Denis Corbeil

Summary

Affiliation: Technical University
Country: Germany

Publications

  1. doi request reprint Expression of distinct splice variants of the stem cell marker prominin-1 (CD133) in glial cells
    Denis Corbeil
    Tissue Engineering Laboratories, BIOTEC and DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden CRTD, Technische Universitat Dresden, Tatzberg 47 49, Dresden, Germany
    Glia 57:860-74. 2009
  2. doi request reprint Prominin-1: a distinct cholesterol-binding membrane protein and the organisation of the apical plasma membrane of epithelial cells
    Denis Corbeil
    Tissue Engineering Laboratories, BIOTEC, Technische Universitat Dresden, Tatzberg 47 49, 01307, Dresden, Germany
    Subcell Biochem 51:399-423. 2010
  3. pmc Haematopoietic stem cell differentiation promotes the release of prominin-1/CD133-containing membrane vesicles--a role of the endocytic-exocytic pathway
    Nicola Bauer
    Tissue Engineering Laboratories BIOTEC, Technische Universitat Dresden, Dresden, Germany
    EMBO Mol Med 3:398-409. 2011
  4. pmc Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain
    József Jászai
    Tissue Engineering Laboratories BIOTEC, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 8:e63457. 2013
  5. doi request reprint The intriguing links between prominin-1 (CD133), cholesterol-based membrane microdomains, remodeling of apical plasma membrane protrusions, extracellular membrane particles, and (neuro)epithelial cell differentiation
    Denis Corbeil
    Tissue Engineering Laboratories, BIOTEC, Technische Universitat Dresden, Dresden, Germany
    FEBS Lett 584:1659-64. 2010
  6. doi request reprint Prominin-2 is a novel marker of distal tubules and collecting ducts of the human and murine kidney
    József Jászai
    Tissue Engineering Laboratories BIOTEC, DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden, Technische Universitat Dresden, Tatzberg 47 49, 01307, Dresden, Germany
    Histochem Cell Biol 133:527-39. 2010
  7. ncbi request reprint Prominin-1 allows prospective isolation of neural stem cells from the adult murine hippocampus
    Tara L Walker
    CRTD Center for Regenerative Therapies Dresden, Technische Universitat Dresden, 01307 Dresden, Germany
    J Neurosci 33:3010-24. 2013
  8. ncbi request reprint New insights into the cell biology of hematopoietic progenitors by studying prominin-1 (CD133)
    Nicola Bauer
    Tissue Engineering Laboratories, BIOTEC, Technische Universitat Dresden, Dresden, Germany
    Cells Tissues Organs 188:127-38. 2008
  9. ncbi request reprint Differential expression of Prominin-1 (CD133) and Prominin-2 in major cephalic exocrine glands of adult mice
    József Jászai
    Tissue Engineering Laboratories, BIOTEC, University of Technology Dresden, Tatzberg 47 49, 01307, Dresden, Germany
    Histochem Cell Biol 128:409-19. 2007
  10. doi request reprint Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol
    Anne Marie Marzesco
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    FEBS Lett 583:897-902. 2009

Collaborators

Detail Information

Publications36

  1. doi request reprint Expression of distinct splice variants of the stem cell marker prominin-1 (CD133) in glial cells
    Denis Corbeil
    Tissue Engineering Laboratories, BIOTEC and DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden CRTD, Technische Universitat Dresden, Tatzberg 47 49, Dresden, Germany
    Glia 57:860-74. 2009
    ..Given that prominin-1 is thought to act as an organizer of plasma membrane protrusions, they further suggest that a specific prominin-1 splice variant might play a role in morphogenesis and/or maintenance of the myelin sheath...
  2. doi request reprint Prominin-1: a distinct cholesterol-binding membrane protein and the organisation of the apical plasma membrane of epithelial cells
    Denis Corbeil
    Tissue Engineering Laboratories, BIOTEC, Technische Universitat Dresden, Tatzberg 47 49, 01307, Dresden, Germany
    Subcell Biochem 51:399-423. 2010
    ....
  3. pmc Haematopoietic stem cell differentiation promotes the release of prominin-1/CD133-containing membrane vesicles--a role of the endocytic-exocytic pathway
    Nicola Bauer
    Tissue Engineering Laboratories BIOTEC, Technische Universitat Dresden, Dresden, Germany
    EMBO Mol Med 3:398-409. 2011
    ..Collectively, these data support the concept that prominin-1-containing lipid rafts may host key determinants necessary to maintain stem cell properties and their quantitative reduction or loss may result in cellular differentiation...
  4. pmc Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain
    József Jászai
    Tissue Engineering Laboratories BIOTEC, Medical Faculty Carl Gustav Carus, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 8:e63457. 2013
    ....
  5. doi request reprint The intriguing links between prominin-1 (CD133), cholesterol-based membrane microdomains, remodeling of apical plasma membrane protrusions, extracellular membrane particles, and (neuro)epithelial cell differentiation
    Denis Corbeil
    Tissue Engineering Laboratories, BIOTEC, Technische Universitat Dresden, Dresden, Germany
    FEBS Lett 584:1659-64. 2010
    ..Intriguingly, the release of these particles has been implicated in (neuro)epithelial cell differentiation...
  6. doi request reprint Prominin-2 is a novel marker of distal tubules and collecting ducts of the human and murine kidney
    József Jászai
    Tissue Engineering Laboratories BIOTEC, DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden, Technische Universitat Dresden, Tatzberg 47 49, 01307, Dresden, Germany
    Histochem Cell Biol 133:527-39. 2010
    ..Urinary detection of this protein might offer novel diagnostic approaches for studying renal diseases affecting distal segments of the nephron...
  7. ncbi request reprint Prominin-1 allows prospective isolation of neural stem cells from the adult murine hippocampus
    Tara L Walker
    CRTD Center for Regenerative Therapies Dresden, Technische Universitat Dresden, 01307 Dresden, Germany
    J Neurosci 33:3010-24. 2013
    ..Remarkably, an upregulation of Prominin-2 was detected in Prominin-1-deficient mice highlighting a potential compensatory mechanism, which might explain the lack of severe symptoms in individuals carrying mutations in the Prom1 gene...
  8. ncbi request reprint New insights into the cell biology of hematopoietic progenitors by studying prominin-1 (CD133)
    Nicola Bauer
    Tissue Engineering Laboratories, BIOTEC, Technische Universitat Dresden, Dresden, Germany
    Cells Tissues Organs 188:127-38. 2008
    ..The aim of this review is to outline the recent discoveries regarding the dynamic reorganization of the plasma membrane of rare CD133+ hematopoietic progenitor cells during cell migration and division...
  9. ncbi request reprint Differential expression of Prominin-1 (CD133) and Prominin-2 in major cephalic exocrine glands of adult mice
    József Jászai
    Tissue Engineering Laboratories, BIOTEC, University of Technology Dresden, Tatzberg 47 49, 01307, Dresden, Germany
    Histochem Cell Biol 128:409-19. 2007
    ..Finally, we report that Prominin-2, like Prominin-1, is released into the human saliva associated with small membrane particles holding the potential for future diagnostic applications...
  10. doi request reprint Release of extracellular membrane vesicles from microvilli of epithelial cells is enhanced by depleting membrane cholesterol
    Anne Marie Marzesco
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    FEBS Lett 583:897-902. 2009
    ....
  11. pmc CD133 is a modifier of hematopoietic progenitor frequencies but is dispensable for the maintenance of mouse hematopoietic stem cells
    Kathrin Arndt
    Regeneration in Hematopoiesis, Center for Regenerative Therapies Dresden CRTD, Technische Universitat Dresden, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 110:5582-7. 2013
    ....
  12. pmc Hematopoietic stem cells in co-culture with mesenchymal stromal cells--modeling the niche compartments in vitro
    Duohui Jing
    Medical Clinic and Policlinic I University Hospital, Dresden, Germany
    Haematologica 95:542-50. 2010
    ..Here we investigated in detail the spatial relationship between hematopoietic stem cells and mesenchymal stromal cells during ex vivo expansion...
  13. pmc Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network
    Ana Violeta Fonseca
    Tissue Engineering Laboratories, Technische Universitat, Dresden, Germany
    J Biol Chem 285:31661-71. 2010
    ..Collectively, our data provide new insights regarding the role of RhoA/ROCK I and the microtubules in the migration of stem cells...
  14. doi request reprint Prominin-1 (CD133) is not restricted to stem cells located in the basal compartment of murine and human prostate
    Ewa Missol-Kolka
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Prostate 71:254-67. 2011
    ..J Cell Sci 2004; 117:3539–3545). Here we re-investigated its general expression in male reproductive tract including mouse and human prostate and in prostate cancer samples using various anti-prominin-1 antibodies...
  15. doi request reprint Robust expression of Prominin-2 all along the adult male reproductive system and urinary bladder
    József Jászai
    Tissue Engineering Laboratories, BIOTEC and DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden CRTD, Technische Universitat Dresden, Tatzberg 47 49, 01307, Dresden, Germany
    Histochem Cell Biol 130:749-59. 2008
    ..Taken together our data indicate that, except for the gonad, Prominin-2 is widely and abundantly expressed along the epithelia of various segments of the adult male genitourinary tract...
  16. ncbi request reprint Prominin-2 is a cholesterol-binding protein associated with apical and basolateral plasmalemmal protrusions in polarized epithelial cells and released into urine
    Mareike Florek
    Medical Clinic and Polyclinic I, Technische Universitat Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Cell Tissue Res 328:31-47. 2007
    ..e. urine. Together, these data show that all the characteristics of prominin-1 are shared by prominin-2, which is in agreement with a possible redundancy in their role as potential organizers of plasma membrane protrusions...
  17. doi request reprint Differential expression of biofunctional GM1 and GM3 gangliosides within the plastic-adherent multipotent mesenchymal stromal cell population
    Daniel Freund
    Tissue Engineering Laboratories, BIOTEC and DFG Research Center and Cluster of Excellence for Regenerative Therapies Dresden CRTD, Technische Universitat Dresden, Dresden, Germany
    Cytotherapy 12:131-42. 2010
    ....
  18. pmc Outer segment formation of transplanted photoreceptor precursor cells
    Dominic Eberle
    DFG Center for Regenerative Therapies Dresden CRTD, Cluster of Excellence TU Dresden, Dresden, Germany
    PLoS ONE 7:e46305. 2012
    ..Given that patients suffering from retinitis pigmentosa lose almost all photoreceptors, our findings are of utmost importance for the development of cell-based therapies...
  19. pmc The cell surface proteome of human mesenchymal stromal cells
    Christian Niehage
    Biotechnology Center, Dresden University of Technology, Dresden, Germany
    PLoS ONE 6:e20399. 2011
    ..Multipotent human mesenchymal stromal cells (hMSCs) are considered as promising biological tools for regenerative medicine. Their antibody-based isolation relies on the identification of reliable cell surface markers...
  20. pmc Distinct and conserved prominin-1/CD133-positive retinal cell populations identified across species
    József Jászai
    Tissue Engineering Laboratories BIOTEC, Technische Universitat Dresden, Dresden, Germany
    PLoS ONE 6:e17590. 2011
    ....
  21. ncbi request reprint OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling
    Simone A Fietz
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Nat Neurosci 13:690-9. 2010
    ..Our findings suggest that maintenance of this epithelial property allows integrin-mediated, repeated asymmetric divisions of OSVZ progenitors, providing a basis for neocortical expansion...
  22. pmc Human Prominin-1 (CD133) Is Detected in Both Neoplastic and Non-Neoplastic Salivary Gland Diseases and Released into Saliva in a Ubiquitinated Form
    Jana Karbanova
    Tissue Engineering Laboratories, BIOTEC, Technische Universitat Dresden, Dresden, Germany Department of Histology and Embryology, Charles University in Prague Faculty of Medicine and University Hospital Hradec Králové, Prague, Czech Republic
    PLoS ONE 9:e98927. 2014
    ..Collectively, our findings bring new insights into the biochemistry and trafficking of prominin-1 as well as its immunohistochemical profile in certain types of salivary gland tumors and inflammatory diseases. ..
  23. ncbi request reprint Focus on molecules: prominin-1 (CD133)
    József Jászai
    Tissue Engineering Laboratories, BIOTEC, Technische Universitat Dresden, Tatzberg 47 51, D 01307 Dresden, Germany
    Exp Eye Res 85:585-6. 2007
  24. ncbi request reprint The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease
    Hagen B Huttner
    Tissue Engineering Laboratories, Biotechnology Center BIOTEC, Technische Universitat Dresden, Tatzberg 47 51, 01307 Dresden, Germany
    Stem Cells 26:698-705. 2008
    ..Hence, analysis of CSF for membrane particles carrying the somatic stem cell marker prominin-1/CD133 offers a novel approach for studying human central nervous system disease...
  25. doi request reprint Immunohistochemical localization and characterization of putative mesenchymal stem cell markers in the retinal capillary network of rodents
    Dierk Wittig
    Institute of Anatomy, TU Dresden, Dresden, Germany
    Cells Tissues Organs 197:344-59. 2013
    ..e. CD146 expression) with archetypal MSCs, which is even more striking in dissociated retinal cultures (i.e. CD105 expression). These findings might have implications for the treatment of retinal pathologies...
  26. ncbi request reprint Polarization of human hematopoietic progenitors during contact with multipotent mesenchymal stromal cells: effects on proliferation and clonogenicity
    Daniel Freund
    Medical Clinic and Polyclinic I, University Hospital Carl Gustav Carus, D 01307, Dresden, Germany
    Stem Cells Dev 15:815-29. 2006
    ..Together, this co-culture offers a unique experimental system to further characterize the biology and role of markers of rare stem cell populations...
  27. ncbi request reprint Increased integration of transplanted CD73-positive photoreceptor precursors into adult mouse retina
    Dominic Eberle
    DFG Center for Regenerative Therapies Dresden CRTD, Cluster of Excellence, Dresden, Germany
    Invest Ophthalmol Vis Sci 52:6462-71. 2011
    ..Purification via cell surface markers represents a new tool for the separation of transplantable photoreceptor precursors from a heterogeneous cell population, avoiding the need of reporter gene expression in target cells...
  28. doi request reprint Characterization of dental pulp stem cells from impacted third molars cultured in low serum-containing medium
    Jana Karbanova
    Department of Histology and Embryology, Charles University in Prague, Faculty of Medicine, Prague, Czech Republic
    Cells Tissues Organs 193:344-65. 2011
    ..Their easy accessibility makes these cells a suitable source of somatic stem cells for tissue engineering...
  29. pmc The stem cell marker CD133 (Prominin-1) is expressed in various human glandular epithelia
    Jana Karbanova
    Department of Histology and Embryology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic
    J Histochem Cytochem 56:977-93. 2008
    ..This manuscript contains online supplemental material at http://www.jhc.org. Please visit this article online to view these materials...
  30. doi request reprint CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges
    Philipp Grosse-Gehling
    Tumor Pathophysiology, OncoRay, National Center for Radiation Research in Oncology, Dresden University of Technology, Fetscherstrasse 74, Dresden, Germany
    J Pathol 229:355-78. 2013
    ..We highlight the link between the tumour microenvironment, tumour cell plasticity, and CD133 expression, and evaluate the utility of CD133 expression as a prognostic marker...
  31. doi request reprint Prominin-1 (CD133): Molecular and Cellular Features Across Species
    Denis Corbeil
    Tissue Engineering Laboratories BIOTEC, Technische Universitat Dresden, Tatzberg 47 49, 01307, Dresden, Germany
    Adv Exp Med Biol 777:3-24. 2013
    ....
  32. pmc CD133 and membrane microdomains: Old facets for future hypotheses
    Christine A Fargeas
    Christine A Fargeas, Jana Karbanová, József Jászai, Denis Corbeil, Tissue Engineering Laboratories BIOTEC, Technische Universitat Dresden, D 01307 Dresden, Germany
    World J Gastroenterol 17:4149-52. 2011
    ..Its association with particular membrane microdomains is highly relevant in these contexts and might also offer new avenues in diagnosis and/or targeting of cancer stem cells...
  33. ncbi request reprint GM1 and GM3 gangliosides highlight distinct lipid microdomains within the apical domain of epithelial cells
    Peggy Janich
    Tissue Engineering Laboratories, BIOTEC, Tatzberg 47 51, Technische Universitat Dresden, 01307 Dresden, Germany
    FEBS Lett 581:1783-7. 2007
    ....
  34. doi request reprint Tyrosine O-sulfation
    Denis Corbeil
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
    Curr Protoc Protein Sci . 2005
    ....
  35. doi request reprint Prominent role of prominin in the retina
    Nagananda Gurudev
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307, Dresden, Germany
    Adv Exp Med Biol 777:55-71. 2013
    ..Here we summarize recent data from various fields, including Drosophila, which will aid to our understanding of its still elusive function...
  36. doi request reprint Sox9 expression of alginate-encapsulated chondrocytes is stimulated by low cell density
    Peter Bernstein
    Department of Orthopaedic Surgery, University Hospital Carl Gustav Carus Dresden, Medical Faculty of Technical University Dresden, Dresden, Germany
    J Biomed Mater Res A 91:910-8. 2009
    ..However, this article reveals discrepancies between Sox9 and the chondrogenic pathway in redifferentiating chondrocytes that should be addressed in further work...