Guido Stoll

Summary

Country: Germany

Publications

  1. ncbi request reprint Degeneration and regeneration of the peripheral nervous system: from Augustus Waller's observations to neuroinflammation
    Guido Stoll
    Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
    J Peripher Nerv Syst 7:13-27. 2002
  2. doi request reprint Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 222:153-60. 2010
  3. doi request reprint Blocking of platelets or intrinsic coagulation pathway-driven thrombosis does not prevent cerebral infarctions induced by photothrombosis
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Germany
    Stroke 39:1262-8. 2008
  4. pmc Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation
    Furat Raslan
    Department of Neurosurgery, University of Wurzburg, Wurzburg, Germany
    J Cereb Blood Flow Metab 30:1477-86. 2010
  5. ncbi request reprint Downregulation of transforming growth factor-beta2 facilitates inflammation in the central nervous system by reciprocal astrocyte/microglia interactions
    Ines Siglienti
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neuropathol Exp Neurol 66:47-56. 2007
  6. doi request reprint Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation
    Michael K Schuhmann
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Immunol 184:1536-42. 2010
  7. doi request reprint FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection
    Peter Kraft
    From the University Clinic Würzburg, Departments of Neurology P K, E G, M K S, G S, C K and Anesthesiology and Critical Care M B, Rudolf Virchow Center, the Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine C D, I T, B N, Institute of Pharmacology and Toxicology, University of Würzburg K L, Wurzburg, Germany Department of Neurology K G, A M H, S G M, Institute of Physiology and Neuropathophysiology S G M, University of Munster, Germany and University Clinic Frankfurt, Department of Neurology, Frankfurt, Germany W P
    Stroke 44:3202-10. 2013
  8. pmc Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Blood 121:679-91. 2013
  9. doi request reprint Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema
    Madeleine Austinat
    Department of Neurology, Julius Maximilians University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Stroke 40:285-93. 2009
  10. doi request reprint Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking
    Kerstin Göbel
    Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    J Autoimmun 36:106-14. 2011

Collaborators

Detail Information

Publications79

  1. ncbi request reprint Degeneration and regeneration of the peripheral nervous system: from Augustus Waller's observations to neuroinflammation
    Guido Stoll
    Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
    J Peripher Nerv Syst 7:13-27. 2002
    ..Similarities and differences between the PNS and CNS in terms of inflammation and microglial activation after nerve injury are discussed, and point towards progress in understanding the failure of nerve fiber regeneration in the CNS...
  2. doi request reprint Deficiency of the negative immune regulator B7-H1 enhances inflammation and neuropathic pain after chronic constriction injury of mouse sciatic nerve
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 222:153-60. 2010
    ..Interestingly, mechanical hyperalgesia was more pronounced in the absence of B7-H1. Our study identifies B7-H1 as an important suppressor of the inflammatory response and neuropathic pain occurring after peripheral nerve injury...
  3. doi request reprint Blocking of platelets or intrinsic coagulation pathway-driven thrombosis does not prevent cerebral infarctions induced by photothrombosis
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Germany
    Stroke 39:1262-8. 2008
    ..Although the ensuing activation of platelets is well established, their contribution for thrombosis and tissue damage has not formally been proved...
  4. pmc Inhibition of bradykinin receptor B1 protects mice from focal brain injury by reducing blood-brain barrier leakage and inflammation
    Furat Raslan
    Department of Neurosurgery, University of Wurzburg, Wurzburg, Germany
    J Cereb Blood Flow Metab 30:1477-86. 2010
    ..We conclude that B1R inhibition may offer a novel therapeutic strategy after acute brain injuries...
  5. ncbi request reprint Downregulation of transforming growth factor-beta2 facilitates inflammation in the central nervous system by reciprocal astrocyte/microglia interactions
    Ines Siglienti
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Neuropathol Exp Neurol 66:47-56. 2007
    ..Downregulation of astrocytic TGFbeta2 by T cell- and microglia-secreted cytokines appears to be a critical step in providing the grounds for acute and chronic neuroinflammation...
  6. doi request reprint Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation
    Michael K Schuhmann
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Immunol 184:1536-42. 2010
    ....
  7. doi request reprint FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection
    Peter Kraft
    From the University Clinic Würzburg, Departments of Neurology P K, E G, M K S, G S, C K and Anesthesiology and Critical Care M B, Rudolf Virchow Center, the Deutsche Forschungsgemeinschaft Research Center for Experimental Biomedicine C D, I T, B N, Institute of Pharmacology and Toxicology, University of Würzburg K L, Wurzburg, Germany Department of Neurology K G, A M H, S G M, Institute of Physiology and Neuropathophysiology S G M, University of Munster, Germany and University Clinic Frankfurt, Department of Neurology, Frankfurt, Germany W P
    Stroke 44:3202-10. 2013
    ..We investigated the mode of FTY720 action in models of cerebral ischemia...
  8. pmc Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Blood 121:679-91. 2013
    ..6 Tesla. In contrast, established immunoregulatory characteristics of Tregs had no functional relevance. We define herein a novel and unexpected role of Tregs in a primary nonimmunologic disease state...
  9. doi request reprint Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema
    Madeleine Austinat
    Department of Neurology, Julius Maximilians University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Stroke 40:285-93. 2009
    ..The effects of kinins are mediated by 2 different receptors (B1 and B2 receptor [B1R and B2R]) and comprise induction of edema formation and release of proinflammatory mediators...
  10. doi request reprint Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking
    Kerstin Göbel
    Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    J Autoimmun 36:106-14. 2011
    ..In contrast, blocking B2R had no significant impact on EAE. We conclude that B1R inhibition can reduce BBB damage and cell invasion during autoimmune CNS disease and may offer a novel anti-inflammatory strategy for the treatment of MS...
  11. doi request reprint Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation
    Christoph Kleinschnitz
    Department of Neurology, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Blood 115:3835-42. 2010
    ..Our data demonstrate that T cells critically contribute to cerebral ischemia, but their detrimental effect neither depends on antigen recognition nor TCR costimulation or thrombus formation...
  12. doi request reprint Transient widespread blood-brain barrier alterations after cerebral photothrombosis as revealed by gadofluorine M-enhanced magnetic resonance imaging
    Guido Stoll
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    J Cereb Blood Flow Metab 29:331-41. 2009
    ..The unique properties of Gf hold promise as a more sensitive contrast agent for monitoring BBB disturbances in neurologic disorders, which appear more widespread than anticipated previously...
  13. pmc Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation
    Friederike Langhauser
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Blood 120:4082-92. 2012
    ..Because KNG appears to be instrumental in pathologic thrombus formation and inflammation but dispensable for hemostasis, KNG inhibition may offer a selective and safe strategy for combating stroke and other thromboembolic diseases...
  14. ncbi request reprint Osteopontin, a macrophage-derived matricellular glycoprotein, inhibits axon outgrowth
    Patrick Küry
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    FASEB J 19:398-400. 2005
    ..Therefore, OPN expression by lesion-associated macrophages may contribute to the nonpermissive nature of the adult CNS preventing axonal regeneration following injury...
  15. ncbi request reprint Spatial diversity of blood-brain barrier alteration and macrophage invasion in experimental autoimmune encephalomyelitis: a comparative MRI study
    Gesa Ladewig
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Exp Neurol 220:207-11. 2009
    ..This holds true despite the use of a more sensitive MR contrast agent for BBB disruption than Gd-DTPA. Our experimental observations may have implications for disease monitoring in MS patients by MRI which guides treatment decisions...
  16. ncbi request reprint Gadofluorine M-enhanced magnetic resonance nerve imaging: comparison between acute inflammatory and chronic degenerative demyelination in rats
    Carsten Wessig
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, Wurzburg, Germany
    Exp Neurol 210:137-43. 2008
    ..Clinical development of Gf may help to further improve the sensitivity of nerve lesion assessment by MRI in patients with peripheral neuropathies...
  17. pmc The neuroprotective impact of the leak potassium channel TASK1 on stroke development in mice
    Sven G Meuth
    University of Wurzburg, Department of Neurology, Wurzburg, Germany
    Neurobiol Dis 33:1-11. 2009
    ..In conclusion, our data provide evidence for an important role of functional TASK channels in limiting tissue damage during cerebral ischemia...
  18. doi request reprint Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment
    Guido Stoll
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Blood 112:3555-62. 2008
    ..This review discusses recent advances related to antithrombotic strategies in experimental stroke research...
  19. ncbi request reprint STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death
    Alejandro Berna-Erro
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Josef Schneider Strasse 2, D15 97080, Wurzburg, Germany
    Sci Signal 2:ra67. 2009
    ..In vivo, Stim2(-/-) mice were markedly protected from neurological damage in a model of focal cerebral ischemia. These results implicate CCE in ischemic neuronal cell death and establish STIM2 as a critical mediator of this process...
  20. ncbi request reprint Lesion-associated expression of transforming growth factor-beta-2 in the rat nervous system: evidence for down-regulating the phagocytic activity of microglia and macrophages
    Guido Stoll
    Department of Neurology, Julius Maximilians Universitat Wurzburg, Germany
    Brain Pathol 14:51-8. 2004
    ..In conclusion, we have identified TGF-beta2 as a nervous system intrinsic cytokine that could account for the differential regulation of phagocytic activities of microglia and macrophages during injury...
  21. doi request reprint Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report
    David Stegner
    University Hospital Wurzburg, Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Arterioscler Thromb Vasc Biol 33:2212-7. 2013
    ..We sought to assess whether pharmacological inhibition of PLD activity affects hemostasis, thrombosis, and thrombo-inflammatory brain infarction in mice...
  22. doi request reprint Vasculitis-like neuropathy in amyotrophic lateral sclerosis unresponsive to treatment
    Grazia Devigili
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080, Wurzburg, Germany
    Acta Neuropathol 122:343-52. 2011
    ..ALS(vasc) appears as a neuropathological subtype in ALS+ suggesting immune-mediated disease components but without response to standard immunosuppressive treatment...
  23. doi request reprint Deficiency of von Willebrand factor protects mice from ischemic stroke
    Christoph Kleinschnitz
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    Blood 113:3600-3. 2009
    ..This study indicates that VWF is critically involved in cerebral ischemia. Hence, targeted inhibition of the GPIbalpha-VWF pathway might become a promising therapeutic option...
  24. ncbi request reprint In vivo detection of developing vessel occlusion in photothrombotic ischemic brain lesions in the rat by iron particle enhanced MRI
    Christoph Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat Wurzburg, Wurzburg, Germany
    J Cereb Blood Flow Metab 25:1548-55. 2005
    ..This new imaging technique may aid to evaluate antithrombotic treatment strategies in the future...
  25. ncbi request reprint In vivo visualization of focal demyelination in peripheral nerves by gadofluorine M-enhanced magnetic resonance imaging
    Carsten Wessig
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Exp Neurol 204:14-9. 2007
    ....
  26. ncbi request reprint Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation
    Attila Braun
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, Wurzburg, Germany
    Blood 113:2056-63. 2009
    ..These results establish Orai1 as the long-sought platelet SOC channel and a crucial mediator of ischemic cardiovascular and cerebrovascular events...
  27. doi request reprint Combating innate inflammation: a new paradigm for acute treatment of stroke?
    Guido Stoll
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Ann N Y Acad Sci 1207:149-54. 2010
    ..Thus, acute ischemic stroke can be redefined as a thrombo-inflammatory disorder, and multifunctional molecules such as GPIb, GPVI, and FXII may provide new therapeutic targets linking inflammation and thrombus formation...
  28. doi request reprint Glucocorticoid insensitivity at the hypoxic blood-brain barrier can be reversed by inhibition of the proteasome
    Christoph Kleinschnitz
    University of Wurzburg, Department of Neurology, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Stroke 42:1081-9. 2011
    ..The reasons for this discrepancy are unresolved...
  29. doi request reprint New approaches to neuroimaging of central nervous system inflammation
    Guido Stoll
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Curr Opin Neurol 23:282-6. 2010
    ..We here review magnetic resonance imaging (MRI)-based techniques to visualize neuroinflammation in vivo...
  30. doi request reprint Only severe thrombocytopenia results in bleeding and defective thrombus formation in mice
    Martina Morowski
    Department of Experimental Biomedicine, University Hospital and Rudolf Virchow Center, Deutsche Forschungsgemeinschaft DFG Research Center for Experimental Biomedicine, University of Wurzburg, Wurzburg, Germany
    Blood 121:4938-47. 2013
    ..These results reveal that arterial thrombosis, cerebral infarction, and hemostasis in mice efficiently occur at unexpectedly low PCs, which may have implications for humans at risk of thrombotic or hemorrhagic disease...
  31. pmc In vivo imaging of stepwise vessel occlusion in cerebral photothrombosis of mice by 19F MRI
    Gesa Weise
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 6:e28143. 2011
    ..In the present study we compared (19)F MRI with iron-enhanced MRI in mice with photothrombosis (PT) at 7 Tesla. PT represents a model of focal cerebral ischemia exhibiting acute vessel occlusion and delayed neuroinflammation...
  32. ncbi request reprint Inflammation and atherosclerosis: novel insights into plaque formation and destabilization
    Guido Stoll
    Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
    Stroke 37:1923-32. 2006
    ..The simplistic view of atherosclerosis as a disorder of pathological lipid deposition has been redefined by the more complex concept of an ongoing inflammatory response...
  33. ncbi request reprint Cytokine profile of iron-laden macrophages: implications for cellular magnetic resonance imaging
    Ines Siglienti
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, 97080 Wurzburg, Germany
    J Neuroimmunol 173:166-73. 2006
    ..During macrophage interaction with T-cells IL-12p40 secretion was inhibited. Based on our in vitro findings, potential immunomodulatory effects of SPIO/USPIO particles in vivo warrant further investigation...
  34. ncbi request reprint Induction of granulocyte colony-stimulating factor mRNA by focal cerebral ischemia and cortical spreading depression
    Christoph Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Brain Res Mol Brain Res 131:73-8. 2004
    ..In conclusion, G-CSF induction in the brain may be part of an intrinsic stress response aimed at limitation of neuronal damage...
  35. doi request reprint Magnetic resonance imaging of the peripheral nervous system
    Guido Stoll
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurol 256:1043-51. 2009
    ..This clinical review provides practical guidelines on the performance of nerve imaging by MRI and will focus on focal lesions exemplified by case presentations...
  36. doi request reprint C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms
    Nadine Heydenreich
    Department of Neurology, University of Wurzburg, Josef Schneider Strasse 11, 97080 Wurzburg, Germany
    Stroke 43:2457-67. 2012
    ..C1-inhibitor counteracts activation of the contact-kinin system at multiple levels. We investigated the therapeutic potential of C1-inhibitor in models of ischemic stroke...
  37. doi request reprint Distal-symmetric focal inflammatory myopathy distinct from focal myositis and polymyositis
    Nico Melzer
    Department of Neurology, University of Wurzburg, Josef Schneider Strabetae 11, 97080 Wurzburg, Germany
    Muscle Nerve 40:309-12. 2009
    ..Our findings add another entity to the spectrum of spatially restricted inflammatory myopathies. Muscle Nerve 40: 309-312, 2009...
  38. ncbi request reprint In vivo monitoring of macrophage infiltration in experimental autoimmune neuritis by magnetic resonance imaging
    Guido Stoll
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080, Wurzburg, Germany
    J Neuroimmunol 149:142-6. 2004
    ..In conclusion, SPIO-enhanced MRI provides a novel in vivo tool to assess the timing of macrophage entry into target tissues during an immunopathologic attack and holds promise to monitor immunotherapeutic interventions...
  39. pmc Deficiency of vasodilator-stimulated phosphoprotein (VASP) increases blood-brain-barrier damage and edema formation after ischemic stroke in mice
    Peter Kraft
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 5:e15106. 2010
    ..Hypoxia has been shown to foster vascular leakage by downregulation of VASP in vitro but the significance of VASP for regulating vascular permeability in the hypoxic brain in vivo awaits clarification...
  40. ncbi request reprint Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding
    Christoph Kleinschnitz
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Circulation 115:2323-30. 2007
    ..In the present study, we addressed the pathogenic role of GPIb, GPVI, and the aggregation receptor GPIIb/IIIa in experimental stroke in mice...
  41. pmc α(2)-adrenoceptors do not mediate neuroprotection in acute ischemic stroke in mice
    Marc Brede
    Department of Anesthesiology and Critical Care, University Clinics of Würzburg, Wurzburg, Germany
    J Cereb Blood Flow Metab 31:e1-7. 2011
    ..In summary, we could not demonstrate a neuroprotective function of α(2)-adrenoceptors in focal cerebral ischemia. Careful controlling of physiological parameters relevant for stroke outcome is recommended in experimental stroke studies...
  42. ncbi request reprint Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system
    Guido Stoll
    Department of Neurology, Heinrich Heine Universitat, Noorenstrasse 5, D 40225 Dusseldorf, Germany
    Adv Exp Med Biol 513:87-113. 2002
    ..The opposing neurotoxic and neuroprotective properties of neuroinflammation during CNS injury provide arich and currently unexplored set of research problems...
  43. ncbi request reprint Assessment of lesion evolution in experimental autoimmune neuritis by gadofluorine M-enhanced MR neurography
    Guido Stoll
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Exp Neurol 197:150-6. 2006
    ..In conclusion, Gf-enhanced MR neurography opens a new avenue for monitoring nerve damage in-vivo during an immune attack...
  44. pmc Thrombin-activatable fibrinolysis inhibitor (TAFI) deficient mice are susceptible to intracerebral thrombosis and ischemic stroke
    Peter Kraft
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    PLoS ONE 5:e11658. 2010
    ..In the present study we analyzed stroke development and post stroke functional outcome in TAFI-/- mice...
  45. ncbi request reprint T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression
    Christoph Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat, Josef Schneider Str 11, D 97080 Wurzburg, Germany
    Exp Neurol 200:480-5. 2006
    ..Our study supports the notion that T cells and T-cell-derived cytokines contribute to the inflammatory response after peripheral nerve injury...
  46. doi request reprint Visualization of inflammation using (19) F-magnetic resonance imaging and perfluorocarbons
    Guido Stoll
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:438-47. 2012
    ..Current restrictions of (19) F/(1) H-MRI in sensitivity may be overcome by improved imaging hardware, imaging sequences and reconstruction techniques, as well as improved label development and cell labelling procedures in the future...
  47. doi request reprint Focal cerebral ischemia
    Stefan Braeuninger
    Department of Neurology, University of Wuerzburg, Wuerzburg, Germany
    Methods Mol Biol 788:29-42. 2012
    ....
  48. pmc Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis
    Christoph Kleinschnitz
    Department of Neurology, Institute for Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, 97080 Wurzburg, Germany
    J Exp Med 203:513-8. 2006
    ..As FXII appears to be instrumental in pathologic fibrin formation but dispensable for hemostasis, FXII inhibition may offer a selective and safe strategy for preventing stroke and other thromboembolic diseases...
  49. ncbi request reprint In vivo monitoring of macrophage infiltration in experimental ischemic brain lesions by magnetic resonance imaging
    Christoph Kleinschnitz
    Department of Neurology, Julius Maximilians Universitat Wurzburg, Germany
    J Cereb Blood Flow Metab 23:1356-61. 2003
    ..In conclusion, we have shown by in vivo monitoring that macrophages enter photothrombotic infarcts at late stages of infarct development, suggesting a role in tissue remodeling rather than neuronal injury...
  50. ncbi request reprint Non-invasive induction of focal cerebral ischemia in mice by photothrombosis of cortical microvessels: characterization of inflammatory responses
    Michael Schroeter
    Department of Neurology, Heinrich Heine Universitaet, Moorenstrasse 5, D 40225 Duesseldorf, Germany
    J Neurosci Methods 117:43-9. 2002
    ..It may provide a useful model to study functional aspects of lesion-associated and remote molecular responses in transgenic mice...
  51. ncbi request reprint Assessment of nerve degeneration by gadofluorine M-enhanced magnetic resonance imaging
    Martin Bendszus
    Department of Neuroradiology, University of Wurzburg, Josef Schneider Strasse 11, D 97080 Wurzburg, Germany
    Ann Neurol 57:388-95. 2005
    ....
  52. ncbi request reprint Caught in the act: in vivo mapping of macrophage infiltration in nerve injury by magnetic resonance imaging
    Martin Bendszus
    Department of Neuroradiology, University of Wurzburg, D 97080 Wurzburg, Germany
    J Neurosci 23:10892-6. 2003
    ..SPIO-enhanced MRI provides a new tool to selectively visualize active periods of macrophage transmigration into the nervous system, thus enabling dynamic views on a fundamental process in a multitude of nerve disorders...
  53. ncbi request reprint Technology insight: visualizing peripheral nerve injury using MRI
    Martin Bendszus
    Department of Neuroradiology, University of Wrzburg, Wrzburg, Germany
    Nat Clin Pract Neurol 1:45-53. 2005
    ..Further clinical development of these MR contrast agents should allow these functional aspects of nerve injury and repair to be assessed in humans, thereby aiding the differential diagnosis of peripheral nerve disorders...
  54. ncbi request reprint Silent cerebral ischaemia: hidden fingerprints of invasive medical procedures
    Martin Bendszus
    Department of Neuroradiology, University of Wurzburg, Germany
    Lancet Neurol 5:364-72. 2006
    ..Thus, DWI emerges as a valuable diagnostic method for the monitoring of periprocedural ischaemic events in the brain, and could be a surrogate parameter for optimising diagnostic and therapeutic vascular procedures in the future...
  55. doi request reprint Imaging of the peripheral nervous system
    Guido Stoll
    Department of Neurology, University of Wurzburg, Wurzburg, Germany Electronic address
    Handb Clin Neurol 115:137-53. 2013
    ..Further advances in contrast-enhanced US has the potential for developing into a tool for the assessment of nerve blood perfusion, paving the way for better assessments of ischemic neuropathies. ..
  56. pmc Von Willebrand factor regulation in patients with acute and chronic cerebrovascular disease: a pilot, case-control study
    Peter Kraft
    Department of Neurology, University Hospital Wurzburg, Wurzburg, Germany Institute of Clinical Epidemiology and Biometry, Comprehensive Heart Failure Center, University of Wurzburg, Wurzburg, Germany
    PLoS ONE 9:e99851. 2014
    ..This study had two aims: to identify predictors of altered VWF levels and to examine whether VWF levels differ between acute cerebrovascular events and chronic cerebrovascular disease (CCD)...
  57. doi request reprint A pure cerebellar syndrome with corresponding ponto-cerebellar atrophy in acquired hepatocerebral degeneration
    Nico Melzer
    Department of Neurology, University of Wuerzburg, Josef Schneider Strasse 11, 97080 Wuerzburg, Germany
    J Neurol Sci 292:96-8. 2010
    ..We report a case of acquired hepatocerebral degeneration (AHCD) presenting as a pure cerebellar syndrome. Magnetic resonance imaging (MRI) showed the typical features of AHCD in conjunction with ponto-cerebellar atrophy...
  58. ncbi request reprint Increased serum levels of the interferon-gamma-inducing cytokine interleukin-18 in myasthenia gravis
    Sebastian Jander
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Neurology 59:287-9. 2002
    ..IL-18 levels were higher in generalized than in ocular myasthenia and tended to decrease on clinical improvement. These findings suggest an unexpected role of IL-18 in B-cell-mediated autoimmune disease...
  59. pmc CD8+ phagocyte recruitment in rat experimental autoimmune encephalomyelitis: association with inflammatory tissue destruction
    Michael Schroeter
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Am J Pathol 163:1517-24. 2003
    ....
  60. pmc Evaluation of soluble junctional adhesion molecule-A as a biomarker of human brain endothelial barrier breakdown
    Axel Haarmann
    Department of Neurology, Julius Maximilian University, Wurzburg, Germany
    PLoS ONE 5:e13568. 2010
    ..Here we studied the regulation of JAM-A expression in cultured brain EC and evaluated sJAM-A as a serum biomarker of blood-brain barrier (BBB) function...
  61. doi request reprint SAR-reduced spin-echo-based Bloch-Siegert B(1)(+) mapping: BS-SE-BURST
    Thomas Christian Basse-Lüsebrink
    Department of Experimental Physics 5, University of Wurzburg, Wurzburg, Germany
    Magn Reson Med 68:529-36. 2012
    ..The proposed BS-SE-BURST sequence was implemented on a conventional 3 T whole body MRI scanner and applied successfully...
  62. pmc Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration
    Christoph Kleinschnitz
    Neurologische Klinik und Poliklinik, Universitat Wurzburg, Wurzburg, Germany
    PLoS Biol 8:. 2010
    ..NOX4 therefore represents a major source of oxidative stress and novel class of drug target for stroke therapy...
  63. ncbi request reprint Interleukin-18 expression after focal ischemia of the rat brain: association with the late-stage inflammatory response
    Sebastian Jander
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    J Cereb Blood Flow Metab 22:62-70. 2002
    ....
  64. pmc COU254, a specific 3-carboxamide-coumarin inhibitor of coagulation factor XII, does not protect mice from acute ischemic stroke
    Peter Kraft
    Department of Neurology, Josef Schneider Str, 11, University Clinic of Wuerzburg, Germany
    Exp Transl Stroke Med 2:5. 2010
    ..Further preclinical evaluation of 3-carboxamide-coumarins is needed before the antithrombotic potential of this novel class of FXII inhibitors can be finally judged...
  65. ncbi request reprint Osteopontin: a novel axon-regulated Schwann cell gene
    Sebastian Jander
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    J Neurosci Res 67:156-66. 2002
    ..The lack of OPN induction in infiltrating macrophages indicates fundamental differences in tissue repair between axonal injury in the peripheral nervous system and structural lesions in other organ systems...
  66. pmc Magnetic resonance imaging of blood brain/nerve barrier dysfunction and leukocyte infiltration: closely related or discordant?
    Gesa Weise
    Department of Neurology, University of Wuerzburg Wuerzburg, Germany Fraunhofer Institute for Cell Therapy and Immunology Leipzig, Germany Translational Center for Regenerative Medicine Leipzig, Germany
    Front Neurol 3:178. 2012
    ..We will illustrate these basic imaging findings in animal models of multiple sclerosis, cerebral ischemia, and traumatic nerve injury and review corresponding findings in patients...
  67. ncbi request reprint Multifocal motor neuropathy presenting as chronic progressive proximal leg weakness
    Mathias Maurer
    Department of Neurology, University of Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Neuromuscul Disord 14:380-2. 2004
    ..The proximal involvement may represent another unusual clinical manifestation of multifocal motor neuropathy...
  68. pmc The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction
    David Varga-Szabo
    Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine, University of Wurzburg, 97078 Wurzburg, Germany
    J Exp Med 205:1583-91. 2008
    ..These results establish STIM1 as an important mediator in the pathogenesis of ischemic cardio- and cerebrovascular events...
  69. ncbi request reprint Autoimmunity and inflammation in the peripheral nervous system
    Hugh Willison
    Dept of Neurology, University of Glasgow, UK
    Trends Neurosci 25:127-9. 2002
    ..Peripheral Nerve Society Biennial Meeting, organized in conjunction with the Austrian Federal Ministry of Education, Research and Culture, held at Telfs, Tyrol, Austria from 8-12 September 2001...
  70. ncbi request reprint Gadofluorine M enhancement allows more sensitive detection of inflammatory CNS lesions than T2-w imaging: a quantitative MRI study
    Martin Bendszus
    Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany
    Brain 131:2341-52. 2008
    ..These unique features of Gadofluorine M in visualizing inflammatory CNS lesions hold promise for future clinical development in multiple sclerosis...
  71. ncbi request reprint Wallerian degeneration after crush or chronic constriction injury of rodent sciatic nerve is associated with a depletion of endoneurial interleukin-10 protein
    Annette George
    Neurologische Universitätsklinik Würzburg, Germany
    Exp Neurol 188:187-91. 2004
    ..These results suggest that changes of the local cytokine network during wallerian degeneration include an early deficiency of the antiinflammatory cytokine IL-10 despite up-regulation at the mRNA level...
  72. ncbi request reprint Is the disruption of the blood-brain barrier a prerequisite for cellular infiltration in autoimmune encephalitis?
    Martin Bendszus
    Brain 128:E25. 2005
  73. ncbi request reprint Effective treatment of adjuvant arthritis with a stimulatory CD28-specific monoclonal antibody
    Marta Rodriguez-Palmero
    Department of Physiology, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain
    J Rheumatol 33:110-8. 2006
    ..JJ316 is a superagonistic Mab that induces polyclonal T cell proliferation in the absence of T cell receptor (TCR) ligation and promotes the expansion of regulatory T cells...
  74. ncbi request reprint Ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging in experimental autoimmune encephalitis
    Martin Bendszus
    J Magn Reson Imaging 21:850; author reply 850-1. 2005
  75. pmc Spatiotemporal pattern of neuroinflammation after impact-acceleration closed head injury in the rat
    Servan Rooker
    Department of Neurosurgery, Univeristy Hospital Antwerp, Edegem, Belgium
    Mediators Inflamm 2006:90123. 2006
    ..Our study shows rapid induction of inflammatory gene expression that exceeds by far the primary impact site and might therefore contribute to tissue damage at remote sites...
  76. ncbi request reprint Iron-enhanced MRI in ischemic stroke: intravascular trapping versus cellular inflammation
    Martin Bendszus
    Stroke 38:e12; author reply e13. 2007
  77. ncbi request reprint Myelin-derived glycolipids and animal models of Guillain-Barré syndrome
    Klaus V Toyka
    Ann Neurol 51:532; author reply 532-3. 2002
  78. doi request reprint Deficiency of bradykinin receptor B2 is not detrimental in experimental stroke
    Christoph Kleinschnitz
    Hypertension 51:e41; author reply e42-3. 2008
  79. ncbi request reprint Iron particles enhance visualization of experimental gliomas with high-resolution sonography
    Ingo Nolte
    Department of Neuroradiology, University of Wurzburg, Germany
    AJNR Am J Neuroradiol 26:1469-74. 2005
    ....