Research Topics
Species | D DobrevSummaryAffiliation: Technical University Country: Germany Publications
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Publications
Remodeling of cardiomyocyte ion channels in human atrial fibrillationDobromir Dobrev
Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät der TU Dresden, Fetscherstr 74, 01307 Dresden, Germany
Basic Res Cardiol 98:137-48. 2003..New therapeutic options could consist of supporting rather than reversing the adaptive mechanisms...- The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillationD Dobrev
Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, Dresden, Germany
Circulation 112:3697-706. 2005..We tested whether constitutively active acetylcholine (ACh)-activated I(K,ACh) contributes to enhanced basal conductance in chronic AF (cAF)... - Electrical remodeling in atrial fibrillationDobromir Dobrev
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
Herz 31:108-12; quiz 142-3. 2006.... 
Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillationDobromir Dobrev
Department of Pharmacology and Toxicology, Dresden University of Technology, Germany
Trends Cardiovasc Med 20:30-4. 2010..In this review, we will summarize new insights into the role of enhanced CaMKII in sarcoplasmic reticulum calcium leak and atrial arrhythmogenesis during atrial fibrillation...- [Molecular basis of remodelling in atrial fibrillation]D Dobrev
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Dtsch Med Wochenschr 129:827-30. 2004 - Cardiomyocyte Ca2+ overload in atrial tachycardia: is blockade of L-type Ca2+ channels a promising approach to prevent electrical remodeling and arrhythmogenesis?Dobromir Dobrev
Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstr 74, 01307, Dresden, Germany
Naunyn Schmiedebergs Arch Pharmacol 376:227-30. 2007..Studies in animal models with established atrial tachycardia remodeling and in patients with AF are clearly warranted to prove the efficacy of Ca(2+) channel blockers that additionally target T-type Ca(2+) channels... 
New concepts in understanding and modulating atrial repolarisation in patients with atrial fibrillationDobromir Dobrev
Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstr 74, 01307 Dresden, Germany
J Interv Card Electrophysiol 22:107-10. 2008....- Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeuticsDobromir Dobrev
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
J Cardiovasc Pharmacol 52:293-9. 2008..This review focuses on the molecular basis of altered Ca handling in AF, with the goal of providing new insights into molecular effective antiarrhythmic therapy... - Human inward rectifier potassium channels in chronic and postoperative atrial fibrillationDobromir Dobrev
Department of Pharmacology and Toxicology, Carl Gustav Carus Medical School, Dresden University of Technology, Dresden, Germany
Cardiovasc Res 54:397-404. 2002..We measured I(K1) and I(K,ACh) in tissue from AF patients with different G beta 3 genotypes and assessed the relation between the I(K1) and I(K,ACh) amplitudes and the incidence of postoperative AF... - Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug targetDobromir Dobrev
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
Naunyn Schmiedebergs Arch Pharmacol 381:195-206. 2010..This article reviews the molecular mechanisms of altered Ca(2+) signaling in AF and discusses the potential value of novel approaches targeting atrial Ca(2+)-handling abnormalities... - Molecular basis of downregulation of G-protein-coupled inward rectifying K(+) current (I(K,ACh) in chronic human atrial fibrillation: decrease in GIRK4 mRNA correlates with reduced I(K,ACh) and muscarinic receptor-mediated shortening of action potentialsD Dobrev
Department of Pharmacology, University of Technology, Dresden, Germany
Circulation 104:2551-7. 2001..However, it is unclear whether changes in G-protein-coupled inward rectifying K(+) current (I(K,ACh)) contribute to chronic AF... - New antiarrhythmic drugs for treatment of atrial fibrillationDobromir Dobrev
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
Lancet 375:1212-23. 2010..We focus on the basic and clinical pharmacology of newly emerging antiarrhythmic drugs and non-traditional approaches such as upstream therapy for atrial fibrillation... - Pathology-specific effects of the IKur/Ito/IK,ACh blocker AVE0118 on ion channels in human chronic atrial fibrillationT Christ
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
Br J Pharmacol 154:1619-30. 2008.... - L-type Ca2+ current downregulation in chronic human atrial fibrillation is associated with increased activity of protein phosphatasesT Christ
Department of Pharmacology, Dresden University of Technology, Dresden, Germany
Circulation 110:2651-7. 2004..CONCLUSIONS: In AF, increased protein phosphatase activity contributes to impaired basal I(Ca,L). We propose that protein phosphatases may be potential therapeutic targets for AF treatment... - Decreased ATP-sensitive K(+) current density during chronic human atrial fibrillationBartosz Balana
Department of Pharmacology and Toxicology, Carl Gustav Carus Medical School, Dresden University of Technology, Fetscherstrasse 74, Dresden D 01307, Germany
J Mol Cell Cardiol 35:1399-405. 2003..We provide evidence that chronic AF is associated with a downregulation of ATP-sensitive K(+) currents. These changes may provide an additional molecular mechanism for electrical remodeling in chronic AF... - Local venous response to N-desethylamiodarone in humansM Grossmann
Institute of Clinical Pharmacology and the Department of Pharmacology and Toxicology, Medical Faculty of the University of Technology, Dresden, Germany
Clin Pharmacol Ther 67:22-31. 2000..It is unknown whether N-desethylamiodarone has acute vascular effects. The aim of this study was to explore the mechanism of action of N-desethylamiodarone in human hand veins... - Autoantibodies against the beta1 adrenoceptor from patients with dilated cardiomyopathy prolong action potential duration and enhance contractility in isolated cardiomyocytesT Christ
Department of Pharmacology and Toxicology, Dresden, Germany
J Mol Cell Cardiol 33:1515-25. 2001..These effects may contribute to beta1-adrenoceptor-mediated cardiotoxicity in heart failure... - Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytesH M Himmel
Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
Mol Pharmacol 58:449-54. 2000..ACh) activation by SPP and SPPC exhibits large species differences. Furthermore, they suggest that SPP-induced I(K.ACh) activation in human atrial myocytes is mediated by the Edg-3 subtype of SPP receptors... - Amiodarone causes endothelium-dependent vasodilation in human hand veins in vivoM Grossman
Institute of Clinical Pharmacology, Faculty of Medicine, University of Technology, Dresden, Germany
Clin Pharmacol Ther 64:302-11. 1998..The aim of the study was to investigate the short-term effects of amiodarone in preconstricted human hand veins and to explore the underlying mechanisms... - [New antiarrhythmic drugs for therapy of atrial fibrillation: I. Ion channel blockers]U Ravens
Technische Universitat Dresden, Institut fur Pharmakologie und Toxikologie, Medizinische Fakultät Carl Gustav Carus, Fetscherstrasse 74, 01307, Dresden, Germany
Herzschrittmacherther Elektrophysiol 17:64-72. 2006..The current review outlines the pathophysiology of atrial fibrillation and focuses on electrical remodeling. The properties of new antiarrhythmic drugs for atrial fibrillation are discussed in detail... - Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillationNiels Voigt
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
Cardiovasc Res 74:426-37. 2007..In chronic atrial fibrillation (cAF) the potassium current IK,ACh develops agonist-independent constitutive activity. We hypothesized that abnormal phosphorylation-dependent regulation underlies the constitutive IK,ACh activity... - Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillationNiels Voigt
Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstr 74, 01307, Dresden, Germany
Naunyn Schmiedebergs Arch Pharmacol 381:251-9. 2010..The efficacy of flecainide to terminate AF may in part result from blockade of I(K,ACh)... - N-desethylamiodarone modulates intracellular calcium concentration in endothelial cellsH M Himmel
Institut fur Pharmakologie und Toxikologie, Universitatsklinikum Carl Gustav Carus, TU Dresden, Germany
Naunyn Schmiedebergs Arch Pharmacol 362:489-96. 2000..In conclusion, the DEAM-induced [Ca2+]i increase in endothelial cells is due to Ca2+ influx from the extracellular space and to Ca2+ release from endoplasmic reticulum and mitochondria and involves enhanced generation of free radicals... - Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytesNiels Voigt
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
Cardiovasc Res 77:35-43. 2008..This study aimed to establish how AT remodelling affects I K,ACh single-channel function... - Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillationNiels Voigt
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
Circ Arrhythm Electrophysiol 3:472-80. 2010..Unequal left-to-right distribution of inward rectifier K(+) currents has been suggested to underlie this dominant frequency gradient, but this hypothesis has never been tested in humans... - Teaching antiarrhythmic therapy and ECG in simulator-based interdisciplinary undergraduate medical educationM P Mueller
Interdisciplinary Simulation Centre, Department of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Dresden University of Technology, Germany
Br J Anaesth 95:300-4. 2005..As part of this course a practical seminar about antiarrhythmic drugs and ECG was set up. This study was conducted to evaluate the use of a simulator in this course... - The effects of verapamil and diltiazem on N-, P- and Q-type calcium channels mediating dopamine release in rat striatumD Dobrev
Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Technology, Dresden, Germany
Br J Pharmacol 127:576-82. 1999..5. Taken together, our results suggest that verapamil can block P- and at higher concentrations possibly N- and Q-type Ca2+ channels linked to [3H]-DA release, whereas diltiazem appears to block P-type Ca2+ channels only... - Acute hemodynamic effects during immunoadsorption in patients with dilated cardiomyopathy positive for beta 1-adrenoceptor autoantibodiesT Christ
Department of Pharmacology and Toxicology, Max Delbruck Centre for Molecular Medicine, Berlin, Germany
Methods Find Exp Clin Pharmacol 23:141-4. 2001..Baseline levels were reached again several hours after therapy ended. We conclude that during immunoadsorption substantial hemodynamic changes occur in patients positive for beta 1-AAB... - Effects of immunoglobulin G from patients with dilated cardiomyopathy on rat cardiomyocytesTorsten Christ
Department of Pharmacology and Toxicology, Medical Faculty, Dresden University of Technology, D 01309 Dresden, Germany
Basic Clin Pharmacol Toxicol 96:445-52. 2005..We conclude that both beta(1)-adrenoceptors and immunoglobulin G derived from patients positive for beta(1)-adrenoceptor autoantibodies mediate the cardiostimulatory effects via beta(1)-adrenoceptors... - Therapeutically relevant concentrations of neomycin selectively inhibit P-type Ca2+ channels in rat striatumDobromir Dobrev
Department of Pharmacology and Toxicology, Carl Gustav Carus Medical School, Dresden University of Technology, Fetscher Str 74, D 01307 Dresden, Germany
Eur J Pharmacol 461:105-11. 2003..In conclusion, therapeutically relevant concentrations of neomycin preferentially block P-type Ca(2+) channels which regulate dopamine release in rat striatum. This block could be responsible for aminoglycoside-induced toxicity... - Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillationErich Wettwer
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
Circulation 110:2299-306. 2004.... - Novel anti-arrhythmic agents for the treatment of atrial fibrillationErich Wettwer
Department of Pharmacology and Toxicology, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
Curr Opin Pharmacol 7:214-8. 2007..However, a major improvement in the pharmacotherapy is still awaited. The promising efficacy of several new drugs in animal models of atrial fibrillation has yet to be demonstrated in clinical studies... - Mechanisms of beta-adrenergic receptor-mediated venodilation in humansChristoph Schindler
Institute of Clinical Pharmacology, Medical Faculty, Dresden University of Technology, Germany
Clin Pharmacol Ther 75:49-59. 2004..This study was designed to elucidate the underlying mechanisms of isoproterenol (INN, isoprenaline)-induced venodilation by investigation of dorsal hand vein responses... - Rate-adaptive pacing using intracardiac impedance shows no evidence for positive feedback during dobutamine stress testTorsten Christ
Department of Pharmacology and Toxicology, Medical Faculty, University of Technology, Dresden, Germany
Europace 4:311-5. 2002..We have addressed this problem in patients with chronotropic incompetence who were subjected to a pharmacological stress test... - What is a good tutorial from the student's point of view? Evaluation of tutorials in a newly established PBL block course "Basics of Drug Therapy"Ursula Ravens
Institut fur Pharmakologie und Toxikologie, Technische Universitat Dresden, Fetscher Strasse 74, 01307 Dresden, Germany
Naunyn Schmiedebergs Arch Pharmacol 366:69-76. 2002..As a consequence we will increase our efforts to optimise case quality as well as support and training of tutors in order to improve our new PBL course... - An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca2+-current by direct interaction with the Cav1.2 subunitTorsten Christ
Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscherstrasse 74, 01309 Dresden, Germany
Naunyn Schmiedebergs Arch Pharmacol 370:474-83. 2004..These findings suggest that the effect of C47 is restricted to the Ca(2+) channel... - Recording atrial monophasic action potentials using standard pacemaker leads: an alternative way to study electrophysiology properties of the human atrium in vivo?Torsten Christ
Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany
Pacing Clin Electrophysiol 27:1632-7. 2004..The method should allow screening patients for electrophysiological alterations even before the onset of AF... - Quantification of G protein Gaalphas subunit splice variants in different human tissues and cells using pyrosequencingUlrich H Frey
Department of Pharmacology, University Hospital Essen, D 45122 Essen, Germany
Gene Expr 12:69-81. 2005..Furthermore, stimulation of cells seemed to affect splice variant ratios. These results are, therefore, suggestive of different biological functions of these variants... - Vascular large conductance calcium-activated potassium channels: functional role and therapeutic potentialBirgit Eichhorn
Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat, TU Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
Naunyn Schmiedebergs Arch Pharmacol 376:145-55. 2007..Further studies are necessary to identify the detailed molecular mechanisms of action and to investigate selective BK Ca channels openers as possible therapeutic agents for clinical use... - Cellular signaling underlying atrial tachycardia remodeling of L-type calcium currentXiao Yan Qi
Montreal Heart Institute and Department of Medicine, Université de Montéal, Quebec, Canada
Circ Res 103:845-54. 2008..These studies elucidate for the first time the molecular feedback mechanisms underlying arrhythmogenic AT remodeling... - Problem-based learning: a new pathway to competence?Ursula Ravens
Trends Pharmacol Sci 23:162-3. 2002 - Four and a half LIM protein 1: a novel chaperone for atrium-specific Kv1.5 channels with a potential role in atrial arrhythmogenesisDobromir Dobrev
Cardiovasc Res 78:411-2. 2008 - Transcription factors for ion channels: active or passive players in cardiac remodeling?Dobromir Dobrev
Cardiovasc Res 60:226-7. 2003 - Muscarinic subtype-2 receptor autoantibodies: actors or bystanders in human atrial fibrillation?Dobromir Dobrev
Eur Heart J 25:1091-2. 2004 - Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillationNathalie Gaborit
Institut du Thorax, INSERM U533, , Nantes, France
Circulation 112:471-81. 2005..Finally, for 13 selected genes, SR restoration reversed ion-channel remodeling. CONCLUSIONS: VHD extensively remodels cardiac ion-channel and transporter expression, and AF alters ion-channel expression in VHD patients... - Defective cardiac ryanodine receptor regulation during atrial fibrillationJohn A Vest
Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Circulation 111:2025-32. 2005..6) causes SR Ca2+ leak in failing hearts and can trigger fatal ventricular arrhythmias. Little is known about the role of RyR2 dysfunction in AF, however... - Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillationAli El-Armouche
Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Center Hamburg-Eppendorf, Germany
Circulation 114:670-80. 2006..Restoration of sarcoplasmic reticulum-associated PP1 function may represent a new therapeutic option for treatment of atrial fibrillation... - Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillationMaura Greiser
Institut fur Physiologie, Universitatsklinikum Aachen, Aachen, Germany
Naunyn Schmiedebergs Arch Pharmacol 375:383-92. 2007..Indirect evidence for an impaired src kinase regulation of I (Ca,L) together with an increased phosphatase activity suggests that a complex alteration in the kinase/phosphatase balance leads to I (Ca,L) dysregulation in chronic AF... - Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillationSubeena Sood
Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA
Heart Rhythm 5:1047-54. 2008..Studies in patients with AF revealed that impaired diastolic closure of sarcoplasmic reticulum (SR) Ca(2+)-release channels (ryanodine receptors, RyR2) is associated with reduced levels of the RyR2-inhibitory subunit FKBP12.6... - Digital lock-in techniques for adaptive power-line interference extractionDobromir Dobrev
Centre of Biomedical Engineering Ivan Daskalov, Bulgarian Academy of Sciences, Sofia, Bulgaria
Physiol Meas 29:803-16. 2008..The same approach can be used for removal of the fundamental frequency of the PL interference as well as its higher harmonics. It is suitable for real-time operation with popular low-cost microcontrollers... - 5-hydroxytryptamine and atrial arrhythmogenesis: a "culprit mechanism" or bystander in patients with chronic atrial fibrillation?Dobromir Dobrev
J Mol Cell Cardiol 42:51-3. 2007 - Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failureAli El-Armouche
Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, D 20246, Germany
J Mol Cell Cardiol 43:223-9. 2007..Thus, the compromised contractile function of the failing heart might be in part attributable to reduced cMyBP-C phosphorylation levels... - Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytesAli El-Armouche
Institute of Experimental and Clinical Pharmacology, Medical Center Hamburg Eppendorf, Hamburg, Germany
Biochem Biophys Res Commun 346:700-6. 2006..The results indicate that calcineurin and PP2A act to maintain a low basal level of phosphorylated (active) I-1 in living cardiac myocytes. Calcineurin may constitute a cross-talk between calcium- and cAMP-dependent pathways... - Do genetics help to better understand the underlying mechanisms of atrial fibrillation?Dobromir Dobrev
Eur Heart J 27:1640-1. 2006 - Cardiac sympathetic innervation and control of potassium channel functionUrsula Ravens
J Mol Cell Cardiol 35:137-9. 2003 - Comparing the global mRNA expression profile of human atrial and ventricular myocardium with high-density oligonucleotide arraysPeter Ellinghaus
Institute of Cardiovascular Research, Bayer AG, Wuppertal, Germany
J Thorac Cardiovasc Surg 129:1383-90. 2005..Our data provide the basis of a comprehensive understanding of chamber-specific gene expression in diseased human hearts and will support the identification of therapeutic targets in the treatment of arrhythmia and heart failure...