Sebastian Suerbaum

Summary

Country: Germany

Publications

  1. pmc The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 100:7901-6. 2003
  2. ncbi request reprint Genome-wide analysis of transcriptional hierarchy and feedback regulation in the flagellar system of Helicobacter pylori
    Eike Niehus
    Institute of Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    Mol Microbiol 52:947-61. 2004
  3. ncbi request reprint Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5
    Sae Kyung Lee
    Institute for Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Microbes Infect 5:1345-56. 2003
  4. ncbi request reprint Growth phase-dependent and differential transcriptional control of flagellar genes in Helicobacter pylori
    Eike Niehus
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Microbiology 148:3827-37. 2002
  5. pmc Downregulation of CXCR1 and CXCR2 expression on human neutrophils by Helicobacter pylori: a new pathomechanism in H. pylori infection?
    Bernd Schmausser
    Institut fur Pathologie, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Infect Immun 72:6773-9. 2004
  6. ncbi request reprint Bacterial genomics: seven years on
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, D 97080, Wurzburg, Germany
    Trends Microbiol 10:351-3. 2002
  7. pmc The complex methylome of the human gastric pathogen Helicobacter pylori
    Juliane Krebes
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Strase 1, 30625 Hannover, Germany, German Center for Infection Research, Hannover Braunschweig Site, Carl Neuberg Strase 1, 30625 Hannover, Germany, New England Biolabs, 240 County Road, Ipswich, MA 01938, USA, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany and Pacific Biosciences, 1380 Willow Road, Menlo Park, CA 94025, USA
    Nucleic Acids Res 42:2415-32. 2014
  8. ncbi request reprint Helicobacter pylori infection
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 347:1175-86. 2002
  9. ncbi request reprint Fatal Clostridium tertium septicemia in a nonneutropenic patient
    Dennis Tappe
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    J Infect 50:76-80. 2005
  10. pmc Genomic changes during chronic Helicobacter pylori infection
    Christian Kraft
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Bacteriol 188:249-54. 2006

Collaborators

Detail Information

Publications24

  1. pmc The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Proc Natl Acad Sci U S A 100:7901-6. 2003
    ....
  2. ncbi request reprint Genome-wide analysis of transcriptional hierarchy and feedback regulation in the flagellar system of Helicobacter pylori
    Eike Niehus
    Institute of Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Strasse 2, D 97080 Wuerzburg, Germany
    Mol Microbiol 52:947-61. 2004
    ..A true master regulator of flagellar biosynthesis is absent in H. pylori, consistent with the essential role of flagellar motility and chemotaxis for this organism...
  3. ncbi request reprint Helicobacter pylori flagellins have very low intrinsic activity to stimulate human gastric epithelial cells via TLR5
    Sae Kyung Lee
    Institute for Hygiene and Microbiology, University of Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    Microbes Infect 5:1345-56. 2003
    ..pylori to preserve the essential function of its flagella during chronic colonization of the stomach and to evade the deleterious host immune responses...
  4. ncbi request reprint Growth phase-dependent and differential transcriptional control of flagellar genes in Helicobacter pylori
    Eike Niehus
    Institute for Hygiene and Microbiology, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    Microbiology 148:3827-37. 2002
    ..Growth phase in vitro had the strongest influence on transcriptional control of H. pylori flaA and flaB, while differences in supplements to a rich culture medium had only a modest modulatory effect on flagellin gene transcription...
  5. pmc Downregulation of CXCR1 and CXCR2 expression on human neutrophils by Helicobacter pylori: a new pathomechanism in H. pylori infection?
    Bernd Schmausser
    Institut fur Pathologie, Universitat Wurzburg, Josef Schneider Strasse 2, 97080 Wurzburg, Germany
    Infect Immun 72:6773-9. 2004
    ..pylori infection. Downregulation of CXCR1 and CXCR2 expression on neutrophils in H. pylori infection by H. pylori itself may represent a new mechanism of modulating neutrophil migration and activation in the gastric mucosa...
  6. ncbi request reprint Bacterial genomics: seven years on
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, D 97080, Wurzburg, Germany
    Trends Microbiol 10:351-3. 2002
  7. pmc The complex methylome of the human gastric pathogen Helicobacter pylori
    Juliane Krebes
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Strase 1, 30625 Hannover, Germany, German Center for Infection Research, Hannover Braunschweig Site, Carl Neuberg Strase 1, 30625 Hannover, Germany, New England Biolabs, 240 County Road, Ipswich, MA 01938, USA, Leibniz Institute DSMZ German Collection of Microorganisms and Cell Cultures, Inhoffenstraße 7B, 38124 Braunschweig, Germany and Pacific Biosciences, 1380 Willow Road, Menlo Park, CA 94025, USA
    Nucleic Acids Res 42:2415-32. 2014
    ..pylori strains will provide a valuable resource for future studies investigating the role of H. pylori R-M systems in limiting transformation as well as in gene regulation and host interaction. ..
  8. ncbi request reprint Helicobacter pylori infection
    Sebastian Suerbaum
    Institute of Hygiene and Microbiology, University of Wurzburg, Wurzburg, Germany
    N Engl J Med 347:1175-86. 2002
  9. ncbi request reprint Fatal Clostridium tertium septicemia in a nonneutropenic patient
    Dennis Tappe
    Institute of Hygiene and Microbiology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    J Infect 50:76-80. 2005
    ..As C. tertium is aerotolerant, often gram-variable and mostly resistant to broad-spectrum cephalosporins, differentiation is difficult and empirical therapeutic strategies may fail...
  10. pmc Genomic changes during chronic Helicobacter pylori infection
    Christian Kraft
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Bacteriol 188:249-54. 2006
    ..These results suggest that adaptation of H. pylori to the host individual may principally occur through sequence changes rather than loss or gain of genes...
  11. pmc Gain and loss of multiple genes during the evolution of Helicobacter pylori
    Helga Gressmann
    Department of Molecular Biology, Max Planck Institut für Infektionsbiologie, Berlin, Germany
    PLoS Genet 1:e43. 2005
    ..Thus, the use of microarrays can reveal patterns of gene gain or loss when examined within a phylogenetic context that is based on sequences of core genes...
  12. ncbi request reprint Pathogenomics of helicobacter
    Christine Josenhans
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Street 1, D 30625 Hannover, Germany
    Int J Med Microbiol 297:589-600. 2007
    ..pylori infection. This review summarizes the available information, emphasizing work performed in the framework of the PathoGenoMik funding initiative (2001-2006) of the German Ministry of Education and Research...
  13. ncbi request reprint Flagellar and global gene regulation in Helicobacter pylori modulated by changes in DNA supercoiling
    Fang Ye
    Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Carl Neuberg Strasse 1, D 30625 Hanover, Germany
    Int J Med Microbiol 297:65-81. 2007
    ..These data indicate that global supercoiling changes may help coordinate temporal (growth phase-related) regulation of flagellar biosynthesis and other cellular functions in Helicobacter...
  14. ncbi request reprint Identification of disulfide reductases in Campylobacterales: a bioinformatics investigation
    Nadeem O Kaakoush
    School of Medical Sciences, The University of New South Wales, Sydney, NSW 2052, Australia
    Antonie Van Leeuwenhoek 92:429-41. 2007
    ..The phylogenetic features of the Campylobacterales thioredoxin reductases suggested a special role for these enzymes in the physiology of these bacteria...
  15. pmc Different Helicobacter hepaticus strains with variable genomic content induce various degrees of hepatitis
    Samuel R Boutin
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 16 825C, Cambridge, MA 02139, USA
    Infect Immun 73:8449-52. 2005
    ..Mice infected with HhG and HhNET developed less-severe hepatitis than male A/JCr mice infected with Hh3B1...
  16. pmc Functional characterization and mutagenesis of the proposed behavioral sensor TlpD of Helicobacter pylori
    Tobias Schweinitzer
    Institute for Medical Microbiology, Hannover Medical School, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    J Bacteriol 190:3244-55. 2008
    ..The proposed energy sensor TlpD was found to mediate a repellent tactic response away from conditions of reduced electron transport...
  17. ncbi request reprint Hepatic temporal gene expression profiling in Helicobacter hepaticus-infected A/JCr mice
    Samuel R Boutin
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Toxicol Pathol 32:678-93. 2004
    ....
  18. ncbi request reprint Helicobacter pylori: recombination, population structure and human migrations
    Sebastian Suerbaum
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Hochschule Hannover, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Int J Med Microbiol 294:133-9. 2004
    ..This review article summarizes recent developments in this rapidly moving field...
  19. ncbi request reprint The diversity within an expanded and redefined repertoire of phase-variable genes in Helicobacter pylori
    Laurence Salaun
    The Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Microbiology 150:817-30. 2004
    ..This study extends and provides new evidence for variation of this type in H. pylori, and of the high degree of diversity of the repertoire of genes which display phase-variable switching within individual strains...
  20. pmc Induction of colitis by a CD4+ T cell clone specific for a bacterial epitope
    Marika C Kullberg
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:15830-5. 2003
    ....
  21. ncbi request reprint Multilocus sequence analysis of Porphyromonas gingivalis indicates frequent recombination
    Andreas Koehler
    Institut für Hygiene und Mikrobiologie der Bayerischen Julius Maximilians Universität, 97080 Wurzburg, Germany
    Microbiology 149:2407-15. 2003
    ..gingivalis. A standardized index of association of 0.0898 indicates that the P. gingivalis genes analysed are close to linkage equilibrium...
  22. ncbi request reprint The role of motility as a virulence factor in bacteria
    Christine Josenhans
    Institute for Hygiene and Microbiology, Wurzburg University, Germany
    Int J Med Microbiol 291:605-14. 2002
    ..Possibilities to exploit bacterial motility as a specific therapeutic antibacterial target to cure or prevent disease are discussed...
  23. ncbi request reprint Functional characterization of the antagonistic flagellar late regulators FliA and FlgM of Helicobacter pylori and their effects on the H. pylori transcriptome
    Christine Josenhans
    Institute for Hygiene and Microbiology, University of Wuerzburg, Germany
    Mol Microbiol 43:307-22. 2002
    ..Like other motile bacteria, H. pylori has a FliA/FlgM pair of sigma and anti-sigma factors, but the genes controlled by these differ markedly from the Salmonella/Escherichia coli paradigm...
  24. ncbi request reprint Helicobacter nemestrinae ATCC 49396T is a strain of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989, and Helicobacter nemestrinae Bronsdon et al. 1991 is therefore a junior heterotypic synonym of Helicobacter pylori
    Sebastian Suerbaum
    Institut fur Hygiene und Mikrobiologie der Universitat Wurzburg, Germany
    Int J Syst Evol Microbiol 52:437-9. 2002
    ..nemestrinae ATCC 49396T is really a strain of H. pylori and that H. nemestrinae Bronsdon et al. 1991 is a junior heterotypic synonym of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989...