Marc Thill

Summary

Country: Germany

Publications

  1. doi request reprint Intraoperative assessment of surgical margins during breast conserving surgery of ductal carcinoma in situ by use of radiofrequency spectroscopy
    Marc Thill
    Department of Obstetrics and Gynaecology, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Breast 20:579-80. 2011
  2. doi request reprint Restrictive dermopathy: a rare laminopathy
    Marc Thill
    Department of Gynecology and Obstetrics, Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach, Germany
    Arch Gynecol Obstet 278:201-8. 2008
  3. ncbi request reprint Influence of calcitriol on prostaglandin- and vitamin D-metabolising enzymes in benign and malignant breast cell lines
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Anticancer Res 32:359-65. 2012
  4. ncbi request reprint Prostaglandin metabolising enzymes and PGE2 are inversely correlated with vitamin D receptor and 25(OH)2D3 in breast cancer
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Anticancer Res 30:1673-9. 2010
  5. ncbi request reprint Expression of prostaglandin- and vitamin D-metabolising enzymes in benign and malignant breast cells
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Anticancer Res 32:367-72. 2012
  6. doi request reprint Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH2)D3) and prostaglandin E2 (PGE2) serum level in ovarian cancer
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Steroid Biochem Mol Biol 121:387-90. 2010
  7. ncbi request reprint Prostaglandin metabolizing enzymes in correlation with vitamin D receptor in benign and malignant breast cell lines
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Luebeck, 23538 Luebeck, Germany
    Anticancer Res 29:3619-25. 2009
  8. ncbi request reprint Expression of prostaglandin metabolising enzymes COX-2 and 15-PGDH and VDR in human granulosa cells
    Marc Thill
    Department of Obstetrics and Gynecology, University Schleswig Holstein, Campus Luebeck, 23538 Luebeck, Germany
    Anticancer Res 29:3611-8. 2009
  9. ncbi request reprint Expression of 25-hydroxyvitamin D3-24-hydroxylase in benign and malignant ovarian cell lines and tissue
    Dorothea Fischer
    KIinik für Frauenheilkunde und Geburtshilfe, Universitatsklinikum Schleswig Holstein, Campus Lubeck, D 23562 Lubeck, Germany
    Anticancer Res 29:3635-9. 2009
  10. ncbi request reprint Vitamin D, calcidiol and calcitriol regulate vitamin D metabolizing enzymes in cervical and ovarian cancer cells
    Martin Kloss
    Department of Obstetrics and Gynecology, University of Lubeck, D 23538 Lubeck, Germany
    Anticancer Res 30:4429-34. 2010

Detail Information

Publications28

  1. doi request reprint Intraoperative assessment of surgical margins during breast conserving surgery of ductal carcinoma in situ by use of radiofrequency spectroscopy
    Marc Thill
    Department of Obstetrics and Gynaecology, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Breast 20:579-80. 2011
    ..Based on permanent histology reporting, the rate of successful procedures was 86%. The improvement in intraoperative assessment with device use was associated with a reduction in re-excision rates, from 38.8 to 18%...
  2. doi request reprint Restrictive dermopathy: a rare laminopathy
    Marc Thill
    Department of Gynecology and Obstetrics, Klinikum Offenbach, Starkenburgring 66, 63069, Offenbach, Germany
    Arch Gynecol Obstet 278:201-8. 2008
    ..Furthermore, polyhydramnios, decreased foetal movement, facial dysmorphisms and arthrogryposis are characteristic of RD. Respiratory insufficiency leads to an early neonatal death...
  3. ncbi request reprint Influence of calcitriol on prostaglandin- and vitamin D-metabolising enzymes in benign and malignant breast cell lines
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Anticancer Res 32:359-65. 2012
    ..Cyclooxygenase-2 (COX-2) is a potential molecular prognostic factor for breast cancer, and calcitriol [1,25(OH)(2)D(3)], the biologically active form of vitamin D, is a promising target in breast cancer therapy...
  4. ncbi request reprint Prostaglandin metabolising enzymes and PGE2 are inversely correlated with vitamin D receptor and 25(OH)2D3 in breast cancer
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany
    Anticancer Res 30:1673-9. 2010
    ..First data suggest a correlation between vitamin D and prostaglandin metabolism...
  5. ncbi request reprint Expression of prostaglandin- and vitamin D-metabolising enzymes in benign and malignant breast cells
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Anticancer Res 32:367-72. 2012
    ..The antiproliferative effects of calcitriol [1,25(OH)(2)D(3)] mediated via the vitamin D receptor (VDR) render vitamin D a promising target in breast cancer therapy...
  6. doi request reprint Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH2)D3) and prostaglandin E2 (PGE2) serum level in ovarian cancer
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    J Steroid Biochem Mol Biol 121:387-90. 2010
    ..Surprisingly, we could not detect any differences between the 25(OH2)D3 serum levels in either group (n=20). These data suggest a correlation between PG- and vitamin D-metabolism in ovarian carcinomas...
  7. ncbi request reprint Prostaglandin metabolizing enzymes in correlation with vitamin D receptor in benign and malignant breast cell lines
    Marc Thill
    Department of Obstetrics and Gynecology, University Hospital Schleswig Holstein, Campus Luebeck, 23538 Luebeck, Germany
    Anticancer Res 29:3619-25. 2009
    ..First references suggest a correlation between vitamin D and prostaglandin metabolism through the impact of 1,25(OH)2D3 on the expression of COX-2 and 15-PGDH...
  8. ncbi request reprint Expression of prostaglandin metabolising enzymes COX-2 and 15-PGDH and VDR in human granulosa cells
    Marc Thill
    Department of Obstetrics and Gynecology, University Schleswig Holstein, Campus Luebeck, 23538 Luebeck, Germany
    Anticancer Res 29:3611-8. 2009
    ..First references suggest a correlation between vitamin D and prostaglandin metabolism through the impact of 1,25(OH)2D3 (calcitriol) on the expression of COX-2 and 15-PGDH...
  9. ncbi request reprint Expression of 25-hydroxyvitamin D3-24-hydroxylase in benign and malignant ovarian cell lines and tissue
    Dorothea Fischer
    KIinik für Frauenheilkunde und Geburtshilfe, Universitatsklinikum Schleswig Holstein, Campus Lubeck, D 23562 Lubeck, Germany
    Anticancer Res 29:3635-9. 2009
    ..01). In the malignant ovarian tissue, the expression was significantly higher in RNA (p<0.001), but lower at the protein level (p<0.01). An increased 24-OHase expression could indicate a decrease in available calcitriol...
  10. ncbi request reprint Vitamin D, calcidiol and calcitriol regulate vitamin D metabolizing enzymes in cervical and ovarian cancer cells
    Martin Kloss
    Department of Obstetrics and Gynecology, University of Lubeck, D 23538 Lubeck, Germany
    Anticancer Res 30:4429-34. 2010
    ..The aim of this study was to obtain further information about the regulation of the aforementioned enzymes by vitamin D, calcidiol and calcitriol in cervical and ovarian cancer...
  11. ncbi request reprint Impact of cyclooxygenase-2 in breast cancer
    Friederike Hoellen
    Department of Gynecology and Obstetrics, University Hospital of Schleswig Holstein, Luebeck Campus, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Anticancer Res 31:4359-67. 2011
    ....
  12. ncbi request reprint The utility of an in vitro angiogenesis score for prognosis assessment in patients with cervical cancer
    Solveig Landt
    Department of Gynecology and Obstetrics, University Hospital Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Anticancer Res 31:2645-9. 2011
    ..The present study examines the relationship between angiogenic factor expression, an angiogenesis-based histoscore and clinical tumour criteria...
  13. doi request reprint Cancer in pregnancy. Part I: basic diagnostic and therapeutic principles and treatment of gynecological malignancies
    Friederike Hoellen
    Department of Obstetrics and Gynecology, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Arch Gynecol Obstet 285:195-205. 2012
    ..To date, clinical guidelines are scarce and experience regarding therapeutic management is limited to case reports...
  14. ncbi request reprint Vitamin D inhibits ovarian cancer cell line proliferation in combination with celecoxib and suppresses cyclooxygenase-2 expression
    Marc Thill
    Department of Gynecology and Obstetrics, Agaplesion Markus Hospital, Frankfurt am Main, Germany
    Anticancer Res 35:1197-203. 2015
    ..Prostaglandin-(PG)E2 is a tumor-promoting tissue hormone anabolized by cyclooxygenase-2 (COX-2). Recently, a link between the PG and vitamin D metabolism was reported...
  15. ncbi request reprint 25-Hydroxyvitamin D3 1alpha-hydroxylase splice variants in benign and malignant ovarian cell lines and tissue
    Dorothea Fischer
    KIinik für Frauenheilkunde und Geburtshilfe, Universitatsklinikum Schleswig Holstein, Campus Lubeck, D 23562 Lubeck, Germany
    Anticancer Res 29:3627-33. 2009
    ..Their increased expression in malignancy is possibly bound to the reduction of enzyme activity, which may lead to the genesis of ovarian cancer. In the future, preventive and therapeutic activities may result from these findings...
  16. ncbi request reprint Influence of a dose-dense adjuvant chemotherapy on sVCAM-1/sICAM-1 serum levels in breast cancer patients with 1-3 positive lymph nodes
    Holm Eggeman
    Department of Gynecology and Obstetrics, University Hospital Magdeburg, Magdeburg, Germany
    Anticancer Res 31:2617-22. 2011
    ..The aim of the present study was to investigate the effects of conventional and dose-dense chemotherapy on serum levels of soluble adhesion molecules sICAM-1 and sVCAM-1 in node-positive patients with breast cancer...
  17. doi request reprint Metastasized hemangiopericytoma of the breast: a rare case
    Britta Ruhland
    Department of Obstetrics and Gynaecology, University of Luebeck, Lubeck, Germany
    Arch Gynecol Obstet 280:491-4. 2009
    ..Two months after initiation of chemotherapy the patient died. Diagnostic criteria and treatment principles in the metastatic situation are presented in addition to the literature to give a review about this rare malignancy...
  18. doi request reprint Cancer in pregnancy. Part II: treatment options of breast and other non-gynecological malignancies
    Friederike Hoellen
    Department of Obstetrics and Gynecology, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Arch Gynecol Obstet 284:1481-94. 2011
    ..In case of non-gynecological solid tumors and hematological malignancies diagnosed during pregnancy, individual diagnostic and treatment options must be established by an interdisciplinary team...
  19. doi request reprint Successful application of vacuum-assisted closure therapy for treatment of mastitis-associated chronic breast wounds
    Doerte W Luedders
    Department of Obstetrics and Gynaecology, University Hospital of Schleswig Holstein, Campus Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Arch Gynecol Obstet 283:1357-62. 2011
    ..In some cases, standard therapy fails and it progresses to a chronic disease. Vacuum-assisted closure (VAC) therapy has shown good results in healing complex wounds...
  20. ncbi request reprint Combined treatment of breast cancer cell lines with vitamin D and COX-2 inhibitors
    Marc Thill
    Department of Gynecology and Obstetrics, Agaplesion Markus Hospital, Frankfurt am Main, Germany
    Anticancer Res 35:1189-95. 2015
    ..Prostaglandin E2 (PGE2) is a proliferation and inflammation activating agent. The production of PGE2 is dependent on the activity of cyclooxygenase-2 (COX-2). A link between vitamin D and PGE2 metabolism was recently shown...
  21. doi request reprint Intraoperative assessment of margins in breast conservative surgery--still in use?
    Marc Thill
    Department of Gynecology and Obstetrics, Breast Center, Agaplesion Markus Hospital, Frankfurt am Main, Germany
    J Surg Oncol 110:15-20. 2014
    ..In this article, options that might become the method of choice in the future are discussed...
  22. doi request reprint Current diagnostic modalities and clinical pitfalls in malignant secondary breast tumours
    Doerte W Luedders
    Department of Obstetrics and Gynaecology, University Hospital of Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany
    Arch Gynecol Obstet 284:687-94. 2011
    ..Current diagnostic concepts of metastatic neoplasm to the breast, including latest imaging modalities and their possible future applications, are presented in this review with special emphasis on possible pitfalls...
  23. pmc Expression of cyclooxygenase-2 in cervical cancer is associated with lymphovascular invasion
    Friederike Hoellen
    Department of Gynecology and Obstetrics, University of Lübeck and University Hospital Schleswig Holstein, Lübeck Campus, Lübeck D 23538, Germany
    Oncol Lett 12:2351-2356. 2016
    ..Further studies including larger patient collectives are required in order to perform analyses of clinical subgroups and patient survival...
  24. ncbi request reprint Lack of difference in acute nephrotoxicity of intravenous bisphosphonates zoledronic acid and ibandronate in women with breast cancer and bone metastases
    Dörte W Luedders
    Department of Obstetrics and Gynaecology, University Hospital Oldenburg, Oldenburg, Germany Department of Obstetrics and Gynaecology, University Hospital of Schleswig Holstein, Luebeck, Germany
    Anticancer Res 35:1797-802. 2015
    ..The mechanism by which the latter occurs is not well-understood, although emerging evidence suggests that the effect of bisphosphonates on the kidney may differ between agents...
  25. doi request reprint Emerging gonadotropin-releasing hormone agonists
    Daniel Alexander Beyer
    University of Schleswig Holstein, Department of Obstetrics and Gynaecology, Campus Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Expert Opin Emerg Drugs 16:323-40. 2011
    ..Although the analogs are a rather defined group of drugs, there have been developments in the past decades and there is still ample room for improvement. New therapeutic strategies in the use of GnRHs are discussed...
  26. ncbi request reprint In vitro vascular tube formation testing as a tool for treatment individualisation in patients with cervical cancer
    Solveig Landt
    Department of Gynecology and Obstetrics, University Hospital Dusseldorf, Moorenstrasse 5, 40225 Dusseldorf, Germany
    Anticancer Res 31:2609-15. 2011
    ..The present study investigates the suitability of vascular in vitro tube formation as a tool for the identification of cervical neoplasms that will respond to bevacizumab therapy...
  27. doi request reprint Targeted Therapy in HER2-Positive Breast Cancer
    Marc Thill
    Department of Gynecology and Obstetrics, Agaplesion Markus Hospital, Frankfurt M, Germany
    Oncol Res Treat 39:295-302. 2016
    ..This review will comment on the key studies in both the (neo)adjuvant and metastatic settings and discusses some of the controversies that still remain today both in clinical care and as research questions. ..
  28. doi request reprint Breast abscess following nipple piercing: a case report and review of the literature
    Smaragda Kapsimalakou
    Department of Radiology, University of Luebeck, Ratzeburger Allee 160, Luebeck, Germany
    Arch Gynecol Obstet 282:623-6. 2010
    ..Nipple piercing gains popularity and social acceptance within the last years, especially among young people. The medical literature reports an increase of complications in the post-piercing period...