Research Topics

Species

M Stumvoll

Summary

Country: Germany

Publications

  1. Stumvoll M, Haring H. The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism. Diabetes. 2002;51:2341-7 pubmed
    ..The precise understanding of its mechanism may lead to novel diagnostic, preventive, and therapeutic approaches for improving the management of type 2 diabetes. ..
  2. Stumvoll M, Fritsche A, Volk A, Stefan N, Madaus A, Maerker E, et al. The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans. Diabetes. 2001;50:882-5 pubmed
    ..It is possible that this polymorphism causes insulin resistance at the level of the beta-cell and contributes to the polygenic etiology of type 2 diabetes. ..
  3. Stumvoll M, Fritsche A, Madaus A, Stefan N, Weisser M, Machicao F, et al. Functional significance of the UCSNP-43 polymorphism in the CAPN10 gene for proinsulin processing and insulin secretion in nondiabetic Germans. Diabetes. 2001;50:2161-3 pubmed
    ..This may be entirely different with specific haplotype combinations. ..
  4. Stumvoll M, Wahl H, Machicao F, Haring H. Insulin sensitivity of glucose disposal and lipolysis: no influence of common genetic variants in IRS-1 and CAPN10. Diabetologia. 2002;45:651-6 pubmed
    ..Neither of the two putatively insulin resistance-related polymorphisms that were tested contributed measurably to the biological variation of insulin sensitivity of lipolysis. ..