A Storch

Summary

Affiliation: Technical University
Country: Germany

Publications

  1. pmc Physical activity and environmental enrichment regulate the generation of neural precursors in the adult mouse substantia nigra in a dopamine-dependent manner
    Philipp Klaissle
    Department of Neurology, Charité University Medicine Berlin CCM, Chariteplatz 1, Berlin, 10117, Germany
    BMC Neurosci 13:132. 2012
  2. doi request reprint Effects of dopaminergic treatment on striatal dopamine turnover in de novo Parkinson disease
    Alexander Storch
    Division of Neurodegenerative Diseases, Dresden University of Technology, Dresden, Germany
    Neurology 80:1754-61. 2013
  3. doi request reprint Nonmotor fluctuations in Parkinson disease: severity and correlation with motor complications
    Alexander Storch
    Department of Neurology, Division of Neurodegenerative Diseases, Dresden University of Technology, Dresden
    Neurology 80:800-9. 2013
  4. doi request reprint Intrathecal application of autologous bone marrow cell preparations in Parkinsonian syndromes
    Alexander Storch
    Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany
    Mov Disord 27:1552-5. 2012
  5. pmc Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation
    Javorina Milosevic
    Translational Centre for Regenerative Medicine Leipzig TRM Leipzig, University of Leipzig, Philipp Rosenthal Strasse 55, 04103 Leipzig, Germany
    Mol Neurodegener 4:25. 2009
  6. pmc Cerebrospinal fluid promotes survival and astroglial differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiation
    Judith Buddensiek
    Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany
    BMC Neurosci 11:48. 2010
  7. ncbi request reprint [Coenzyme Q10 in Parkinson's disease. Symptomatic or neuroprotective effects?]
    A Storch
    Klinik und Poliklinik fur Neurologie, Technische Universitat Dresden, Fetscherstrasse 74, Dresden, Germany
    Nervenarzt 78:1378-82. 2007
  8. ncbi request reprint Dopamine transporter: involvement in selective dopaminergic neurotoxicity and degeneration
    A Storch
    Department of Neurology, University of Ulm, Germany
    J Neural Transm 111:1267-86. 2004
  9. ncbi request reprint Midbrain-derived neural stem cells: from basic science to therapeutic approaches
    Alexander Storch
    Department of Neurology, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Cell Tissue Res 318:15-22. 2004
  10. ncbi request reprint Testing for acanthocytosis A prospective reader-blinded study in movement disorder patients
    Alexander Storch
    Dept of Neurology, University of Ulm, 89081 Ulm, Germany
    J Neurol 252:84-90. 2005

Collaborators

Detail Information

Publications86

  1. pmc Physical activity and environmental enrichment regulate the generation of neural precursors in the adult mouse substantia nigra in a dopamine-dependent manner
    Philipp Klaissle
    Department of Neurology, Charité University Medicine Berlin CCM, Chariteplatz 1, Berlin, 10117, Germany
    BMC Neurosci 13:132. 2012
    ..We investigated the role of dopamine in NG2-generation and differentiation in the adult SN stimulated by physical activity and environmental enrichment...
  2. doi request reprint Effects of dopaminergic treatment on striatal dopamine turnover in de novo Parkinson disease
    Alexander Storch
    Division of Neurodegenerative Diseases, Dresden University of Technology, Dresden, Germany
    Neurology 80:1754-61. 2013
    ....
  3. doi request reprint Nonmotor fluctuations in Parkinson disease: severity and correlation with motor complications
    Alexander Storch
    Department of Neurology, Division of Neurodegenerative Diseases, Dresden University of Technology, Dresden
    Neurology 80:800-9. 2013
    ..To evaluate frequency, severity, and correlation of nonmotor symptoms (NMS) with motor complications in fluctuating Parkinson disease (PD)...
  4. doi request reprint Intrathecal application of autologous bone marrow cell preparations in Parkinsonian syndromes
    Alexander Storch
    Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany
    Mov Disord 27:1552-5. 2012
    ..We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes...
  5. pmc Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation
    Javorina Milosevic
    Translational Centre for Regenerative Medicine Leipzig TRM Leipzig, University of Leipzig, Philipp Rosenthal Strasse 55, 04103 Leipzig, Germany
    Mol Neurodegener 4:25. 2009
    ..In conclusion, a reduction of LRRK2 expression in hmNPCs severely impaired dopaminergic differentiation and/or survival of dopaminergic neurons most likely via preserving or reactivating the cell cycle...
  6. pmc Cerebrospinal fluid promotes survival and astroglial differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiation
    Judith Buddensiek
    Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany
    BMC Neurosci 11:48. 2010
    ..Existing in vitro studies focused on embryonic cell lines and embryonic CSF. We therefore studied the effects of adult human leptomeningeal CSF on the behaviour of adult human NSCs (ahNSCs)...
  7. ncbi request reprint [Coenzyme Q10 in Parkinson's disease. Symptomatic or neuroprotective effects?]
    A Storch
    Klinik und Poliklinik fur Neurologie, Technische Universitat Dresden, Fetscherstrasse 74, Dresden, Germany
    Nervenarzt 78:1378-82. 2007
    ..CoQ10 is well tolerated and safe as both monotherapy and add-on medication in PD patients. The present review discusses the current knowledge on neuroprotective and symptomatic actions of CoQ10 in PD...
  8. ncbi request reprint Dopamine transporter: involvement in selective dopaminergic neurotoxicity and degeneration
    A Storch
    Department of Neurology, University of Ulm, Germany
    J Neural Transm 111:1267-86. 2004
    ..Taken together, there is large body of evidence from morphological, molecular biological and toxicological studies indicating that the DAT might be responsible for the selectivity of DA cell death in PD...
  9. ncbi request reprint Midbrain-derived neural stem cells: from basic science to therapeutic approaches
    Alexander Storch
    Department of Neurology, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Cell Tissue Res 318:15-22. 2004
    ..This review discusses new data concerning the cell biology and therapeutic potential of NSCs derived from the midbrain region of the central nervous system...
  10. ncbi request reprint Testing for acanthocytosis A prospective reader-blinded study in movement disorder patients
    Alexander Storch
    Dept of Neurology, University of Ulm, 89081 Ulm, Germany
    J Neurol 252:84-90. 2005
    ..The use of isotonically diluted blood samples combined with unfixed wet blood preparation with a normal range of <6.3% of total erythrocytes is recommended to search for significant acanthocytosis in movement disorders...
  11. doi request reprint [Depression in Parkinson's disease. Part 1: epidemiology, signs and symptoms, pathophysiology and diagnosis]
    A Storch
    Klinik und Poliklinik fur Neurologie, Universitatsklinikum Carl Gustav Carus, Dresden
    Fortschr Neurol Psychiatr 76:715-24. 2008
    ..The present review summarizes the current knowledge on epidemiology, pathogenesis and diagnosis of depression in PD and proposes on this data base a standard procedure for screening and diagnosis of depressive symptoms in PD...
  12. ncbi request reprint High-dose treatment with pergolide in Parkinson's disease patients with motor fluctuations and dyskinesias
    Alexander Storch
    Department of Neurology, University of Ulm, Ulm, Germany
    Parkinsonism Relat Disord 11:393-8. 2005
    ..Controlled trials are needed to further substantiate the efficacy and safety of this treatment strategy...
  13. ncbi request reprint Cytotoxicity of chloral-derived beta-carbolines is not specific towards neuronal nor dopaminergic cells
    A Storch
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    J Neural Transm 113:1895-901. 2006
    ..Our results suggest that TaClo and related analogs are strong cytotoxins without selectivity towards dopaminergic cells...
  14. ncbi request reprint [Gene expression profiling of classic mitochondrial disorders. Its value in finding therapeutic strategies]
    S Mende
    Klinik und Poliklinik fur Neurologie, Technische Universitat Dresden
    Nervenarzt 78:1155-9. 2007
    ..This review article focuses on the most recent gene expression profiling studies in the field of classic mitochondrial disorders...
  15. ncbi request reprint Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease
    Alexander Storch
    Department of Neurology, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Arch Neurol 64:938-44. 2007
    ..Coenzyme Q(10) (CoQ(10)) is an electron acceptor bridging mitochondrial complexes I and II/III and a potent antioxidant that consistently partially recovers the function of dopaminergic neurons...
  16. ncbi request reprint New developments in diagnosis and treatment of Parkinson's disease--from basic science to clinical applications
    Alexander Storch
    Technical University of Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany
    J Neurol 251:VI/33-8. 2004
    ..Furthermore, we discuss the major problems in the translation of results from preclinical research into successful clinical trials...
  17. doi request reprint Chocolate consumption is increased in Parkinson's disease. Results from a self-questionnaire study
    Martin Wolz
    Dept of Neurology, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany
    J Neurol 256:488-92. 2009
    ..Although reasons for increased chocolate consumption in PD remain elusive, it may hypothetically be a consequence of the high content of various biogenic amines and/or caffeine analogues with potential antiparkinsonian effects...
  18. doi request reprint Viliuisk encephalomyelitis in Northeastern Siberia is not caused by Borrelia burgdorferi infection
    Alexander Storch
    Department of Neurology, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Neurol Sci 29:11-4. 2008
    ..Our data provide the first evidence of the presence of Borrelia burgdorferi or similar pathogens in Northeastern Siberia, but do not support a causative role of these pathogens in the aetiopathogenesis of VE...
  19. doi request reprint [Non-motor Symptoms Questionnaire and Scale for Parkinson's disease. Cross-cultural adaptation into the German language]
    A Storch
    Klinik und Poliklinik fur Neurologie, Technische Universitat Dresden, Fetscherstrasse 74, 01307, Dresden, Deutschland
    Nervenarzt 81:980-5. 2010
    ..We used international guidelines for cross-cultural adaptation of questionnaires to provide standard versions of both non-motor symptoms questionnaires in the German language...
  20. doi request reprint [Depression in Parkinson's disease--Part 2: Therapy and management]
    A Storch
    Die Institutsangaben sind am Ende des Beitrags gelistet
    Fortschr Neurol Psychiatr 78:456-67. 2010
    ..This survey gives an overview on the pharmacological, somatic and psychological procedures of treatment applied in this group of patients, along with useful suggestions...
  21. ncbi request reprint Protective effects of riluzole on dopamine neurons: involvement of oxidative stress and cellular energy metabolism
    A Storch
    Department of Neurology, University of Ulm Medical School, Ulm, Germany
    J Neurochem 75:2259-69. 2000
    ..These results provide further impetus to explore the neuroprotective potential of riluzole in Parkinson's disease...
  22. ncbi request reprint Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells
    A Storch
    Department of Neurology, University of Ulm Medical School, Ulm, Germany
    Exp Neurol 170:317-25. 2001
    ....
  23. ncbi request reprint HEK-293 cells expressing the human dopamine transporter are susceptible to low concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolism
    A Storch
    Department of Neurology, University of Ulm Medical School, Germany
    Neurochem Int 35:393-403. 1999
    ..This cell system may serve as a screening system for endogenous and exogenous compounds with similar effects compared to MPP+ as well as protective agents...
  24. ncbi request reprint 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism
    A Storch
    Department of Neurology, University of Ulm Medical School, Oberer Eselsberg 45, 89081, Ulm, Germany
    Brain Res 855:67-75. 2000
    ..These results suggest that cell death induced by salsolinol is due to impairment of cellular energy supply, caused in particular by inhibition of mitochondrial complex II (succinate-Q reductase), but not complex I...
  25. ncbi request reprint Efficacy and safety of high-dose cabergoline in Parkinson's disease
    P Odin
    Department of Neurology, Central Hospital, D 27574 Bremerhaven, Germany
    Acta Neurol Scand 113:18-24. 2006
    ..To assess the efficacy and safety of high-dose (up to 20 mg/day) cabergoline in Parkinson's disease (PD) patients with motor fluctuations and/or dyskinesias...
  26. ncbi request reprint Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons
    A Storch
    Department of Neurology, University of Ulm Medical School, Ulm, Germany
    Mol Pharmacol 57:589-94. 2000
    ..These data demonstrate that COMT inhibition attenuates L-dopa toxicity toward DA neurons in vitro, but probably not by preventing 3-O-methyldopa production or cellular S-adenosyl-L-methionine depletion...
  27. ncbi request reprint Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitro
    A G Ludolph
    Department of Child and Adolescent Psychiatry, University of Ulm, Ulm, Germany
    J Neural Transm 113:1927-34. 2006
    ..The neurotoxic effects of MPP(+) could be significantly reduced by co-application of MPH, an effect that is most likely explained by MPH blocking the DAT...
  28. ncbi request reprint High doses of pergolide improve clinical global impression in advanced Parkinson's disease:- a preliminary open label study
    Guy Arnold
    Department of Neurology, Charite, University Hospital Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
    Arch Gerontol Geriatr 41:239-53. 2005
    ..A possible relationship to the study medication was assumed for two serious adverse events reporting psychosis. We conclude that high doses of pergolide are efficacious in advanced stages of PD if given in appropriate regimens...
  29. doi request reprint Depression in Parkinson's disease
    J Schwarz
    Department of Neurology, University of Leipzig, Liebigstr 20, 04103 Leipzig, Germany
    J Neurol 258:S336-8. 2011
    ..Data on specific diagnostic tools or treatment for depressive symptoms in PD patients are still sparse. Here we summarize an expert opinion based on available data and clinical experience...
  30. doi request reprint [Parainfectious polyneuropathy and miller-fisher-syndrome in combination with anemia in Mycoplasma pneumoniae infection]
    K F Loewenbrück
    Klinik und Poliklinik fur Neurologie, Universitätsklinik Carl Gustav Carus Dresden
    Fortschr Neurol Psychiatr 76:361-5. 2008
    ..With this report we would like to stress the importance to include M.p. in the diagnostic procedures in the case of inflammatory neurological syndromes, especially when combined with alterations of the blood count...
  31. doi request reprint Potassium channel blocker 4-aminopyridine is effective in interictal cerebellar symptoms in episodic ataxia type 2--a video case report
    Matthias Lohle
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    Mov Disord 23:1314-6. 2008
    ..i.d., there was pronounced improvement in gait and stance ataxia. Within 24 hours SARA score lowered from 8.5 to 4.5 points. We conclude that 4-AP may be beneficial for interictal cerebellar ataxia in late onset EA2...
  32. ncbi request reprint Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signaling
    Javorina Milosevic
    Department of Neurology, University of Leipzig, 04103 Leipzig, Germany
    J Neurosci 27:412-21. 2007
    ..In conclusion, HIF-1alpha seems to be a transcription factor relevant to the development and survival of substantia nigra dopaminergic neurons involving VEGF signaling...
  33. ncbi request reprint Developmental perspectives on human midbrain-derived neural stem cells
    Johannes Schwarz
    Department of Neurology, University of Leipzig, Leipzig, Germany
    Neurodegener Dis 3:45-9. 2006
    ..Neural stem cells derived from human fetal midbrain tissue maintain a considerable capacity to self-renew and to differentiate into DA neurons. Therefore, these cells may be a promising source to generate functional human DA neurons...
  34. doi request reprint Beyond tremor and rigidity: non-motor features of Parkinson's disease
    Matthias Lohle
    Department of Neurology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    J Neural Transm 116:1483-92. 2009
    ..This article aims to provide an overview of frequently observed non-motor features in PD and discusses prospects and limitations of currently available options for symptomatic treatment of these disturbances...
  35. ncbi request reprint Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease
    Vera Lehmensiek
    Department of Neurology, University of Ulm, Germany
    Neurochem Int 48:329-40. 2006
    ....
  36. ncbi request reprint Neural stem cells and Parkinson's disease
    Alexander Storch
    Department of Neurology, University of Ulm, 89081 Ulm, Germany
    J Neurol 249:III/30-2. 2002
    ..These cells will hopefully enable restorative treatment of patients with Parkinson's disease in the near future...
  37. doi request reprint [Neurogenesis in the adult brain: from bench to bedside?]
    M D Brandt
    Klinik und Poliklinik für Neurologie und Center for Regenerative Therapies Dresden CRTD, Technische Universitat Dresden, Germany
    Fortschr Neurol Psychiatr 76:517-29. 2008
    ..This review summarizes the neurobiological bases of adult neurogenesis in their relevance for the future trend of novel therapeutic strategies...
  38. doi request reprint Altered migration and adhesion potential of pro-neurally converted human bone marrow stromal cells
    H J Habisch
    Department of Neurology, University of Ulm, Ulm, Germany
    Cytotherapy 10:824-33. 2008
    ..We have previously introduced the pro-neural conversion of human MSC to neural stem cell-like cells (m-NSC) by culturing them in suspension culture under serum-free conditions...
  39. doi request reprint Stage-dependent vulnerability of fetal mesencephalic neuroprogenitors towards dopaminergic neurotoxins
    Michael Sabolek
    Department of Neurology, University of Ulm, Ulm, Germany
    Neurotoxicology 29:714-21. 2008
    ..This cell system seems not suitable as a screening tool for selective dopaminergic toxicity...
  40. ncbi request reprint Dexamethasone blocks astroglial differentiation from neural precursor cells
    Michael Sabolek
    Department of Neurology, University of Ulm, Ulm, Germany
    Neuroreport 17:1719-23. 2006
    ....
  41. ncbi request reprint Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signalling
    Javorina Milosevic
    Department of Neurology, University of Leipzig, Leipzig, Germany
    J Neurochem 99:913-23. 2006
    ..We conclude that uracil nucleotides exert specific P2 receptor-mediated effects on midbrain-derived human NPCs, and may be used to enhance both proliferation and dopaminergic differentiation...
  42. ncbi request reprint Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells
    Alexander Storch
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    J Chem Neuroanat 26:133-42. 2003
    ....
  43. doi request reprint Restorative approaches in Parkinson's Disease: which cell type wins the race?
    Anne K Meyer
    Department of Neurology, Dresden University of Technology, Dresden, Germany
    J Neurol Sci 289:93-103. 2010
    ..This review discusses recent data on stem cell technology with respect to cell replacement strategies in PD as well as endogenous dopaminergic regeneration...
  44. ncbi request reprint Catechol-O-methyltransferase inhibition protects against 3,4-dihydroxyphenylalanine (DOPA) toxicity in primary mesencephalic cultures: new insights into levodopa toxicity
    Heike Blessing
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
    Neurochem Int 42:139-51. 2003
    ..In addition, we demonstrate a second mechanism of L-DOPA toxicity in vitro mediated by a COMT- and glia-dependent pathway, which is blocked by COMT inhibitors, most likely due to enhanced glial uptake of L-DOPA...
  45. ncbi request reprint Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation
    Stefan Liebau
    Department of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    J Neurochem 99:426-37. 2006
    ..3 by Psora-4, increased NPC proliferation. These findings underline the regulatory role of K(+) channels on the cell cycle and imply that K(+) channel modulators might be used therapeutically to activate endogenous NPCs...
  46. ncbi request reprint Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitro
    Javorina Milosevic
    Translational Centre for Regenerative Medicine, Leipzig, 04103 Leipzig, Germany, Department of Neurology, University of Leipzig, 04103, Germany
    Stem Cells Dev 16:625-35. 2007
    ..Our data question the relevance of neuroregenerative effects of dopamine agonists for human predopaminergic cells as well as patients with Parkinson's disease...
  47. doi request reprint [Possible applications of new stem cell sources in neurology]
    A Hermann
    Bereich Neurodegenerative Erkrankungen, Klinik und Poliklinik fur Neurologie, Technische Universitat Dresden, Dresden, Deutschland
    Nervenarzt 84:943-8. 2013
    ..The future will show whether and how stem cells will lead to successful restorative therapies and/or to suitable cell models for neurological diseases. ..
  48. ncbi request reprint Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects
    H J Habisch
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neural Transm 114:1395-406. 2007
    ....
  49. ncbi request reprint Low atmospheric oxygen avoids maturation, senescence and cell death of murine mesencephalic neural precursors
    Javorina Milosevic
    Department of Neurology, University of Leipzig, Germany
    J Neurochem 92:718-29. 2005
    ..Gene regulation governed by low oxygen tension may be relevant to the normal development and survival of midbrain neurons...
  50. doi request reprint "Silenced" polydendrocytes: a new cell type within the oligodendrocyte progenitor cell population?
    Andreas Hermann
    Department of Neurology and Center for Regenerative Therapies Dresden, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany
    Cell Tissue Res 340:45-50. 2010
    ..Within this review, we focus on the identification of this new subset of polydendrocytes and their possible functions within cortical networks...
  51. doi request reprint Utility of the WHO-Five Well-being Index as a screening tool for depression in Parkinson's disease
    Christine B Schneider
    Department of Neurology, Dresden University of Technology, Dresden, Germany
    Mov Disord 25:777-83. 2010
    ..234). The optimal cut-off value for detection of depression was 12 of 13 points. WHO-5 is a useful, brief, and easy instrument for identifying PD subjects with depression in daily practice...
  52. doi request reprint Isolation of neural crest derived chromaffin progenitors from adult adrenal medulla
    Kuei Fang Chung
    Carl Gustav Carus University Medical School, Medical Clinic III, Dresden University of Technology, Dresden, Germany
    Stem Cells 27:2602-13. 2009
    ....
  53. ncbi request reprint Multipotent neural stem cells from the adult tegmentum with dopaminergic potential develop essential properties of functional neurons
    Andreas Hermann
    Department of Neurology, University of Ulm, Germany
    Stem Cells 24:949-64. 2006
    ..Here, we demonstrate the existence of adult tNSCs with functional neurogenic and dopaminergic potential, a prerequisite for future endogenous cell replacement strategies in Parkinson's disease...
  54. ncbi request reprint Transplantation of human neural precursor cells in the 6-OHDA lesioned rats: effect of immunosuppression with cyclosporine A
    Sigrid C Schwarz
    Department of Neurology, University of Leipzig, Liebigstrasse 22a, 04103 Leipzig, Saxony, Germany
    Parkinsonism Relat Disord 12:302-8. 2006
    ..There was no evidence for tumor formation. Immunosuppression of rats, xenotransplanted with human NPC did not improve graft survival or function...
  55. ncbi request reprint Neurotoxic mechanisms of 2,9-dimethyl-beta-carbolinium ion in primary dopaminergic culture
    Juliane Hamann
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    J Neurochem 98:1185-99. 2006
    ..These data underline the preferential susceptibility of dopaminergic neurones to 2,9-Me(2)NH(+) as a potent, oxidative stress generating neurotoxin...
  56. ncbi request reprint Valvular heart disease in Parkinson's disease patients treated with dopamine agonists: a reader-blinded monocenter echocardiography study
    Susann Junghanns
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    Mov Disord 22:234-8. 2007
    ..Our data suggest that ergot DAs are associated with higher prevalence of VHD compared to non-ergot DAs and controls. Standard echocardiography seems sufficient to detect VHD in PD patients treated with DAs...
  57. ncbi request reprint Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell state
    Martina Maisel
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    Stem Cells 25:1231-40. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  58. ncbi request reprint Maturation of synaptic contacts in differentiating neural stem cells
    Stefan Liebau
    Institute of Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    Stem Cells 25:1720-9. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  59. ncbi request reprint Formation of cellular projections in neural progenitor cells depends on SK3 channel activity
    Stefan Liebau
    Department of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
    J Neurochem 101:1338-1350. 2007
    ..Both effects could be prevented by the pre-incubation of NPCs with ScTX. Our study gives first evidence that the formation and prolongation of filopodia in NPCs is, at least in part, effectively induced and regulated by SK3 channels...
  60. doi request reprint Genome-wide expression profiling and functional network analysis upon neuroectodermal conversion of human mesenchymal stem cells suggest HIF-1 and miR-124a as important regulators
    Martina Maisel
    Department of Neurology, Dresden University of Technology, Dresden, Germany
    Exp Cell Res 316:2760-78. 2010
    ....
  61. ncbi request reprint Neurorestoration in Parkinson's disease by cell replacement and endogenous regeneration
    Andreas Hermann
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Expert Opin Biol Ther 4:131-43. 2004
    ..However, one major problem is the control of growth and differentiation of these cells. This review discusses new data on stem cell technology in cell replacement strategies in PD as well as endogenous dopaminergic regeneration...
  62. ncbi request reprint Neural stem cells and neurodegeneration
    Alexander Storch
    Department of Neurology, University of Ulm, Germany
    Curr Opin Investig Drugs 3:774-81. 2002
    ..These cells can be grown in vitro while retaining the potential to differentiate into nervous tissue. This review focuses on regenerative therapy in neurodegenerative diseases using NSC...
  63. doi request reprint Histopathological analysis of skeletal muscle in patients with Parkinson's disease and 'dropped head'/'bent spine' syndrome
    Hans Jürgen Gdynia
    University of Ulm, Dept of Neurology, Oberer Eselsberg 45, 89081 Ulm, Germany
    Parkinsonism Relat Disord 15:633-9. 2009
    ..Similar symptoms are known in patients with parkinsonian syndromes, but their pathophysiology remains unclear. One hypothesis is a relation between the movement disorder and the skeletal muscle pathology...
  64. doi request reprint Initiation of dopaminergic differentiation of Nurr1(-) mesencephalic precursor cells depends on activation of multiple mitogen-activated protein kinase pathways
    Michael Sabolek
    Department of Neurology, University of Ulm, Ulm, Germany
    Stem Cells 27:2009-21. 2009
    ..Our results indicate that induction of terminal dopaminergic specification of Nurr1(-) mdNPCs by IL-1beta depends on activation of the ERK1/2 and p38 MAP kinase pathway...
  65. ncbi request reprint Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells
    Andreas Hermann
    Department of Neurology, University of Ulm, Helmholtzstr 8 1, 89081 Ulm, Germany
    J Cell Sci 117:4411-22. 2004
    ..Our cell culture system provides a powerful tool for investigating the molecular mechanisms of neural differentiation in adult human NSCs. hmNSCs may therefore ultimately help to treat acute and chronic neurodegenerative diseases...
  66. doi request reprint Levodopa-induced striatal activation in Parkinson's disease: a functional MRI study
    Eduard Kraft
    Department of Neurology, University of Ulm, Ulm, Germany
    Parkinsonism Relat Disord 15:558-63. 2009
    ..To assess the effect of a single levodopa dose (200 mg levodopa, 50 mg carbidopa=sdLD) on cortical and subcortical motor-circuit activation during bimanual grip force in patients with Parkinson's disease (PD)...
  67. ncbi request reprint Increased periodontal pathology in Parkinson's disease
    Johannes Schwarz
    Dept of Neurology, University of Leipzig, Liebigstr 22a, 04103, Leipzig, Germany
    J Neurol 253:608-11. 2006
    ..We believe that problems in oral hygiene contribute to this increased periodontal pathology in patients with Parkinson's disease, which may further compromise the quality of life...
  68. ncbi request reprint Mesodermal cell types induce neurogenesis from adult human hippocampal progenitor cells
    Andreas Hermann
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    J Neurochem 98:629-40. 2006
    ..Our findings reinforce the emerging view that the differentiation capacity of adult hNPCs is critically influenced by non-neuronal mesodermal feeder cells...
  69. ncbi request reprint Comparative analysis of neuroectodermal differentiation capacity of human bone marrow stromal cells using various conversion protocols
    Andreas Hermann
    Department of Neurology, Technical University of Dresden, Dresden, Germany
    J Neurosci Res 83:1502-14. 2006
    ..Analysis of marker gene expression for characterization of neural cells derived from MSCs has to take into account that several early and late neuroectodermal genes are already expressed in undifferentiated MSCs...
  70. ncbi request reprint Spontaneous apoptosis in murine free-floating neurospheres
    Javorina Milosevic
    Department of Neurology, University of Leipzig, Leipzig, Germany
    Exp Cell Res 294:9-17. 2004
    ..Pro-apoptotic proteins of the Bcl-2 family, Bax and Bak, exhibited conformational changes in neural precursors expanding in vitro. Key molecules such as executioner caspase-3 may be useful targets to reduce the amount of apoptosis...
  71. doi request reprint Non-viral gene transfer by nucleofection allows stable gene expression in human neural progenitor cells
    Maja Theresa Dieterlen
    Department of Neurology, University of Leipzig, Liebigstrasse 22a, 04103 Leipzig, Germany
    J Neurosci Methods 178:15-23. 2009
    ..These data provide a basis for future studies using hNPCs to investigate the neuronal differentiation in vivo after transplantation, the feasibility as a vector for gene (protein) therapy, and the induction of pluripotent stem cells...
  72. ncbi request reprint Loss of dopamine transporter binding in Parkinson's disease follows a single exponential rather than linear decline
    Johannes Schwarz
    Department of Neurology, University of Leipzig, Leipzig, Germany
    J Nucl Med 45:1694-7. 2004
    ..Most follow-up studies have provided data best fitted by a linear decline of their outcome measure. However, in these studies, patients were repeatedly scanned during their first years after a diagnosis had been established...
  73. doi request reprint Rostro-caudal gradual loss of cellular diversity within the periventricular regions of the ventricular system
    Andreas Hermann
    Department of Neurology, Dresden University of Technology, Dresden, Germany
    Stem Cells 27:928-41. 2009
    ..Our data provide the histological framework for future studies on orthotopic regenerative approaches in PD by recruiting endogenous predopaminergic progenitors from the midbrain PVR...
  74. ncbi request reprint Low extracellular calcium is sufficient for survival and proliferation of murine mesencephalic neural precursor cells
    Javorina Milosevic
    Department of Neurology, University of Leipzig, Leipzig, Germany
    Cell Tissue Res 324:377-84. 2006
    ..0 mM) are not required, a concentration of 0.5 mM being adequate for cell maintenance...
  75. ncbi request reprint Epigenetic conversion of human adult bone mesodermal stromal cells into neuroectodermal cell types for replacement therapy of neurodegenerative disorders
    Andreas Hermann
    Technical University of Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany
    Expert Opin Biol Ther 6:653-70. 2006
    ..These cells provide a powerful tool for investigating the molecular mechanisms of neural differentiation, and might serve as an autologous cell source to treat acute and chronic neurodegenerative diseases...
  76. ncbi request reprint Early diagnosis of Parkinson's disease
    Jörg Spiegel
    Dept of Neurology, Saarland University, Kirrberger Strasse, 66421, Homburg Saar, Germany
    J Neurol 253:IV2-7. 2006
    ..All these methods and primarily their combination allow the detection of PD in early and--probably--preclinical stages. This requires sufficient therapeutic strategies to prevent and treat preclinical and early PD...
  77. doi request reprint Adult cerebrospinal fluid inhibits neurogenesis but facilitates gliogenesis from fetal rat neural stem cells
    Judith Buddensiek
    Department of Neurology, EMA University of Greifswald, Greifswald, Germany
    J Neurosci Res 87:3054-66. 2009
    ..Our data suggest that CSF contains factors such as BMPs regulating NSC behavior, and we hypothesize that fast differentiation of NSCs in CSF leads to a rapid loss of migration capacity of intrathecally transplanted NSCs...
  78. ncbi request reprint Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter
    Alexander Storch
    Department of Neurology, University of Ulm Medical School, Oberer Eselsberg 45, 89081, Ulm, Germany
    Biochem Pharmacol 63:909-20. 2002
    ....
  79. doi request reprint Age-dependent neuroectodermal differentiation capacity of human mesenchymal stromal cells: limitations for autologous cell replacement strategies
    Andreas Hermann
    Department of Neurology, Dresden University of Technology, Dresden, Germany
    Cytotherapy 12:17-30. 2010
    ..Although it is of pivotal interest for cell replacement therapies for neurologic disorders, no data exist on the influence of the donor's age on this multipotent differentiation behavior...
  80. ncbi request reprint Orally disintegrating selegiline for the treatment of Parkinson's disease
    Matthias Lohle
    Technische Universitat Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany
    Expert Opin Pharmacother 9:2881-91. 2008
    ..We conclude that this novel formulation offers an interesting treatment option, especially for patients who report adverse events after initial treatment with conventional selegiline or who suffer from swallowing difficulties...
  81. doi request reprint Directed growth of adult human white matter stem cell-derived neurons on aligned fibrillar collagen
    Babette Lanfer
    Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials, Dresden, Germany
    Tissue Eng Part A 16:1103-13. 2010
    ....
  82. ncbi request reprint Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake
    Alexander Storch
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neurochem 89:685-94. 2004
    ..Our data suggest that DAT-mediated cellular uptake of 2[N]-methylated betaCs represents a potential mechanism for selective toxicity towards dopaminergic neurons and may be relevant for the pathogenesis of Parkinson's disease...
  83. ncbi request reprint Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro
    Vera Lehmensiek
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    Neuroreport 13:1279-83. 2002
    ..Our data suggest a new mechanism of MPP+-induced dopaminergic toxicity by an interaction between mutant alpha-synucleins and the DAT, which is independent of the function of the proteasome...
  84. ncbi request reprint Chorein detection for the diagnosis of chorea-acanthocytosis
    Carol Dobson-Stone
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Ann Neurol 56:299-302. 2004
    ..However, chorein expression was absent or noticeably reduced in ChAc patient cells, but not McLeod syndrome and Huntington's disease cells. This suggests that loss of chorein expression is a diagnostic feature of ChAc...
  85. ncbi request reprint Cryopreservation does not affect proliferation and multipotency of murine neural precursor cells
    Javorina Milosevic
    Department of Neurology, University of Leipzig, Leipzig, Germany
    Stem Cells 23:681-8. 2005
    ..We conclude that cryopreservation (up to 1 month at -70 degrees C and up to 1 year in liquid nitrogen) does not markedly alter the rate of proliferation and multipotency of murine neural precursor cells...
  86. ncbi request reprint Association of mitochondrial disorders with lymphoid malignancies
    Susanne Mende
    Mitochondrion 7:401-3. 2007