Christian Thiede

Summary

Affiliation: Technical University
Country: Germany

Publications

  1. ncbi request reprint Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Fetscherstrasse 74, 01307 Dresden, Germany
    Blood 107:4011-20. 2006
  2. ncbi request reprint Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Blood 99:4326-35. 2002
  3. ncbi request reprint MLL-PTD as a marker for minimal residual disease studies: quantification counts
    Christian Thiede
    Medical Dept, Laboratory for Molecular Diagnostics, University Hospital Carl Gustav Carus, University of Techniques Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Haematologica 90:865B. 2005
  4. ncbi request reprint Strategies and clinical implications of chimerism diagnostics after allogeneic hematopoietic stem cell transplantation
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Acta Haematol 112:16-23. 2004
  5. pmc Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Haematologica 94:1613-7. 2009
  6. doi request reprint Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts
    Angela Jacobi
    Department of Pediatrics, University Clinic Carl Gustav Carus Dresden, Dresden, Germany
    Exp Hematol 38:180-90. 2010
  7. ncbi request reprint Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia
    Christine Steudel
    Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Custav Carus der Technischen Universität Dresden, Germany
    Genes Chromosomes Cancer 37:237-51. 2003
  8. doi request reprint Prophylactic transfer of BCR-ABL-, PR1-, and WT1-reactive donor T cells after T cell-depleted allogeneic hematopoietic cell transplantation in patients with chronic myeloid leukemia
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Blood 117:7174-84. 2011
  9. doi request reprint The level of residual disease based on mutant NPM1 is an independent prognostic factor for relapse and survival in AML
    Nona Shayegi
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Blood 122:83-92. 2013
  10. doi request reprint Clonal evolution including partial loss of human leukocyte antigen genes favoring extramedullary acute myeloid leukemia relapse after matched related allogeneic hematopoietic stem cell transplantation
    Friedrich Stölzel
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Transplantation 93:744-9. 2012

Detail Information

Publications60

  1. ncbi request reprint Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Fetscherstrasse 74, 01307 Dresden, Germany
    Blood 107:4011-20. 2006
    ..In conclusion, NPM1 mutations represent a common genetic abnormality in adult AML. If not associated with FLT3-ITD mutations, mutant NPM1 appears to identify patients with improved response toward treatment...
  2. ncbi request reprint Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Blood 99:4326-35. 2002
    ..Constitutive activation may be associated with monocytoid differentiation. A high mutant/wt ratio in ITD-positive patients appears to have a major impact on the prognostic relevance...
  3. ncbi request reprint MLL-PTD as a marker for minimal residual disease studies: quantification counts
    Christian Thiede
    Medical Dept, Laboratory for Molecular Diagnostics, University Hospital Carl Gustav Carus, University of Techniques Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Haematologica 90:865B. 2005
  4. ncbi request reprint Strategies and clinical implications of chimerism diagnostics after allogeneic hematopoietic stem cell transplantation
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Acta Haematol 112:16-23. 2004
    ..In addition, the potential impact of novel procedures, e.g. subset chimerism or real-time PCR-based procedures, is discussed...
  5. pmc Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Haematologica 94:1613-7. 2009
    ..Monitoring of CD34(+) donor chimerism in the peripheral blood allows prediction of imminent relapse after allogeneic stem cell transplantation even when a disease-specific marker is lacking...
  6. doi request reprint Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts
    Angela Jacobi
    Department of Pediatrics, University Clinic Carl Gustav Carus Dresden, Dresden, Germany
    Exp Hematol 38:180-90. 2010
    ..The aim of this study was to evaluate the impact of FLT3-ITD on cell proliferation and CXCR4-dependent migration in human hematopoietic progenitor cells and to investigate their response to CXCR4 inhibition...
  7. ncbi request reprint Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia
    Christine Steudel
    Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Custav Carus der Technischen Universität Dresden, Germany
    Genes Chromosomes Cancer 37:237-51. 2003
    ..Although associated with inferior disease-free survival, the results of this study do not unequivocally support the notion that MLL PTD mutations represent an independent prognostic factor...
  8. doi request reprint Prophylactic transfer of BCR-ABL-, PR1-, and WT1-reactive donor T cells after T cell-depleted allogeneic hematopoietic cell transplantation in patients with chronic myeloid leukemia
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Blood 117:7174-84. 2011
    ..This trial was registered at www.clinicaltrials.gov as #NCT00460629...
  9. doi request reprint The level of residual disease based on mutant NPM1 is an independent prognostic factor for relapse and survival in AML
    Nona Shayegi
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Blood 122:83-92. 2013
    ..Our results in a large data set define and optimize cutoff values for early diagnosis of molecular relapse. These results may be especially important for defining triggers for early therapeutic intervention...
  10. doi request reprint Clonal evolution including partial loss of human leukocyte antigen genes favoring extramedullary acute myeloid leukemia relapse after matched related allogeneic hematopoietic stem cell transplantation
    Friedrich Stölzel
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Transplantation 93:744-9. 2012
    ..We hypothesized that this mechanism applies to extramedullary AML relapse which occurs frequently after allogeneic HSCT and might also not be restricted to haploidentical HSCT...
  11. doi request reprint Gemtuzumab ozogamicin as part of reduced-intensity conditioning for allogeneic hematopoietic cell transplantation in patients with relapsed acute myeloid leukemia
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Clin Cancer Res 14:5585-93. 2008
    ..We hypothesized that GO might be safe and effective as part of a reduced-intensity conditioning regimen as salvage therapy of CD33+ acute myeloid leukemia...
  12. doi request reprint HLA-DRneg patients without acute promyelocytic leukemia show distinct immunophenotypic, genetic, molecular, and cytomorphologic characteristics compared to acute promyelocytic leukemia
    Uta Oelschlaegel
    University Hospital, University of Technics, Medical Clinic and Policlinic I, Dresden, Germany
    Cytometry B Clin Cytom 76:321-7. 2009
    ..The purpose of this study was to investigate whether further biological characterization of the HLA-DR(neg) acute myeloid leukemia patients would allow more clearly define criteria to separate APL from non-APL patients...
  13. doi request reprint 188Re anti-CD66 radioimmunotherapy combined with reduced-intensity conditioning and in-vivo T cell depletion in elderly patients undergoing allogeneic haematopoietic cell transplantation
    Anett Lauter
    Medizinische Klinik und Poliklinik I, University Hospital Carl Gustav Carus, Fetscherstrasse 74, Dresden, Germany
    Br J Haematol 148:910-7. 2010
    ..Further optimisation, probably involving less T cell depletion, is necessary before a randomized comparison with standard conditioning can be planned...
  14. doi request reprint A novel prognostic model in elderly patients with acute myeloid leukemia: results of 909 patients entered into the prospective AML96 trial
    Christoph Rollig
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Fetscherstrasse 74, Dresden, Germany
    Blood 116:971-8. 2010
    ..5%, 30%, 10.6%, and 3.3%, respectively. The risk model allows further stratification of patients with intermediate-risk karyotype into 2 prognostic groups with implications for the therapeutic strategy...
  15. doi request reprint Long-term prognosis of acute myeloid leukemia according to the new genetic risk classification of the European LeukemiaNet recommendations: evaluation of the proposed reporting system
    Christoph Rollig
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Dresden, Germany
    J Clin Oncol 29:2758-65. 2011
    ..We assessed the prognostic value of the new risk classification in a large cohort of patients...
  16. ncbi request reprint MDR1 and MRP1 gene expression are independent predictors for treatment outcome in adult acute myeloid leukaemia
    Markus Schaich
    Medizinische Klinik und Poliklinik I, Universitätsklinikum C G Carus, Dresden, Germany
    Br J Haematol 128:324-32. 2005
    ..Our study shows that resistance gene expression should be considered together with age, cytogenetics and FLT3 mutational status for risk-adapted treatment strategies in AML in the future...
  17. doi request reprint Cytarabine dose of 36 g/m² compared with 12 g/m² within first consolidation in acute myeloid leukemia: results of patients enrolled onto the prospective randomized AML96 study
    Markus Schaich
    Medizinische Klinik I, Universitätsklinikum C G Carus, Dresden, Germany
    J Clin Oncol 29:2696-702. 2011
    ..To assess the optimal cumulative dose of cytarabine for treatment of young adults with acute myeloid leukemia (AML) within a prospective multicenter treatment trial...
  18. doi request reprint Reconstitution of 6-Sulfo LacNAc Dendritic Cells After Allogeneic Stem-Cell Transplantation
    Konrad Mager
    1 Department of Medicine I, University Hospital Carl Gustav Carus, Dresden, Germany 2 Institute of Immunology, Medical Faculty, Technical University of Dresden, Dresden, Germany 3 Center for Regenerative Therapies, Technical University of Dresden, Dresden, Germany
    Transplantation 93:1270-5. 2012
    ..We investigated for the first time the reconstitution of slanDCs in the blood of patients after SCT and the modulation of their frequency by bacterial infection, cytomegalovirus (CMV) reactivation, and acute GvHD...
  19. doi request reprint Graft-versus-host disease prophylaxis with everolimus and tacrolimus is associated with a high incidence of sinusoidal obstruction syndrome and microangiopathy: results of the EVTAC trial
    Uwe Platzbecker
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Biol Blood Marrow Transplant 15:101-8. 2009
    ..Although this new combination appears to be effective as a prophylactic regimen for acute GVHD, the incidence of TMA and SOS is considerably higher than seen with other regimens...
  20. ncbi request reprint Gene-expression profiling of CD34+ hematopoietic cells expanded in a collagen I matrix
    Joachim Oswald
    Med Klinik und Poliklinik I, University Hospital Carl Gustav Carus, Liebniz Institute of Polymer Research Dresden, Germany
    Stem Cells 24:494-500. 2006
    ..Together, these data show that the expansion of CD34+ cord blood cells in a culture system containing a three-dimensional collagen I matrix induces a qualitative change in the gene-expression profile of cultivated HSCs...
  21. doi request reprint High-dose cytarabine consolidation with or without additional amsacrine and mitoxantrone in acute myeloid leukemia: results of the prospective randomized AML2003 trial
    Markus Schaich
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    J Clin Oncol 31:2094-102. 2013
    ..To assess the treatment outcome benefit of multiagent consolidation in young adults with acute myeloid leukemia (AML) in a prospective, randomized, multicenter trial...
  22. ncbi request reprint Fast appearance of donor dendritic cells in human skin: dynamics of skin and blood dendritic cells after allogeneic hematopoietic cell transplantation
    Susanne Auffermann-Gretzinger
    Medizinische Klinik und Poliklinik I Universitätsklinikum Carl Gustav Carus der Technischen Universität, Fetscherstrasse 74, D 01307 Dresden, Germany
    Transplantation 81:866-73. 2006
    ..Both number and origin (donor vs. host) of dendritic cells (DC) are associated with acute graft-versus-host disease (aGvHD), relapse and graft failure after human allogeneic hematopoietic cell transplantation (aHCT)...
  23. doi request reprint Cup-like acute myeloid leukemia: new disease or artificial phenomenon?
    Frank P Kroschinsky
    First Medical Department, Dresden University Hospital, Dresden, Germany
    Haematologica 93:283-6. 2008
    ..1% in cases without this morphology (p=0.001). There was no influence on response to treatment or survival. Therefore, cup-like nuclear morphology is an indicator of normal karyotype and should guide more specific molecular analyses...
  24. doi request reprint Matched unrelated or matched sibling donors result in comparable survival after allogeneic stem-cell transplantation in elderly patients with acute myeloid leukemia: a report from the cooperative German Transplant Study Group
    Johannes Schetelig
    Medizinische KIinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    J Clin Oncol 26:5183-91. 2008
    ..We sought to determine whether donor type is a prognostic factor in elderly patients in the era of high-resolution DNA-based HLA typing...
  25. doi request reprint Genetic variations of interleukin-23R (1143A>G) and BPI (A645G), but not of NOD2, are associated with acute graft-versus-host disease after allogeneic transplantation
    Martin Wermke
    Department of Medicine I, University Hospital Carl Gustav Carus, Fetscherstraße 74, Dresden, Germany
    Biol Blood Marrow Transplant 16:1718-27. 2010
    ..The importance of these markers in prediction models for GVHD and relapse remain to be defined in large prospective clinical trials...
  26. doi request reprint Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells
    Friedrich Stölzel
    Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus Dresden der TU Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Ann Hematol 89:653-62. 2010
    ..In summary, resistance against PKC412 appears to be mediated by up-regulation of anti-apoptotic genes and down-regulation of proapoptotic signals as well as genes that are involved in normal and malignant hematopoiesis...
  27. ncbi request reprint MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients
    Thomas Illmer
    Medical Clinic and Polyclinic I, University Hospital of the Technical University, 01307 Dresden, Germany
    Cancer Res 62:4955-62. 2002
    ....
  28. ncbi request reprint Expression and regulation of NFAT (nuclear factors of activated T cells) in human CD34+ cells: down-regulation upon myeloid differentiation
    Alexander Kiani
    Department of Medicine I, University Hospital Carl Gustav Carus, University of Dresden Technical Center, Germany
    J Leukoc Biol 76:1057-65. 2004
    ..These results suggest a novel and unexpected role for members of the NFAT transcription factor family in the hematopoietic system...
  29. ncbi request reprint Activation of the RAS pathway is predictive for a chemosensitive phenotype of acute myelogenous leukemia blasts
    Thomas Illmer
    Medical Clinic and Policlinic I, University Hospital of the Technical University, Dresden, Germany
    Clin Cancer Res 11:3217-24. 2005
    ..This could be due to alternative initiating events for activation of the RAS pathway like constitutive tyrosine kinase activation or mutations in Ras-regulating genes...
  30. doi request reprint Abnormal localization and accumulation of FLT3-ITD, a mutant receptor tyrosine kinase involved in leukemogenesis
    Sina Koch
    Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Gustav Carus der technischen Universität Dresden, Dresden, Deutschland
    Cells Tissues Organs 188:225-35. 2008
    ..Based on our data and the immature glycosylation pattern of FLT3-ITD, we speculate that the mutant protein resides most probably in an unidentified compartment of the secretory pathway between the ER and the Golgi apparatus...
  31. pmc Aberrant methylation of the M-type phospholipase A(2) receptor gene in leukemic cells
    Mario Menschikowski
    Institut fur Klinische Chemie und Laboratoriumsmedizin, Technische Universitat Dresden, Fetscherstrasse 74, D 01307, Dresden, Germany
    BMC Cancer 12:576. 2012
    ..This study examined the expression and methylation of the PLA2R1 gene in Jurkat and U937 leukemic cell lines and its methylation in patients with myelodysplastic syndrome (MDS) or acute leukemia...
  32. ncbi request reprint Chimerism analysis after allogeneic stem cell transplantation
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Haematologica 90:1301A. 2005
  33. ncbi request reprint Expression profiling of gastric cancer samples by oligonucleotide microarray analysis reveals low degree of intra-tumor variability
    Karolin Trautmann
    Medical Department I, Fetscherstr 74, 01307 Dresden, Germany
    World J Gastroenterol 11:5993-6. 2005
    ....
  34. pmc In Vivo Expansion of Co-Transplanted T Cells Impacts on Tumor Re-Initiating Activity of Human Acute Myeloid Leukemia in NSG Mice
    Malte von Bonin
    Regeneration in Hematopoiesis, Center for Regenerative Therapies Dresden CRTD, DFG Research Center and Cluster of Excellence, Technische Universitat Dresden, Dresden, Germany Medizinische Klinik und Poliklinik 1, Universitatsklinikum Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 8:e60680. 2013
    ..Engraftment of mainly myeloid cell types can be enforced by the prevention of T cell expansion through the depletion of lymphocytes from the graft prior transplantation...
  35. ncbi request reprint Conditioning with fludarabine and targeted busulfan for transplantation of allogeneic hematopoietic stem cells
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Blood 102:820-6. 2003
    ..Based on these encouraging results, further studies of fludarabine and targeted busulfan are warranted in standard-risk patients...
  36. ncbi request reprint Diagnostic chimerism analysis after allogeneic stem cell transplantation: new methods and markers
    Christian Thiede
    Medical Department, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    Am J Pharmacogenomics 4:177-87. 2004
    ..Whether this will ultimately improve the survival of patients with leukemia after transplantation has to be shown in prospective studies...
  37. ncbi request reprint Hematopoietic stem cell transplantation for complete IFN-gamma receptor 1 deficiency: a multi-institutional survey
    Joachim Roesler
    Department of Pediatrics and the Department of Internal Medicine, University Clinic Carl Gustav Carus, Dresden, Germany
    J Pediatr 145:806-12. 2004
    ..To evaluate the outcome of hematopoietic stem cell transplantation (HSCT) in a series of patients with inherited complete IFN-gamma receptor 1 (IFNgammaR1) deficiency...
  38. pmc Targeted isolation of cloned genomic regions by recombineering for haplotype phasing and isogenic targeting
    Marta Nedelkova
    Technische Universitaet Dresden, Genomics, BioInnovationsZentrum, Dresden, Germany
    Nucleic Acids Res 39:e137. 2011
    ..These methods will facilitate work to understand the linkage between personal variations and disease propensity, as well as possibilities for personal genome surgery...
  39. ncbi request reprint Successful combination of anti-CD33 antibody (gemtuzumab ozogamicin) and minimal conditioning before second allografting in recurrent acute myeloid leukaemia
    Mathias Hänel
    Br J Haematol 120:1093-4. 2003
  40. ncbi request reprint Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor
    Rebekka Grundler
    Department of Internal Medicine III, Laboratory of Leukemogenesis, Technical University of Munich, Germany
    Blood 102:646-51. 2003
    ..These results suggest that it may be useful to determine the exact kind of FLT3 mutation when applying receptor kinase inhibitors in clinical trials...
  41. ncbi request reprint Prognostic significance of N-RAS and K-RAS mutations in 232 patients with acute myeloid leukemia
    Markus Ritter
    Haematologica 89:1397-9. 2004
    ..A peptide nucleic acid (PNA)-based technique was used on 232 AML samples to detect point mutations of the hotspots in N-RAS and K-RAS. No significant correlations between RAS mutations and clinical features, karyotype or FLT3 were found...
  42. ncbi request reprint RGS2 is an important target gene of Flt3-ITD mutations in AML and functions in myeloid differentiation and leukemic transformation
    Joachim Schwable
    Department of Medicine, Hematology, and Oncology, and the Interdisciplinary Clinical Research Center IZKF, University Hospital Munster, Albert Schweitzer Strasse 33, 48129 Munster, Germany
    Blood 105:2107-14. 2005
    ..Taken together, RGS2 is a novel mediator of myeloid differentiation, and its repression is an important event in Flt3-ITD-induced transformation...
  43. ncbi request reprint Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations
    Stefan Fröhling
    Department of Internal Medicine III, University Hospital of Ulm, Robert Koch Strasse 8, 89081 Ulm, Germany
    Genes Chromosomes Cancer 42:427-32. 2005
    ..Loss of a critical segment of 9q, most likely in 9q22, and disruption of CEBPA function possibly cooperate in the pathogenesis of del(9q) AML...
  44. ncbi request reprint Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML
    Martin Bornhauser
    Blood 109:2264-5; author reply 2265. 2007
  45. ncbi request reprint FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model
    Rebekka Grundler
    Department of Internal Medicine III, Technical University of Munich, Ismaningerstr 22, 81675 Munich, Germany
    Blood 105:4792-9. 2005
    ..Indeed strong signal transducers and activators of transcription 5 (STAT5) activation could only be demonstrated for FLT3-ITDs...
  46. ncbi request reprint Kinetics of stem cell engraftment and clearance of leukaemia cells after allogeneic stem cell transplantation with reduced intensity conditioning in chronic myeloid leukaemia
    Karl Anton Kreuzer
    Medizinische Klinik und Poliklinik m S Hämatologie und Onkologie, Universitatsklinikum Charite, Campus Virchow, Klinikum, Humboldt Universitat zu Berlin, Germany
    Eur J Haematol 69:7-10. 2002
    ..The close relation (P = 0.0075) between the first occurrence of graft-vs.-host disease and the complete clearance of bcr/abl positive blood cells argues in favour of an effective graft-vs.-leukaemia reaction...
  47. doi request reprint A one-mutation mathematical model can explain the age incidence of acute myeloid leukemia with mutated nucleophosmin (NPM1)
    Arcangelo Liso
    Institute of Hematology, University of Foggia, Foggia, Italy
    Haematologica 93:1219-26. 2008
    ..This model fits with the hypothesis that NPMc(+) acute myeloid leukemia arises from an NPM1 mutation with haploinsufficiency of the wild-type NPM1 allele...
  48. pmc Patients with acute myeloid leukemia and RAS mutations benefit most from postremission high-dose cytarabine: a Cancer and Leukemia Group B study
    Andreas Neubauer
    Department for Hematology, Oncology and Immunology, Philipps University, Marburg, Germany
    J Clin Oncol 26:4603-9. 2008
    ..RAS mutations occur in 12% to 27% of patients with acute myeloid leukemia (AML) and enhance sensitivity to cytarabine in vitro. We examined whether RAS mutations impact response to cytarabine in vivo...
  49. ncbi request reprint Acute graft-versus-host disease of the heart
    Stephen S Roberts
    Division of Pediatric Hematology Oncology, Department of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA
    Pediatr Blood Cancer 47:624-8. 2006
    ..All but one of the reported cases have occurred in pediatric patients and six of those patients died, suggesting that this may be a rare but frequently fatal complication of pediatric allogeneic stem cell transplant...
  50. ncbi request reprint BAALC expression and FLT3 internal tandem duplication mutations in acute myeloid leukemia patients with normal cytogenetics: prognostic implications
    Claudia D Baldus
    Charite, Universitatsmedizin Berlin, Campus Benjamin Franklin, Medizinische Klinik III, Berlin, Germany
    J Clin Oncol 24:790-7. 2006
    ....
  51. ncbi request reprint Allogeneic transplantation after reduced conditioning in high risk patients is complicated by a high incidence of acute and chronic graft-versus-host disease
    Johannes Schetelig
    Kliniken für Innere Medizin m S Hämatologie und Onkologie, Charite, Campus Virchow Klinikum and Campus Charite Mitte, Berlin, Germany
    Haematologica 87:299-305. 2002
    ..In conclusion, the regimen itself can be carried out safely in patients with relative contraindications against myeloablative conditioning. However, GVHD causes significant non-relapse mortality in high risk patients...
  52. ncbi request reprint Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication
    Thomas Wündisch
    Klinik für Hämatologie, Onkologie und Immunologie, Klinikum der Philipps Universität, Marburg, Germany
    J Clin Oncol 23:8018-24. 2005
    ..We tracked the long-term stability of remissions in this prospective, multicenter trial...
  53. ncbi request reprint Correction of complete interferon-gamma receptor 1 deficiency by bone marrow transplantation
    Ursula Reuter
    University Children s Hospital Ulm, Germany
    Blood 100:4234-5. 2002
    ..Liver disease has not further deteriorated. This experience shows that correction of IFNgammaR1 deficiency is possible by BMT and complications of the disease can be controlled...
  54. ncbi request reprint B-cell monoclonality is associated with lymphoid follicles in gastritis
    Thomas Wündisch
    Klinik für Hämatologie, Onkologie und Immunologie, Philipps Universitat Marburg, Germany
    Am J Surg Pathol 27:882-7. 2003
    ..We found B-cell monoclonality to be a more frequent than expected finding in gastritis and to be strongly associated with the presence of lymphoid follicles; thus, its presence is of little significance in patient management...
  55. ncbi request reprint Tyrosine kinase mutations of JAK2 are rare events in AML but influence prognosis of patients with CBF-leukemias
    Thomas Illmer
    Haematologica 92:137-8. 2007
    ..6% (p<0.01). Moreover, JAK2 V617F mutations in CBF leukemias were associated with an aggressive clinical course with 80% of the patients relapsing...
  56. ncbi request reprint Telomere length and hTERT expression in patients with acute myeloid leukemia correlates with chromosomal abnormalities
    Ulrike Hartmann
    Dept of Hematology and Oncology, University of Tubingen, Germany
    Haematologica 90:307-16. 2005
    ..The aim of this study was to analyze whether telomere length and/or hTERT expression are correlated with clonal chromosomal aberrations in AML...
  57. ncbi request reprint A highly sensitive method for the detection of PKC412 (CGP41251) and its metabolites by high-performance liquid chromatography
    Thomas Illmer
    Medical Clinic and Policlinic I, Technical University Dresden, Germany
    J Pharmacol Toxicol Methods 56:23-7. 2007
    ..Therefore, we established a new isocratic HPLC method, which sensitively detects PKC412 and five of its metabolites...
  58. ncbi request reprint MLD according to the WHO classification in AML has no correlation with age and no independent prognostic relevance as analyzed in 1766 patients
    Hannes Wandt
    Klinikum Nürnberg, Medizinische Klinik 5, Hämatologie Onkologie, Nurnberg, Germany
    Blood 111:1855-61. 2008
    ..Our data support a reassessment of the WHO classification in the light of a more biologic understanding of AML. This study is registered at www.ClinicalTrials.gov as #NCT00180115...
  59. ncbi request reprint Mesenchymal stem cells obtained after bone marrow transplantation or peripheral blood stem cell transplantation originate from host tissue
    Andreas Dickhut
    Department of Hematology, Oncology and Immunology, Philipps University of Marburg, 35033, Marburg, Germany
    Ann Hematol 84:722-7. 2005
    ..We conclude that even if trace amounts of MSC are co-transplanted during PBSCT or BMT, they do not expand significantly in the host bone marrow...
  60. doi request reprint Identification of acute myeloid leukaemia associated microRNA expression patterns
    Fabienne Isken
    Department of Medicine A, Haematology and Oncology, University of Munster, Munster, Germany
    Br J Haematol 140:153-61. 2008
    ..Nonetheless, the presence of two or more miRNA binding sites within the mRNA was usually associated with a decrease in mRNA levels. Taken together, these findings provide evidence that specific miRNA expression patterns exist in AML...