- The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticusSebastian Suerbaum
Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
Proc Natl Acad Sci U S A 100:7901-6. 2003....
- Genome-wide analysis of transcriptional hierarchy and feedback regulation in the flagellar system of Helicobacter pyloriEike Niehus
Institute of Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
Mol Microbiol 52:947-61. 2004..A true master regulator of flagellar biosynthesis is absent in H. pylori, consistent with the essential role of flagellar motility and chemotaxis for this organism...
- Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5Sae Kyung Lee
Institute for Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
Microbes Infect 5:1345-56. 2003..pylori to preserve the essential function of its flagella during chronic colonization of the stomach and to evade the deleterious host immune responses...
- Growth phase-dependent and differential transcriptional control of flagellar genes in Helicobacter pyloriEike Niehus
Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
Microbiology 148:3827-37. 2002..Growth phase in vitro had the strongest influence on transcriptional control of H. pylori flaA and flaB, while differences in supplements to a rich culture medium had only a modest modulatory effect on flagellin gene transcription...
- Downregulation of CXCR1 and CXCR2 expression on human neutrophils by Helicobacter pylori: a new pathomechanism in H. pylori infection?Bernd Schmausser
Institut fur Pathologie, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
Infect Immun 72:6773-9. 2004..pylori infection. Downregulation of CXCR1 and CXCR2 expression on neutrophils in H. pylori infection by H. pylori itself may represent a new mechanism of modulating neutrophil migration and activation in the gastric mucosa...
- Bacterial genomics: seven years onSebastian Suerbaum
Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, D 97080, Wurzburg, Germany
Trends Microbiol 10:351-3. 2002
- Helicobacter pylori infectionSebastian Suerbaum
Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
N Engl J Med 347:1175-86. 2002
- Fatal Clostridium tertium septicemia in a nonneutropenic patientDennis Tappe
Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
J Infect 50:76-80. 2005..As C. tertium is aerotolerant, often gram-variable and mostly resistant to broad-spectrum cephalosporins, differentiation is difficult and empirical therapeutic strategies may fail...
- Genomic changes during chronic Helicobacter pylori infectionChristian Kraft
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
J Bacteriol 188:249-54. 2006..These results suggest that adaptation of H. pylori to the host individual may principally occur through sequence changes rather than loss or gain of genes...
- Gain and loss of multiple genes during the evolution of Helicobacter pyloriHelga Gressmann
Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Berlin, Germany
PLoS Genet 1:e43. 2005..Thus, the use of microarrays can reveal patterns of gene gain or loss when examined within a phylogenetic context that is based on sequences of core genes...
- Pathogenomics of helicobacterChristine Josenhans
Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Street 1, D 30625 Hannover, Germany
Int J Med Microbiol 297:589-600. 2007..pylori infection. This review summarizes the available information, emphasizing work performed in the framework of the PathoGenoMik funding initiative (2001-2006) of the German Ministry of Education and Research...
- Identification of disulfide reductases in Campylobacterales: a bioinformatics investigationNadeem O Kaakoush
School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia
Antonie Van Leeuwenhoek 92:429-41. 2007..The phylogenetic features of the Campylobacterales thioredoxin reductases suggested a special role for these enzymes in the physiology of these bacteria...
- Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitisSamuel R Boutin
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16 825C, Cambridge, MA 02139, USA
Infect Immun 73:8449-52. 2005..Mice infected with HhG and HhNET developed less-severe hepatitis than male A/JCr mice infected with Hh3B1...
- Flagellar and global gene regulation in Helicobacter pylori modulated by changes in DNA supercoilingFang Ye
Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hanover, Germany
Int J Med Microbiol 297:65-81. 2007..These data indicate that global supercoiling changes may help coordinate temporal (growth phase-related) regulation of flagellar biosynthesis and other cellular functions in Helicobacter...
- Hepatic temporal gene expression profiling in Helicobacter hepaticus-infected A/JCr miceSamuel R Boutin
Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Toxicol Pathol 32:678-93. 2004....
- Helicobacter pylori: recombination, population structure and human migrationsSebastian Suerbaum
Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
Int J Med Microbiol 294:133-9. 2004..This review article summarizes recent developments in this rapidly moving field...
- Helicobacter nemestrinae ATCC 49396T is a strain of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989, and Helicobacter nemestrinae Bronsdon et al. 1991 is therefore a junior heterotypic synonym of Helicobacter pyloriSebastian Suerbaum
Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Germany
Int J Syst Evol Microbiol 52:437-9. 2002..nemestrinae ATCC 49396T is really a strain of H. pylori and that H. nemestrinae Bronsdon et al. 1991 is a junior heterotypic synonym of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989...
- The diversity within an expanded and redefined repertoire of phase-variable genes in Helicobacter pyloriLaurence Salaun
The Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Microbiology 150:817-30. 2004..This study extends and provides new evidence for variation of this type in H. pylori, and of the high degree of diversity of the repertoire of genes which display phase-variable switching within individual strains...
- Induction of colitis by a CD4+ T cell clone specific for a bacterial epitopeMarika C Kullberg
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 100:15830-5. 2003....
- Multilocus sequence analysis of Porphyromonas gingivalis indicates frequent recombinationAndreas Koehler
Institut für Hygiene und Mikrobiologie der Bayerischen Julius Maximilians Universität, 97080 Wurzburg, Germany
Microbiology 149:2407-15. 2003..gingivalis. A standardized index of association of 0.0898 indicates that the P. gingivalis genes analysed are close to linkage equilibrium...
- The role of motility as a virulence factor in bacteriaChristine Josenhans
Institute for Hygiene and Microbiology, Wurzburg University, Germany
Int J Med Microbiol 291:605-14. 2002..Possibilities to exploit bacterial motility as a specific therapeutic antibacterial target to cure or prevent disease are discussed...
- Functional characterization of the antagonistic flagellar late regulators FliA and FlgM of Helicobacter pylori and their effects on the H. pylori transcriptomeChristine Josenhans
Institute for Hygiene and Microbiology, University of Wuerzburg, Germany
Mol Microbiol 43:307-22. 2002..Like other motile bacteria, H. pylori has a FliA/FlgM pair of sigma and anti-sigma factors, but the genes controlled by these differ markedly from the Salmonella/Escherichia coli paradigm...
- Functional characterization and mutagenesis of the proposed behavioral sensor TlpD of Helicobacter pyloriTobias Schweinitzer
Institute for Medical Microbiology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
J Bacteriol 190:3244-55. 2008..The proposed energy sensor TlpD was found to mediate a repellent tactic response away from conditions of reduced electron transport...