J P Ley

Summary

Affiliation: Symrise GmbH and Co. KG
Country: Germany

Publications

  1. ncbi Synthesis of lipophilic clovamide derivatives and their antioxidative potential against lipid peroxidation
    Jakob P Ley
    Symrise, Research and Development, P O Box 1253, 37601 Holzminden, Germany
    J Agric Food Chem 51:4596-602. 2003
  2. ncbi Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae)
    Jakob P Ley
    Research and Development, Symrise GmbH and Company, KG, P O Box 1253, 37601 Holzminden, Germany
    J Agric Food Chem 53:6061-6. 2005
  3. ncbi Identification of enterodiol as a masker for caffeine bitterness by using a pharmacophore model based on structural analogues of homoeriodictyol
    Jakob P Ley
    Symrise AG, Flavor and Nutrition, Research and Technology, P O Box 1253, D 37601 Holzminden, Germany
    J Agric Food Chem 60:6303-11. 2012
  4. ncbi Isolation and synthesis of acmellonate, a new unsaturated long chain 2-ketol ester from Spilanthes acmella
    J P Ley
    Symrise GmbH and Co KG, Research and Development, PO Box 1253, 37603 Holzminden, Germany
    Nat Prod Res 20:798-804. 2006
  5. ncbi New bitter-masking compounds: hydroxylated benzoic acid amides of aromatic amines as structural analogues of homoeriodictyol
    Jakob P Ley
    Symrise GmbH and Co KG, Flavor and Nutrititon Research and Innovation, 37601 Holzminden, Germany
    J Agric Food Chem 54:8574-9. 2006
  6. ncbi Structural analogues of homoeriodictyol as flavor modifiers. Part III: short chain gingerdione derivatives
    Jakob P Ley
    Symrise GmbH and Co KG, Flavor and Nutrition Research and Innovation, P O Box 1253, 37601 Holzminden, Germany
    J Agric Food Chem 56:6656-64. 2008
  7. ncbi Hydroxy- or methoxy-substituted benzaldoximes and benzaldehyde-O-alkyloximes as tyrosinase inhibitors
    J P Ley
    Haarmann and Reimer GmbH, Flavor Division, Research and Development Flavors, PO Box 1253, D 37601 Holzminden, Germany
    Bioorg Med Chem 9:1879-85. 2001
  8. ncbi High-impact sulfur compounds: constitutional and configurational assignment of sulfur-containing heterocycles
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, D 01062 Dresden
    Chem Biodivers 5:1204-12. 2008

Collaborators

  • Gerhard E Krammer
  • Christoph Krafft
  • Jörg Grunenberg
  • Stefan Brennecke
  • Berthold Weber
  • Reiner Salzer
  • Michael Backes
  • Frank Ott

Detail Information

Publications8

  1. ncbi Synthesis of lipophilic clovamide derivatives and their antioxidative potential against lipid peroxidation
    Jakob P Ley
    Symrise, Research and Development, P O Box 1253, 37601 Holzminden, Germany
    J Agric Food Chem 51:4596-602. 2003
    ..N-Caffeoyl L-tyrosine methyl ester and the N-cinnamoyl L-DOPA alkyl esters especially were potent antioxidants in bulk lipids and moderate protectants in emulsions...
  2. ncbi Evaluation of bitter masking flavanones from Herba Santa (Eriodictyon californicum (H. and A.) Torr., Hydrophyllaceae)
    Jakob P Ley
    Research and Development, Symrise GmbH and Company, KG, P O Box 1253, 37601 Holzminden, Germany
    J Agric Food Chem 53:6061-6. 2005
    ..Due to these facts, homoeriodictyol sodium salt (1-Na) seems to be a very interesting new taste modifier for food applications and pharmaceuticals...
  3. ncbi Identification of enterodiol as a masker for caffeine bitterness by using a pharmacophore model based on structural analogues of homoeriodictyol
    Jakob P Ley
    Symrise AG, Flavor and Nutrition, Research and Technology, P O Box 1253, D 37601 Holzminden, Germany
    J Agric Food Chem 60:6303-11. 2012
    ..Enterodiol (25 mg L(-1)) reduced the bitterness of the 500 mg L(-1) caffeine solution by about 30%, whereas enterolactone showed no masking but a slight bitter-enhancing effect...
  4. ncbi Isolation and synthesis of acmellonate, a new unsaturated long chain 2-ketol ester from Spilanthes acmella
    J P Ley
    Symrise GmbH and Co KG, Research and Development, PO Box 1253, 37603 Holzminden, Germany
    Nat Prod Res 20:798-804. 2006
    ..Acmellonate shows a weak tingling and numbing effect on the tongue and contributes only to a small extend to the overall flavour of Jambu...
  5. ncbi New bitter-masking compounds: hydroxylated benzoic acid amides of aromatic amines as structural analogues of homoeriodictyol
    Jakob P Ley
    Symrise GmbH and Co KG, Flavor and Nutrititon Research and Innovation, 37601 Holzminden, Germany
    J Agric Food Chem 54:8574-9. 2006
    ..In the future, the new amides may be alternatives for the expensive flavanones to create flavor solutions to mask bitterness of pharmaceuticals or foodstuffs...
  6. ncbi Structural analogues of homoeriodictyol as flavor modifiers. Part III: short chain gingerdione derivatives
    Jakob P Ley
    Symrise GmbH and Co KG, Flavor and Nutrition Research and Innovation, P O Box 1253, 37601 Holzminden, Germany
    J Agric Food Chem 56:6656-64. 2008
    ..The isomer 1-(3-hydroxy-4-methoxyphenyl)hexa-3,5-dione ([2]-isogingerdione) at 100 mg kg (-1) caused a significant and synergistic increase of 27% of sweet taste of a 5% sucrose solution...
  7. ncbi Hydroxy- or methoxy-substituted benzaldoximes and benzaldehyde-O-alkyloximes as tyrosinase inhibitors
    J P Ley
    Haarmann and Reimer GmbH, Flavor Division, Research and Development Flavors, PO Box 1253, D 37601 Holzminden, Germany
    Bioorg Med Chem 9:1879-85. 2001
    ..The IC(50) of 3,4-dihydroxybenzaldehyde-O-ethyloxime (0.3 +/- 0.1 micromol L(-1)) is of the same magnitude as tropolone (0.13 +/- 0.08 micromol L(-1)), one of the best tyrosinase inhibitors known so far...
  8. ncbi High-impact sulfur compounds: constitutional and configurational assignment of sulfur-containing heterocycles
    Christoph Krafft
    Institute for Analytical Chemistry, Dresden University of Technology, D 01062 Dresden
    Chem Biodivers 5:1204-12. 2008
    ..Dialkyl-tetrathianes and dialkyl-pentathiepanes are interesting components to be used in flavor applications due to their unique olfactory impact and facets...