Frank M Strutz

Summary

Country: Germany

Publications

  1. ncbi request reprint Interstitial pathomechanisms underlying progressive tubulointerstitial damage
    F Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Kidney Blood Press Res 22:71-80. 1999
  2. pmc Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis
    Carsten P Bramlage
    Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Arthritis Res Ther 8:R58. 2006
  3. doi request reprint EMT and proteinuria as progression factors
    Frank M Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Kidney Int 75:475-81. 2009
  4. ncbi request reprint Renal fibroblasts and myofibroblasts in chronic kidney disease
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Goettingen, Germany
    J Am Soc Nephrol 17:2992-8. 2006
  5. ncbi request reprint Renal fibrosis and the origin of the renal fibroblast
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Robert Koch Str 40, 37099 Goettingen
    Nephrol Dial Transplant 21:3368-70. 2006
  6. ncbi request reprint Effect of three months' treatment with irbesartan on blood and pulse pressure of hypertensive type 2 diabetic patients: open, observational study in 31,793 patients
    F Strutz
    Department of Nephrology and Rheumatology, Georg August University of Gottingen, Gottingen, Germany
    Curr Med Res Opin 21:1433-40. 2005
  7. ncbi request reprint ["Peculiar infection" with fever, splenomegaly and acute kidney failure in a 24-year-old forestry student]
    F Strutz
    Abteilung Nephrologie und Rheumatologie, Georg August Universitat Gottingen
    Internist (Berl) 44:1575-8. 2003
  8. doi request reprint Pathogenesis of tubulointerstitial fibrosis in chronic allograft dysfunction
    Frank Strutz
    Department of Nephrology, Deutsche Klinik fur Diagnostik, Wiesbaden, Germany
    Clin Transplant 23:26-32. 2009
  9. ncbi request reprint Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Kidney Int 61:1714-28. 2002
  10. ncbi request reprint Cortical fibroblast culture from human biopsies
    F Strutz
    Department of Nephrology and Rheumatology, Georg August University, Gottingen, Germany
    J Nephrol 14:190-7. 2001

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Interstitial pathomechanisms underlying progressive tubulointerstitial damage
    F Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Kidney Blood Press Res 22:71-80. 1999
    ..Finally, a brief overview is listed on new therapeutic approaches to limit the progressive nature of fibrogenesis...
  2. pmc Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis
    Carsten P Bramlage
    Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Arthritis Res Ther 8:R58. 2006
    ..In comparison with previous reports, these data underline the complex impact of these factors on homeostasis and remodeling in joint physiology and pathology...
  3. doi request reprint EMT and proteinuria as progression factors
    Frank M Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Kidney Int 75:475-81. 2009
    ..However, the association between proteinuria and EMT and vice versa is far from clear and has not been carefully studied...
  4. ncbi request reprint Renal fibroblasts and myofibroblasts in chronic kidney disease
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Goettingen, Germany
    J Am Soc Nephrol 17:2992-8. 2006
  5. ncbi request reprint Renal fibrosis and the origin of the renal fibroblast
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Robert Koch Str 40, 37099 Goettingen
    Nephrol Dial Transplant 21:3368-70. 2006
  6. ncbi request reprint Effect of three months' treatment with irbesartan on blood and pulse pressure of hypertensive type 2 diabetic patients: open, observational study in 31,793 patients
    F Strutz
    Department of Nephrology and Rheumatology, Georg August University of Gottingen, Gottingen, Germany
    Curr Med Res Opin 21:1433-40. 2005
    ....
  7. ncbi request reprint ["Peculiar infection" with fever, splenomegaly and acute kidney failure in a 24-year-old forestry student]
    F Strutz
    Abteilung Nephrologie und Rheumatologie, Georg August Universitat Gottingen
    Internist (Berl) 44:1575-8. 2003
    ..Renal involvement is frequent, but usually has a good prognosis, especially if jaundice has not developed. Treatment with doxycycline or penicillin can shorten the disease course and exudation, possibly also the nephritis, or hinder it...
  8. doi request reprint Pathogenesis of tubulointerstitial fibrosis in chronic allograft dysfunction
    Frank Strutz
    Department of Nephrology, Deutsche Klinik fur Diagnostik, Wiesbaden, Germany
    Clin Transplant 23:26-32. 2009
    ..Protocols using CNI-free immunosuppression are interesting options to prevent fibrosis in chronic allograft dysfunction...
  9. ncbi request reprint Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Kidney Int 61:1714-28. 2002
    ....
  10. ncbi request reprint Cortical fibroblast culture from human biopsies
    F Strutz
    Department of Nephrology and Rheumatology, Georg August University, Gottingen, Germany
    J Nephrol 14:190-7. 2001
    ..Human cortical fibroblasts are believed to be key effector cells in fibrogenesis. Thus, a reliable culture of these cells is necessary for studies of their pathophysiology...
  11. ncbi request reprint Relationship of antibodies to endotoxin core to mortality in medical patients with sepsis syndrome
    F Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Intensive Care Med 25:435-44. 1999
    ..The findings were correlated with clinical outcome, endotoxin levels and sepsis score...
  12. ncbi request reprint Basic fibroblast growth factor expression is increased in human renal fibrogenesis and may mediate autocrine fibroblast proliferation
    F Strutz
    Department of Nephrology and Rheumatology, Georg August University Gottingen, Germany
    Kidney Int 57:1521-38. 2000
    ....
  13. ncbi request reprint TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)
    F Strutz
    Department of Nephrology and Rheumatology, Georg August University Gottingen, Gottingen, Germany
    Kidney Int 59:579-92. 2001
    ..The present study examined the interaction between TGF-beta 1 and FGF-2 in human renal fibroblasts...
  14. ncbi request reprint Potential methods to prevent interstitial fibrosis in renal disease
    F Strutz
    Department of Nephrology and Rheumatology, Georg August University, Robert Koch Str 40, 37075 Gottingen, Germany
    Expert Opin Investig Drugs 10:1989-2001. 2001
    ..However, some very promising reagents may enhance our clinical arsenal within a relatively short period of time...
  15. ncbi request reprint DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition
    Debra F Higgins
    Department of Medicine and Therapeutics, University College Dublin, Dublin, Ireland
    Kidney Int 64:2079-91. 2003
    ..Here we have used DNA microarray technology to monitor the transcriptomic responses to murine unilateral ureteral obstruction (UUO) with a view to identifying molecular modulators of tubulointerstitial fibrosis...
  16. ncbi request reprint The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway
    Malte H J Heeg
    Department of Nephrology and Rheumatology, Georg August University, Gottingen, Germany
    Kidney Int 68:96-109. 2005
    ..The aims of this study were to identify potential anti-fibrotic effects of relaxin on human renal fibroblasts in vitro and to analyze their mechanisms...
  17. ncbi request reprint Epithelial-mesenchymal transition of tubular epithelial cells in human renal biopsies
    Maria P Rastaldi
    Renal Research Association, Renal Immunopathology Centre, San Carlo Borromeo Hospital, Via Pio II, 3, 20153 Milan, Italy
    Kidney Int 62:137-46. 2002
    ..According to this theory, they should proceed through several activating steps, such as proliferation and phenotype changes, to eventually synthesize extracellular matrix (ECM)...
  18. ncbi request reprint Oncostatin M-induced effects on EMT in human proximal tubular cells: differential role of ERK signaling
    Verena Pollack
    Division of Nephrology, Department of Internal Medicine, Innsbruck Medical University, Anichstrasse 35, A 6020 Innsbruck, Austria
    Am J Physiol Renal Physiol 293:F1714-26. 2007
    ..Furthermore, functional ERK1/2 signaling is necessary for basal claudin-2 expression...
  19. ncbi request reprint CCR1 blockade reduces interstitial inflammation and fibrosis in mice with glomerulosclerosis and nephrotic syndrome
    Volker Vielhauer
    Nephrologisches Zentrum, Medizinische Poliklinik Innenstadt, Ludwig Maximilians University, Munich, Germany
    Kidney Int 66:2264-78. 2004
    ..We therefore studied the effect of the small-molecule CCR1 antagonist BX471 in a murine model of adriamycin-induced focal segmental glomerulosclerosis (FSGS) with nephrotic syndrome and progressive interstitial inflammation and fibrosis...
  20. ncbi request reprint Transforming growth factor-beta1 stimulates collagen matrix remodeling through increased adhesive and contractive potential by human renal fibroblasts
    Shuji Kondo
    Department of Pediatrics, School of Medicine, University of Tokushima, Kuramoto cho 3 chome, Tokushima 770 8503, Japan
    Biochim Biophys Acta 1693:91-100. 2004
    ....
  21. ncbi request reprint Impact of chronic LDL-apheresis treatment on Achilles tendon affection in patients with severe familial hypercholesterolemia: a clinical and ultrasonographic 3-year follow-up study
    Alexander K Scheel
    Department of Medicine, Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Atherosclerosis 174:133-9. 2004
    ..LDL-apheresis (LA) represents the most effective lipid lowering regimen. Aim of this investigation was to determine clinical and ultrasonographic reduction of AT xanthomas in patients with severe FH undergoing regular LA...
  22. pmc A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation
    Hans Joachim Anders
    Nephrological Center, Medizinische Poliklinik, Innenstadt, Universitat Munchen, Munchen, Germany
    J Clin Invest 109:251-9. 2002
    ..We therefore conclude that CCR1 blockade may represent a new therapeutic strategy for reducing cellular infiltration and renal fibrosis as major factors in the progression to end-stage renal failure...
  23. ncbi request reprint [Metformin-associated lactic acidosis with acute renal failure in type 2 diabetes mellitus]
    Beate Berner
    Abteilung Nephrologie und Rheumatologie, Zentrum Innere Medizin, Georg August Universitat Gottingen
    Med Klin (Munich) 97:99-103. 2002
    ..For prevention the renal function should be monitored closely and metaformin therapy should be stopped, if a deterioration of renal function is observed...
  24. ncbi request reprint Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models
    Michael Zeisberg
    Center for Matrix Biology, Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Renal Physiol 285:F1060-7. 2003
    ..Collectively, these studies provide further evidence for rhBMP-7 as an important bone-associated protein with protective function against renal pathology...
  25. ncbi request reprint BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    Michael Zeisberg
    Center for Matrix Biology, Gastroenterology and Renal Divisions, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 9:964-8. 2003
    ..Collectively, these results provide evidence of cross talk between BMP-7 and TGF-beta1 in the regulation of EMT in health and disease...
  26. ncbi request reprint Glucose-induced fibronectin and collagen type III expression in renal fibroblasts can occur independent of TGF-beta1
    Suzanne Lam
    Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands
    Kidney Int 63:878-88. 2003
    ..The present study examined the effect of high ambient glucose and transforming growth factor-beta1 (TGF-beta1) on matrix production by human renal fibroblasts...
  27. doi request reprint Chronic course of a hemolytic uremic syndrome caused by a deficiency of factor H-related proteins (CFHR1 and CFHR3)
    Michael J Koziolek
    Department of Nephrology and Rheumatology, Georg August University Goettingen, Goettingen, Germany
    Kidney Int 74:384-8. 2008
  28. ncbi request reprint Direct contact between human peripheral blood mononuclear cells and renal fibroblasts facilitates the expression of monocyte chemoattractant protein-1
    Lirong Hao
    Department of Nephrology, Saitama Medical School, Irumagun, Saitama, Japan
    Am J Nephrol 23:208-13. 2003
    ..In this study, we investigated whether the cell-to-cell interaction between immune cells and renal fibroblasts induces MCP-1 gene expression, which may be involved in interstitial inflammation in the kidney...
  29. ncbi request reprint Characterization of diabetic nephropathy by urinary proteomic analysis: identification of a processed ubiquitin form as a differentially excreted protein in diabetic nephropathy patients
    Hassan Dihazi
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Goettingen, Germany
    Clin Chem 53:1636-45. 2007
    ..We established a proteomics approach for identification of diabetic nephropathy-related biomarkers in urine...
  30. ncbi request reprint New insights into mechanisms of fibrosis in immune renal injury
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Gottingen, Robert Koch Str 40, Gottingen, Germany
    Springer Semin Immunopathol 24:459-76. 2003
    ..Eventually, the collagenous matrix of fibrogenesis destroys blood supply and the perimeter of viability for fibroblasts regresses to the point where scars become acellular...
  31. ncbi request reprint Tubular cell apoptosis and cidofovir-induced acute renal failure
    Alberto Ortiz
    Unidad de Dialisis, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Antivir Ther 10:185-90. 2005
    ..The prophylactic administration of factors with survival activity for tubular epithelium should be further explored in cidofovir renal injury...