Research Topics
Genomes and Genes | Martin KorteSummaryAffiliation: Technical University of Braunschweig Country: Germany Publications
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Detail Information
Publications
The hnRNP and cytoskeletal protein raver1 contributes to synaptic plasticityInes Lahmann
Cell and Molecular Biology, Institute for Biochemistry and Biotechnology, Technical University of Braunschweig, Braunschweig, Germany
Exp Cell Res 314:1048-60. 2008..Our results provide evidence that raver1 may play an important role for the regulation of neuronal synaptic plasticity, possibly by controlling especially the late LTP via posttranscriptional mechanisms...- Neuroscience. A protoplasmic kiss to rememberMartin Korte
Zoological Institute, Division of Cellular Neurobiology, TU Braunschweig, D-38106 Germany
Science 319:1627-8. 2008 
The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse modelsMartin Korte
Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig, Spielmannstr 7, 38106 Braunschweig, Germany
Exp Brain Res 217:435-40. 2012..Analysis of such activity patterns in tissue from mice with altered expression of APP/APLP has just started and may shed further light on the importance of these proteins for cognitive functions...- Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage-dependent calcium channelsSheeja Navakkode
Division of Cellular Neurobiology, Zoological Institute, Braunschweig D 38106, Germany
Learn Mem 19:294-9. 2012..We report that dopaminergic modulation of LTP is lamina-specific at the Schaffer collateral/commissural synapses in the CA1 region... - Different compartments of apical CA1 dendrites have different plasticity thresholds for expressing synaptic tagging and captureSreedharan Sajikumar
Division of Cellular Neurobiology, Zoological Institute, TU, Braunschweig D 38106, Germany
Learn Mem 18:327-31. 2011.... - Nogo-A stabilizes the architecture of hippocampal neuronsMarta Zagrebelsky
Zoological Institute, Division of Cellular Neurobiology, University of Braunschweig, D 38106 Braunschweig, Germany
J Neurosci 30:13220-34. 2010..Mechanistically, although the majority of the activity of Nogo-A relies on a receptor-mediated mechanism involving NgR1, its cell-autonomous function plays a minor role... 
Neuronal profilin isoforms are addressed by different signalling pathwaysKai Murk
Cellular Neurobiology, Zoological Institute, TU Braunschweig, Braunschweig, Germany
PLoS ONE 7:e34167. 2012..Furthermore, they suggest a functional role for both profilins in neuronal nuclei...- NogoA restricts synaptic plasticity in the adult hippocampus on a fast time scaleAndrea Delekate
Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig, 38106 Braunschweig, Germany
Proc Natl Acad Sci U S A 108:2569-74. 2011..NogoA could thus serve as an important negative regulator of functional and structural plasticity in mature neuronal networks... - Fine-tuning of neuronal architecture requires two profilin isoformsKristin Michaelsen
Zoological Institute, University of Braunschweig, Germany
Proc Natl Acad Sci U S A 107:15780-5. 2010.... - Metaplasticity governs compartmentalization of synaptic tagging and capture through brain-derived neurotrophic factor (BDNF) and protein kinase Mzeta (PKMzeta)Sreedharan Sajikumar
Division of Cellular Neurobiology, Zoological Institute, TU Braunschweig, D 38106 Braunschweig, Germany
Proc Natl Acad Sci U S A 108:2551-6. 2011..These clusters will then prepare the synaptic network to form long-term memories... - Suppression of p75 neurotrophin receptor surface expression with intrabodies influences Bcl-xL mRNA expression and neurite outgrowth in PC12 cellsCongcong Zhang
Institute for Biochemistry and Biotechnology, Technische Universitat Braunschweig, Braunschweig, Germany
PLoS ONE 7:e30684. 2012..In this study, p75NTR surface expression was suppressed for the first time at the protein level by endoplasmic reticulum (ER) retained intrabodies... - A role for synaptopodin and the spine apparatus in hippocampal synaptic plasticityThomas Deller
Institute of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
Ann Anat 189:5-16. 2007..Future studies will be aimed at finding the molecular link between synaptopodin, the spine apparatus organelle, and synaptic plasticity... - Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient miceTheofilos Papadopoulos
Department of Neurochemistry, Max Planck Institute for Brain Research, Frankfurt, Germany
EMBO J 26:3888-99. 2007..Together, our data indicate that Cb is essential for gephyrin-dependent clustering of a specific set of GABA(A) receptors, but not required for glycine receptor postsynaptic localization... - Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticityThomas Deller
Institute of Anatomy, University of Freiburg, P O Box 111, D 79001 Freiburg, Germany
Proc Natl Acad Sci U S A 100:10494-9. 2003..This genetic analysis points to a role of the spine apparatus in synaptic plasticity... - Hippocampal plasticity requires postsynaptic ephrinBsIlona C Grunwald
Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, 82152 Munich Martinsried, Germany
Nat Neurosci 7:33-40. 2004..This work raises the intriguing possibility that depending on the type of synapse, Eph/ephrins can be involved in activity-dependent plasticity in converse ways, with ephrinBs on the pre- or the postsynaptic side... - Differentiation of mouse embryonic stem cells into a defined neuronal lineageMiriam Bibel
Friedrich Miescher Institute, CH-4058 Basel, Switzerland
Nat Neurosci 7:1003-9. 2004..As they do in vivo, these cells went on to generate neurons with remarkably uniform biochemical and electrophysiological characteristics... - The neurotrophin receptor p75NTR modulates long-term depression and regulates the expression of AMPA receptor subunits in the hippocampusHarald Rösch
Department of Cellular and Systems Neurobiology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
Proc Natl Acad Sci U S A 102:7362-7. 2005..These results implicate p75NTR in activity-dependent synaptic plasticity and extend the concept of functional antagonism of the neurotrophin signaling system... - The p75 neurotrophin receptor negatively modulates dendrite complexity and spine density in hippocampal neuronsMarta Zagrebelsky
Department of Cellular and Systems Neurobiology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
J Neurosci 25:9989-99. 2005..These results show that p75NTR negatively modulates dendritic morphology in adult hippocampal pyramidal neurons and documents a new case of functional antagonism between Trk and p75NTR signaling... - Hippocampal long-term potentiation is supported by presynaptic and postsynaptic tyrosine receptor kinase B-mediated phospholipase Cgamma signalingAnnette Gärtner
Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
J Neurosci 26:3496-504. 2006..Blockade of presynaptic or postsynaptic signaling alone did not result in a significant reduction of LTP... - Homeostatic shutdown of long-term potentiation in the adult hippocampusClaudia Roth-Alpermann
Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany
Proc Natl Acad Sci U S A 103:11039-44. 2006..Thus, adult neurons can sustain a substantial amount of synaptic strengthening but, once a certain threshold of potentiation is exceeded, homeostatic regulation ensures that no further strengthening can occur... - The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient miceSabine Ring
Department of Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, D 69120 Heidelberg, Germany
J Neurosci 27:7817-26. 2007..Together, our data suggest that the APP C terminus is dispensable and that APPs alpha is sufficient to mediate the physiological functions of APP assessed by these tests... - Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNFTomoya Matsumoto
Biozentrum, University of Basel, Klingelbergstrasse 50 70, CH 4056 Basel, Switzerland
Nat Neurosci 11:131-3. 2008..Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input... - Mechanism of TrkB-mediated hippocampal long-term potentiationLiliana Minichiello
European Molecular Biology Laboratory, Via Ramarini 32, 00016, Monterotondo, Italy
Neuron 36:121-37. 2002..Our results provide genetic evidence that TrkB mediates hippocampal plasticity via recruitment of PLCgamma, and by subsequent phosphorylation of CaMKIV and CREB...