Research Topics

Species

M Stumvoll

Summary

Country: Germany

Publications

  1. Stumvoll M, Fritsche A, Volk A, Stefan N, Madaus A, Maerker E, et al. The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans. Diabetes. 2001;50:882-5 pubmed
    ..It is possible that this polymorphism causes insulin resistance at the level of the beta-cell and contributes to the polygenic etiology of type 2 diabetes. ..
  2. Stumvoll M, Fritsche A, Madaus A, Stefan N, Weisser M, Machicao F, et al. Functional significance of the UCSNP-43 polymorphism in the CAPN10 gene for proinsulin processing and insulin secretion in nondiabetic Germans. Diabetes. 2001;50:2161-3 pubmed
    ..This may be entirely different with specific haplotype combinations. ..
  3. Stumvoll M, Wahl H, Machicao F, Haring H. Insulin sensitivity of glucose disposal and lipolysis: no influence of common genetic variants in IRS-1 and CAPN10. Diabetologia. 2002;45:651-6 pubmed
    ..Neither of the two putatively insulin resistance-related polymorphisms that were tested contributed measurably to the biological variation of insulin sensitivity of lipolysis. ..

Detail Information

Publications3

  1. Stumvoll M, Fritsche A, Volk A, Stefan N, Madaus A, Maerker E, et al. The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans. Diabetes. 2001;50:882-5 pubmed
    ..It is possible that this polymorphism causes insulin resistance at the level of the beta-cell and contributes to the polygenic etiology of type 2 diabetes. ..
  2. Stumvoll M, Fritsche A, Madaus A, Stefan N, Weisser M, Machicao F, et al. Functional significance of the UCSNP-43 polymorphism in the CAPN10 gene for proinsulin processing and insulin secretion in nondiabetic Germans. Diabetes. 2001;50:2161-3 pubmed
    ..This may be entirely different with specific haplotype combinations. ..
  3. Stumvoll M, Wahl H, Machicao F, Haring H. Insulin sensitivity of glucose disposal and lipolysis: no influence of common genetic variants in IRS-1 and CAPN10. Diabetologia. 2002;45:651-6 pubmed
    ..Neither of the two putatively insulin resistance-related polymorphisms that were tested contributed measurably to the biological variation of insulin sensitivity of lipolysis. ..