U I Schwarz

Summary

Affiliation: Technical University
Country: Germany

Publications

  1. ncbi request reprint Unexpected effect of verapamil on oral bioavailability of the beta-blocker talinolol in humans
    U I Schwarz
    Institute of Clinical Pharmacology, Faculty of Medicine, University of Technology, Dresden, Germany
    Clin Pharmacol Ther 65:283-90. 1999
  2. ncbi request reprint Clinical relevance of genetic polymorphisms in the human CYP2C9 gene
    U I Schwarz
    Institute of Clinical Pharmacology, Medical Faculty, Technical University, Dresden, Germany
    Eur J Clin Invest 33:23-30. 2003
  3. ncbi request reprint Induction of intestinal P-glycoprotein by St John's wort reduces the oral bioavailability of talinolol
    U I Schwarz
    Medical Faculty, Institute of Clinical Pharmacology, Technical University Dresden, Dresden, Germany
    Clin Pharmacol Ther 81:669-78. 2007
  4. ncbi request reprint Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans
    L J Dickmann
    Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA
    Mol Pharmacol 60:382-7. 2001

Collaborators

Detail Information

Publications4

  1. ncbi request reprint Unexpected effect of verapamil on oral bioavailability of the beta-blocker talinolol in humans
    U I Schwarz
    Institute of Clinical Pharmacology, Faculty of Medicine, University of Technology, Dresden, Germany
    Clin Pharmacol Ther 65:283-90. 1999
    ..To quantitate the effect of verapamil administered orally, a calcium channel blocker and potent inhibitor of P-glycoprotein on oral pharmacokinetics of the beta1-adrenergic receptor antagonist talinolol, a substrate of P-glycoprotein...
  2. ncbi request reprint Clinical relevance of genetic polymorphisms in the human CYP2C9 gene
    U I Schwarz
    Institute of Clinical Pharmacology, Medical Faculty, Technical University, Dresden, Germany
    Eur J Clin Invest 33:23-30. 2003
    ..Subjects who are carriers of one or more variant alleles may be at risk for adverse drug reactions/toxicities when prescribed drugs extensively metabolized by CYP2C9...
  3. ncbi request reprint Induction of intestinal P-glycoprotein by St John's wort reduces the oral bioavailability of talinolol
    U I Schwarz
    Medical Faculty, Institute of Clinical Pharmacology, Technical University Dresden, Dresden, Germany
    Clin Pharmacol Ther 81:669-78. 2007
    ..Interestingly, the magnitude of induction appeared to be affected by MDR1 genotype...
  4. ncbi request reprint Identification and functional characterization of a new CYP2C9 variant (CYP2C9*5) expressed among African Americans
    L J Dickmann
    Department of Medicinal Chemistry, University of Washington, Seattle, Washington, USA
    Mol Pharmacol 60:382-7. 2001
    ..The corresponding ratio for CYP2C9*3 was 4 to 13%. Accordingly, the in vitro data suggest that carriers of the CYP2C9*5 allele would eliminate CYP2C9 substrates at slower rates relative to persons expressing the wild-type protein...