Oliver Zierau

Summary

Affiliation: Technical University
Country: Germany

Publications

  1. doi request reprint Effects of genistein and estrogen receptor subtype-specific agonists in ArKO mice following different administration routes
    Anja Bliedtner
    Chair of Molecular Cell Physiology and Endocrinology, Institute for Zoology, Technische Universitat Dresden, Germany
    Mol Cell Endocrinol 314:41-52. 2010
  2. doi request reprint Detection of anabolic steroid abuse using a yeast transactivation system
    Oliver Zierau
    Molecular Cell Physiology and Endocrinology, Institute of Zoology, Technical University Dresden, Germany
    Steroids 73:1143-7. 2008
  3. doi request reprint Time dependency of uterine effects of naringenin type phytoestrogens in vivo
    Oliver Zierau
    Molecular Cell Physiology and Endocrinology, Institute for Zoology, Technische Universitat Dresden, Germany
    Mol Cell Endocrinol 294:92-9. 2008
  4. doi request reprint Prenylation has a compound specific effect on the estrogenicity of naringenin and genistein
    Georg Kretzschmar
    Institute of Zoology, Technische Universitat Dresden, Dresden, Germany
    J Steroid Biochem Mol Biol 118:1-6. 2010
  5. ncbi request reprint Regulation of gene expression by 8-prenylnaringenin in uterus and liver of Wistar rats
    Patrick Diel
    Molekulare Zellphysiologie and Endokrinologie, Institut fur Zoologie, Technische Universitat Dresden, Dresden, Germany
    Planta Med 70:39-44. 2004
  6. doi request reprint Age dependency of estrogen responsiveness in the uterus and adipose tissue of aromatase-knockout (ArKO) mice
    Manuela I Bader
    Institute for Zoology, Molecular Cell Physiology and Endocrinology, Technische Universitat Dresden, Dresden, Germany
    J Steroid Biochem Mol Biol 128:29-37. 2012
  7. doi request reprint The rat prepubertal uterine myometrium and not the luminal epithelium is predominantly affected by a chronic dietary genistein exposure
    Frank Josef Möller
    Institute for Zoology, Molecular Cell Physiology and Endocrinology, Technical University Dresden, 01062, Dresden, Germany
    Arch Toxicol 86:1899-910. 2012
  8. ncbi request reprint Effects of the chemically synthesized flavanone 7-(O-prenyl)naringenin-4'-acetate on the estrogen signaling pathway in vivo and in vitro
    Georg Kretzschmar
    Institut fur Zoologie, Technische Universitat Dresden, Germany
    J Steroid Biochem Mol Biol 107:114-9. 2007
  9. ncbi request reprint Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells
    Frank Möller
    Molekulare Zellphysiologie and Endokrinologie, Institut fur Zoologie, Technische Universitat Dresden, 01062 Dresden, Germany
    Phytomedicine 14:716-26. 2007
  10. ncbi request reprint Estrogenic activity of griffonianone C, an isoflavone from the root bark of Millettia griffoniana: regulation of the expression of estrogen responsive genes in uterus and liver of ovariectomized rats
    Germain Jean Magloire Ketcha Wanda
    Molecular Cell Physiology and Endocrinology, Technische Universitat Dresden, Dresden, Germany
    Planta Med 73:512-8. 2007

Collaborators

Detail Information

Publications38

  1. doi request reprint Effects of genistein and estrogen receptor subtype-specific agonists in ArKO mice following different administration routes
    Anja Bliedtner
    Chair of Molecular Cell Physiology and Endocrinology, Institute for Zoology, Technische Universitat Dresden, Germany
    Mol Cell Endocrinol 314:41-52. 2010
    ..In summary, we showed the utility of ArKO mice to detect ER-specific effects, in particular those of PPT and DPN also when applied orally...
  2. doi request reprint Detection of anabolic steroid abuse using a yeast transactivation system
    Oliver Zierau
    Molecular Cell Physiology and Endocrinology, Institute of Zoology, Technical University Dresden, Germany
    Steroids 73:1143-7. 2008
    ....
  3. doi request reprint Time dependency of uterine effects of naringenin type phytoestrogens in vivo
    Oliver Zierau
    Molecular Cell Physiology and Endocrinology, Institute for Zoology, Technische Universitat Dresden, Germany
    Mol Cell Endocrinol 294:92-9. 2008
    ..Therefore, 6-DMAN is an exciting candidate molecule for future investigations and potentially a natural occurring selective estrogen receptor modulator...
  4. doi request reprint Prenylation has a compound specific effect on the estrogenicity of naringenin and genistein
    Georg Kretzschmar
    Institute of Zoology, Technische Universitat Dresden, Dresden, Germany
    J Steroid Biochem Mol Biol 118:1-6. 2010
    ..In summary, this study demonstrates that prenylation often found in plant secondary metabolism differentially modifies estrogenic properties of PEs depending on the basic structure of the respective PE...
  5. ncbi request reprint Regulation of gene expression by 8-prenylnaringenin in uterus and liver of Wistar rats
    Patrick Diel
    Molekulare Zellphysiologie and Endokrinologie, Institut fur Zoologie, Technische Universitat Dresden, Dresden, Germany
    Planta Med 70:39-44. 2004
    ....
  6. doi request reprint Age dependency of estrogen responsiveness in the uterus and adipose tissue of aromatase-knockout (ArKO) mice
    Manuela I Bader
    Institute for Zoology, Molecular Cell Physiology and Endocrinology, Technische Universitat Dresden, Dresden, Germany
    J Steroid Biochem Mol Biol 128:29-37. 2012
    ..It remains to be elucidated whether or not this is associated with weight gain caused by an increase in body fat mass...
  7. doi request reprint The rat prepubertal uterine myometrium and not the luminal epithelium is predominantly affected by a chronic dietary genistein exposure
    Frank Josef Möller
    Institute for Zoology, Molecular Cell Physiology and Endocrinology, Technical University Dresden, 01062, Dresden, Germany
    Arch Toxicol 86:1899-910. 2012
    ....
  8. ncbi request reprint Effects of the chemically synthesized flavanone 7-(O-prenyl)naringenin-4'-acetate on the estrogen signaling pathway in vivo and in vitro
    Georg Kretzschmar
    Institut fur Zoologie, Technische Universitat Dresden, Germany
    J Steroid Biochem Mol Biol 107:114-9. 2007
    ....
  9. ncbi request reprint Subtype-specific activation of estrogen receptors by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds in U2OS human osteosarcoma cells
    Frank Möller
    Molekulare Zellphysiologie and Endokrinologie, Institut fur Zoologie, Technische Universitat Dresden, 01062 Dresden, Germany
    Phytomedicine 14:716-26. 2007
    ....
  10. ncbi request reprint Estrogenic activity of griffonianone C, an isoflavone from the root bark of Millettia griffoniana: regulation of the expression of estrogen responsive genes in uterus and liver of ovariectomized rats
    Germain Jean Magloire Ketcha Wanda
    Molecular Cell Physiology and Endocrinology, Technische Universitat Dresden, Dresden, Germany
    Planta Med 73:512-8. 2007
    ..This suggests that some of the biological effects attributed to Millettia griffoniana are probably related to estrogen-mediated function...
  11. doi request reprint Comparative assessment of estrogenic responses with relevance to the metabolic syndrome and to menopausal symptoms in wild-type and aromatase-knockout mice
    Manuela I Bader
    Institute of Zoology, Technische Universitat Dresden, 01062 Dresden, Germany
    J Steroid Biochem Mol Biol 127:428-34. 2011
    ..Our studies demonstrate that the cause of estrogen deficiency significantly impacts on estrogen responsiveness and may be of relevance for investigations on aspects of estrogen deficiency and metabolic and/or menopausal symptoms...
  12. doi request reprint Long-term effects of the rhapontic rhubarb extract ERr 731® on estrogen-regulated targets in the uterus and on the bone in ovariectomized rats
    Annekathrin Martina Keiler
    Institute for Zoology, Molecular Cell Physiology and Endocrinology, Technical University Dresden, Dresden, Germany
    J Steroid Biochem Mol Biol 128:62-8. 2012
    ....
  13. ncbi request reprint Uterine effects of the phytoestrogen 6-(1,1-dimethylallyl)naringenin in rats
    Oliver Zierau
    Institut fur Zoologie, Technische Universitat Dresden, Zellescher Weg 20, Eg, Raum 28a, 01217 Dresden, Germany
    Planta Med 70:590-3. 2004
    ..These findings make 6-DMAN a very interesting candidate substance for further characterization, as it potentially represents a naturally occurring selective estrogen receptor modulator...
  14. ncbi request reprint Regulation of uterine AHR battery gene expression by 17β-Estradiol is predominantly mediated by estrogen receptor α
    Felicitas Rataj
    Molecular Cell Physiology and Endocrinology, Institute for Zoology, Technische Universitat Dresden, 01062 Dresden, Germany
    Arch Toxicol 86:1603-12. 2012
    ..Furthermore they give an insight into how the AHR and its related genes may participate in E2 dependent uterine physiological processes and provide another potential mechanism of action for xenoestrogens...
  15. ncbi request reprint Long-term dietary isoflavone exposure enhances estrogen sensitivity of rat uterine responsiveness mediated through estrogen receptor alpha
    Frank Josef Möller
    Institute for Zoology, Technical University Dresden, 01062 Dresden, Germany
    Toxicol Lett 196:142-53. 2010
    ..Whether this estrogen sensitivity shift is beneficial or adverse to health remains to be elucidated. However, this is highly relevant for interpreting data from regional differences in endocrine cancer...
  16. doi request reprint Effects of the special extract ERr 731 from Rheum rhaponticum on estrogen-regulated targets in the uterotrophy model of ovariectomized rats
    Anja Papke
    Institute for Zoology, Molecular Cell Physiology and Endocrinology, Technical University Dresden, Dresden, Germany
    J Steroid Biochem Mol Biol 117:176-84. 2009
    ....
  17. doi request reprint Comparison of estrogenic responses in bone and uterus depending on the parity status in Lewis rats
    Annekathrin Martina Keiler
    Institute of Zoology, Molecular Cell Physiology and Endocrinology, Technische Universitat Dresden, 01062 Dresden, Germany
    J Steroid Biochem Mol Biol 133:101-9. 2013
    ....
  18. doi request reprint Long-term detection of methyltestosterone (ab-) use by a yeast transactivation system
    Sylvi Wolf
    Molecular Cell Physiology and Endocrinology, Institute of Zoology, Technical University Dresden, Zellescher Weg 20b, Room 248, 01217 Dresden, Germany
    Arch Toxicol 85:285-92. 2011
    ....
  19. ncbi request reprint Activation of estrogen receptor-beta by a special extract of Rheum rhaponticum (ERr 731), its aglycones and structurally related compounds
    Jannette Wober
    Molekulare Zellphysiologie und Endokrinologie, Technische Universitat Dresden, 01062 Dresden, Germany
    J Steroid Biochem Mol Biol 107:191-201. 2007
    ..The ERbeta agonistic activity by ERr 731 could be of importance for its clinical use, as central functions relevant to climacteric complaints are proposed to be mediated via ERbeta activation...
  20. doi request reprint Hop extracts and hop substances in treatment of menopausal complaints
    Annekathrin M Keiler
    Institute of Zoology, Molecular Cell Physiology and Endocrinology, Technische Universitat Dresden, Dresden, Germany
    Planta Med 79:576-9. 2013
    ..In conclusion, although hop extract and especially 8-PN are promising candidates as a relief for climacteric symptoms, data on the safety and efficacy is still scarce...
  21. ncbi request reprint Naringenin-type flavonoids show different estrogenic effects in mammalian and teleost test systems
    Oliver Zierau
    Institute of Zoology, Dresden University of Technology, 01062 Dresden, Germany
    Biochem Biophys Res Commun 326:909-16. 2005
    ..In the medaka sex reversal/vtg gene expression assay no estrogenic effects of the naringenin-type flavonoids were observed, while mammalian in vitro systems showed a similar and graded response to the test compounds...
  22. doi request reprint Estradiol regulates aryl hydrocarbon receptor expression in the rat uterus
    Georg Kretzschmar
    Molecular Cell Physiology and Endocrinology, Institute for Zoology, Technische Universitat Dresden, Dresden, Germany
    Mol Cell Endocrinol 321:253-7. 2010
    ..These results show that members of the AHR pathway are regulated by E2 in the uterus. AHR may therefore play an important role in the mediation of uterine estrogenic effects...
  23. doi request reprint Long-term effects of dietary isoflavones on uterine gene expression profiles
    Frank Josef Möller
    Institute for Zoology, Molecular Cell Physiology and Endocrinology, Technical University Dresden, Dresden, Germany
    J Steroid Biochem Mol Biol 113:296-303. 2009
    ..In conclusion, both the time point on which phytoestrogen exposure starts together with the composition of the ingested phytoestrogen containing diet are of great importance for the biological response of the offspring...
  24. ncbi request reprint No estrogen-like effects of an isopropanolic extract of Rhizoma Cimicifugae racemosae on uterus and vena cava of rats after 17 day treatment
    Georg Kretzschmar
    Institut fur Zoologie, Technische Universitat Dresden, Germany
    J Steroid Biochem Mol Biol 97:271-7. 2005
    ..Contrary to earlier suggestions C. racemosa does not seem to act as an estrogen agonist, but possibly as a weak antiestrogen...
  25. ncbi request reprint Analysis of the promoter-specific estrogenic potency of the phytoestrogens genistein, daidzein and coumestrol
    Oliver Zierau
    Institute for Zoology, Technische Universitat Dresden, Zellescher Weg 20, 02127 Dresden, Germany
    Planta Med 72:184-6. 2006
    ..We assume that the demonstrated promoter-specific potency therefore could be an important mechanism to explain a tissue-specific action of some of these compounds...
  26. ncbi request reprint Antiandrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin
    Oliver Zierau
    Institut fur Zoologie, Technische Universitat Dresden, Zellescher Weg 20, 01217 Dresden, Germany
    Planta Med 69:856-8. 2003
    ..In conclusion, we demonstrated the ability of prenylated naringenins not only to act via the estrogen receptor but also through the androgen receptor...
  27. ncbi request reprint Two major metabolites of 8-prenylnaringenin are estrogenic in vitro
    Oliver Zierau
    Institute of Zoology, Dresden University of Technology, D 01062 Dresden, Germany
    J Steroid Biochem Mol Biol 92:107-10. 2004
    ..These results represent an important piece of information towards the discussion of safety of use of preparations containing 8-prenylnaringenin...
  28. ncbi request reprint Tamoxifen exerts agonistic effects on clusterin and complement C3 gene expression in RUCA-I primary xenografts and metastases but not normal uterus
    Oliver Zierau
    Institute for Zoology, Technische Universitat Dresden, Dresden, Germany
    Endocr Relat Cancer 11:823-30. 2004
    ....
  29. doi request reprint Estimation of an early meaningful time point of bone parameter changes in application to an osteoporotic rat model with in vivo microcomputed tomography measurements
    Annekathrin Martina Keiler
    Institute of Zoology, Molecular Cell Physiology and Endocrinology, Technische Universitat Dresden, 01062 Dresden, Germany
    Lab Anim 46:237-44. 2012
    ..Interestingly, changes of trabecular morphology were also found in the sham animals as a consequence of senescence...
  30. doi request reprint A novel combined approach to detect androgenic activities with yeast based assays in Schizosaccharomyces pombe and Saccharomyces cerevisiae
    Sylvi Wolf
    Institute of Zoology, Dresden University of Technology, Germany
    Toxicol Lett 199:410-5. 2010
    ..g. as pre-screening in doping analysis or cattle feeding. A combination of both assays, exploiting these two phylogenetic very different yeasts, allows detection of the activity of a wide range of androgenic substances...
  31. ncbi request reprint Impact of a functionalized olive oil extract on the uterus and the bone in a model of postmenopausal osteoporosis
    Annekathrin Martina Keiler
    Institute of Zoology, Molecular Cell Physiology and Endocrinology, Technische Universitat Dresden, 01062, Dresden, Germany
    Eur J Nutr 53:1073-81. 2014
    ....
  32. ncbi request reprint Assessment of the proliferative capacity of the flavanones 8-prenylnaringenin, 6-(1.1-dimethylallyl)naringenin and naringenin in MCF-7 cells and the rat mammary gland
    Janina Helle
    Institute of Zoology, Technische Universitat Dresden, Zellescher Weg 20b, 01062 Dresden, Germany Electronic address
    Mol Cell Endocrinol 392:125-35. 2014
    ....
  33. ncbi request reprint Increased bone remodelling around titanium implants coated with chondroitin sulfate in ovariectomized rats
    Jan Dudeck
    Department of Trauma and Reconstructive Surgery, University Hospital Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 74, Dresden 01307, Germany Institute of Immunology, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Fetscherstrasse 74, Dresden 01307, Germany Electronic address
    Acta Biomater 10:2855-65. 2014
    ..05). Coatings with collagen and CS appear to improve both the quantity and quality of bone formed around Ti implants in ovarectomized rats. A simultaneous ethinyl estradiol- and genistein-rich diet seems to enhance these effects...
  34. ncbi request reprint Endocrine modulation and the fragile balance of homeostasis--an overview
    Günter Vollmer
    Molecular Cell Physiology and Endocrinology, Faculty for Mathematics and Science, Institute for Zoology, Technical University Dresden, Mommsenstrasse 13, 01062 Dresden, Germany
    Neuro Endocrinol Lett 23:37-42. 2002
    ..Nevertheless both activities are likely...
  35. ncbi request reprint Antiestrogenic activities of Cimicifuga racemosa extracts
    Oliver Zierau
    Molecular Cell Physiology and Endocrinology, Technical University Dresden, Mommsen street 13, 01062 Dresden, Germany
    J Steroid Biochem Mol Biol 80:125-30. 2002
    ..From these results we conclude, that extracts from the rhizome of Cimicifuga racemosa contain compounds with antiestrogenic properties...
  36. pmc Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors
    Günter Vollmer
    Molekulare Zellphysiologie and Endokrinologie, Fachrichtung Biologie, Technische Universitat Dresden, Dresden, Germany
    Chin Med 5:7. 2010
    ..However, the molecular basis of its clinical effectiveness remains obscure. This article reviews the in vitro and in vivo data of its estrogenic actions, particularly those mediated by estrogen receptor-beta (ERbeta)...
  37. ncbi request reprint [What are phytoestrogens and phyto-SERMS]
    Günter Vollmer
    Molekulare Zellphysiologie und Endokrinologie, Institut fur Zoologie, Technische Universitat Dresden
    Pharm Unserer Zeit 33:378-83. 2004
  38. ncbi request reprint Estrogenic activity of the phytoestrogens naringenin, 6-(1,1-dimethylallyl)naringenin and 8-prenylnaringenin
    Oliver Zierau
    Planta Med 68:449-51. 2002
    ....