Nuernberg, Germany
    J Neurol Sci 263:211-3. 2007
  6. doi request reprint Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition
    Jan Thone
    Institute of Physiology, University of Duisburg Essen, Essen, Germany
    Epilepsy Res 79:105-11. 2008
  7. doi request reprint Effective immunosuppressant therapy with cyclophosphamide and corticosteroids in paraneoplastic cerebellar degeneration
    Jan Thone
    Department of Neurology, Clinical Center Nuernberg South, Breslauerstr 201, 90471 Nuernberg, Germany
    J Neurol Sci 272:171-3. 2008
  8. doi request reprint Guillain-Barré syndrome as leading manifestation of graft-versus-host disease in an allogeneic bone marrow transplanted patient
    Jan Thone
    Department of Neurology, Clinical Center Nuernberg South, Breslauerstr 201, 90471 Nuernberg, Germany
    J Neurol Sci 292:114-6. 2010
  9. doi request reprint Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior
    Isabella Peruga
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Universitatsstr 150, Bochum, Germany
    Behav Brain Res 229:325-32. 2012
  10. pmc Levetiracetam inhibits Na+-dependent Cl-/HCO3- exchange of adult hippocampal CA3 neurons from guinea-pigs
    Tobias Leniger
    Department of Neurology, University of Essen, Hufelandstr 55, Essen 45122, Germany
    Br J Pharmacol 142:1073-80. 2004

Collaborators

Detail Information

Publications17

  1. doi request reprint Anti-inflammatory effects of levetiracetam in experimental autoimmune encephalomyelitis
    Jan Thone
    Department of Neurology at St Josef Hospital, Ruhr University Bochum, Germany
    Int Immunopharmacol 14:9-12. 2012
    ..In summary, LEV showed only minor anti-inflammatory effects not sufficient to ameliorate disease course in an autoimmune inflammatory disease of CNS...
  2. pmc Components of acquisition-to-acquisition variance in continuous arterial spin labelling (CASL) imaging
    Roberto Viviani
    Department of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12, Ulm, Germany
    BMC Neurosci 11:30. 2010
    ..Little is known about the spatial determinants of this variation during the acquisition process and their impact on voxel-by-voxel estimates of effects...
  3. doi request reprint Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor
    Jan Thone
    Department of Neurology at St Josef Hospital, Group for Molecular Cell Biology, Ruhr University Bochum, Bochum, Germany
    Am J Pathol 180:267-74. 2012
    ..Consistent with immunomodulatory properties, laquinimod skewed monocytes toward a regulatory phenotype and also acted via modulation of BDNF, which may contribute to neuroprotection in MS patients...
  4. doi request reprint Laquinimod: a promising oral medication for the treatment of relapsing-remitting multiple sclerosis
    Jan Thone
    Ruhr University Bochum, Department of Neurology at St Josef Hospital Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Expert Opin Drug Metab Toxicol 7:365-70. 2011
    ..Hopefully, the two current pivotal Phase III trials currently underway will shed some light on laquinimod confirming its clinical potential and add to the current armamentarium for the treatment of RRMS...
  5. ncbi request reprint Severe spinal cord ischemia subsequent to fibrocartilaginous embolism
    Jan Thone
    Department of Neurology, Clinical Center Nuernberg South, Breslauerstr 201, 90471 Nuernberg, Germany
    J Neurol Sci 263:211-3. 2007
    ..Altogether, clinical presentation, neuroimaging and lack of evidence of other plausible diagnosis suggest fibrocartilaginous embolism as the most probable diagnosis...
  6. doi request reprint Antiepileptic activity of zonisamide on hippocampal CA3 neurons does not depend on carbonic anhydrase inhibition
    Jan Thone
    Institute of Physiology, University of Duisburg Essen, Essen, Germany
    Epilepsy Res 79:105-11. 2008
    ..Clinically relevant concentrations of ZNS strongly inhibit 4-AP induced epileptiform activity of hippocampal CA3 neurons in vitro, but this effect was unlikely based on carbonic anhydrase inhibition or changes of neuronal pHi...
  7. doi request reprint Effective immunosuppressant therapy with cyclophosphamide and corticosteroids in paraneoplastic cerebellar degeneration
    Jan Thone
    Department of Neurology, Clinical Center Nuernberg South, Breslauerstr 201, 90471 Nuernberg, Germany
    J Neurol Sci 272:171-3. 2008
    ..This case demonstrates the benefit of immunosuppressive therapy in an anti-Yo positive patient with severe PCD secondary to an ovarian cancer...
  8. doi request reprint Guillain-Barré syndrome as leading manifestation of graft-versus-host disease in an allogeneic bone marrow transplanted patient
    Jan Thone
    Department of Neurology, Clinical Center Nuernberg South, Breslauerstr 201, 90471 Nuernberg, Germany
    J Neurol Sci 292:114-6. 2010
    ..In contrast to former case reports both IVIg and plasma exchange failed while resumption of immunosuppressive medication improved the condition of the patient clearly...
  9. doi request reprint Endogenous ciliary neurotrophic factor modulates anxiety and depressive-like behavior
    Isabella Peruga
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Universitatsstr 150, Bochum, Germany
    Behav Brain Res 229:325-32. 2012
    ..These data imply that endogenous CNTF plays a pivotal role for the structural maintenance of hippocampal functions and thus has an important impact on the modulation of affective behavior in rodent models of anxiety and depression...
  10. pmc Levetiracetam inhibits Na+-dependent Cl-/HCO3- exchange of adult hippocampal CA3 neurons from guinea-pigs
    Tobias Leniger
    Department of Neurology, University of Essen, Hufelandstr 55, Essen 45122, Germany
    Br J Pharmacol 142:1073-80. 2004
    ..These data show that LEV at clinically relevant concentrations inhibits Na+-dependent Cl-/HCO3- exchange, lowers neuronal pHi, and thereby may contribute to its anticonvulsive activity...
  11. pmc Topiramate modulates pH of hippocampal CA3 neurons by combined effects on carbonic anhydrase and Cl-/HCO3- exchange
    Tobias Leniger
    Department of Neurology, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Br J Pharmacol 142:831-42. 2004
    ..The apparent decrease of steady-state pHi may contribute to the anticonvulsive property of TPM...
  12. ncbi request reprint Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neurons
    Jan Thone
    Institute of Physiology, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Epilepsy Res 76:73-6. 2007
    ..In contrast, ZNS failed to alter epileptiform bursting. We conclude that 5-HT augmenting effects of ZNS are missing or are not sufficient to inhibit epileptiform activity in hippocampal slice preparations...
  13. doi request reprint Inflammation modulates anxiety in an animal model of multiple sclerosis
    Isabella Peruga
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, 44791 Bochum, Germany
    Behav Brain Res 220:20-9. 2011
    ..These data imply that chronic inflammation in the CNS may impact on emotional responses in rodent models of anxiety...
  14. pmc Constitutive activity of NF-kappa B in myeloid cells drives pathogenicity of monocytes and macrophages during autoimmune neuroinflammation
    Gisa Ellrichmann
    Department of Neurology, St Josef Hospital Bochum, Ruhr University Bochum, Germany
    J Neuroinflammation 9:15. 2012
    ..In summary, myeloid cell derived NF-κB plays a crucial role in autoimmune inflammation of the CNS and drives a pathogenic role of monocytes and macrophages independently from T-cells...
  15. pmc Anti-inflammatory effects of the anticonvulsant drug levetiracetam on electrophysiological properties of astroglia are mediated via TGFβ1 regulation
    Martin N Stienen
    Institute of Neuroanatomy, Ruhr University, Bochum, Germany
    Br J Pharmacol 162:491-507. 2011
    ..Evidence so far suggests a mode of action different from that of classical AEDs. We have shown that LEV restored functional gap junction coupling and basic membrane properties in an astrocytic inflammatory model in vitro...
  16. doi request reprint Natalizumab-associated reversible encephalopathy syndrome mimicking progressive multifocal leukoencephalopathy
    Bernhard F Décard
    Department of Neurology at St Josef Hospital, Ruhr University Bochum, Germany
    Mult Scler 19:249-51. 2013
    ..To our knowledge, this is the first case of its kind. Our case suggests that awareness ought to be sharpened for reversible leukoencephalopathy syndrome in the follow-up of natalizumab treated multiple sclerosis patients...
  17. pmc Oral available agents in the treatment of relapsing remitting multiple sclerosis: an overview of merits and culprits
    Jan Thone
    Department of Neurology, St JosefHospital Bochum, Ruhr University Bochum, Bochum, Germany
    Drug Healthc Patient Saf 5:37-47. 2013
    ..In this article, we review the pharmaceutical properties of fingolimod, laquinimod, teriflunomide, cladribine, and BG-12; and their suggested mechanisms of action, clinical efficacy, and side-effect profiles...