M Stumvoll

Summary

Country: Germany

Publications

  1. ncbi Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humans
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
    J Clin Endocrinol Metab 85:3740-5. 2000
  2. ncbi Clinical features of insulin resistance and beta cell dysfunction and the relationship to type 2 diabetes
    M Stumvoll
    Medical Clinic, Department of Endocrinology, Metabolism and Pathobiochemistry, , , Germany
    Clin Lab Med 21:31-51. 2001
  3. ncbi No influence of the PPARgamma2 Pro12Ala genotype on serum adiponectin concentrations in healthy Europeans
    Claus Thamer
    Metabolism 52:798; author reply 798-9. 2003
  4. ncbi For debate: Starling's curve of the pancreas--overuse of a concept?
    M Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Horm Metab Res 35:391-5. 2003
  5. ncbi Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight
    Norbert Stefan
    The Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Metabolism 53:904-11. 2004
  6. ncbi Interaction effect between common polymorphisms in PPARgamma2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity
    Michael Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Mol Med (Berl) 80:33-8. 2002
  7. ncbi Functional significance of the UCSNP-43 polymorphism in the CAPN10 gene for proinsulin processing and insulin secretion in nondiabetic Germans
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 50:2161-3. 2001
  8. ncbi Glucose allostasis
    Michael Stumvoll
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 52:903-9. 2003
  9. ncbi Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, D 72076 Tubingen, Germany
    J Lipid Res 42:1782-8. 2001
  10. ncbi Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes
    Michael Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 51:37-41. 2002

Detail Information

Publications95

  1. ncbi Suppression of systemic, intramuscular, and subcutaneous adipose tissue lipolysis by insulin in humans
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
    J Clin Endocrinol Metab 85:3740-5. 2000
    ..Inadequate suppression of im lipolysis resulting in excessive local availability of free fatty acids may represent a novel mechanism contributing to the pathogenesis of impaired glucose disposal, i.e. insulin resistance, in muscle...
  2. ncbi Clinical features of insulin resistance and beta cell dysfunction and the relationship to type 2 diabetes
    M Stumvoll
    Medical Clinic, Department of Endocrinology, Metabolism and Pathobiochemistry, , , Germany
    Clin Lab Med 21:31-51. 2001
    ..Recently, indices calculated parameters of the OGTT have been proposed as surrogates for assessing both insulin sensitivity and beta cell function in clinical situations and epidemiologic studies...
  3. ncbi No influence of the PPARgamma2 Pro12Ala genotype on serum adiponectin concentrations in healthy Europeans
    Claus Thamer
    Metabolism 52:798; author reply 798-9. 2003
  4. ncbi For debate: Starling's curve of the pancreas--overuse of a concept?
    M Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Horm Metab Res 35:391-5. 2003
    ....
  5. ncbi Endogenous glucose production, insulin sensitivity, and insulin secretion in normal glucose-tolerant Pima Indians with low birth weight
    Norbert Stefan
    The Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Metabolism 53:904-11. 2004
    ..We conclude that interaction of multiple defects may contribute to increased susceptibility to type 2 diabetes among individuals with LBW...
  6. ncbi Interaction effect between common polymorphisms in PPARgamma2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity
    Michael Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Mol Med (Berl) 80:33-8. 2002
    ..Allowing for gene-gene interaction effects may reveal novel information regarding metabolic effects of genetic variants...
  7. ncbi Functional significance of the UCSNP-43 polymorphism in the CAPN10 gene for proinsulin processing and insulin secretion in nondiabetic Germans
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 50:2161-3. 2001
    ..This may be entirely different with specific haplotype combinations...
  8. ncbi Glucose allostasis
    Michael Stumvoll
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 52:903-9. 2003
    ..With increasing severity and over time, the allostatic load (increase in glycemia) may have pathological consequences, such as the development of type 2 diabetes...
  9. ncbi Two novel prevalent polymorphisms in the hormone-sensitive lipase gene have no effect on insulin sensitivity of lipolysis and glucose disposal
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, D 72076 Tubingen, Germany
    J Lipid Res 42:1782-8. 2001
    ..Neither of the polymorphisms we identified in the coding region, however, contributed measurably to the biological variation of insulin sensitivity in our lean, healthy population...
  10. ncbi Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes
    Michael Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 51:37-41. 2002
    ..In contrast, in individuals who are already burdened by other genetic factors, this small effect may be very hard to detect...
  11. ncbi Clinical characterization of insulin secretion as the basis for genetic analyses
    Michael Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 51:S122-9. 2002
    ..In conclusion, we believe that careful clinical characterization of beta-cell function (and dysfunction) is one way of identifying and understanding the genetic factors leading to the insulin secretory failure of type 2 diabetes...
  12. ncbi Thiazolidinediones -- some recent developments
    Michael Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Expert Opin Investig Drugs 12:1179-87. 2003
    ..g., inflammatory bowel disease). Long-term data will be necessary for a final risk-benefit assessment of these substances...
  13. ncbi Glitazones: clinical effects and molecular mechanisms
    Michael Stumvoll
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Ann Med 34:217-24. 2002
    ..Long-term data are indispensable for a final risk-benefit assessment of these substances...
  14. ncbi The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism
    Michael Stumvoll
    University Hospital, Department of Endocrinology, Metabolism and Pathobiochemistry, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 51:2341-7. 2002
    ..The precise understanding of its mechanism may lead to novel diagnostic, preventive, and therapeutic approaches for improving the management of type 2 diabetes...
  15. ncbi Insulin sensitivity of glucose disposal and lipolysis: no influence of common genetic variants in IRS-1 and CAPN10
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Diabetologia 45:651-6. 2002
    ....
  16. ncbi The role of glucose allostasis in type 2 diabetes
    Michael Stumvoll
    , , 72076 Tuebingen, Germany
    Rev Endocr Metab Disord 5:99-103. 2004
  17. ncbi The Gly972Arg polymorphism in the insulin receptor substrate-1 gene contributes to the variation in insulin secretion in normal glucose-tolerant humans
    M Stumvoll
    Medical Clinic, Department of Endocrinology, Metabolism, and Pathobiochemistry, University of Tubingen, Germany
    Diabetes 50:882-5. 2001
    ..It is possible that this polymorphism causes insulin resistance at the level of the beta-cell and contributes to the polygenic etiology of type 2 diabetes...
  18. ncbi Genetic determinants of insulin action in polycystic ovary syndrome
    M Haap
    Department of Endocrinology, Metabolism and Clinical Chemistry, University of Tubingen, Germany
    Exp Clin Endocrinol Diabetes 113:275-81. 2005
    ..There is an association of T2 D with several polymorphisms in candidate genes related to insulin resistance. However, there is limited information about the association of these polymorphisms with PCOS...
  19. ncbi Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat
    N Stefan
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Germany
    Diabetologia 48:2282-91. 2005
    ..The aim of this study was to investigate whether genetic variants of the genes encoding ADIPOR1 and ADIPOR2 play a role in human metabolism...
  20. ncbi Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator--activated receptor-gamma2 gene
    N Stefan
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 50:1143-8. 2001
    ..8). In conclusion, these results provide evidence that the Pro12Ala polymorphism in the PPAR-gamma2 gene might be involved in a differential regulation of insulin secretion in response to increased FFAs in humans...
  21. ncbi Serum adiponectin levels predict the effect of short-term dietary interventions on insulin sensitivity in humans
    C Thamer
    Department of Endocrinology and Metabolism, Eberhard-Karls-University, , Germany
    Diabetologia 47:1303-5. 2004
    ..Thus it is possible that the restriction of dietary fat and a diet high in carbohydrates might be particularly effective in subjects with low adiponectin such as obese or Type 2 diabetic individuals...
  22. ncbi The PPARgamma2 polymorphism pro12Ala is associated with better insulin sensitivity in the offspring of type 2 diabetic patients
    S Jacob
    Dept of Endocrinology, University of Tubingen, Germany
    Horm Metab Res 32:413-6. 2000
    ..9) compared to the control group (6.1 +/- 0.7, p = 0.097). In conclusion, these data suggest that the PPARgamma2-Pro12Ala mutation is associated with better insulin sensitivity of glucose disposal and possibly, also of antilipolysis...
  23. ncbi Association of the -514C-->T polymorphism in the hepatic lipase gene (LIPC) promoter with elevated fasting insulin concentrations, but not insulin resistance, in non-diabetic Germans
    F Machicao
    Department of Endocrinology, Metabolism, and Pathobiochemistry, Medical Clinic Tübingen, Eberhard Karls University, Tubingen, Germany
    Horm Metab Res 36:303-6. 2004
    ..Since no corresponding difference in insulin sensitivity was seen in the clamp-subgroup, an effect of this polymorphism on insulin clearance has to be considered...
  24. ncbi [Polymorphism of pro12Ala in peroxisome proliferator activated receptor gamma 2 (PPAgamma2): beta cell function and insulin sensitivity]
    A Fritsche
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Dtsch Med Wochenschr 126:580-4. 2001
    ..Therefore, the aim of the present study was to assess the mechanism by which the Ala allele of this polymorphism contributes to the reduced risk for type 2 diabetes...
  25. ncbi Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity
    M Stumvoll
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 50:876-81. 2001
    ....
  26. ncbi Induction of adiponectin gene expression in human myotubes by an adiponectin-containing HEK293 cell culture supernatant
    H Staiger
    Department of Endocrinology, Metabolism, and Pathobiochemistry, Medical Clinic Tübingen, Eberhard Karls University, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    Diabetologia 46:956-60. 2003
    ..In this study, we asked whether adiponectin is able to regulate ten selected genes possibly associated with insulin sensitivity in human skeletal muscle cells...
  27. ncbi The Gly482Ser variant in the peroxisome proliferator-activated receptor gamma coactivator-1 is not associated with diabetes-related traits in non-diabetic German and Dutch populations
    M Stumvoll
    Department of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Germany
    Exp Clin Endocrinol Diabetes 112:253-7. 2004
    ..We conclude, that the Gly482Ser variant in PGC-1 is not associated with diabetes-related traits or skeletal muscle fiber type composition in a non-diabetic German and Dutch population...
  28. ncbi A novel use of the hyperinsulinemic-euglycemic clamp technique to estimate insulin sensitivity of systemic lipolysis
    M Stumvoll
    Department of Endocrinology and Metabolism, , , Germany
    Horm Metab Res 33:89-95. 2001
    ..In healthy subjects, the parameter best suited to estimate the insulin EC50 (by linear correlation) was the percentage decrease of glycerol Ra at 60 min...
  29. ncbi Relationship between serum adiponectin concentration and intramyocellular lipid stores in humans
    C Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Horm Metab Res 34:646-9. 2002
    ..These results are consistent with animal data, where adiponectin could be shown to enhance lipid oxidation and reduce muscle triglycerides...
  30. ncbi Age and gender related effects on adipose tissue compartments of subjects with increased risk for type 2 diabetes: a whole body MRI/MRS study
    J Machann
    Section on Experimental Radiology, Department of Diagnostic Radiology, Eberhard Karls University of Tubingen, Hoppe Seyler Str 3, 72076, Tubingen, Germany
    MAGMA 18:128-37. 2005
    ....
  31. ncbi The prevalent Gly1057Asp polymorphism in the insulin receptor substrate-2 gene is not associated with impaired insulin secretion
    A Fritsche
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Otfried Muller Strasse 10, D 72076 Tubingen, Germany
    J Clin Endocrinol Metab 86:4822-5. 2001
    ..The normal maximal insulin secretory response makes it unlikely that this common polymorphism results in abnormal beta-cell development...
  32. ncbi Effect of the pattern of elevated free fatty acids on insulin sensitivity and insulin secretion in healthy humans
    N Stefan
    Medizinische Klinik, , Stoffwechsel und Pathobiochemie, , , Germany
    Horm Metab Res 33:432-8. 2001
    ..The FFA pattern low in polyunsaturated FFAs reduced insulin sensitivity more than the pattern high in polyunsaturated FFAs. In contrast, no effect on insulin secretion was observed...
  33. ncbi Acute stimulation of leptin concentrations in humans during hyperglycemic hyperinsulinemia. Influence of free fatty acids and fasting
    N Stefan
    Medizinische Klinik, , Stoffwechsel und Pathobiochemie, , , Germany
    Int J Obes Relat Metab Disord 25:138-42. 2001
    ..Overall, our findings are compatible with the hypothesis that leptin secretion may be coupled to triglyceride synthesis rather than to the absolute lipid content of the adipocyte. International Journal of Obesity (2001) 25, 138-142..
  34. ncbi Evidence against a rate-limiting role of proinsulin processing for maximal insulin secretion in subjects with impaired glucose tolerance and beta-cell dysfunction
    M Stumvoll
    Medizinische Klinik, , Stoffwechsel und Pathobiochemie, , 72076 Tubingen, Germany
    J Clin Endocrinol Metab 86:1235-9. 2001
    ..This strongly argues against the hypothesis that defective processing of proinsulin to insulin represents a major component of the beta-cell dysfunction in IGT...
  35. ncbi Elevated serum GGT concentrations predict reduced insulin sensitivity and increased intrahepatic lipids
    C Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls University, Tubingen, Germany
    Horm Metab Res 37:246-51. 2005
    ..In the absence of overt liver disease, elevated serum GGT concentrations may point the clinician to incipient disturbances in the glucose metabolism...
  36. ncbi Evidence for greater oxidative substrate flexibility in male carriers of the Pro 12 Ala polymorphism in PPARgamma2
    C Thamer
    Department of Endocrinology and Metabolism, Eberhard Karls Universitat, Tubingen, Germany
    Horm Metab Res 34:132-6. 2002
    ..It is unclear why this could be demonstrated only in males, although gender differences in substrate oxidation are well documented...
  37. ncbi Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans
    O P Bachmann
    Department of Endocrinology and Metabolism, Eberhard-Karls University, , Germany
    Diabetes 50:2579-84. 2001
    ..Similar effects could be induced by a high-fat diet, thereby underlining the physiological relevance of these observations...
  38. ncbi Adiponectin is functionally active in human islets but does not affect insulin secretory function or beta-cell lipoapoptosis
    K Staiger
    Department of Internal Medicine, University of Tubingen, Otfried Muller Strasse 10, 72076 Tubingen, Germany
    J Clin Endocrinol Metab 90:6707-13. 2005
    ..Whether adiponectin affects insulin secretion and beta-cell apoptosis and whether plasma adiponectin is associated with beta-cell function in humans is under investigation...
  39. ncbi Adiponectin receptor gene expression in human skeletal muscle cells is not regulated by fibrates and thiazolidinediones
    S Kaltenbach
    Department of Endocrinology, Metabolism and Pathobiochemistry, , , Germany
    Int J Obes (Lond) 29:760-5. 2005
    ..PPARalpha activation was assessed by measuring PDHK4 mRNA expression. CONCLUSION: Induction of AdipoR gene expression in human skeletal muscle cells is not involved in the insulin-sensitizing effects of thiazolidinediones or fibrates...
  40. ncbi Reversal of hypoglycemia unawareness in a long-term type 1 diabetic patient by improvement of beta-adrenergic sensitivity after prevention of hypoglycemia
    A Fritsche
    Department IV Internal Medicine, Endocrinology, and Pathobiochemistry, University of Tubingen, Germany
    J Clin Endocrinol Metab 85:523-5. 2000
    ..25 microg, reflecting improved beta-adrenergic sensitivity. In conclusion, the reduced beta-adrenergic sensitivity in this patient was probably the reason for hypoglycemia unawareness and was reversed by strict avoidance of hypoglycemia...
  41. ncbi Exaggerated insulin secretion in Pima Indians and African-Americans but higher insulin resistance in Pima Indians compared to African-Americans and Caucasians
    N Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA
    Diabet Med 21:1090-5. 2004
    ....
  42. ncbi Adiponectin--its role in metabolism and beyond
    N Stefan
    Clinical Nutrition and Metabolism Section, NIDDK, NIH, Phoenix, Arizona 85016, USA
    Horm Metab Res 34:469-74. 2002
    ..This suggests that adiponectin may reflect PPAR-gamma activity in vivo. Finally, reversal or alleviation of hypoadiponectinemia may represent a target for development of drugs improving insulin sensitivity and glucose tolerance...
  43. ncbi Skeletal muscle cells from insulin-resistant (non-diabetic) individuals are susceptible to insulin desensitization by palmitate
    C Kausch
    Department of Endocrinology, Metabolism and Pathobiochemistry, Eberhard-Karls-University, , Germany
    Horm Metab Res 35:570-6. 2003
    ....
  44. ncbi A 60 minute hyperglycemic clamp is sufficient to assess both phases of insulin secretion
    M Stumvoll
    Medizinische Klinik, , Stoffwechsel und Pathobiochemie, , , Germany
    Horm Metab Res 32:230-2. 2000
    ..In conclusion, a one-hour hyperglycemic clamp can provide the standard measurement of first phase insulin secretion plus a good approximation of second phase insulin secretion...
  45. ncbi Human serum adiponectin levels are not under short-term negative control by free fatty acids in vivo
    H Staiger
    Department of Endocrinology, Metabolism, and Pathobiochemistry, Medical Clinic, Eberhard-Karls-University, , Germany
    Horm Metab Res 34:601-3. 2002
  46. ncbi Insulin resistance and insulin sensitizers
    M Stumvoll
    Medizinische Klinik, , Stoffwechsel und Pathobiochemie, , , Germany
    Horm Res 55:3-13. 2001
    ..They act through regulation of PPARgamma-dependent genes and probably interfere favourably with factors released from adipocytes which mediate obesity-associated insulin resistance...
  47. ncbi [White blood cell count as a predictor of glucose tolerance and insulin sensitivity. The role of inflammation in the pathogenesis of type 2 diabetes mellitus]
    A Fritsche
    Medizinische Universitatsklinik, Abteilung Innere Medizin IV, Eberhard Karls Universitat Tubingen
    Dtsch Med Wochenschr 129:244-8. 2004
    ..In the present study we examined whether an association exists between a non-specific inflammatory marker such as white blood count (WBC) and factors relevant to the pathogenesis of type 2 diabetes...
  48. ncbi The role of beta-adrenergic sensitivity in the pathogenesis of hypoglycaemia unawareness
    A Fritsche
    Medizinische Klinik, , Stoffwechsel und Pathobiochemie, , , Germany
    Diabetes Nutr Metab 15:357-61; discussion 361-2. 2002
  49. ncbi Fatty acids and insulin resistance in muscle and liver
    Peter Kovacs
    3rd Medical Department, University of Leipzig, Philipp-Rosenthal-Str. 27, 04103, Germany
    Best Pract Res Clin Endocrinol Metab 19:625-35. 2005
    ..Finally, the role of thiazolidinediones as modulators of FFA-induced insulin resistance will be discussed...
  50. ncbi Troglitazone downregulates delta-6 desaturase gene expression in human skeletal muscle cell cultures
    Hans Günther Wahl
    Department of Endocrinology and Metabolism, University of Tubingen, Tubingen, Germany
    Diabetes 51:1060-5. 2002
    ..These results add new aspects to the known thiazolidinedione effects on lipid metabolism...
  51. ncbi Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity
    Matthias Bluher
    University of Leipzig, Medical Department III, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes 55:3053-60. 2006
    ..Thus, the endocannabinoid system may represent a primary target for the treatment of abdominal obesity and associated metabolic changes...
  52. ncbi Metabolic characterization of a woman homozygous for the Ser113Leu missense mutation in carnitine palmitoyl transferase II
    Michael Haap
    Department of Endocrinology, Metabolism and Pathobiochemistry Eberhard Karls Universität Tübingen, Tubingen D 72076, Germany
    J Clin Endocrinol Metab 87:2139-43. 2002
    ..Reduced basal lipolysis may represent a compensatory mechanism for the reduced oxidative FFA disposal characteristic for this disease...
  53. ncbi Upstream transcription factor 1 gene polymorphisms are associated with high antilipolytic insulin sensitivity and show gene-gene interactions
    Konstantinos Kantartzis
    Department of Internal Medicine, Division of Endocrinology, Diabetology, Nephrology, Vascular Medicine and Clinical Chemistry, University of Tubingen, Otfried Muller Str 10, 72076, Tubingen, Germany
    J Mol Med (Berl) 85:55-61. 2007
    ..01). In conclusion, subjects carrying the T allele of SNP usf1s1 and the A allele of SNP usf1s2 have a higher antilipolytic insulin sensitivity. Moreover, both SNPs may interact with the -514C > T SNP in LIPC to determine liver fat...
  54. ncbi ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children
    Yvonne Bottcher
    Medical Department III, University of Leipzig, Philipp Rosenthal Strasse 27, D 04103 Leipzig, Germany
    J Clin Endocrinol Metab 91:4948-52. 2006
    ..Hence, variants in this gene may be related to obesity and insulin resistance...
  55. ncbi A functional Tyr1306Cys variant in LARG is associated with increased insulin action in vivo
    Peter Kovacs
    Diabetes Molecular Genetics Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 445 North 5th Street, Phoenix, AZ 85004, USA
    Diabetes 55:1497-503. 2006
    ..05). We propose that the Tyr1306Cys substitution in LARG, through its differential activation of RhoA, increases insulin sensitivity in nondiabetic Pima Indians...
  56. ncbi Vaspin gene expression in human adipose tissue: association with obesity and type 2 diabetes
    Nora Kloting
    University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany
    Biochem Biophys Res Commun 339:430-6. 2006
    ..In conclusion, our data indicate that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism...
  57. ncbi Genetic variation in the visfatin gene (PBEF1) and its relation to glucose metabolism and fat-depot-specific messenger ribonucleic acid expression in humans
    Yvonne Bottcher
    Medical Department III, University of Leipzig, Philipp Rosenthal Strasse 27, D 04103 Leipzig, Germany
    J Clin Endocrinol Metab 91:2725-31. 2006
    ..Visfatin is a peptide suggested to play a role in glucose homeostasis. In the present study, we investigated the role of genetic variation in the visfatin gene in the pathophysiology of obesity/type 2 diabetes mellitus (T2DM)...
  58. ncbi Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance
    Andreas Oberbach
    Junior Research Group N03, IZKF Leipzig, Faculty of Medicine, University of Leipzig, Germany
    Eur J Endocrinol 154:577-85. 2006
    ....
  59. ncbi Long-term exercise training decreases interleukin-6 (IL-6) serum levels in subjects with impaired glucose tolerance: effect of the -174G/C variant in IL-6 gene
    Andreas Oberbach
    Department of Medicine, Faculty of Medicine, University of Leipzig, Philipp Rosenthal Str 27, D 04103 Leipzig, Germany
    Eur J Endocrinol 159:129-36. 2008
    ..However, there are heterogeneous data on whether circulating IL-6 is altered by exercise training. We therefore hypothesize that genetic factors modify the individual changes in IL-6 levels after long-term training...
  60. ncbi Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals
    Anke Tonjes
    University of Leipzig, IIIrd Medical Department, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes Care 29:2489-97. 2006
    ..The purpose of the present study was to reveal a significant association with pre-diabetic phenotypes in nondiabetic individuals based on a systematic meta-analysis of all available published evidence...
  61. ncbi TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children
    Antje Körner
    University Hospital for Children and Adolescents, University of Leipzig, Oststrasse 21 25, 04317 Leipzig, Germany
    J Clin Endocrinol Metab 92:1956-60. 2007
    ....
  62. ncbi Phenotype of a patient with a de novo mutation in the hepatocyte nuclear factor 1beta/maturity-onset diabetes of the young type 5 gene
    Christof Mayer
    University of Leipzig, Department of Internal Medicine III, 04103 Leipzig, Germany
    Metabolism 57:416-20. 2008
    ..Of note, the low birth weight of the patient in contrast to his healthy twin sister provides interesting support for the fetal insulin hypothesis for reduced birth weight...
  63. ncbi R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians
    Yvonne Bottcher
    Medical Department III, University of Leipzig, Philipp Rosenthal Str 27, 04103 Leipzig, Germany
    J Hum Genet 53:365-7. 2008
    ..Our study replicated associations of the R1467H with increased risk of T2D or T2D/IGT, thus, implicating a potential role of ARHGEF11 in the aetiology of T2D and IGT...
  64. ncbi Polygenic contribution to obesity: genome-wide strategies reveal new targets
    Antje Körner
    University Hospital for Children and Adolescents, Research Laboratory, University of Leipzig, Leipzig, Germany
    Front Horm Res 36:12-36. 2008
    ..Considering the function of the encoded proteins, it will now be of interest to investigate the cellular and molecular mechanisms, how these genetic variations affect body weight, energy metabolism and/or obesity-associated morbidity...
  65. ncbi Serum vaspin concentrations in human obesity and type 2 diabetes
    Byung Soo Youn
    University of Leipzig, Department of Medicine, Ph Rosenthal Str 27, 04103 Leipzig, Germany
    Diabetes 57:372-7. 2008
    ..We have recently shown that vaspin mRNA expression in adipose tissue is related to parameters of obesity and glucose metabolism. However, the regulation of vaspin serum concentrations in human obesity and type 2 diabetes is unknown...
  66. ncbi Serum levels of the adipokine vaspin in relation to metabolic and renal parameters
    Jeannette Seeger
    Department of Internal Medicine III, University of Leipzig, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 93:247-51. 2008
    ..Recently, vaspin was identified as an insulin-sensitizing adipokine. However, regulation of this adipocyte-secreted factor in human disease has not been determined...
  67. ncbi Variation of the gene encoding the nuclear bile salt receptor FXR and gallstone susceptibility in mice and humans
    Peter Kovacs
    University of Leipzig, Department of Medicine III, Leipzig, Germany
    J Hepatol 48:116-24. 2008
    ..Here, we investigated further an association of the gene encoding FXR and gallstone susceptibility in mice and humans...
  68. ncbi Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training
    Matthias Bluher
    Department of Internal Medicine III, University of Leipzig, Leipzig, Germany
    Diabetes Care 30:3110-5. 2007
    ..We also studied whether their expression in visceral and subcutaneous fat depots is associated with metabolic parameters and whether their expression is regulated by intensive physical exercise...
  69. ncbi Effects of genetic variation in the human retinol binding protein-4 gene (RBP4) on insulin resistance and fat depot-specific mRNA expression
    Peter Kovacs
    Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
    Diabetes 56:3095-100. 2007
    ..Serum retinol binding protein 4 (RBP4) is a new liver- and adipocyte-derived signal that may contribute to insulin resistance. Therefore, the RBP4 gene represents a plausible candidate gene involved in susceptibility to type 2 diabetes...
  70. ncbi The role of the Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma in diabetes risk
    Anke Tonjes
    Department of Medicine, University of Leipzig, Leipzig, Germany
    Curr Opin Clin Nutr Metab Care 10:410-4. 2007
    ..To provide a timely update of the literature regarding the role of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma gene in type 2 diabetes and related phenotypes...
  71. ncbi CAPN10 mRNA splicing and decay is not affected by a SNP associated with susceptibility to type 2 diabetes
    Eduardo López-Orduña
    Departamento de Genetica y Biologia Molecular, CINVESTAV IPN, Apartado Postal 14 740, Mexico DF 07360, Mexico
    Biochem Biophys Res Commun 358:831-6. 2007
    ..We propose a defective CAPN10 pre-mRNA processing is responsible for the decreased levels of SNP-43 A-allele transcripts in peripheral white cells of healthy and T2D individuals...
  72. ncbi Plasma visfatin concentrations and fat depot-specific mRNA expression in humans
    Janin Berndt
    University of Leipzig, D 04103 Leipzig, Germany
    Diabetes 54:2911-6. 2005
    ..In addition, we did not find differences in visfatin mRNA expression between visceral and subcutaneous adipose tissue in humans...
  73. ncbi Reduced lipolysis as possible cause for greater weight gain in subjects with the Pro12Ala polymorphism in PPARgamma2?
    Michael Stumvoll
    Diabetologia 45:152-3. 2002
  74. ncbi The prevalent Glu23Lys polymorphism in the potassium inward rectifier 6.2 (KIR6.2) gene is associated with impaired glucagon suppression in response to hyperglycemia
    Otto Tschritter
    Department of Endocrinology, Metabolism and Pathobiochemistry, Medizinische Klinik, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 51:2854-60. 2002
    ..Our findings thus confirm its functional relevance for glucose metabolism in humans...
  75. ncbi Multiple symmetric lipomatosis: a paradigm of metabolically innocent obesity?
    Michael Haap
    Department of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Tubingen, Germany
    Diabetes Care 27:794-5. 2004
  76. ncbi Genetic factors and insulin secretion: gene variants in the IGF genes
    Leen M 't Hart
    Deparment of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Diabetes 53:S26-30. 2004
    ..Further studies are needed to examine the exact contributions of the IGF-I CA repeat alleles to variations in ISI and DI...
  77. ncbi Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans
    Andreas Fritsche
    Medizinische Klinik, , Stoffwechsel und Pathobiochemie, , , Germany
    Diabetes 51:S234-9. 2002
    ..The age effect on insulin secretion appears to be attributable at least in part to an impairment of proinsulin conversion to insulin...
  78. ncbi Relationship of serum adiponectin and leptin concentrations with body fat distribution in humans
    Harald Staiger
    Department of Endocrinology, Metabolism, and Pathobiochemistry, Medical Clinic, Eberhard Karls University, Tubingen, Germany
    Obes Res 11:368-72. 2003
    ..We investigated whether serum concentrations of adiponectin are determined by body fat distribution and compared the findings with leptin...
  79. ncbi Reduced skeletal muscle oxygen uptake and reduced beta-cell function: two early abnormalities in normal glucose-tolerant offspring of patients with type 2 diabetes
    Claus Thamer
    Department of Endocrinology and Metabolism, Eberhard-Karls-University, , Germany
    Diabetes Care 26:2126-32. 2003
    ..Because habitual physical activity was not different, genetic factors may be involved. Conceivably, reduced VO(2max) precedes skeletal muscle insulin resistance, providing a partial explanation for discrepancies in the literature...
  80. ncbi Assessing the shape of the glucose curve during an oral glucose tolerance test
    Otto Tschritter
    Medizinische Klinik, , Stoffwechsel und Pathobiochemie, , , Germany
    Diabetes Care 26:1026-33. 2003
    ..In addition, genetic factors seem to play a role. The shape index may be a useful metabolic screening parameter in epidemiological and genetic association studies...
  81. ncbi Intramyocellular lipids: anthropometric determinants and relationships with maximal aerobic capacity and insulin sensitivity
    Claus Thamer
    Department of Endocrinology and Metabolism, Eberhard-Karls-University, , Germany
    J Clin Endocrinol Metab 88:1785-91. 2003
    ..Thus, measurements of aerobic fitness and body fat are indispensable for the interpretation of IMCL and its relationship with insulin sensitivity...
  82. ncbi Increased insulin clearance in peroxisome proliferator-activated receptor gamma2 Pro12Ala
    Otto Tschritter
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat Tubingen, Tubingen, Germany
    Metabolism 52:778-83. 2003
    ..Because PPARgamma(2) is mainly expressed in adipose tissue, one of the main regulatory effects of the polymorphism may well be the more efficient suppression of (possibly intra-abdominal) lipolysis...
  83. ncbi Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 4212 N 16th Street, Room 5 41, Phoenix, AZ 85016, USA
    Diabetes 52:1544-50. 2003
    ....
  84. ncbi C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity
    Norbert Stefan
    Department of Internal Medicine, Division of Endocrinology, Metabolism and Pathobiochemistry, University of Tubingen, Germany
    Obes Res 12:679-83. 2004
    ..We investigated whether this polymorphism contributed to the variability in obesity in our population from southern Germany and whether it was associated with insulin sensitivity of lipolysis and/or glucose disposal...
  85. ncbi Relationship between moderate alcohol consumption and adiponectin and insulin sensitivity in a large heterogeneous population
    Claus Thamer
    Diabetes Care 27:1240. 2004
  86. ncbi Low plasma adiponectin concentrations do not predict weight gain in humans
    Barbora Vozarova
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes 51:2964-7. 2002
    ..Therefore, the predictive effect of low plasma adiponectin concentrations on the development of type 2 diabetes seems to be mediated by factors other than increased adiposity...
  87. ncbi Plasma adiponectin and endogenous glucose production in humans
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, Department of Health and Human Services, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona, USA
    Diabetes Care 26:3315-9. 2003
    ..Whereas associations of plasma adiponectin with muscle insulin sensitivity in humans have been examined, this has not been done for the liver...
  88. ncbi Standardized assessment of whole body adipose tissue topography by MRI
    Jürgen Machann
    Section on Experimental Radiology, University of Tubingen, Tubingen, Germany
    J Magn Reson Imaging 21:455-62. 2005
    ....
  89. ncbi Adiponectin, obesity, and cardiovascular disease
    Mathias Fasshauer
    Department of Internal Medicine III, University of Leipzig, Rosenthal-Street 27, 04103 Leipzig, Germany
    Biochimie 86:779-84. 2004
    ..The current knowledge on regulation and function of adiponectin in obesity, insulin resistance, and cardiovascular disease is summarized in this review and its clinical implications are discussed...
  90. ncbi Intrahepatic lipids are predicted by visceral adipose tissue mass in healthy subjects
    Claus Thamer
    Department of Endocrinology and Metabolism, Eberhard-Karls-University, , Germany
    Diabetes Care 27:2726-9. 2004
  91. ncbi Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism
    Otto Tschritter
    Medizinische Klinik, Abteilung für Endokrinologie, Stoffwechsel und Pathobiochemie, Eberhard Karls Universitat, Tubingen, Germany
    Diabetes 52:239-43. 2003
    ..This suggests pleiotropic insulin sensitizing effects of adiponectin in humans...
  92. ncbi Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism
    Harald Staiger
    Department of Internal Medicine IV, Medical Clinic Tübingen, Otfried Muller Str 10, D 72076 Tubingen, Germany
    Diabetes 53:2195-201. 2004
    ..AdipoR1, but not AdipoR2, expression correlated with insulin secretion. The molecular nature of this link between muscle and beta-cells needs to be further clarified...
  93. ncbi Altered homeostatic adaptation of first- and second-phase beta-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess beta-cell function
    Riccardo C Bonadonna
    Division of Endocrinology and Metabolic Diseases, University of Verona and Azienda Ospedaliera di Verona, Italy
    Diabetes 52:470-80. 2003
    ..Under conditions leading to decreased insulin sensitivity, these disturbed relationships may lead to progression to diabetes in OfT2D...
  94. ncbi Elevated plasma nonesterified fatty acids are associated with deterioration of acute insulin response in IGT but not NGT
    Norbert Stefan
    Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA
    Am J Physiol Endocrinol Metab 284:E1156-61. 2003
    ..However, in subjects who have progressed to a state of IGT, chronically elevated NEFA seem to have a deleterious effect on insulin-secretory capacity...
  95. ncbi Genetic variation in the human winged helix/forkhead transcription factor gene FOXC2 in Pima Indians
    Peter Kovacs
    Department of Health and Human Services, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, 4212 N 16th Street, Phoenix, AZ 85016, USA
    Diabetes 52:1292-5. 2003
    ....