Rolf Teschke

Summary

Country: Germany

Publications

  1. ncbi Clinical and causality assessment in herbal hepatotoxicity
    Rolf Teschke
    Academic Teaching Hospital of the Goethe University of Frankfurt Main, Department of Internal Medicine II, Klinikum Hanau, Leimenstrasse 20, D 63450 Hanau, Germany 49 6181 21859
    Expert Opin Drug Saf 12:339-66. 2013
  2. ncbi Greater Celandine hepatotoxicity: a clinical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
    Ann Hepatol 11:838-48. 2012
  3. ncbi Herbal hepatotoxicity: a critical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Frankfurt Main, Germany
    Br J Clin Pharmacol 75:630-6. 2013
  4. ncbi [Pharmacovigilance and herbal hepatotoxicity: critical aspects and solutions]
    R Teschke
    Medizinische Klinik II, Klinikum Hanau, Akademisches Lehrkrankenhaus der Medizinischen Fakultät der Goethe Universität Frankfurt Main
    Dtsch Med Wochenschr 138:281-4. 2013
  5. ncbi Herbal hepatotoxicity and WHO global introspection method
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt, Main, Germany
    Ann Hepatol 12:11-21. 2013
  6. ncbi Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University of Frankfurt Main, Hanau, Germany
    Br J Clin Pharmacol 73:170-4. 2012
  7. ncbi Herbal hepatotoxicity by Greater Celandine (Chelidonium majus): causality assessment of 22 spontaneous reports
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University Frankfurt Main, Germany
    Regul Toxicol Pharmacol 61:282-91. 2011
  8. ncbi Herbal hepatotoxicity: a tabular compilation of reported cases
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University, Frankfurt Main, Germany
    Liver Int 32:1543-56. 2012
  9. ncbi [Diagnostic approach in cases of herbal hepatotoxicity]
    R Teschke
    Medizinische Klinik II, Klinikum Hanau, Akademisches Lehrkrankenhaus der Medizinischen Fakultät der Goethe Universität Frankfurt Main
    Z Gastroenterol 50:776-91. 2012
  10. ncbi  Initially purported hepatotoxicity by Pelargonium sidoides: the dilemma of pharmacovigilance and proposals for improvement
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
    Ann Hepatol 11:500-12. 2012

Detail Information

Publications34

  1. ncbi Clinical and causality assessment in herbal hepatotoxicity
    Rolf Teschke
    Academic Teaching Hospital of the Goethe University of Frankfurt Main, Department of Internal Medicine II, Klinikum Hanau, Leimenstrasse 20, D 63450 Hanau, Germany 49 6181 21859
    Expert Opin Drug Saf 12:339-66. 2013
    ..Expert opinion: The authors call for substantial improvements in data quality of herbal products and case characteristics and strongly recommend using the CIOMS scale to assess causality in suspected herbal hepatotoxicity...
  2. ncbi Greater Celandine hepatotoxicity: a clinical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
    Ann Hepatol 11:838-48. 2012
    ..The present detailed review of GC hepatotoxicity may serve as an example for clinical causality assessments of future cases of liver injury due to other herbs...
  3. ncbi Herbal hepatotoxicity: a critical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Frankfurt Main, Germany
    Br J Clin Pharmacol 75:630-6. 2013
    ..We propose steps for improvements with impact on future cases of liver injury by herbs, herbal drugs and herbal supplements...
  4. ncbi [Pharmacovigilance and herbal hepatotoxicity: critical aspects and solutions]
    R Teschke
    Medizinische Klinik II, Klinikum Hanau, Akademisches Lehrkrankenhaus der Medizinischen Fakultät der Goethe Universität Frankfurt Main
    Dtsch Med Wochenschr 138:281-4. 2013
    ..This is the only way to circumvent future absolute unnecessary and redundant scientific discussions in the regulatory field...
  5. ncbi Herbal hepatotoxicity and WHO global introspection method
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt, Main, Germany
    Ann Hepatol 12:11-21. 2013
    ..CIOMS based assessments will ensure the correct diagnosis and exclude alternative diagnosis that may require other specific therapies...
  6. ncbi Kava hepatotoxicity in traditional and modern use: the presumed Pacific kava paradox hypothesis revisited
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University of Frankfurt Main, Hanau, Germany
    Br J Clin Pharmacol 73:170-4. 2012
    ..Rigorous testing of kava raw material is urgently advised, in addition to Pan-Pacific kava manufacturing quality standards...
  7. ncbi Herbal hepatotoxicity by Greater Celandine (Chelidonium majus): causality assessment of 22 spontaneous reports
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University Frankfurt Main, Germany
    Regul Toxicol Pharmacol 61:282-91. 2011
    ..Toxicological studies are now warranted to elucidate the mechanism(s) of human GC hepatotoxicity that represents a European issue...
  8. ncbi Herbal hepatotoxicity: a tabular compilation of reported cases
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University, Frankfurt Main, Germany
    Liver Int 32:1543-56. 2012
    ..Herbal hepatotoxicity is a field that has rapidly grown over the last few years along with increased use of herbal products worldwide...
  9. ncbi [Diagnostic approach in cases of herbal hepatotoxicity]
    R Teschke
    Medizinische Klinik II, Klinikum Hanau, Akademisches Lehrkrankenhaus der Medizinischen Fakultät der Goethe Universität Frankfurt Main
    Z Gastroenterol 50:776-91. 2012
    ..Other shortcomings are low data quality that additionally complicates adequate evaluation...
  10. ncbi  Initially purported hepatotoxicity by Pelargonium sidoides: the dilemma of pharmacovigilance and proposals for improvement
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
    Ann Hepatol 11:500-12. 2012
    ..Water/ethanol extracts derived from its roots are available as registered herbal drugs for the treatment of upper respiratory tract infections including acute bronchitis...
  11. ncbi Spontaneous reports of primarily suspected herbal hepatotoxicity by Pelargonium sidoides: was causality adequately ascertained?
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University Frankfurt Main, Germany
    Regul Toxicol Pharmacol 63:1-9. 2012
    ..Thus, convincing evidence is lacking that PS was a potential hepatotoxin in the analyzed cases...
  12. ncbi Suspected Greater Celandine hepatotoxicity: liver-specific causality evaluation of published case reports from Europe
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital, Hanau, Germany
    Eur J Gastroenterol Hepatol 24:270-80. 2012
    ..has been causally related to liver injury, but a variety of confounding variables were evident that might have offset causality. This study reanalyses causality levels in these cases with a liver-specific causality evaluation method...
  13. ncbi Proposal for a kava quality standardization code
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University of Frankfurt Main, Germany
    Food Chem Toxicol 49:2503-16. 2011
    ..In conclusion, a sophisticated approach to establish kava quality standardizations is needed for safe human use of kava as relaxing traditional beverages, the anxiolytic drugs, and recreational dietary supplements...
  14. ncbi Spontaneous reports of assumed herbal hepatotoxicity by black cohosh: is the liver-unspecific Naranjo scale precise enough to ascertain causality?
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University Frankfurt Main, Hanau, Germany
    Pharmacoepidemiol Drug Saf 20:567-82. 2011
    ..To evaluate various causality assessing methods in cases with suspected herbal hepatotoxicity, two different scales were now used for reasons of comparison...
  15. ncbi Herb induced liver injury presumably caused by black cohosh: a survey of initially purported cases and herbal quality specifications
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University, Frankfurt Main, Germany
    Ann Hepatol 10:249-59. 2011
    ..It is concluded that the use of BC may not exert an overt hepatotoxicity risk, but quality problems in a few BC products were evident that require additional regulatory quality specifications...
  16. ncbi Herbal hepatotoxicity by kava: update on pipermethystine, flavokavain B, and mould hepatotoxins as primarily assumed culprits
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Goethe University of Frankfurt Main, Germany
    Dig Liver Dis 43:676-81. 2011
    ..Whether kava hepatotoxicity may be due to aflatoxicosis or other mould hepatotoxins, requires further studies...
  17. ncbi Kava, the anxiolytic herb: back to basics to prevent liver injury?
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
    Br J Clin Pharmacol 71:445-8. 2011
    ..This analysis shows poor quality of kava raw material as a cause for its toxicity and suggests preventative measures by going back to the traditional use of kava for the sake of the patients and the South Pacific economy...
  18. ncbi Suspected black cohosh hepatotoxicity--challenges and pitfalls of causality assessment
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University, Frankfurt Main, Germany
    Maturitas 63:302-14. 2009
    ..Recently, however, reports have appeared about the occurrence of rare toxic liver disease in an assumed relationship with the use of BC...
  19. ncbi Severe hepatotoxicity by Indian Ayurvedic herbal products: a structured causality assessment
    Rolf Teschke
    Department of Internal Medicine II, University of Frankfurt Main and University of Duesseldorf, Germany
    Ann Hepatol 8:258-66. 2009
    ..The case is the first report of Indian Ayurvedic herbal products being potentially hepatotoxic in analogy to some other herbs...
  20. ncbi Black cohosh and suspected hepatotoxicity: inconsistencies, confounding variables, and prospective use of a diagnostic causality algorithm. A critical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Hanau, Germany
    Menopause 17:426-40. 2010
    ....
  21. ncbi Kava hepatotoxicity: pathogenetic aspects and prospective considerations
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University, Frankfurt Main, Hanau, Germany
    Liver Int 30:1270-9. 2010
    ....
  22. ncbi Kava hepatotoxicity--a clinical review
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
    Ann Hepatol 9:251-65. 2010
    ....
  23. ncbi Kava hepatotoxicity solution: A six-point plan for new kava standardization
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Leimenstrasse 20, D 63450 Hanau, Germany
    Phytomedicine 18:96-103. 2011
    ..In conclusion, at different levels of responsibility, new mandatory approaches are now required to implement quality specification for international acceptance of kava as a safe and effective anxiolytic herb...
  24. ncbi Regulatory causality evaluation methods applied in kava hepatotoxicity: are they appropriate?
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Germany
    Regul Toxicol Pharmacol 59:1-7. 2011
    ....
  25. ncbi Kava hepatotoxicity: comparative study of two structured quantitative methods for causality assessment
    R Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Hanau, Germany
    J Clin Pharm Ther 35:545-63. 2010
    ..Ingestion of the medicinal herb kava has been associated with hepatotoxicity. We aimed to compare two different quantitative methods of causality assessment of patients with assumed hepatotoxicity by the herb...
  26. ncbi Black cohosh hepatotoxicity: quantitative causality evaluation in nine suspected cases
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Hanau, Germany
    Menopause 16:956-65. 2009
    ..Recently, worldwide discussions have emerged as to whether its use maybe associated with the risk of rare hepatotoxicity in a few susceptible women...
  27. ncbi Suspected hepatotoxicity by Cimicifugae racemosae rhizoma (black cohosh, root): critical analysis and structured causality assessment
    Rolf Teschke
    Medical Department II, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Hanau, Germany
    Phytomedicine 16:72-84. 2009
    ..Using a thorough causality assessment in the form of a diagnostic algorithm we have shown that there is no evidence for a causal relationship between treatment by black cohosh and the observed liver disease in the 4 patients...
  28. ncbi Causality assessment in hepatotoxicity by drugs and dietary supplements
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Hanau, Germany
    Br J Clin Pharmacol 66:758-66. 2008
    ..Concomitant genotyping of cytochrome P450 and other enzymes may also be useful in future to minimize the risk of unwanted side-effects, including toxic liver disease elicited by DDS...
  29. ncbi Suspected herbal hepatotoxicity: requirements for appropriate causality assessment by the US Pharmacopeia
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Academic Teaching Hospital of the Medical Faculty of the Goethe University, FrankfurtMain, Germany
    Drug Saf 35:1091-7. 2012
    ..In essence, the USP and other regulatory agencies should apply validated liver-specific causality assessment methods rather than liver unspecific and not validated assessment methods in suspected HILI cases...
  30. ncbi Kava hepatotoxicity: a clinical survey and critical analysis of 26 suspected cases
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
    Eur J Gastroenterol Hepatol 20:1182-93. 2008
    ..Hepatotoxicity has been previously suspected by national regulatory agencies in 26 patients in causal relationship with the treatment by kava extracts commonly used as herbal anxiolytic drugs...
  31. ncbi Kava hepatotoxicity: comparison of aqueous, ethanolic, acetonic kava extracts and kava-herbs mixtures
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Leimenstrasse 20, D 63450 Hanau, Germany
    J Ethnopharmacol 123:378-84. 2009
    ....
  32. ncbi Hepatotoxicity by drugs and dietary supplements: safety perspectives on clinical and regulatory issues
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University Frankfurt Main, Germany
    Ann Hepatol 8:184-95. 2009
    ..Safety aspects in DDS hepatotoxicity represent a major clinical and regulatory issue and should consequently be addressed...
  33. ncbi Kava hepatotoxicity: a European view
    Rolf Teschke
    Department of Internal Medicine II, Klinikum Hanau, Teaching Hospital of the Johann Wolfgang Goethe University of Frankfurt Main, Leimenstrasse 20, D 63450 Hanau, Germany
    N Z Med J 121:90-8. 2008
    ..A medical advisory is also recommended as part of the labelling...
  34. ncbi Contaminant hepatotoxins as culprits for kava hepatotoxicity - fact or fiction?
    Rolf Teschke
    Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Teaching Hospital of the Medical Faculty of the Goethe University of Frankfurt Main, Germany
    Phytother Res 27:472-4. 2013
    ..Copyright © 2012 John Wiley & Sons, Ltd...