Thomas Illmer

Summary

Affiliation: Technical University
Country: Germany

Publications

  1. ncbi request reprint MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients
    Thomas Illmer
    Medical Clinic and Polyclinic I, University Hospital of the Technical University, 01307 Dresden, Germany
    Cancer Res 62:4955-62. 2002
  2. ncbi request reprint P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate
    T Illmer
    Medical Clinic and Policlinic I, University Hospital of the Technical University, Dresden, Germany
    Leukemia 18:401-8. 2004
  3. ncbi request reprint MDR1 and MRP1 gene expression are independent predictors for treatment outcome in adult acute myeloid leukaemia
    Markus Schaich
    Medizinische Klinik und Poliklinik I, Universitätsklinikum C G Carus, Dresden, Germany
    Br J Haematol 128:324-32. 2005
  4. pmc Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Haematologica 94:1613-7. 2009
  5. doi request reprint Gemtuzumab ozogamicin as part of reduced-intensity conditioning for allogeneic hematopoietic cell transplantation in patients with relapsed acute myeloid leukemia
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Clin Cancer Res 14:5585-93. 2008
  6. doi request reprint HLA-DRneg patients without acute promyelocytic leukemia show distinct immunophenotypic, genetic, molecular, and cytomorphologic characteristics compared to acute promyelocytic leukemia
    Uta Oelschlaegel
    University Hospital, University of Technics, Medical Clinic and Policlinic I, Dresden, Germany
    Cytometry B Clin Cytom 76:321-7. 2009
  7. ncbi request reprint A sensitive model for prediction of relapse in adult acute myeloid leukaemia with t(8;21) using white blood cell count, CD56 and MDR1 gene expression at diagnosis
    Markus Schaich
    Department of Medicine I, University Hospital C G Carus, Dresden, Germany
    Br J Haematol 125:477-9. 2004
  8. ncbi request reprint Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Fetscherstrasse 74, 01307 Dresden, Germany
    Blood 107:4011-20. 2006
  9. ncbi request reprint Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient
    Christoph Pöhlmann
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Clin Infect Dis 44:e118-20. 2007
  10. ncbi request reprint Intensified double induction therapy with high dose mitoxantrone, etoposide, m-amsacrine and high dose ara-C for elderly acute myeloid leukemia patients aged 61-65 years
    Markus Schaich
    Medizinische Klinik und Poliklinik I, Universit tsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Haematologica 87:808-15. 2002

Collaborators

Detail Information

Publications34

  1. ncbi request reprint MDR1 gene polymorphisms affect therapy outcome in acute myeloid leukemia patients
    Thomas Illmer
    Medical Clinic and Polyclinic I, University Hospital of the Technical University, 01307 Dresden, Germany
    Cancer Res 62:4955-62. 2002
    ....
  2. ncbi request reprint P-glycoprotein-mediated drug efflux is a resistance mechanism of chronic myelogenous leukemia cells to treatment with imatinib mesylate
    T Illmer
    Medical Clinic and Policlinic I, University Hospital of the Technical University, Dresden, Germany
    Leukemia 18:401-8. 2004
    ..MDR1 overexpression must therefore be considered as an important clinical mechanism in the diversity of resistance development to imatinib treatment...
  3. ncbi request reprint MDR1 and MRP1 gene expression are independent predictors for treatment outcome in adult acute myeloid leukaemia
    Markus Schaich
    Medizinische Klinik und Poliklinik I, Universitätsklinikum C G Carus, Dresden, Germany
    Br J Haematol 128:324-32. 2005
    ..Our study shows that resistance gene expression should be considered together with age, cytogenetics and FLT3 mutational status for risk-adapted treatment strategies in AML in the future...
  4. pmc Monitoring of donor chimerism in sorted CD34+ peripheral blood cells allows the sensitive detection of imminent relapse after allogeneic stem cell transplantation
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Haematologica 94:1613-7. 2009
    ..Monitoring of CD34(+) donor chimerism in the peripheral blood allows prediction of imminent relapse after allogeneic stem cell transplantation even when a disease-specific marker is lacking...
  5. doi request reprint Gemtuzumab ozogamicin as part of reduced-intensity conditioning for allogeneic hematopoietic cell transplantation in patients with relapsed acute myeloid leukemia
    Martin Bornhauser
    Medizinische Klinik und Poliklinik I, University Hospital, Dresden, Germany
    Clin Cancer Res 14:5585-93. 2008
    ..We hypothesized that GO might be safe and effective as part of a reduced-intensity conditioning regimen as salvage therapy of CD33+ acute myeloid leukemia...
  6. doi request reprint HLA-DRneg patients without acute promyelocytic leukemia show distinct immunophenotypic, genetic, molecular, and cytomorphologic characteristics compared to acute promyelocytic leukemia
    Uta Oelschlaegel
    University Hospital, University of Technics, Medical Clinic and Policlinic I, Dresden, Germany
    Cytometry B Clin Cytom 76:321-7. 2009
    ..The purpose of this study was to investigate whether further biological characterization of the HLA-DR(neg) acute myeloid leukemia patients would allow more clearly define criteria to separate APL from non-APL patients...
  7. ncbi request reprint A sensitive model for prediction of relapse in adult acute myeloid leukaemia with t(8;21) using white blood cell count, CD56 and MDR1 gene expression at diagnosis
    Markus Schaich
    Department of Medicine I, University Hospital C G Carus, Dresden, Germany
    Br J Haematol 125:477-9. 2004
    ..A calculated logit out of these three variables was a strong independent prognostic factor for overall (P = 0.007) and disease-free survival (P = 0.002)...
  8. ncbi request reprint Prevalence and prognostic impact of NPM1 mutations in 1485 adult patients with acute myeloid leukemia (AML)
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Fetscherstrasse 74, 01307 Dresden, Germany
    Blood 107:4011-20. 2006
    ..In conclusion, NPM1 mutations represent a common genetic abnormality in adult AML. If not associated with FLT3-ITD mutations, mutant NPM1 appears to identify patients with improved response toward treatment...
  9. ncbi request reprint Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient
    Christoph Pöhlmann
    Institut fur Medizinische Mikrobiologie und Hygiene, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Clin Infect Dis 44:e118-20. 2007
    ..Cidofovir and foscarnet combination therapy may be beneficial for reducing mortality of (neutropenic) stem cell transplant recipients with human herpesvirus 6 encephalitis...
  10. ncbi request reprint Intensified double induction therapy with high dose mitoxantrone, etoposide, m-amsacrine and high dose ara-C for elderly acute myeloid leukemia patients aged 61-65 years
    Markus Schaich
    Medizinische Klinik und Poliklinik I, Universit tsklinikum Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany
    Haematologica 87:808-15. 2002
    ..We, therefore, tried to escalate induction therapy further in a group of young elderly AML patients...
  11. ncbi request reprint A highly sensitive method for the detection of PKC412 (CGP41251) and its metabolites by high-performance liquid chromatography
    Thomas Illmer
    Medical Clinic and Policlinic I, Technical University Dresden, Germany
    J Pharmacol Toxicol Methods 56:23-7. 2007
    ..Therefore, we established a new isocratic HPLC method, which sensitively detects PKC412 and five of its metabolites...
  12. pmc Influence of enzyme-inducing antiepileptic drugs on trough level of imatinib in glioblastoma patients
    Stefan Pursche
    Carl Gustav Carus University, Internal Medicine I, Division of Hematology and Oncology, Dresden, Germany
    Curr Clin Pharmacol 3:198-203. 2008
    ..Since CYP3A4 is the major isozyme involved in the metabolism of imatinib, we investigated the influence of EIAEDs on imatinib pharmacokinetics (pk)...
  13. doi request reprint High-dose cytarabine consolidation with or without additional amsacrine and mitoxantrone in acute myeloid leukemia: results of the prospective randomized AML2003 trial
    Markus Schaich
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    J Clin Oncol 31:2094-102. 2013
    ..To assess the treatment outcome benefit of multiagent consolidation in young adults with acute myeloid leukemia (AML) in a prospective, randomized, multicenter trial...
  14. doi request reprint Clonal evolution including partial loss of human leukocyte antigen genes favoring extramedullary acute myeloid leukemia relapse after matched related allogeneic hematopoietic stem cell transplantation
    Friedrich Stölzel
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Dresden, Germany
    Transplantation 93:744-9. 2012
    ..We hypothesized that this mechanism applies to extramedullary AML relapse which occurs frequently after allogeneic HSCT and might also not be restricted to haploidentical HSCT...
  15. ncbi request reprint Kinetics of CXCR-4 and adhesion molecule expression during autologous stem cell mobilisation with G-CSF plus AMD3100 in patients with multiple myeloma
    Uta Oelschlaegel
    Medical Clinic and Polyclinic I, University Hospital of the Technical University of Dresden, House 66, Fetscherstrasse 74, 01307 Dresden, Germany
    Ann Hematol 86:569-73. 2007
    ..Further studies will define the possible prognostic role of AMD3100 mediated changes in CXCR-4 expression for the prediction of stem cell yield attainable with this new mobilisation regimen...
  16. doi request reprint BCR/ABL expression of myeloid progenitors increases beta1-integrin mediated adhesion to stromal cells
    Fernando A Fierro
    Medical Clinic and Policlinic I, Technical University, Dresden, Germany
    J Mol Biol 377:1082-93. 2008
    ....
  17. ncbi request reprint Activation of the RAS pathway is predictive for a chemosensitive phenotype of acute myelogenous leukemia blasts
    Thomas Illmer
    Medical Clinic and Policlinic I, University Hospital of the Technical University, Dresden, Germany
    Clin Cancer Res 11:3217-24. 2005
    ..This could be due to alternative initiating events for activation of the RAS pathway like constitutive tyrosine kinase activation or mutations in Ras-regulating genes...
  18. ncbi request reprint Increased myelotoxicity of idarubicin: is there a pharmacological basis? Results of a pharmacokinetic and an in vitro cytotoxicity study
    Frank Kroschinsky
    1st Medical Department, Carl Gustav Carus University Hospital, Fetscherstrasse 74, 01307, Dresden, Germany
    Cancer Chemother Pharmacol 53:61-7. 2004
    ..IDA is known to be less sensitive towards multidrug resistance mediated by P-glycoprotein (P-gp). This phenotype is a major impediment to successful antineoplastic treatment, but P-gp is also expressed on hematopoietic stem cells (HSC)...
  19. ncbi request reprint Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis
    Christian Thiede
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus der Technischen Universität, Dresden, Germany
    Blood 99:4326-35. 2002
    ..Constitutive activation may be associated with monocytoid differentiation. A high mutant/wt ratio in ITD-positive patients appears to have a major impact on the prognostic relevance...
  20. doi request reprint The efficacy of arsenic trioxide for the treatment of relapsed and refractory multiple myeloma: a systematic review
    Christoph Rollig
    Medizinische Klinik und Poliklinik I, University Hospital Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Cancer Treat Rev 35:425-30. 2009
    ..With respect to the higher evidence level of new substances such as bortezomib or lenalidomide, at present ATO has no role in routine management of relapsed or refractory myeloma...
  21. ncbi request reprint Mdr1 gene expression and mutations in Ras proto-oncogenes in acute myeloid leukemia
    Markus Schaich
    Department of Medicine I, University Hospital C G Carus, Dresden, Germany
    Leuk Lymphoma 43:1345-54. 2002
    ..Taking this up the potential possibilities of Ras influence on mdr1 activity and their implications on treatment outcome in AML are discussed...
  22. ncbi request reprint Outcome and prognostic features of intensive care unit treatment in patients with hematological malignancies
    Frank Kroschinsky
    Medizinische Klinik und Poliklinik I, Universitatsklinikum Carl Gustav Carus, Technische Universitat, Fetscherstrasse 74, 01307 Dresden, Germany
    Intensive Care Med 28:1294-300. 2002
    ..To assess the outcome of intensive care unit (ICU) treatment in patients with hematological malignancies...
  23. doi request reprint Detection of herpesvirus and adenovirus co-infections with diagnostic DNA-microarrays
    René Müller
    The Calicilab, Institut fur Virologie, Medizinische Fakultät Carl Gustav Carus, Dresden, Germany
    J Virol Methods 155:161-6. 2009
    ..Those features make the DNA-microarray an attractive device for the management of viral infections in immunocompromised patients...
  24. doi request reprint Posaconazole prophylaxis during induction therapy of patients with acute lymphoblastic leukaemia
    Thomas Illmer
    Medical Clinic I, University Clinic of Technical University Dresden, Dresden, Germany
    Mycoses 54:e143-7. 2011
    ..Therefore, the observations indicate a favourable toxicity profile of posaconazole in ALL therapy. Efficacy of the drug has to be further validated in prospective clinical trials...
  25. ncbi request reprint Association of specific cytogenetic aberrations with mdr1 gene expression in adult myeloid leukemia and its implication in treatment outcome
    Markus Schaich
    Medizinische Klinik und Poliklinik I, Universitätsklinikum C G Carus, Fetscherstr 74, 01307 Dresden, Germany
    Haematologica 87:455-64. 2002
    ..The association, however, between specific cytogenetic aberrations and mdr1 expression has not yet been examined in a large cohort of patients...
  26. ncbi request reprint FLT3 kinase inhibitors in the management of acute myeloid leukemia
    Thomas Illmer
    Medical Clinic and Policlinic I, Hospital of the Technical University, Technical University Dresden, Fetscherstrasse 74, Dresden, Germany
    Clin Lymphoma Myeloma 8:S24-34. 2007
    ..Herein, we summarize results from studies using FLT3 TKIs as single agents and report on the first clinical trials investigating FLT3 TKIs in combination with chemotherapy...
  27. ncbi request reprint Arsenic-induced APL differentiation in cerebrospinal fluid
    Annett Helwig
    Medical Clinic and Policlinic I, University Hospital of the Technical University, Fetscherstrasse 74, 01307 Dresden, Germany
    Leuk Res 31:703-5. 2007
    ..Since arsenic trioxide could be identified in the CNS, we provide evidence that the drug can cross the blood-brain barrier and can be used for treatment of extramedullary APL...
  28. ncbi request reprint Detection of beta-herpesviruses in allogenic stem cell recipients by quantitative real-time PCR
    Julian Sassenscheidt
    Institut fur Virologie, Medizinische Fakultät Carl Gustav Carus, Medizinisch Theoretisches Zentrum, Fiedlerstrasse 42, 01307 Dresden, Germany
    J Virol Methods 138:40-8. 2006
    ..No evidence for a potential interaction of the roseoloviruses and CMV infections was found...
  29. ncbi request reprint Prognosis of acute myeloid leukemia patients up to 60 years of age exhibiting trisomy 8 within a non-complex karyotype: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup
    Markus Schaich
    Department of Internal Medicine I, University of Dresden, Germany
    Haematologica 92:763-70. 2007
    ..Additional prognostic indicators are needed to further classify these patients and determine their appropriate management...
  30. ncbi request reprint Elimination of imatinib mesylate and its metabolite N-desmethyl-imatinib
    Martin Bornhauser
    J Clin Oncol 23:3855-6; author reply 3857-8. 2005
  31. ncbi request reprint Comparative analysis of MLL partial tandem duplication and FLT3 internal tandem duplication mutations in 956 adult patients with acute myeloid leukemia
    Christine Steudel
    Medizinische Klinik und Poliklinik I, Universitätsklinikum Carl Custav Carus der Technischen Universität Dresden, Germany
    Genes Chromosomes Cancer 37:237-51. 2003
    ..Although associated with inferior disease-free survival, the results of this study do not unequivocally support the notion that MLL PTD mutations represent an independent prognostic factor...
  32. ncbi request reprint Tyrosine kinase mutations of JAK2 are rare events in AML but influence prognosis of patients with CBF-leukemias
    Thomas Illmer
    Haematologica 92:137-8. 2007
    ..6% (p<0.01). Moreover, JAK2 V617F mutations in CBF leukemias were associated with an aggressive clinical course with 80% of the patients relapsing...
  33. doi request reprint Identification of acute myeloid leukaemia associated microRNA expression patterns
    Fabienne Isken
    Department of Medicine A, Haematology and Oncology, University of Munster, Munster, Germany
    Br J Haematol 140:153-61. 2008
    ..Nonetheless, the presence of two or more miRNA binding sites within the mRNA was usually associated with a decrease in mRNA levels. Taken together, these findings provide evidence that specific miRNA expression patterns exist in AML...
  34. ncbi request reprint Improved outcome after stem-cell transplantation in FLT3/ITD-positive AML
    Martin Bornhauser
    Blood 109:2264-5; author reply 2265. 2007