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Genomes and GenesSpecies | A StorchSummaryAffiliation: Technical University Country: Germany Publications
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Publications
Intrathecal application of autologous bone marrow cell preparations in parkinsonian syndromesAlexander Storch
Division of Neurodegenerative Diseases, Department of Neurology, Dresden University of Technology, Dresden, Germany German Center for Neurodegenerative Diseases DZNE, Deutsches Zentrum für Neurodegenerative Erkrankungen, Research Site Dresden, Dresden, Germany Center for Regenerative Therapies Dresden CRTD, Dresden, Germany
Mov Disord 27:1552-5. 2012..We provide first clinical data on efficacy and safety of this highly experimental treatment approach in parkinsonian syndromes...
Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiationJavorina Milosevic
Translational Centre for Regenerative Medicine Leipzig TRM Leipzig, University of Leipzig, Philipp Rosenthal Strasse 55, 04103 Leipzig, Germany
Mol Neurodegener 4:25. 2009..In conclusion, a reduction of LRRK2 expression in hmNPCs severely impaired dopaminergic differentiation and/or survival of dopaminergic neurons most likely via preserving or reactivating the cell cycle...- Cerebrospinal fluid promotes survival and astroglial differentiation of adult human neural progenitor cells but inhibits proliferation and neuronal differentiationJudith Buddensiek
Department of Neurology, Ernst Moritz Arndt University of Greifswald, Germany
BMC Neurosci 11:48. 2010..Existing in vitro studies focused on embryonic cell lines and embryonic CSF. We therefore studied the effects of adult human leptomeningeal CSF on the behaviour of adult human NSCs (ahNSCs)... 
Dopamine transporter: involvement in selective dopaminergic neurotoxicity and degenerationA Storch
Department of Neurology, University of Ulm, Germany
J Neural Transm 111:1267-86. 2004..Taken together, there is large body of evidence from morphological, molecular biological and toxicological studies indicating that the DAT might be responsible for the selectivity of DA cell death in PD...- Midbrain-derived neural stem cells: from basic science to therapeutic approachesAlexander Storch
Department of Neurology, Technical University Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Cell Tissue Res 318:15-22. 2004..This review discusses new data concerning the cell biology and therapeutic potential of NSCs derived from the midbrain region of the central nervous system... - Testing for acanthocytosis A prospective reader-blinded study in movement disorder patientsAlexander Storch
Dept of Neurology, University of Ulm, 89081 Ulm, Germany
J Neurol 252:84-90. 2005..The use of isotonically diluted blood samples combined with unfixed wet blood preparation with a normal range of <6.3% of total erythrocytes is recommended to search for significant acanthocytosis in movement disorders... - [Depression in Parkinson's disease. Part 1: epidemiology, signs and symptoms, pathophysiology and diagnosis]A Storch
Klinik und Poliklinik fur Neurologie, Universitatsklinikum Carl Gustav Carus, Dresden
Fortschr Neurol Psychiatr 76:715-24. 2008..The present review summarizes the current knowledge on epidemiology, pathogenesis and diagnosis of depression in PD and proposes on this data base a standard procedure for screening and diagnosis of depressive symptoms in PD... - High-dose treatment with pergolide in Parkinson's disease patients with motor fluctuations and dyskinesiasAlexander Storch
Department of Neurology, University of Ulm, Ulm, Germany
Parkinsonism Relat Disord 11:393-8. 2005..Controlled trials are needed to further substantiate the efficacy and safety of this treatment strategy... - Viliuisk encephalomyelitis in Northeastern Siberia is not caused by Borrelia burgdorferi infectionAlexander Storch
Department of Neurology, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Neurol Sci 29:11-4. 2008..Our data provide the first evidence of the presence of Borrelia burgdorferi or similar pathogens in Northeastern Siberia, but do not support a causative role of these pathogens in the aetiopathogenesis of VE... - [Coenzyme Q10 in Parkinson's disease. Symptomatic or neuroprotective effects?]A Storch
Klinik und Poliklinik fur Neurologie, Technische Universitat Dresden, Fetscherstrasse 74, Dresden, Germany
Nervenarzt 78:1378-82. 2007..CoQ10 is well tolerated and safe as both monotherapy and add-on medication in PD patients. The present review discusses the current knowledge on neuroprotective and symptomatic actions of CoQ10 in PD... - Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson diseaseAlexander Storch
Department of Neurology, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Arch Neurol 64:938-44. 2007..Coenzyme Q(10) (CoQ(10)) is an electron acceptor bridging mitochondrial complexes I and II/III and a potent antioxidant that consistently partially recovers the function of dopaminergic neurons... - [Gene expression profiling of classic mitochondrial disorders. Its value in finding therapeutic strategies]S Mende
Klinik und Poliklinik fur Neurologie, Technische Universitat Dresden
Nervenarzt 78:1155-9. 2007..This review article focuses on the most recent gene expression profiling studies in the field of classic mitochondrial disorders... - Cytotoxicity of chloral-derived beta-carbolines is not specific towards neuronal nor dopaminergic cellsA Storch
Department of Neurology, Technical University of Dresden, Dresden, Germany
J Neural Transm 113:1895-901. 2006..Our results suggest that TaClo and related analogs are strong cytotoxins without selectivity towards dopaminergic cells... - New developments in diagnosis and treatment of Parkinson's disease--from basic science to clinical applicationsAlexander Storch
Technical University of Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany
J Neurol 251:VI/33-8. 2004..Furthermore, we discuss the major problems in the translation of results from preclinical research into successful clinical trials... - Chocolate consumption is increased in Parkinson's disease. Results from a self-questionnaire studyMartin Wolz
Dept of Neurology, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany
J Neurol 256:488-92. 2009..Although reasons for increased chocolate consumption in PD remain elusive, it may hypothetically be a consequence of the high content of various biogenic amines and/or caffeine analogues with potential antiparkinsonian effects... - [Non-motor Symptoms Questionnaire and Scale for Parkinson's disease. Cross-cultural adaptation into the German language]A Storch
Klinik und Poliklinik fur Neurologie, Technische Universitat Dresden, Fetscherstrasse 74, 01307, Dresden, Deutschland
Nervenarzt 81:980-5. 2010..We used international guidelines for cross-cultural adaptation of questionnaires to provide standard versions of both non-motor symptoms questionnaires in the German language... - [Depression in Parkinson's disease--Part 2: Therapy and management]A Storch
Die Institutsangaben sind am Ende des Beitrags gelistet
Fortschr Neurol Psychiatr 78:456-67. 2010..This survey gives an overview on the pharmacological, somatic and psychological procedures of treatment applied in this group of patients, along with useful suggestions... - Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cellsA Storch
Department of Neurology, University of Ulm Medical School, Ulm, Germany
Exp Neurol 170:317-25. 2001.... - Protective effects of riluzole on dopamine neurons: involvement of oxidative stress and cellular energy metabolismA Storch
Department of Neurology, University of Ulm Medical School, Ulm, Germany
J Neurochem 75:2259-69. 2000..These results provide further impetus to explore the neuroprotective potential of riluzole in Parkinson's disease... - 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolismA Storch
Department of Neurology, University of Ulm Medical School, Oberer Eselsberg 45, 89081, Ulm, Germany
Brain Res 855:67-75. 2000..These results suggest that cell death induced by salsolinol is due to impairment of cellular energy supply, caused in particular by inhibition of mitochondrial complex II (succinate-Q reductase), but not complex I... - HEK-293 cells expressing the human dopamine transporter are susceptible to low concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolismA Storch
Department of Neurology, University of Ulm Medical School, Germany
Neurochem Int 35:393-403. 1999..This cell system may serve as a screening system for endogenous and exogenous compounds with similar effects compared to MPP+ as well as protective agents... - Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neuronsA Storch
Department of Neurology, University of Ulm Medical School, Ulm, Germany
Mol Pharmacol 57:589-94. 2000..These data demonstrate that COMT inhibition attenuates L-dopa toxicity toward DA neurons in vitro, but probably not by preventing 3-O-methyldopa production or cellular S-adenosyl-L-methionine depletion... - Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitroA G Ludolph
Department of Child and Adolescent Psychiatry, University of Ulm, Ulm, Germany
J Neural Transm 113:1927-34. 2006..The neurotoxic effects of MPP(+) could be significantly reduced by co-application of MPH, an effect that is most likely explained by MPH blocking the DAT... - High doses of pergolide improve clinical global impression in advanced Parkinson's disease:- a preliminary open label studyGuy Arnold
Department of Neurology, Charite, University Hospital Berlin, Schumannstrasse 20 21, D 10117 Berlin, Germany
Arch Gerontol Geriatr 41:239-53. 2005..A possible relationship to the study medication was assumed for two serious adverse events reporting psychosis. We conclude that high doses of pergolide are efficacious in advanced stages of PD if given in appropriate regimens... - Efficacy and safety of high-dose cabergoline in Parkinson's diseaseP Odin
Department of Neurology, Central Hospital, D 27574 Bremerhaven, Germany
Acta Neurol Scand 113:18-24. 2006..To assess the efficacy and safety of high-dose (up to 20 mg/day) cabergoline in Parkinson's disease (PD) patients with motor fluctuations and/or dyskinesias... - Depression in Parkinson's diseaseJ Schwarz
Department of Neurology, University of Leipzig, Liebigstr 20, 04103 Leipzig, Germany
J Neurol 258:S336-8. 2011..Data on specific diagnostic tools or treatment for depressive symptoms in PD patients are still sparse. Here we summarize an expert opinion based on available data and clinical experience... - [Parainfectious polyneuropathy and miller-fisher-syndrome in combination with anemia in Mycoplasma pneumoniae infection]K F Loewenbrück
Klinik und Poliklinik fur Neurologie, Universitätsklinik Carl Gustav Carus Dresden
Fortschr Neurol Psychiatr 76:361-5. 2008..With this report we would like to stress the importance to include M.p. in the diagnostic procedures in the case of inflammatory neurological syndromes, especially when combined with alterations of the blood count... - Lack of hypoxia-inducible factor-1 alpha impairs midbrain neural precursor cells involving vascular endothelial growth factor signalingJavorina Milosevic
Department of Neurology, University of Leipzig, 04103 Leipzig, Germany
J Neurosci 27:412-21. 2007..In conclusion, HIF-1alpha seems to be a transcription factor relevant to the development and survival of substantia nigra dopaminergic neurons involving VEGF signaling... - Developmental perspectives on human midbrain-derived neural stem cellsJohannes Schwarz
Department of Neurology, University of Leipzig, Leipzig, Germany
Neurodegener Dis 3:45-9. 2006..Neural stem cells derived from human fetal midbrain tissue maintain a considerable capacity to self-renew and to differentiate into DA neurons. Therefore, these cells may be a promising source to generate functional human DA neurons... - Beyond tremor and rigidity: non-motor features of Parkinson's diseaseMatthias Lohle
Department of Neurology, University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
J Neural Transm 116:1483-92. 2009..This article aims to provide an overview of frequently observed non-motor features in PD and discusses prospects and limitations of currently available options for symptomatic treatment of these disturbances... - Potassium channel blocker 4-aminopyridine is effective in interictal cerebellar symptoms in episodic ataxia type 2--a video case reportMatthias Lohle
Department of Neurology, Technical University of Dresden, Dresden, Germany
Mov Disord 23:1314-6. 2008..i.d., there was pronounced improvement in gait and stance ataxia. Within 24 hours SARA score lowered from 8.5 to 4.5 points. We conclude that 4-AP may be beneficial for interictal cerebellar ataxia in late onset EA2... - Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's diseaseVera Lehmensiek
Department of Neurology, University of Ulm, Germany
Neurochem Int 48:329-40. 2006.... - Neural stem cells and Parkinson's diseaseAlexander Storch
Department of Neurology, University of Ulm, 89081 Ulm, Germany
J Neurol 249:III/30-2. 2002..These cells will hopefully enable restorative treatment of patients with Parkinson's disease in the near future... - [Neurogenesis in the adult brain: from bench to bedside?]M D Brandt
Klinik und Poliklinik für Neurologie und Center for Regenerative Therapies Dresden CRTD, Technische Universitat Dresden, Germany
Fortschr Neurol Psychiatr 76:517-29. 2008..This review summarizes the neurobiological bases of adult neurogenesis in their relevance for the future trend of novel therapeutic strategies... - Altered migration and adhesion potential of pro-neurally converted human bone marrow stromal cellsH J Habisch
Department of Neurology, University of Ulm, Ulm, Germany
Cytotherapy 10:824-33. 2008..We have previously introduced the pro-neural conversion of human MSC to neural stem cell-like cells (m-NSC) by culturing them in suspension culture under serum-free conditions... - Stage-dependent vulnerability of fetal mesencephalic neuroprogenitors towards dopaminergic neurotoxinsMichael Sabolek
Department of Neurology, University of Ulm, Ulm, Germany
Neurotoxicology 29:714-21. 2008..This cell system seems not suitable as a screening tool for selective dopaminergic toxicity... - Uracil nucleotides stimulate human neural precursor cell proliferation and dopaminergic differentiation: involvement of MEK/ERK signallingJavorina Milosevic
Department of Neurology, University of Leipzig, Leipzig, Germany
J Neurochem 99:913-23. 2006..We conclude that uracil nucleotides exert specific P2 receptor-mediated effects on midbrain-derived human NPCs, and may be used to enhance both proliferation and dopaminergic differentiation... - Restorative approaches in Parkinson's Disease: which cell type wins the race?Anne K Meyer
Department of Neurology, Dresden University of Technology, Dresden, Germany
J Neurol Sci 289:93-103. 2010..This review discusses recent data on stem cell technology with respect to cell replacement strategies in PD as well as endogenous dopaminergic regeneration... - Dexamethasone blocks astroglial differentiation from neural precursor cellsMichael Sabolek
Department of Neurology, University of Ulm, Ulm, Germany
Neuroreport 17:1719-23. 2006.... - Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferationStefan Liebau
Department of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
J Neurochem 99:426-37. 2006..3 by Psora-4, increased NPC proliferation. These findings underline the regulatory role of K(+) channels on the cell cycle and imply that K(+) channel modulators might be used therapeutically to activate endogenous NPCs... - Catechol-O-methyltransferase inhibition protects against 3,4-dihydroxyphenylalanine (DOPA) toxicity in primary mesencephalic cultures: new insights into levodopa toxicityHeike Blessing
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
Neurochem Int 42:139-51. 2003..In addition, we demonstrate a second mechanism of L-DOPA toxicity in vitro mediated by a COMT- and glia-dependent pathway, which is blocked by COMT inhibitors, most likely due to enhanced glial uptake of L-DOPA... - Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cellsAlexander Storch
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
J Chem Neuroanat 26:133-42. 2003.... - Dopamine D2/D3 receptor stimulation fails to promote dopaminergic neurogenesis of murine and human midbrain-derived neural precursor cells in vitroJavorina Milosevic
Translational Centre for Regenerative Medicine, Leipzig, 04103 Leipzig, Germany, Department of Neurology, University of Leipzig, 04103, Germany
Stem Cells Dev 16:625-35. 2007..Our data question the relevance of neuroregenerative effects of dopamine agonists for human predopaminergic cells as well as patients with Parkinson's disease... - Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effectsH J Habisch
Department of Neurology, University of Ulm, Ulm, Germany
J Neural Transm 114:1395-406. 2007.... - Multipotent neural stem cells from the adult tegmentum with dopaminergic potential develop essential properties of functional neuronsAndreas Hermann
Department of Neurology, University of Ulm, Germany
Stem Cells 24:949-64. 2006..Here, we demonstrate the existence of adult tNSCs with functional neurogenic and dopaminergic potential, a prerequisite for future endogenous cell replacement strategies in Parkinson's disease... - Isolation of neural crest derived chromaffin progenitors from adult adrenal medullaKuei Fang Chung
Carl Gustav Carus University Medical School, Medical Clinic III, Dresden University of Technology, Dresden, Germany
Stem Cells 27:2602-13. 2009.... - Utility of the WHO-Five Well-being Index as a screening tool for depression in Parkinson's diseaseChristine B Schneider
Department of Neurology, Dresden University of Technology, Dresden, Germany
Mov Disord 25:777-83. 2010..234). The optimal cut-off value for detection of depression was 12 of 13 points. WHO-5 is a useful, brief, and easy instrument for identifying PD subjects with depression in daily practice... - Transplantation of human neural precursor cells in the 6-OHDA lesioned rats: effect of immunosuppression with cyclosporine ASigrid C Schwarz
Department of Neurology, University of Leipzig, Liebigstrasse 22a, 04103 Leipzig, Saxony, Germany
Parkinsonism Relat Disord 12:302-8. 2006..There was no evidence for tumor formation. Immunosuppression of rats, xenotransplanted with human NPC did not improve graft survival or function... - Low atmospheric oxygen avoids maturation, senescence and cell death of murine mesencephalic neural precursorsJavorina Milosevic
Department of Neurology, University of Leipzig, Germany
J Neurochem 92:718-29. 2005..Gene regulation governed by low oxygen tension may be relevant to the normal development and survival of midbrain neurons... - "Silenced" polydendrocytes: a new cell type within the oligodendrocyte progenitor cell population?Andreas Hermann
Department of Neurology and Center for Regenerative Therapies Dresden, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany
Cell Tissue Res 340:45-50. 2010..Within this review, we focus on the identification of this new subset of polydendrocytes and their possible functions within cortical networks... - Neurotoxic mechanisms of 2,9-dimethyl-beta-carbolinium ion in primary dopaminergic cultureJuliane Hamann
Department of Neurology, Technical University of Dresden, Dresden, Germany
J Neurochem 98:1185-99. 2006..These data underline the preferential susceptibility of dopaminergic neurones to 2,9-Me(2)NH(+) as a potent, oxidative stress generating neurotoxin... - Formation of cellular projections in neural progenitor cells depends on SK3 channel activityStefan Liebau
Department of Anatomy and Cell Biology, University of Ulm, Ulm, Germany
J Neurochem 101:1338-1350. 2007..Both effects could be prevented by the pre-incubation of NPCs with ScTX. Our study gives first evidence that the formation and prolongation of filopodia in NPCs is, at least in part, effectively induced and regulated by SK3 channels... - Maturation of synaptic contacts in differentiating neural stem cellsStefan Liebau
Institute of Anatomy and Cell Biology, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
Stem Cells 25:1720-9. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell stateMartina Maisel
Department of Neurology, Technical University of Dresden, Dresden, Germany
Stem Cells 25:1231-40. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Valvular heart disease in Parkinson's disease patients treated with dopamine agonists: a reader-blinded monocenter echocardiography studySusann Junghanns
Department of Neurology, Technical University of Dresden, Dresden, Germany
Mov Disord 22:234-8. 2007..Our data suggest that ergot DAs are associated with higher prevalence of VHD compared to non-ergot DAs and controls. Standard echocardiography seems sufficient to detect VHD in PD patients treated with DAs... - Levodopa-induced striatal activation in Parkinson's disease: a functional MRI studyEduard Kraft
Department of Neurology, University of Ulm, Ulm, Germany
Parkinsonism Relat Disord 15:558-63. 2009..To assess the effect of a single levodopa dose (200 mg levodopa, 50 mg carbidopa=sdLD) on cortical and subcortical motor-circuit activation during bimanual grip force in patients with Parkinson's disease (PD)... - Initiation of dopaminergic differentiation of Nurr1(-) mesencephalic precursor cells depends on activation of multiple mitogen-activated protein kinase pathwaysMichael Sabolek
Department of Neurology, University of Ulm, Ulm, Germany
Stem Cells 27:2009-21. 2009..Our results indicate that induction of terminal dopaminergic specification of Nurr1(-) mdNPCs by IL-1beta depends on activation of the ERK1/2 and p38 MAP kinase pathway... - Non-viral gene transfer by nucleofection allows stable gene expression in human neural progenitor cellsMaja Theresa Dieterlen
Department of Neurology, University of Leipzig, Liebigstrasse 22a, 04103 Leipzig, Germany
J Neurosci Methods 178:15-23. 2009..These data provide a basis for future studies using hNPCs to investigate the neuronal differentiation in vivo after transplantation, the feasibility as a vector for gene (protein) therapy, and the induction of pluripotent stem cells... - Histopathological analysis of skeletal muscle in patients with Parkinson's disease and 'dropped head'/'bent spine' syndromeHans Jürgen Gdynia
University of Ulm, Dept of Neurology, Oberer Eselsberg 45, 89081 Ulm, Germany
Parkinsonism Relat Disord 15:633-9. 2009..Similar symptoms are known in patients with parkinsonian syndromes, but their pathophysiology remains unclear. One hypothesis is a relation between the movement disorder and the skeletal muscle pathology... - Genome-wide expression profiling and functional network analysis upon neuroectodermal conversion of human mesenchymal stem cells suggest HIF-1 and miR-124a as important regulatorsMartina Maisel
Department of Neurology, Dresden University of Technology, Dresden, Germany
Exp Cell Res 316:2760-78. 2010.... - Neurorestoration in Parkinson's disease by cell replacement and endogenous regenerationAndreas Hermann
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
Expert Opin Biol Ther 4:131-43. 2004..However, one major problem is the control of growth and differentiation of these cells. This review discusses new data on stem cell technology in cell replacement strategies in PD as well as endogenous dopaminergic regeneration... - Neural stem cells and neurodegenerationAlexander Storch
Department of Neurology, University of Ulm, Germany
Curr Opin Investig Drugs 3:774-81. 2002..These cells can be grown in vitro while retaining the potential to differentiate into nervous tissue. This review focuses on regenerative therapy in neurodegenerative diseases using NSC... - Rostro-caudal gradual loss of cellular diversity within the periventricular regions of the ventricular systemAndreas Hermann
Department of Neurology, Dresden University of Technology, Dresden, Germany
Stem Cells 27:928-41. 2009..Our data provide the histological framework for future studies on orthotopic regenerative approaches in PD by recruiting endogenous predopaminergic progenitors from the midbrain PVR... - Comparative analysis of neuroectodermal differentiation capacity of human bone marrow stromal cells using various conversion protocolsAndreas Hermann
Department of Neurology, Technical University of Dresden, Dresden, Germany
J Neurosci Res 83:1502-14. 2006..Analysis of marker gene expression for characterization of neural cells derived from MSCs has to take into account that several early and late neuroectodermal genes are already expressed in undifferentiated MSCs... - Spontaneous apoptosis in murine free-floating neurospheresJavorina Milosevic
Department of Neurology, University of Leipzig, Leipzig, Germany
Exp Cell Res 294:9-17. 2004..Pro-apoptotic proteins of the Bcl-2 family, Bax and Bak, exhibited conformational changes in neural precursors expanding in vitro. Key molecules such as executioner caspase-3 may be useful targets to reduce the amount of apoptosis... - Mesodermal cell types induce neurogenesis from adult human hippocampal progenitor cellsAndreas Hermann
Department of Neurology, Technical University of Dresden, Dresden, Germany
J Neurochem 98:629-40. 2006..Our findings reinforce the emerging view that the differentiation capacity of adult hNPCs is critically influenced by non-neuronal mesodermal feeder cells... - Loss of dopamine transporter binding in Parkinson's disease follows a single exponential rather than linear declineJohannes Schwarz
Department of Neurology, University of Leipzig, Leipzig, Germany
J Nucl Med 45:1694-7. 2004..Most follow-up studies have provided data best fitted by a linear decline of their outcome measure. However, in these studies, patients were repeatedly scanned during their first years after a diagnosis had been established... - Increased periodontal pathology in Parkinson's diseaseJohannes Schwarz
Dept of Neurology, University of Leipzig, Liebigstr 22a, 04103, Leipzig, Germany
J Neurol 253:608-11. 2006..We believe that problems in oral hygiene contribute to this increased periodontal pathology in patients with Parkinson's disease, which may further compromise the quality of life... - Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cellsAndreas Hermann
Department of Neurology, University of Ulm, Helmholtzstr. 8/1, 89081 Ulm, Germany
J Cell Sci 117:4411-22. 2004..Our cell culture system provides a powerful tool for investigating the molecular mechanisms of neural differentiation in adult human NSCs. hmNSCs may therefore ultimately help to treat acute and chronic neurodegenerative diseases... - Low extracellular calcium is sufficient for survival and proliferation of murine mesencephalic neural precursor cellsJavorina Milosevic
Department of Neurology, University of Leipzig, Leipzig, Germany
Cell Tissue Res 324:377-84. 2006..0 mM) are not required, a concentration of 0.5 mM being adequate for cell maintenance... - Adult cerebrospinal fluid inhibits neurogenesis but facilitates gliogenesis from fetal rat neural stem cellsJudith Buddensiek
Department of Neurology, EMA University of Greifswald, Greifswald, Germany
J Neurosci Res 87:3054-66. 2009..Our data suggest that CSF contains factors such as BMPs regulating NSC behavior, and we hypothesize that fast differentiation of NSCs in CSF leads to a rapid loss of migration capacity of intrathecally transplanted NSCs... - Epigenetic conversion of human adult bone mesodermal stromal cells into neuroectodermal cell types for replacement therapy of neurodegenerative disordersAndreas Hermann
Technical University of Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany
Expert Opin Biol Ther 6:653-70. 2006..These cells provide a powerful tool for investigating the molecular mechanisms of neural differentiation, and might serve as an autologous cell source to treat acute and chronic neurodegenerative diseases... - Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporterAlexander Storch
Department of Neurology, University of Ulm Medical School, Oberer Eselsberg 45, 89081, Ulm, Germany
Biochem Pharmacol 63:909-20. 2002.... - Early diagnosis of Parkinson's diseaseJörg Spiegel
Dept of Neurology, Saarland University, Kirrberger Strasse, 66421, Homburg Saar, Germany
J Neurol 253:IV2-7. 2006..All these methods and primarily their combination allow the detection of PD in early and--probably--preclinical stages. This requires sufficient therapeutic strategies to prevent and treat preclinical and early PD... - Age-dependent neuroectodermal differentiation capacity of human mesenchymal stromal cells: limitations for autologous cell replacement strategiesAndreas Hermann
Department of Neurology, Dresden University of Technology, Dresden, Germany
Cytotherapy 12:17-30. 2010..Although it is of pivotal interest for cell replacement therapies for neurologic disorders, no data exist on the influence of the donor's age on this multipotent differentiation behavior... - Directed growth of adult human white matter stem cell-derived neurons on aligned fibrillar collagenBabette Lanfer
Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials, Dresden, Germany
Tissue Eng Part A 16:1103-13. 2010.... - Orally disintegrating selegiline for the treatment of Parkinson's diseaseMatthias Lohle
Technische Universitat Dresden, Department of Neurology, Fetscherstrasse 74, 01307 Dresden, Germany
Expert Opin Pharmacother 9:2881-91. 2008..We conclude that this novel formulation offers an interesting treatment option, especially for patients who report adverse events after initial treatment with conventional selegiline or who suffer from swallowing difficulties... - Expression of mutant alpha-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitroVera Lehmensiek
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
Neuroreport 13:1279-83. 2002..Our data suggest a new mechanism of MPP+-induced dopaminergic toxicity by an interaction between mutant alpha-synucleins and the DAT, which is independent of the function of the proteasome... - Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptakeAlexander Storch
Department of Neurology, University of Ulm, Ulm, Germany
J Neurochem 89:685-94. 2004..Our data suggest that DAT-mediated cellular uptake of 2[N]-methylated betaCs represents a potential mechanism for selective toxicity towards dopaminergic neurons and may be relevant for the pathogenesis of Parkinson's disease... - Association of mitochondrial disorders with lymphoid malignanciesSusanne Mende
Mitochondrion 7:401-3. 2007 - Cryopreservation does not affect proliferation and multipotency of murine neural precursor cellsJavorina Milosevic
Department of Neurology, University of Leipzig, Leipzig, Germany
Stem Cells 23:681-8. 2005..We conclude that cryopreservation (up to 1 month at -70 degrees C and up to 1 year in liquid nitrogen) does not markedly alter the rate of proliferation and multipotency of murine neural precursor cells... - Chorein detection for the diagnosis of chorea-acanthocytosisCarol Dobson-Stone
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Ann Neurol 56:299-302. 2004..However, chorein expression was absent or noticeably reduced in ChAc patient cells, but not McLeod syndrome and Huntington's disease cells. This suggests that loss of chorein expression is a diagnostic feature of ChAc...