U Ravens

Summary

Affiliation: Technical University
Country: Germany

Publications

  1. doi [New developments in the antiarrhythmic therapy of atrial fibrillation]
    Ursula Ravens
    Medizinische Fakultät Carl Gustav Carus, Institut fur Pharmakologie und Toxikologie, Technische Universitat Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland
    Herzschrittmacherther Elektrophysiol 25:41-6. 2014
  2. doi The new antiarrhythmic drug vernakalant: ex vivo study of human atrial tissue from sinus rhythm and chronic atrial fibrillation
    Erich Wettwer
    Department of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Fetscherstraße 74, Dresden D 01307, Germany
    Cardiovasc Res 98:145-54. 2013
  3. doi Role of potassium currents in cardiac arrhythmias
    Ursula Ravens
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Dresden, Germany
    Europace 10:1133-7. 2008
  4. ncbi Potassium channels in atrial fibrillation: targets for atrial and pathology-specific therapy?
    Ursula Ravens
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Heart Rhythm 5:758-9. 2008
  5. ncbi [Electrophysiological properties of stem cells]
    Ursula Ravens
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät der TU Dresden, Dresden
    Herz 31:123-6. 2006
  6. ncbi Novel pharmacological approaches for antiarrhythmic therapy
    Ursula Ravens
    Department of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 381:187-93. 2010
  7. ncbi [New antiarrhythmic drugs for therapy of atrial fibrillation: I. Ion channel blockers]
    U Ravens
    Technische Universitat Dresden, Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany
    Herzschrittmacherther Elektrophysiol 17:64-72. 2006
  8. ncbi Mechano-electric feedback and arrhythmias
    Ursula Ravens
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus der Technischen Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
    Prog Biophys Mol Biol 82:255-66. 2003
  9. ncbi What is a good tutorial from the student's point of view? Evaluation of tutorials in a newly established PBL block course "Basics of Drug Therapy"
    Ursula Ravens
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Dresden, Fetscher Strasse 74, 01307 Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 366:69-76. 2002
  10. ncbi [Does gender have an effect on pharmacotherapy?]
    U Ravens
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden
    Dtsch Med Wochenschr 131:740-2. 2006

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. doi [New developments in the antiarrhythmic therapy of atrial fibrillation]
    Ursula Ravens
    Medizinische Fakultät Carl Gustav Carus, Institut fur Pharmakologie und Toxikologie, Technische Universitat Dresden, Fetscherstraße 74, 01307, Dresden, Deutschland
    Herzschrittmacherther Elektrophysiol 25:41-6. 2014
    ..The mechanisms of action will be discussed in the context of the present understanding of the pathophysiology of onset and maintenance of atrial fibrillation. ..
  2. doi The new antiarrhythmic drug vernakalant: ex vivo study of human atrial tissue from sinus rhythm and chronic atrial fibrillation
    Erich Wettwer
    Department of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Fetscherstraße 74, Dresden D 01307, Germany
    Cardiovasc Res 98:145-54. 2013
    ..Vernakalant is a newly developed antiarrhythmic drug against atrial fibrillation (AF). However, its electrophysiological actions on human myocardium are unknown...
  3. doi Role of potassium currents in cardiac arrhythmias
    Ursula Ravens
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Dresden, Germany
    Europace 10:1133-7. 2008
    ..Atrial-selective drugs for the treatment of AF without affecting the ventricles could target structures such as I(Kur) or constitutively active I(K,ACh) channels...
  4. ncbi Potassium channels in atrial fibrillation: targets for atrial and pathology-specific therapy?
    Ursula Ravens
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Heart Rhythm 5:758-9. 2008
  5. ncbi [Electrophysiological properties of stem cells]
    Ursula Ravens
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät der TU Dresden, Dresden
    Herz 31:123-6. 2006
    ..This pathomechanism could serve as an explanation for the enhanced clinical risk of arrhythmia after transplantation of myoblasts into the infarcted hearts...
  6. ncbi Novel pharmacological approaches for antiarrhythmic therapy
    Ursula Ravens
    Department of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, 01307, Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 381:187-93. 2010
    ..In ventricular arrhythmias implantable cardioverter-defibrillator devices rather than antiarrhythmic drugs are the safest treatment option. The domain for new approaches to drug treatment is atrial fibrillation...
  7. ncbi [New antiarrhythmic drugs for therapy of atrial fibrillation: I. Ion channel blockers]
    U Ravens
    Technische Universitat Dresden, Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany
    Herzschrittmacherther Elektrophysiol 17:64-72. 2006
    ..The current review outlines the pathophysiology of atrial fibrillation and focuses on electrical remodeling. The properties of new antiarrhythmic drugs for atrial fibrillation are discussed in detail...
  8. ncbi Mechano-electric feedback and arrhythmias
    Ursula Ravens
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus der Technischen Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
    Prog Biophys Mol Biol 82:255-66. 2003
    ..Detailed understanding of how mechanical strain on myocardial cells is translated into channel activation will allow to identify new targets for putative antiarrhythmic drugs...
  9. ncbi What is a good tutorial from the student's point of view? Evaluation of tutorials in a newly established PBL block course "Basics of Drug Therapy"
    Ursula Ravens
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Dresden, Fetscher Strasse 74, 01307 Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 366:69-76. 2002
    ..As a consequence we will increase our efforts to optimise case quality as well as support and training of tutors in order to improve our new PBL course...
  10. ncbi [Does gender have an effect on pharmacotherapy?]
    U Ravens
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden
    Dtsch Med Wochenschr 131:740-2. 2006
  11. doi Antiarrhythmic therapy in atrial fibrillation
    Ursula Ravens
    Department of Pharmacology und Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, D 01307 Dresden
    Pharmacol Ther 128:129-45. 2010
    ..The final section will speculate about some putative targets for antiarrhythmic drug action in the context of the remodelled atria...
  12. doi Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implications
    Ursula Ravens
    Department of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, Dresden 01307, Germany
    Cardiovasc Res 89:776-85. 2011
    ..Some new compounds developed as I(Kur) blockers are described and their efficacy in treatment of atrial fibrillation (AF) is discussed. Current evidence suggests that pure I(Kur) channel block may not be sufficient to suppress AF...
  13. doi Atrial-selective drugs for treatment of atrial fibrillation
    U Ravens
    Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstr 74, 01307, Dresden, Deutschland
    Herzschrittmacherther Elektrophysiol 21:217-21. 2010
    ..Finally, atrial-selective targets may evolve due to disease-specific processes (e.g., rate-dependent Na(+) channel blockers, selective drugs against constitutively active I(K,ACh) channels)...
  14. ncbi Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potentials
    D Dobrev
    Department of Pharmacology, University of Technology, Dresden, Germany
    Circulation 104:2551-7. 2001
    ..However, it is unclear whether changes in G-protein-coupled inward rectifying K(+) current (I(K,ACh)) contribute to chronic AF...
  15. pmc Murine ventricular L-type Ca(2+) current is enhanced by zinterol via beta(1)-adrenoceptors, and is reduced in TG4 mice overexpressing the human beta(2)-adrenoceptor
    J F Heubach
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus der TU Dresden, D 01307 Dresden, Germany
    Br J Pharmacol 133:73-82. 2001
    ..In the mouse model of beta(2)-AR overexpression I(Ca(L)) is reduced due to tonic activation of Gi-proteins...
  16. pmc Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillation
    T Christ
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Br J Pharmacol 154:1619-30. 2008
    ....
  17. ncbi Decreased ATP-sensitive K(+) current density during chronic human atrial fibrillation
    Bartosz Balana
    Department of Pharmacology and Toxicology, Carl Gustav Carus Medical School, Dresden University of Technology, Fetscherstrasse 74, Dresden D 01307, Germany
    J Mol Cell Cardiol 35:1399-405. 2003
    ..We provide evidence that chronic AF is associated with a downregulation of ATP-sensitive K(+) currents. These changes may provide an additional molecular mechanism for electrical remodeling in chronic AF...
  18. ncbi Autoantibodies against the beta1 adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in isolated cardiomyocytes
    T Christ
    Department of Pharmacology and Toxicology, Dresden, Germany
    J Mol Cell Cardiol 33:1515-25. 2001
    ..These effects may contribute to beta1-adrenoceptor-mediated cardiotoxicity in heart failure...
  19. ncbi Different responses to drugs against overactive bladder in detrusor muscle of pig, guinea pig and mouse
    Melinda Wüst
    Institute of Pharmacology and Toxicology, Faculty of Medicine, Dresden University of Technology, Fetscherstrasse 74, Dresden D 01307, Germany
    Eur J Pharmacol 454:59-69. 2002
    ..Thus, a comparison of drug effects is only feasible in the same animal model and the results cannot easily be transferred to humans...
  20. ncbi Three thiadiazinone derivatives, EMD 60417, EMD 66430, and EMD 66398, with class III antiarrhythmic activity but different electrophysiologic profiles
    H M Himmel
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    J Cardiovasc Pharmacol 38:438-49. 2001
    ..INa is inhibited at higher concentrations by EMD 66430 and EMD 60417. EMD 66398 is more potent and selective for IKr than EMD 60417 and EMD 66430, and thus resembles E-4031 in structure and function...
  21. ncbi The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation
    D Dobrev
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Dresden, Germany
    Circulation 112:3697-706. 2005
    ..We tested whether constitutively active acetylcholine (ACh)-activated I(K,ACh) contributes to enhanced basal conductance in chronic AF (cAF)...
  22. doi Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation
    Niels Voigt
    Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstr 74, 01307, Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 381:251-9. 2010
    ..The efficacy of flecainide to terminate AF may in part result from blockade of I(K,ACh)...
  23. ncbi N-desethylamiodarone modulates intracellular calcium concentration in endothelial cells
    H M Himmel
    Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Carl Gustav Carus, TU Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 362:489-96. 2000
    ..In conclusion, the DEAM-induced [Ca2+]i increase in endothelial cells is due to Ca2+ influx from the extracellular space and to Ca2+ release from endoplasmic reticulum and mitochondria and involves enhanced generation of free radicals...
  24. ncbi Voltage-sensitive Ca2+ channels, intracellular Ca2+ stores and Ca2+-release-activated Ca2+ channels contribute to the ATP-induced [Ca2+]i increase in differentiated neuroblastoma x glioma NG 108-15 cells
    M Brater
    Institute of Pharmacology and Toxicology, Dresden University of Technology, Germany
    Neurosci Lett 264:97-100. 1999
    ..The remainder (i.e. total [Ca2+]i increase minus nifedipine-, omegaCT- and thapsigargin-sensitive [Ca2+]i increases) should, therefore, represent Ca2+ influx via P2X7 non-selective cation channels...
  25. ncbi Molecular and functional expression of voltage-operated calcium channels during osteogenic differentiation of human mesenchymal stem cells
    Ihor Zahanich
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus der TU Dresden, Dresden, Germany
    J Bone Miner Res 20:1637-46. 2005
    ..This study suggests that osteogenic differentiation of hMSCs does not require L-type Ca2+ channel function...
  26. ncbi Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation
    Niels Voigt
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Cardiovasc Res 74:426-37. 2007
    ..In chronic atrial fibrillation (cAF) the potassium current IK,ACh develops agonist-independent constitutive activity. We hypothesized that abnormal phosphorylation-dependent regulation underlies the constitutive IK,ACh activity...
  27. ncbi Effects of azelastine on contractility, action potentials and L-type Ca(2+) current in guinea pig cardiac preparations
    S Li
    Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, D-01307, Dresden, Germany
    Eur J Pharmacol 418:7-14. 2001
    ....
  28. ncbi The hyperpolarization-activated current If in ventricular myocytes of non-transgenic and beta2-adrenoceptor overexpressing mice
    E M Graf
    , , Germany
    Naunyn Schmiedebergs Arch Pharmacol 364:131-9. 2001
    ..Increased maximum If amplitude in TG4 myocytes is in line with enhanced expression of HCN channels. Both mechanisms could contribute to larger inward current at physiological diastolic potentials...
  29. doi Anticholinergic effects of cis- and trans-isomers of two metabolites of propiverine
    Stefan Propping
    Department of Urology, University Hospital Carl Gustav Carus, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 381:329-38. 2010
    ..However, at higher concentration ranges, all four compounds seem to have additional effects on Ca(2+) influx...
  30. doi Adult zebrafish heart as a model for human heart? An electrophysiological study
    Petros Nemtsas
    Biotechnology Center and Center for Regenerative Therapies, Dresden University of Technology, Dresden, Germany
    J Mol Cell Cardiol 48:161-71. 2010
    ..Interestingly, in most mammals T-type Ca(2+) channels are only expressed in the developing heart or under pathophysiological conditions, indicating that adult zebrafish cardiomyocytes display a more immature phenotype...
  31. ncbi Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts
    Susanne Radicke
    Medical Faculty, Dresden University of Technology, Fetscherstr 74, Dresden, 01307 Germany
    Cardiovasc Res 71:695-703. 2006
    ..Here we aimed to determine the regional expression of Kv4.3, KChIP2, and KCNE mRNAs in non-failing and failing human hearts and to investigate the functional consequences of subunit coexpression in heterologous expression systems...
  32. ncbi Electrophysiological profile of propiverine--relationship to cardiac risk
    Torsten Christ
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 376:431-40. 2008
    ..We propose that lack of torsadogenic risk of propiverine is related to enhancement of repolarization reserve by block of I(Ca,L)...
  33. ncbi L-type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatases
    T Christ
    Department of Pharmacology, Dresden University of Technology, Dresden, Germany
    Circulation 110:2651-7. 2004
    ..Here, we tested whether reduced I(Ca,L) in AF is associated with alterations in phosphorylation-dependent channel regulation...
  34. ncbi Teaching antiarrhythmic therapy and ECG in simulator-based interdisciplinary undergraduate medical education
    M P Mueller
    Interdisciplinary Simulation Centre, Department of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Dresden University of Technology, Germany
    Br J Anaesth 95:300-4. 2005
    ..As part of this course a practical seminar about antiarrhythmic drugs and ECG was set up. This study was conducted to evaluate the use of a simulator in this course...
  35. pmc Inotropy and L-type Ca2+ current, activated by beta1- and beta2-adrenoceptors, are differently controlled by phosphodiesterases 3 and 4 in rat heart
    Torsten Christ
    Department of Pharmacology, Dresden University of Technology, Dresden, Germany
    Br J Pharmacol 156:62-83. 2009
    ..We investigated the influence of the PDE3 inhibitor cilostamide (300 nmol x L(-1)) and the PDE4 inhibitor rolipram (1 micromol x L(-1)) on the effects of (-)-catecholamines...
  36. ncbi Cilostamide potentiates more the positive inotropic effects of (-)-adrenaline through beta(2)-adrenoceptors than the effects of (-)-noradrenaline through beta (1)-adrenoceptors in human atrial myocardium
    T Christ
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 374:249-53. 2006
    ..The results are consistent with a greater PDE3-catalysed hydrolysis of inotropically relevant cyclic AMP produced through beta(2)-adrenoceptors than beta(1)-adrenoceptors in human atrium...
  37. ncbi Microvascular endothelial cells from human omentum lack an inward rectifier K+ current
    H M Himmel
    Institute of Pharmacology and Toxicology, Faculty of Medicine Carl Gustav Carus, Technical University, Dresden, Germany
    Physiol Res 50:547-55. 2001
    ..Thus, the lack of I(K1) in human omentum EC suggests that resting membrane potential is determined by Na+ and Cl- currents in addition to K+ outward currents...
  38. doi Receptor-independent sensitization of the adenylyl cylase after chronic treatment with cyclosporine A
    G Simonis
    Department of Medicine Cardiology, Dresden University of Technology, Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 378:253-60. 2008
    ..These data suggest that CyA modulates the activity of the sympathoadrenergic system by a direct, receptor-independent sensitization of AC, suggesting that this pathway contributes to hypertension in patients treated with CyA...
  39. ncbi Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes
    Niels Voigt
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Cardiovasc Res 77:35-43. 2008
    ..This study aimed to establish how AT remodelling affects I K,ACh single-channel function...
  40. ncbi Interaction between autoantibodies against the beta1-adrenoceptor and isoprenaline in enhancing L-type Ca2+ current in rat ventricular myocytes
    Torsten Christ
    Department of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    J Mol Cell Cardiol 41:716-23. 2006
    ....
  41. ncbi An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca2+-current by direct interaction with the Cav1.2 subunit
    Torsten Christ
    Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstrasse 74, 01309 Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 370:474-83. 2004
    ..These findings suggest that the effect of C47 is restricted to the Ca(2+) channel...
  42. doi Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation
    Niels Voigt
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Circ Arrhythm Electrophysiol 3:472-80. 2010
    ..Unequal left-to-right distribution of inward rectifier K(+) currents has been suggested to underlie this dominant frequency gradient, but this hypothesis has never been tested in humans...
  43. pmc Electrophysiological properties of human mesenchymal stem cells
    Jürgen F Heubach
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus der TU Dresden, Fetscherstrasse 74, D 01307 Dresden, Germany
    J Physiol 554:659-72. 2004
    ..We conclude that undifferentiated hMSC express a distinct pattern of ion channel mRNA and functional ion channels that might contribute to physiological cell function...
  44. ncbi Risperidone-induced action potential prolongation is attenuated by increased repolarization reserve due to concomitant block of I(Ca,L)
    Torsten Christ
    Department of Pharmacology and Toxicology, Medical Faculty, University of Technology, Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 371:393-400. 2005
    ..This behaviour may explain the small APD-prolonging effect of risperidone despite the drug's robust blocking of I(Kr)...
  45. pmc Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3
    Susanne Radicke
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Fetscherstr 74, Dresden, 01307 Germany
    J Physiol 565:751-6. 2005
    ..3 and KChIP2a produced similar current kinetics as in human ventricular myocytes. We therefore propose that DPPX is an essential component of the native cardiac I(to) channel complex in human heart...
  46. doi The transmembrane beta-subunits KCNE1, KCNE2, and DPP6 modify pharmacological effects of the antiarrhythmic agent tedisamil on the transient outward current Ito
    Susanne Radicke
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Fetscherstr 74, 01307, Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 379:617-26. 2009
    ..It is concluded that apparent effects of DPP6 and deletion mutants (KCNE2 and DPP6) are due to the acceleration or slowing effects of the beta-subunits on I(to) kinetics...
  47. pmc The effects of verapamil and diltiazem on N-, P- and Q-type calcium channels mediating dopamine release in rat striatum
    D Dobrev
    Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Technology, Dresden, Germany
    Br J Pharmacol 127:576-82. 1999
    ..5. Taken together, our results suggest that verapamil can block P- and at higher concentrations possibly N- and Q-type Ca2+ channels linked to [3H]-DA release, whereas diltiazem appears to block P-type Ca2+ channels only...
  48. ncbi Selectivity of blocking of low- versus high-voltage activated calcium currents by the dihydropyridine derivatives Bay E5759 and Bay A4339 in neuroblastoma--glioma NG 108-15 cells
    H M Himmel
    Department of Pharmacology and Toxicology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
    Pharmacol Res 44:113-6. 2001
    ..4 nM) > Bay A4339 (2.5 nM) approximately = nisoldipine (4 nM) >> mibefradil (3.8 microM). Thus Bay E5759 and Bay A4339 are highly potent and selective blockers of HVACC, presumably L-type Ca(2+)channels...
  49. ncbi Four different components contribute to outward current in rat ventricular myocytes
    H M Himmel
    Institut fur Pharmakologie, Universität Gesamthochschule Essen, D 45122 Essen, Germany
    Am J Physiol 277:H107-18. 1999
    ..In conclusion, on the basis of electrophysiological and pharmacological evidence, at least four components contribute to outward current in rat ventricular myocytes...
  50. doi Impaired vascular function in small resistance arteries of LOX-1 overexpressing mice on high-fat diet
    Birgit Eichhorn
    Department of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, University of Technology, Fetscherstr 74, D 01307 Dresden, Germany
    Cardiovasc Res 82:493-502. 2009
    ..LOX-1 is a major vascular receptor for oxidized low-density lipoprotein (oxLDL). In this study, we analysed the impact of LOX-1 overexpression and high dietary fat intake on vascular function in small resistance arteries...
  51. ncbi Propiverine and metabolites: differences in binding to muscarinic receptors and in functional models of detrusor contraction
    Melinda Wuest
    Medizinische Fakultat, Institut fur Pharmakologie und Toxikologie, TU Dresden, Fetscherstrasse 74, Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 374:87-97. 2006
    ..Change from a tertiary to a secondary amine (M-14) results in lower binding affinity and reduced potency. Oxidation of the nitrogen (M-5) further lowers binding affinity as well as functional potency...
  52. ncbi Cardiostimulant and cardiodepressant effects through overexpressed human beta2-adrenoceptors in murine heart: regional differences and functional role of beta1-adrenoceptors
    Jürgen F Heubach
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus der TU Dresden, 01307 Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 367:380-90. 2003
    ..The function of murine cardiac beta(1)-adrenoceptors is suppressed by overexpressed human beta(2)-adrenoceptors...
  53. ncbi 5-Azacytidine induces changes in electrophysiological properties of human mesenchymal stem cells
    Bartosz Balana
    Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstr 74, D 01307 Dresden, Germany
    Cell Res 16:949-60. 2006
    ..Our results suggest that despite the absence of differentiation of hMSC into cardiomyocytes, treatment with 5-azacytidine caused profound changes in current density...
  54. ncbi Novel anti-arrhythmic agents for the treatment of atrial fibrillation
    Erich Wettwer
    Department of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Curr Opin Pharmacol 7:214-8. 2007
    ..However, a major improvement in the pharmacotherapy is still awaited. The promising efficacy of several new drugs in animal models of atrial fibrillation has yet to be demonstrated in clinical studies...
  55. ncbi Contribution of Ca2+ influx to carbachol-induced detrusor contraction is different in human urinary bladder compared to pig and mouse
    Melinda Wuest
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Eur J Pharmacol 565:180-9. 2007
    ....
  56. ncbi Therapeutically relevant concentrations of neomycin selectively inhibit P-type Ca2+ channels in rat striatum
    Dobromir Dobrev
    Department of Pharmacology and Toxicology, Carl Gustav Carus Medical School, Dresden University of Technology, Fetscher Str 74, D 01307 Dresden, Germany
    Eur J Pharmacol 461:105-11. 2003
    ..In conclusion, therapeutically relevant concentrations of neomycin preferentially block P-type Ca(2+) channels which regulate dopamine release in rat striatum. This block could be responsible for aminoglycoside-induced toxicity...
  57. ncbi Chelerythrine treatment influences the balance of pro- and anti-apoptotic signaling pathways in the remote myocardium after infarction
    Gregor Simonis
    Department of Medicine and Cardiology, Dresden University of Technology, Fetscherstr 76, 01307 Dresden, Germany
    Mol Cell Biochem 310:119-28. 2008
    ..The modulation of apoptosis by pro- and anti-apoptotic pathways in the myocardium remote from the infarction, including its link to protein kinase C (PKC), was focus of the present study...
  58. ncbi Muscarinic receptor expression and receptor-mediated detrusor contraction: comparison of juvenile and adult porcine tissue
    Melinda Wuest
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Fetscherstrasse 74, 01307 Dresden, Germany
    Pflugers Arch 456:349-58. 2008
    ..Therefore, similar responses to antimuscarinic compounds could be expected in young and adult patients...
  59. ncbi Rate-adaptive pacing using intracardiac impedance shows no evidence for positive feedback during dobutamine stress test
    Torsten Christ
    Department of Pharmacology and Toxicology, Medical Faculty, University of Technology, Dresden, Germany
    Europace 4:311-5. 2002
    ..We have addressed this problem in patients with chronotropic incompetence who were subjected to a pharmacological stress test...
  60. doi Tissue slices from adult mammalian hearts as a model for pharmacological drug testing
    Alexandra Bussek
    Department of Pharmacology and Toxicology, University of Technology, Dresden, Germany
    Cell Physiol Biochem 24:527-36. 2009
    ..The aim of our study is to investigate adult mammalian ventricular slices as an alternative preparation...
  61. doi Adipocyte fatty acid-binding protein suppresses cardiomyocyte contraction: a new link between obesity and heart disease
    Valeria Lamounier-Zepter
    Medical Clinic III, Dresden University of Technology, Fetscherstr 74, 01307 Dresden, Germany
    Circ Res 105:326-34. 2009
    ..We have recently reported that secretory products from human adipocytes directly and acutely depressed cardiac contractile function...
  62. doi Catecholamines relax detrusor through beta 2-adrenoceptors in mouse and beta 3-adrenoceptors in man
    Melinda Wuest
    Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscher Strasse 74, 01307 Dresden, Germany
    J Pharmacol Exp Ther 328:213-22. 2009
    ..In contrast, detrusor relaxation in man is mediated exclusively via beta(3)-AR...
  63. ncbi Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation
    Dobromir Dobrev
    Department of Pharmacology and Toxicology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
    Cardiovasc Res 54:397-404. 2002
    ..We measured I(K1) and I(K,ACh) in tissue from AF patients with different G beta 3 genotypes and assessed the relation between the I(K1) and I(K,ACh) amplitudes and the incidence of postoperative AF...
  64. doi Effects of three metabolites of propiverine on voltage-dependent L-type calcium currents in human atrial myocytes
    Melinda Wuest
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Eur J Pharmacol 598:94-7. 2008
    ..6). We conclude, that propiverine and M-14 reduce cardiac I(Ca)(,L) at higher concentrations than in detrusor cells and therefore preferentially reduce I(Ca)(,L) in the urinary bladder than in the heart...
  65. ncbi Tissue distribution of a human Ca v 1.2 alpha1 subunit splice variant with a 75 bp insertion
    Eva M Graf
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus der TU Dresden, Fetscherstr 74, D 01307 Dresden, Germany
    Cell Calcium 38:11-21. 2005
    ..We conclude that the +9* variant is present in all human tissues investigated so far, and suggest that expression in human atrium is associated with vascular smooth muscle and/or connective tissue cells...
  66. ncbi Effects of immunoglobulin G from patients with dilated cardiomyopathy on rat cardiomyocytes
    Torsten Christ
    Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, D 01309 Dresden, Germany
    Basic Clin Pharmacol Toxicol 96:445-52. 2005
    ..We conclude that both beta(1)-adrenoceptors and immunoglobulin G derived from patients positive for beta(1)-adrenoceptor autoantibodies mediate the cardiostimulatory effects via beta(1)-adrenoceptors...
  67. pmc Pharmacodynamics of propiverine and three of its main metabolites on detrusor contraction
    Melinda Wuest
    Institute of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstrasse 74, D 01307 Dresden, Germany
    Br J Pharmacol 145:608-19. 2005
    ..5. The investigated responses to propiverine and its metabolites suggest that impairment of maximum CCh-induced contractions is due to strong effect on I(Ca) and that this may be associated with the presence of the aliphatic side chain...
  68. ncbi Silencing the cardiac potassium channel Kv4.3 by RNA interference in a CHO expression system
    Diego Cotella
    Department of Pharmacology and Toxicology, Carl Gustav Carus Medical Faculty, University of Technology, Dresden, Germany
    Biochem Biophys Res Commun 330:555-60. 2005
    ....
  69. ncbi Juvenile pig detrusor: effects of propiverine and three of its metabolites
    Melinda Wuest
    Institute of Pharmacology and Toxicology, Dresden University of Technology, Germany
    Eur J Pharmacol 524:145-8. 2005
    ..Nevertheless order of potency and efficacy of propiverine and its metabolites M-5 and M-14 are similar in juvenile and mature pigs, while M-6 only reduces atropine-sensitive contractions in the juvenile organism...
  70. ncbi Effect of rilmakalim on detrusor contraction in the presence and absence of urothelium
    Melinda Wuest
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
    Naunyn Schmiedebergs Arch Pharmacol 372:203-12. 2005
    ..We conclude that with this one exception, the responses to rilmakalim in detrusor contractions were not mediated by KATP channel opening...
  71. ncbi Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation
    Erich Wettwer
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Circulation 110:2299-306. 2004
    ....
  72. ncbi Remodeling of cardiomyocyte ion channels in human atrial fibrillation
    Dobromir Dobrev
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät der TU Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Basic Res Cardiol 98:137-48. 2003
    ..New therapeutic options could consist of supporting rather than reversing the adaptive mechanisms...
  73. ncbi Acute hemodynamic effects during immunoadsorption in patients with dilated cardiomyopathy positive for beta 1-adrenoceptor autoantibodies
    T Christ
    Department of Pharmacology and Toxicology, Max Delbruck Centre for Molecular Medicine, Berlin, Germany
    Methods Find Exp Clin Pharmacol 23:141-4. 2001
    ..Baseline levels were reached again several hours after therapy ended. We conclude that during immunoadsorption substantial hemodynamic changes occur in patients positive for beta 1-AAB...
  74. ncbi Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes
    H M Himmel
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    Mol Pharmacol 58:449-54. 2000
    ..ACh) activation by SPP and SPPC exhibits large species differences. Furthermore, they suggest that SPP-induced I(K.ACh) activation in human atrial myocytes is mediated by the Edg-3 subtype of SPP receptors...
  75. ncbi Epinephrine activates both Gs and Gi pathways, but norepinephrine activates only the Gs pathway through human beta2-adrenoceptors overexpressed in mouse heart
    Jürgen F Heubach
    Institute of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Germany
    Mol Pharmacol 65:1313-22. 2004
    ..For one site involved in receptor coupling to G(s), both epinephrine and norepinephrine compete. The other site, recognized by epinephrine but not by norepinephrine, leads to receptor G(i) coupling...
  76. ncbi The effects of levosimendan on myocardial function in ropivacaine toxicity in isolated guinea pig heart preparations
    Sebastian N Stehr
    Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany
    Anesth Analg 105:641-7. 2007
    ..Therefore, we investigated the effects of levosimendan on the negative inotropic response to ropivacaine in isolated heart preparations of guinea pigs...
  77. ncbi Cholinergic and purinergic responses in isolated human detrusor in relation to age
    Melinda Wuest
    Institute of Pharmacology and Toxicology, Dresden University of Technology, Department of Urology, University Hospital Carl Gustav Carus, Dresden, Germany
    J Urol 173:2182-9. 2005
    ....
  78. pmc Physiological antagonism between ventricular beta 1-adrenoceptors and alpha 1-adrenoceptors but no evidence for beta 2- and beta 3-adrenoceptor function in murine heart
    Jürgen F Heubach
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus der TU Dresden, D 01307 Dresden, Germany
    Br J Pharmacol 136:217-29. 2002
    ..Both G(i) protein and alpha(1)-adrenoceptors restrain (-)-adrenaline-evoked increases in right ventricular force mediated through beta(1)-adrenoceptors...
  79. ncbi Recording atrial monophasic action potentials using standard pacemaker leads: an alternative way to study electrophysiology properties of the human atrium in vivo?
    Torsten Christ
    Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
    Pacing Clin Electrophysiol 27:1632-7. 2004
    ..The method should allow screening patients for electrophysiological alterations even before the onset of AF...
  80. ncbi Reproducibility of dorsal hand vein responses to phenylephrine and prostaglandin F2 alpha using the dorsal hand vein compliance method
    C Schindler
    Institute of Clinical Pharmacology, Medical Faculty of the University of Technology Dresden, Fiedlerstrasse 27, D 01307 Dresden, Germany
    J Clin Pharmacol 43:228-36. 2003
    ..However, in such studies, phenylephrine appears to be a more reliable tool than PGF2 alpha...
  81. pmc The function of alpha- and beta-adrenoceptors of the saphenous artery in caveolin-1 knockout and wild-type mice
    S Neidhold
    Department of Pharmacology, Technical University of Dresden, Dresden, Germany
    Br J Pharmacol 150:261-70. 2007
    ..Adrenoceptors can associate with cardiac caveolae. To investigate the function of vascular caveolae, adrenoceptor-mediated effects were compared in the saphenous artery of caveolin-1 knockout (cav-1KO) and wild-type (WT) mice...
  82. ncbi New approaches in the modulation of bladder smooth muscle cells on viable detrusor constructs
    Gouya Ram-Liebig
    Department of Urology, Technical University of Dresden, Fetscherstrasse 74, 01307, Dresden, Germany
    World J Urol 24:429-37. 2006
    ..SMC-phenotype can be modulated in viable detrusor constructs by applying selected combinations of urothelial-conditioned media and mechanical stimulation under stepwise reduction and elimination of serum...
  83. ncbi Muscarinic subtype-2 receptor autoantibodies: actors or bystanders in human atrial fibrillation?
    Dobromir Dobrev
    Eur Heart J 25:1091-2. 2004
  84. ncbi Defective cardiac ryanodine receptor regulation during atrial fibrillation
    John A Vest
    Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Circulation 111:2025-32. 2005
    ..6) causes SR Ca2+ leak in failing hearts and can trigger fatal ventricular arrhythmias. Little is known about the role of RyR2 dysfunction in AF, however...
  85. ncbi Specific beta(2)AR blocker ICI 118,551 actively decreases contraction through a G(i)-coupled form of the beta(2)AR in myocytes from failing human heart
    Haibin Gong
    National Heart and Lung Institute, Imperial College School of Medicine, London, UK
    Circulation 105:2497-503. 2002
    ..In this study we characterize the effect in parallel in human myocytes and in myocytes from animal models where beta(2)ARs or G(i) proteins are overexpressed...
  86. ncbi Problem-based learning: a new pathway to competence?
    Ursula Ravens
    Trends Pharmacol Sci 23:162-3. 2002
  87. ncbi Beta adrenergic receptor-mediated atrial specific up-regulation of RGS5
    Gael Jean-Baptiste
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Life Sci 76:1533-45. 2005
    ..Taken together, these results indicate that RGS5 is a housekeeping RGS in the heart and in skeletal muscle while its beta adrenergic-mediated induction in the atrium suggests that it also has a highly specialized function...
  88. ncbi Cardiac mechano-electric feedback: past, present, and prospect
    Peter Kohl
    Prog Biophys Mol Biol 82:3-9. 2003
    ..This volume of Progress in Biophysics and Molecular Biology incorporates clinical and basic science results, and it is fitting that its publication coincides with a special session on cardiac MEF at the 2003 meeting of NASPE...
  89. ncbi Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation
    Ali El-Armouche
    Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Center Hamburg Eppendorf, Germany
    Circulation 114:670-80. 2006
    ..Here, we assessed the phosphorylation levels of key proteins involved in altered Ca2+ handling and contractility in cAF patients...
  90. ncbi [German Competence Network on Atrial Fibrillation (AFNET). A nationwide cooperation for better research and patient care]
    Angelika Leute
    Kompetenznetz Vorhofflimmern, Universitatsklinikum Munster, Munster, Germany
    Med Klin (Munich) 101:662-6. 2006
    ..Experimental basic research projects are focusing on different aspects of atrial remodeling in order to find out in which way the molecular mechanisms can be manipulated by new methods of treatment. First results are presented...
  91. ncbi Letter by Christ et al regarding article, "Angiotensin II potentiates the slow component of delayed rectifier K+ current via the AT1 receptor in guinea pig atrial myocytes"
    Torsten Christ
    Circulation 114:e565; author reply e566. 2006
  92. ncbi Two centuries of excitation-contraction coupling
    Susan Wray
    Physiological Laboratory, Liverpool University, Crown Street, P O Box 147, Liverpool L69 3BX, UK
    Cell Calcium 35:485-9. 2004
  93. ncbi Regulation of cardiac sodium channels by tyrosine kinases - contribution to excitability?
    Ursula Ravens
    J Mol Cell Cardiol 42:733-4. 2007
  94. ncbi Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart
    Peter Molenaar
    Department of Medicine, The Prince Charles Hospital, University of Queensland, Australia
    Cardiovasc Res 69:128-39. 2006
    ..To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart beta1- and beta2-adrenoceptors...
  95. pmc Identification and characterization of G beta 3s2, a novel splice variant of the G-protein beta 3 subunit
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, D 45122 Essen, Germany
    Biochem J 371:223-32. 2003
    ..Together, these results suggest that G beta 3s2 is a biologically active G beta variant which may play a role in the manifestation of the complex phenotype associated with the 825T-allele...
  96. ncbi Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643)
    Rie Schultz Hansen
    Neurosearch A S, Pederstrupvej 93, 2750 Ballerup, Denmark
    Mol Pharmacol 69:266-77. 2006
    ..In conclusion, HERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents an interesting new antiarrhythmic approach...
  97. ncbi Changes in morphology and inward rectifier currents in human atrial myocytes depend on culture conditions
    Herbert M Himmel
    Bayer AG, Abt Sicherheitsstudien, Wuppertal, Germany
    Basic Res Cardiol 97:434-44. 2002
    ..In conclusion, morphological and electrophysiological changes depended on serum in the culture medium rather than on adherence surface being coated with laminin or polylysin...
  98. ncbi Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation
    Maura Greiser
    Institut fur Physiologie, Universitatsklinikum Aachen, Aachen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 375:383-92. 2007
    ..Indirect evidence for an impaired src kinase regulation of I (Ca,L) together with an increased phosphatase activity suggests that a complex alteration in the kinase/phosphatase balance leads to I (Ca,L) dysregulation in chronic AF...
  99. ncbi Cardiac tissue engineering
    Thomas Eschenhagen
    Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Clinical Pharmacology, Friedrich Alexander University Erlangen Nuremberg, Erlangen, Germany
    Transpl Immunol 9:315-21. 2002
    ..Thus, EHTs may serve as material for a novel tissue replacement approach...
  100. ncbi Pharmacological modulation of ion channels and transporters
    Ursula Ravens
    Department of Pharmacology and Pharmacotherapy, Medical University of Szeged, Dom ter 12, H 6701 Szeged, Hungary
    Cell Calcium 35:575-82. 2004
    ..However, irrespective of their primary indication, all compounds targeted against ion channels and transporter proteins possess potential proarrhythmic activity...
  101. ncbi A new toxin from the sea anemone Condylactis gigantea with effect on sodium channel inactivation
    Ludger Ständker
    IPF PharmaCeuticals GmbH, Feodor Lynen Strasse 31, 30625 Hannover, Germany
    Toxicon 48:211-20. 2006
    ..Toxicon, 39, 693-702]. Comprehensive analysis of the purified active fractions suggests that CgNa may represent the main peptide toxin of this sea anemone species...