Research Topics
Species | Frank M StrutzSummaryCountry: Germany Publications
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Detail Information
Publications
Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritisCarsten P Bramlage
Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
Arthritis Res Ther 8:R58. 2006..In comparison with previous reports, these data underline the complex impact of these factors on homeostasis and remodeling in joint physiology and pathology...
Interstitial pathomechanisms underlying progressive tubulointerstitial damageF Strutz
Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
Kidney Blood Press Res 22:71-80. 1999..Finally, a brief overview is listed on new therapeutic approaches to limit the progressive nature of fibrogenesis...
EMT and proteinuria as progression factorsFrank M Strutz
Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
Kidney Int 75:475-81. 2009..However, the association between proteinuria and EMT and vice versa is far from clear and has not been carefully studied...- Renal fibroblasts and myofibroblasts in chronic kidney diseaseFrank Strutz
Department of Nephrology and Rheumatology, Georg-August-University Medical Center, Goettingen, Germany
J Am Soc Nephrol 17:2992-8. 2006 - Renal fibrosis and the origin of the renal fibroblastFrank Strutz
Department of Nephrology and Rheumatology, Georg-August-University Medical Center, Robert-Koch-Str. 40, 37099 Goettingen
Nephrol Dial Transplant 21:3368-70. 2006 - Effect of three months' treatment with irbesartan on blood and pulse pressure of hypertensive type 2 diabetic patients: open, observational study in 31,793 patientsF Strutz
Department of Nephrology and Rheumatology, Georg August University of Gottingen, Gottingen, Germany
Curr Med Res Opin 21:1433-40. 2005.... - ["Peculiar infection" with fever, splenomegaly and acute kidney failure in a 24-year-old forestry student]F Strutz
Abteilung Nephrologie und Rheumatologie, Georg August Universitat Gottingen
Internist (Berl) 44:1575-8. 2003..Renal involvement is frequent, but usually has a good prognosis, especially if jaundice has not developed. Treatment with doxycycline or penicillin can shorten the disease course and exudation, possibly also the nephritis, or hinder it... - Pathogenesis of tubulointerstitial fibrosis in chronic allograft dysfunctionFrank Strutz
Department of Nephrology, Deutsche Klinik fur Diagnostik, Wiesbaden, Germany
Clin Transplant 23:26-32. 2009..Protocols using CNI-free immunosuppression are interesting options to prevent fibrosis in chronic allograft dysfunction... - Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformationFrank Strutz
Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
Kidney Int 61:1714-28. 2002.... - Cortical fibroblast culture from human biopsiesF Strutz
Department of Nephrology and Rheumatology, Georg August University, Gottingen, Germany
J Nephrol 14:190-7. 2001..Human cortical fibroblasts are believed to be key effector cells in fibrogenesis. Thus, a reliable culture of these cells is necessary for studies of their pathophysiology... - Relationship of antibodies to endotoxin core to mortality in medical patients with sepsis syndromeF Strutz
Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
Intensive Care Med 25:435-44. 1999..The findings were correlated with clinical outcome, endotoxin levels and sepsis score... - Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferationF Strutz
Department of Nephrology and Rheumatology, Georg August University Gottingen, Germany
Kidney Int 57:1521-38. 2000.... - TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)F Strutz
Department of Nephrology and Rheumatology, Georg August University Gottingen, Gottingen, Germany
Kidney Int 59:579-92. 2001..The present study examined the interaction between TGF-beta 1 and FGF-2 in human renal fibroblasts... - Potential methods to prevent interstitial fibrosis in renal diseaseF Strutz
Department of Nephrology and Rheumatology, Georg August University, Robert Koch Str 40, 37075 Gottingen, Germany
Expert Opin Investig Drugs 10:1989-2001. 2001..However, some very promising reagents may enhance our clinical arsenal within a relatively short period of time... - DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transitionDebra F Higgins
Department of Medicine and Therapeutics, University College Dublin, Dublin, Ireland
Kidney Int 64:2079-91. 2003..Here we have used DNA microarray technology to monitor the transcriptomic responses to murine unilateral ureteral obstruction (UUO) with a view to identifying molecular modulators of tubulointerstitial fibrosis... - The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathwayMalte H J Heeg
Department of Nephrology and Rheumatology, Georg-August-University, , Germany
Kidney Int 68:96-109. 2005..Furthermore, it induces ECM degradation by induction of MMP-2 and MMP-9. These effects are mediated, at least in part, by inhibition of TGF-beta1 signaling... - Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsiesMaria P Rastaldi
Renal Research Association, Renal Immunopathology Centre, San Carlo Borromeo Hospital, Via Pio II, 3, 20153 Milan, Italy
Kidney Int 62:137-46. 2002..According to this theory, they should proceed through several activating steps, such as proliferation and phenotype changes, to eventually synthesize extracellular matrix (ECM)... - Oncostatin M-induced effects on EMT in human proximal tubular cells: differential role of ERK signalingVerena Pollack
Division of Nephrology, Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
Am J Physiol Renal Physiol 293:F1714-26. 2007..Furthermore, functional ERK1/2 signaling is necessary for basal claudin-2 expression... - CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndromeVolker Vielhauer
Nephrologisches Zentrum, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munich, Germany
Kidney Int 66:2264-78. 2004..We therefore studied the effect of the small-molecule CCR1 antagonist BX471 in a murine model of adriamycin-induced focal segmental glomerulosclerosis (FSGS) with nephrotic syndrome and progressive interstitial inflammation and fibrosis... - Transforming growth factor-beta1 stimulates collagen matrix remodeling through increased adhesive and contractive potential by human renal fibroblastsShuji Kondo
Department of Pediatrics, School of Medicine, University of Tokushima, Kuramoto-cho-3-chome, Tokushima 770-8503, Japan
Biochim Biophys Acta 1693:91-100. 2004.... - Impact of chronic LDL-apheresis treatment on Achilles tendon affection in patients with severe familial hypercholesterolemia: a clinical and ultrasonographic 3-year follow-up studyAlexander K Scheel
Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
Atherosclerosis 174:133-9. 2004..LDL-apheresis (LA) represents the most effective lipid lowering regimen. Aim of this investigation was to determine clinical and ultrasonographic reduction of AT xanthomas in patients with severe FH undergoing regular LA... 
A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligationHans Joachim Anders
Nephrological Center, Medizinische Poliklinik, Innenstadt, Universitat Munchen, Munchen, Germany
J Clin Invest 109:251-9. 2002..We therefore conclude that CCR1 blockade may represent a new therapeutic strategy for reducing cellular infiltration and renal fibrosis as major factors in the progression to end-stage renal failure...- [Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus]Beate Berner
Abteilung Nephrologie und Rheumatologie, Zentrum Innere Medizin, Georg August Universitat Gottingen
Med Klin (Munich) 97:99-103. 2002..For prevention the renal function should be monitored closely and metaformin therapy should be stopped, if a deterioration of renal function is observed... - Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse modelsMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
Am J Physiol Renal Physiol 285:F1060-7. 2003..Collectively, these studies provide further evidence for rhBMP-7 as an important bone-associated protein with protective function against renal pathology... - BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injuryMichael Zeisberg
Center for Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
Nat Med 9:964-8. 2003..Collectively, these results provide evidence of cross talk between BMP-7 and TGF-beta1 in the regulation of EMT in health and disease... - Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur independent of TGF-beta1Suzanne Lam
Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
Kidney Int 63:878-88. 2003..The present study examined the effect of high ambient glucose and transforming growth factor-beta1 (TGF-beta1) on matrix production by human renal fibroblasts... - Chronic course of a hemolytic uremic syndrome caused by a deficiency of factor H-related proteins (CFHR1 and CFHR3)Michael J Koziolek
Department of Nephrology and Rheumatology, Georg-August-University Goettingen, Goettingen, Germany
Kidney Int 74:384-8. 2008 - Direct contact between human peripheral blood mononuclear cells and renal fibroblasts facilitates the expression of monocyte chemoattractant protein-1Lirong Hao
Department of Nephrology, Saitama Medical School, Irumagun, Saitama, Japan
Am J Nephrol 23:208-13. 2003..ICAM-1 on renal fibroblasts may be involved in the direct cell-to-cell interaction inducing MCP-1 gene expression, which seems to be involved in renal interstitial inflammation... - Characterization of diabetic nephropathy by urinary proteomic analysis: identification of a processed ubiquitin form as a differentially excreted protein in diabetic nephropathy patientsHassan Dihazi
Department of Nephrology and Rheumatology, Georg August University Medical Center, Goettingen, Germany
Clin Chem 53:1636-45. 2007..We established a proteomics approach for identification of diabetic nephropathy-related biomarkers in urine... - New insights into mechanisms of fibrosis in immune renal injuryFrank Strutz
Department of Nephrology and Rheumatology, , Robert-Koch-Str. 40, , Germany
Springer Semin Immunopathol 24:459-76. 2003..Eventually, the collagenous matrix of fibrogenesis destroys blood supply and the perimeter of viability for fibroblasts regresses to the point where scars become acellular... - Tubular cell apoptosis and cidofovir-induced acute renal failureAlberto Ortiz
Unidad de Dialisis, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
Antivir Ther 10:185-90. 2005..The prophylactic administration of factors with survival activity for tubular epithelium should be further explored in cidofovir renal injury...