Rolf Teschke

Summary

Country: Germany

Publications

  1. ncbi Herbal hepatotoxicity: Analysis of cases with initially reported positive re-exposure tests
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University, Frankfurt Main, Germany Electronic address
    Dig Liver Dis 46:264-9. 2014
  2. pmc Herbal hepatotoxicity: challenges and pitfalls of causality assessment methods
    Rolf Teschke
    Division of Gastroenterology and Hepatology, Department of Internal Medicine II, Klinikum Hanau, D 63450 Hanau, Germany
    World J Gastroenterol 19:2864-82. 2013
  3. doi Clinical and causality assessment in herbal hepatotoxicity
    Rolf Teschke
    Academic Teaching Hospital of Goethe University of Frankfurt Main, Department of Internal Medicine II, Klinikum Hanau, Leimenstrasse 20, D 63450 Hanau, Germany
    Expert Opin Drug Saf 12:339-66. 2013
  4. ncbi Greater Celandine hepatotoxicity: a clinical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
    Ann Hepatol 11:838-48. 2012
  5. pmc Herbal hepatotoxicity: a critical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Frankfurt Main, Germany
    Br J Clin Pharmacol 75:630-6. 2013
  6. doi [Pharmacovigilance and herbal hepatotoxicity: critical aspects and solutions]
    R Teschke
    Medizinische Klinik II, Klinikum Hanau, Akademisches Lehrkrankenhaus der Medizinischen Fakultät der Goethe Universität Frankfurt Main
    Dtsch Med Wochenschr 138:281-4. 2013
  7. ncbi Herbal hepatotoxicity and WHO global introspection method
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt, Main, Germany
    Ann Hepatol 12:11-21. 2013
  8. pmc Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University of Frankfurt Main, Hanau, Germany
    Br J Clin Pharmacol 73:170-4. 2012
  9. doi Herbal hepatotoxicity by Greater Celandine (Chelidonium majus): causality assessment of 22 spontaneous reports
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University Frankfurt Main, Germany
    Regul Toxicol Pharmacol 61:282-91. 2011
  10. doi Herbal hepatotoxicity: a tabular compilation of reported cases
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University, Frankfurt Main, Germany
    Liver Int 32:1543-56. 2012

Detail Information

Publications39

  1. ncbi Herbal hepatotoxicity: Analysis of cases with initially reported positive re-exposure tests
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University, Frankfurt Main, Germany Electronic address
    Dig Liver Dis 46:264-9. 2014
    ..Positive re-exposure tests are diagnostic hallmarks for hepatotoxicity...
  2. pmc Herbal hepatotoxicity: challenges and pitfalls of causality assessment methods
    Rolf Teschke
    Division of Gastroenterology and Hepatology, Department of Internal Medicine II, Klinikum Hanau, D 63450 Hanau, Germany
    World J Gastroenterol 19:2864-82. 2013
    ..In conclusion, HILI causality assessment is challenging and is best achieved by the liver specific CIOMS scale, avoiding pitfalls commonly observed with other approaches...
  3. doi Clinical and causality assessment in herbal hepatotoxicity
    Rolf Teschke
    Academic Teaching Hospital of Goethe University of Frankfurt Main, Department of Internal Medicine II, Klinikum Hanau, Leimenstrasse 20, D 63450 Hanau, Germany
    Expert Opin Drug Saf 12:339-66. 2013
    ..This review discusses overt shortcomings in its clinical and causality assessment and suggests improvements...
  4. ncbi Greater Celandine hepatotoxicity: a clinical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
    Ann Hepatol 11:838-48. 2012
    ..The present detailed review of GC hepatotoxicity may serve as an example for clinical causality assessments of future cases of liver injury due to other herbs...
  5. pmc Herbal hepatotoxicity: a critical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Frankfurt Main, Germany
    Br J Clin Pharmacol 75:630-6. 2013
    ..We propose steps for improvements with impact on future cases of liver injury by herbs, herbal drugs and herbal supplements...
  6. doi [Pharmacovigilance and herbal hepatotoxicity: critical aspects and solutions]
    R Teschke
    Medizinische Klinik II, Klinikum Hanau, Akademisches Lehrkrankenhaus der Medizinischen Fakultät der Goethe Universität Frankfurt Main
    Dtsch Med Wochenschr 138:281-4. 2013
    ..This is the only way to circumvent future absolute unnecessary and redundant scientific discussions in the regulatory field...
  7. ncbi Herbal hepatotoxicity and WHO global introspection method
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt, Main, Germany
    Ann Hepatol 12:11-21. 2013
    ..CIOMS based assessments will ensure the correct diagnosis and exclude alternative diagnosis that may require other specific therapies...
  8. pmc Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University of Frankfurt Main, Hanau, Germany
    Br J Clin Pharmacol 73:170-4. 2012
    ..Rigorous testing of kava raw material is urgently advised, in addition to Pan-Pacific kava manufacturing quality standards...
  9. doi Herbal hepatotoxicity by Greater Celandine (Chelidonium majus): causality assessment of 22 spontaneous reports
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University Frankfurt Main, Germany
    Regul Toxicol Pharmacol 61:282-91. 2011
    ..Toxicological studies are now warranted to elucidate the mechanism(s) of human GC hepatotoxicity that represents a European issue...
  10. doi Herbal hepatotoxicity: a tabular compilation of reported cases
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University, Frankfurt Main, Germany
    Liver Int 32:1543-56. 2012
    ..Herbal hepatotoxicity is a field that has rapidly grown over the last few years along with increased use of herbal products worldwide...
  11. ncbi [Diagnostic approach in cases of herbal hepatotoxicity]
    R Teschke
    Medizinische Klinik II, Klinikum Hanau, Akademisches Lehrkrankenhaus der Medizinischen Fakultät der Goethe Universität Frankfurt Main
    Z Gastroenterol 50:776-91. 2012
    ..Other shortcomings are low data quality that additionally complicates adequate evaluation...
  12. ncbi  Initially purported hepatotoxicity by Pelargonium sidoides: the dilemma of pharmacovigilance and proposals for improvement
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
    Ann Hepatol 11:500-12. 2012
    ..Water/ethanol extracts derived from its roots are available as registered herbal drugs for the treatment of upper respiratory tract infections including acute bronchitis...
  13. doi Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: was causality adequately ascertained?
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
    Regul Toxicol Pharmacol 63:1-9. 2012
    ..Thus, convincing evidence is lacking that PS was a potential hepatotoxin in the analyzed cases...
  14. doi Suspected Greater Celandine hepatotoxicity: liver-specific causality evaluation of published case reports from Europe
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital, Hanau, Germany
    Eur J Gastroenterol Hepatol 24:270-80. 2012
    ..has been causally related to liver injury, but a variety of confounding variables were evident that might have offset causality. This study reanalyses causality levels in these cases with a liver-specific causality evaluation method...
  15. doi Spontaneous reports of assumed herbal hepatotoxicity by black cohosh: is the liver-unspecific Naranjo scale precise enough to ascertain causality?
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University Frankfurt Main, Hanau, Germany
    Pharmacoepidemiol Drug Saf 20:567-82. 2011
    ..To evaluate various causality assessing methods in cases with suspected herbal hepatotoxicity, two different scales were now used for reasons of comparison...
  16. ncbi Herb induced liver injury presumably caused by black cohosh: a survey of initially purported cases and herbal quality specifications
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University, Frankfurt Main, Germany
    Ann Hepatol 10:249-59. 2011
    ..It is concluded that the use of BC may not exert an overt hepatotoxicity risk, but quality problems in a few BC products were evident that require additional regulatory quality specifications...
  17. doi Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University of Frankfurt Main, Germany
    Dig Liver Dis 43:676-81. 2011
    ..Whether kava hepatotoxicity may be due to aflatoxicosis or other mould hepatotoxins, requires further studies...
  18. pmc Kava, the anxiolytic herb: back to basics to prevent liver injury?
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
    Br J Clin Pharmacol 71:445-8. 2011
    ..This analysis shows poor quality of kava raw material as a cause for its toxicity and suggests preventative measures by going back to the traditional use of kava for the sake of the patients and the South Pacific economy...
  19. doi Suspected black cohosh hepatotoxicity--challenges and pitfalls of causality assessment
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Maturitas 63:302-14. 2009
    ..Recently, however, reports have appeared about the occurrence of rare toxic liver disease in an assumed relationship with the use of BC...
  20. ncbi Severe hepatotoxicity by Indian Ayurvedic herbal products: a structured causality assessment
    Rolf Teschke
    Department of Internal Medicine II, University of Frankfurt Main and University of Duesseldorf, Germany
    Ann Hepatol 8:258-66. 2009
    ..The case is the first report of Indian Ayurvedic herbal products being potentially hepatotoxic in analogy to some other herbs...
  21. doi Black cohosh and suspected hepatotoxicity: inconsistencies, confounding variables, and prospective use of a diagnostic causality algorithm. A critical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Hanau, Germany
    Menopause 17:426-40. 2010
    ....
  22. doi Kava hepatotoxicity: pathogenetic aspects and prospective considerations
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University, Frankfurt Main, Hanau, Germany
    Liver Int 30:1270-9. 2010
    ....
  23. ncbi Kava hepatotoxicity--a clinical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
    Ann Hepatol 9:251-65. 2010
    ....
  24. doi Proposal for a kava quality standardization code
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University of Frankfurt Main, Germany
    Food Chem Toxicol 49:2503-16. 2011
    ..In conclusion, a sophisticated approach to establish kava quality standardizations is needed for safe human use of kava as relaxing traditional beverages, the anxiolytic drugs, and recreational dietary supplements...
  25. doi Kava hepatotoxicity solution: A six-point plan for new kava standardization
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Leimenstrasse 20, D 63450 Hanau, Germany
    Phytomedicine 18:96-103. 2011
    ..In conclusion, at different levels of responsibility, new mandatory approaches are now required to implement quality specification for international acceptance of kava as a safe and effective anxiolytic herb...
  26. doi Regulatory causality evaluation methods applied in kava hepatotoxicity: are they appropriate?
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Germany
    Regul Toxicol Pharmacol 59:1-7. 2011
    ....
  27. ncbi Kava hepatotoxicity: comparative study of two structured quantitative methods for causality assessment
    R Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Hanau, Germany
    J Clin Pharm Ther 35:545-63. 2010
    ..Ingestion of the medicinal herb kava has been associated with hepatotoxicity. We aimed to compare two different quantitative methods of causality assessment of patients with assumed hepatotoxicity by the herb...
  28. doi Black cohosh hepatotoxicity: quantitative causality evaluation in nine suspected cases
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Hanau, Germany
    Menopause 16:956-65. 2009
    ..Recently, worldwide discussions have emerged as to whether its use maybe associated with the risk of rare hepatotoxicity in a few susceptible women...
  29. ncbi Herbal hepatotoxicity: suspected cases assessed for alternative causes
    Rolf Teschke
    aDepartment of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty bInstitute of Industrial, Environmental and Social Medicine, Medical Faculty, Goethe University, Frankfurt Main cDepartment of Medicine I, University Medical Center, Hamburg Eppendorf, Germany
    Eur J Gastroenterol Hepatol 25:1093-8. 2013
    ..1% of analyzed cases. This raised the question of whether a similar frequency may prevail in cases of assumed herb-induced liver injury (HILI)...
  30. doi Suspected hepatotoxicity by Cimicifugae racemosae rhizoma (black cohosh, root): critical analysis and structured causality assessment
    Rolf Teschke
    Medical Department II, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Hanau, Germany
    Phytomedicine 16:72-84. 2009
    ..Using a thorough causality assessment in the form of a diagnostic algorithm we have shown that there is no evidence for a causal relationship between treatment by black cohosh and the observed liver disease in the 4 patients...
  31. pmc Causality assessment in hepatotoxicity by drugs and dietary supplements
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Hanau, Germany
    Br J Clin Pharmacol 66:758-66. 2008
    ..Concomitant genotyping of cytochrome P450 and other enzymes may also be useful in future to minimize the risk of unwanted side-effects, including toxic liver disease elicited by DDS...
  32. doi Suspected herbal hepatotoxicity: requirements for appropriate causality assessment by the US Pharmacopeia
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University, FrankfurtMain, Germany
    Drug Saf 35:1091-7. 2012
    ..In essence, the USP and other regulatory agencies should apply validated liver-specific causality assessment methods rather than liver unspecific and not validated assessment methods in suspected HILI cases...
  33. doi Kava hepatotoxicity: comparison of aqueous, ethanolic, acetonic kava extracts and kava-herbs mixtures
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Leimenstrasse 20, D 63450 Hanau, Germany
    J Ethnopharmacol 123:378-84. 2009
    ....
  34. doi Kava hepatotoxicity: a clinical survey and critical analysis of 26 suspected cases
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
    Eur J Gastroenterol Hepatol 20:1182-93. 2008
    ..Hepatotoxicity has been previously suspected by national regulatory agencies in 26 patients in causal relationship with the treatment by kava extracts commonly used as herbal anxiolytic drugs...
  35. ncbi Drug induced liver injury: accuracy of diagnosis in published reports
    Rolf Teschke
    Department of Internal Medicine, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
    Ann Hepatol 13:248-55. 2014
    ..In conclusion, alternative diagnoses are common in primarily suspected DILI cases and should be excluded early in future cases, requiring a thorough clinical and causality assessment. ..
  36. ncbi Hepatotoxicity by drugs and dietary supplements: safety perspectives on clinical and regulatory issues
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
    Ann Hepatol 8:184-95. 2009
    ..Safety aspects in DDS hepatotoxicity represent a major clinical and regulatory issue and should consequently be addressed...
  37. ncbi Kava hepatotoxicity: a European view
    Rolf Teschke
    Department of Internal Medicine II, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Leimenstrasse 20, D 63450 Hanau, Germany
    N Z Med J 121:90-8. 2008
    ..A medical advisory is also recommended as part of the labelling...
  38. doi Contaminant hepatotoxins as culprits for kava hepatotoxicity - fact or fiction?
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University of Frankfurt Main, Germany
    Phytother Res 27:472-4. 2013
    ..Copyright © 2012 John Wiley & Sons, Ltd...
  39. ncbi Drug induced liver injury: do we still need a routine liver biopsy for diagnosis today?
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
    Ann Hepatol 13:121-6. 2013
    ....