Oliver Stoeltzing

Summary

Country: Germany

Publications

  1. doi request reprint Staged surgery with neoadjuvant 90Y-DOTATOC therapy for down-sizing synchronous bilobular hepatic metastases from a neuroendocrine pancreatic tumor
    Oliver Stoeltzing
    Departments of Surgery and Surgical Oncology, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, 93042, Regensburg, Germany
    Langenbecks Arch Surg 395:185-92. 2010
  2. doi request reprint Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes
    Sven A Lang
    Departments of Surgery and Surgical Oncology, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, Regensburg, Germany
    Mol Cancer Ther 7:3509-18. 2008
  3. pmc Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition
    Christina Hackl
    Department of Surgery, University of Regensburg Medical Center, Franz Josef Straus Allee 11, 93042 Regensburg, Germany
    BMC Cancer 10:668. 2010
  4. doi request reprint Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells
    Sven A Lang
    Department of Surgery, University Medical Center Regensburg, Regensburg, Germany
    Biochim Biophys Acta 1803:435-42. 2010
  5. doi request reprint Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer
    Johannes Taeger
    Department of Surgery, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Mol Cancer Ther 10:2157-67. 2011
  6. doi request reprint Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis
    Christian Moser
    Departments of Surgery and Surgical Oncology, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Eur J Cancer 44:1577-86. 2008
  7. doi request reprint Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models
    Christina Hackl
    Department of Surgery, University of Regensburg Medical Center, Regensburg, Germany
    Surgery 147:704-12. 2010
  8. pmc ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo
    Christian Moser
    Department of Surgery, Regensburg Medical Center, Regensburg, Germany
    BMC Cancer 8:206. 2008
  9. pmc STAT5b as molecular target in pancreatic cancer--inhibition of tumor growth, angiogenesis, and metastases
    Christian Moser
    Department of Surgery, University of Regensburg Medical Center, Regensburg, Germany
    Neoplasia 14:915-25. 2012
  10. ncbi request reprint Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer
    Christian Moser
    Department of Surgery, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Anticancer Res 32:2551-61. 2012

Detail Information

Publications17

  1. doi request reprint Staged surgery with neoadjuvant 90Y-DOTATOC therapy for down-sizing synchronous bilobular hepatic metastases from a neuroendocrine pancreatic tumor
    Oliver Stoeltzing
    Departments of Surgery and Surgical Oncology, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, 93042, Regensburg, Germany
    Langenbecks Arch Surg 395:185-92. 2010
    ..We proposed that (90)Y-DOTATOC could be used in a neoadjuvant intention for improving therapy of hepatic NET metastases...
  2. doi request reprint Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes
    Sven A Lang
    Departments of Surgery and Surgical Oncology, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, Regensburg, Germany
    Mol Cancer Ther 7:3509-18. 2008
    ..Dual targeting of Raf and VEGFR2 appears to be a valid strategy for therapy of pancreatic cancer...
  3. pmc Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition
    Christina Hackl
    Department of Surgery, University of Regensburg Medical Center, Franz Josef Straus Allee 11, 93042 Regensburg, Germany
    BMC Cancer 10:668. 2010
    ..Here we followed-up on our previous observation that inhibition of Hsp90 may increase ATF3 expression and sought to determine the role of ATF3 in colon cancer...
  4. doi request reprint Implication of RICTOR in the mTOR inhibitor-mediated induction of insulin-like growth factor-I receptor (IGF-IR) and human epidermal growth factor receptor-2 (Her2) expression in gastrointestinal cancer cells
    Sven A Lang
    Department of Surgery, University Medical Center Regensburg, Regensburg, Germany
    Biochim Biophys Acta 1803:435-42. 2010
    ..In conclusion, inhibition of mTORC2 may abrogate unfavorable signaling effects of mTOR inhibitors, hence providing a novel rationale for therapy...
  5. doi request reprint Targeting FGFR/PDGFR/VEGFR impairs tumor growth, angiogenesis, and metastasis by effects on tumor cells, endothelial cells, and pericytes in pancreatic cancer
    Johannes Taeger
    Department of Surgery, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Mol Cancer Ther 10:2157-67. 2011
    ..These data provide evidence that targeting FGFR/PDFGR/VEGFR with TKI258 may be effective in human pancreatic cancer and warrants further clinical evaluation...
  6. doi request reprint Inhibition of insulin-like growth factor-I receptor (IGF-IR) using NVP-AEW541, a small molecule kinase inhibitor, reduces orthotopic pancreatic cancer growth and angiogenesis
    Christian Moser
    Departments of Surgery and Surgical Oncology, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Eur J Cancer 44:1577-86. 2008
    ..In conclusion, the IGF-IR inhibitor NVP-AEW541 effectively disrupts IGF-I signalling and reduces pancreatic tumour growth. Hence, blocking IGF-IR could prove valuable for targeted therapy of pancreatic cancer...
  7. doi request reprint Effect of heat-shock protein-90 (HSP90) inhibition on human hepatocytes and on liver regeneration in experimental models
    Christina Hackl
    Department of Surgery, University of Regensburg Medical Center, Regensburg, Germany
    Surgery 147:704-12. 2010
    ..In this study, we investigated the impact of HSP90 inhibition on liver regeneration in murine models...
  8. pmc ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo
    Christian Moser
    Department of Surgery, Regensburg Medical Center, Regensburg, Germany
    BMC Cancer 8:206. 2008
    ..We hypothesized that therapeutic inhibition of HIF-1alpha could be achieved by using a novel tubulin-binding agent (ENMD-1198). ENMD-1198 is an analog of 2-methoxyestradiol (2ME2) with antiproliferative and antiangiogenic activity...
  9. pmc STAT5b as molecular target in pancreatic cancer--inhibition of tumor growth, angiogenesis, and metastases
    Christian Moser
    Department of Surgery, University of Regensburg Medical Center, Regensburg, Germany
    Neoplasia 14:915-25. 2012
    ..Taken together, our results suggest that STAT5b might be a potential novel target for human DPAC...
  10. ncbi request reprint Targeting HSP90 by the novel inhibitor NVP-AUY922 reduces growth and angiogenesis of pancreatic cancer
    Christian Moser
    Department of Surgery, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Anticancer Res 32:2551-61. 2012
    ..To evaluate the impact of heat-shock protein 90 (HSP90) blockade by the novel inhibitor NVP-AUY922, on tumor growth and angiogenesis in pancreatic cancer...
  11. doi request reprint Targeting heat-shock protein 90 improves efficacy of rapamycin in a model of hepatocellular carcinoma in mice
    Sven A Lang
    Departments of Surgery and Surgical Oncology, University of Regensburg Medical Center, Regensburg, Germany
    Hepatology 49:523-32. 2009
    ....
  12. ncbi request reprint Blocking heat shock protein-90 inhibits the invasive properties and hepatic growth of human colon cancer cells and improves the efficacy of oxaliplatin in p53-deficient colon cancer tumors in vivo
    Christian Moser
    Department of Surgery, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Mol Cancer Ther 6:2868-78. 2007
    ..Hence, targeting Hsp90 could prove valuable for treatment of advanced colorectal cancer by effectively inhibiting colon cancer growth and hepatic metastasis and improving the efficacy of oxaliplatin...
  13. ncbi request reprint Oncogenic MST1R activity in pancreatic and gastric cancer represents a valid target of HSP90 inhibitors
    Christian Moser
    Department of Surgery, University of Regensburg Medical Center, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Anticancer Res 32:427-37. 2012
    ..To evaluate the effects of HSP90 blockade by EC154 on the oncogenic receptor tyrosine kinase macrophage-stimulating 1 receptor (MST1R) in gastric and pancreatic cancer...
  14. doi request reprint Up-regulation of Kr├╝ppel-like factor 5 in pancreatic cancer is promoted by interleukin-1beta signaling and hypoxia-inducible factor-1alpha
    Akira Mori
    Department of Surgery and Surgical Oncology, University of Regensburg Medical Center, Regensburg, Germany
    Mol Cancer Res 7:1390-8. 2009
    ..In conclusion, overexpression of KLF5 in human pancreatic cancer cells is not mediated by KRAS/Raf/MAPK/Erk signaling, but involves the IL-1beta/IL-1R system, p38, and the transcription factor HIF-1alpha...
  15. doi request reprint Dual inhibition of Raf and VEGFR2 reduces growth and vascularization of hepatocellular carcinoma in an experimental model
    Sven Arke Lang
    Department of Surgery, University of Regensburg Medical Center, Regensburg, Germany
    Langenbecks Arch Surg 393:333-41. 2008
    ..We hypothesized that concomitant inhibition of Raf and vascular endothelial growth factor receptor 2 (VEGFR2) will affect tumor growth and angiogenesis of HCC...
  16. ncbi request reprint Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer
    Christian Moser
    Department of Surgery, University of Regensburg Medical Center, 93042 Regensburg, Germany
    Anticancer Res 29:2031-42. 2009
    ..Against this background, the following review focuses on the current preclinical experience and value of targeting Hsp90 for the therapy of gastrointestinal carcinomas...
  17. ncbi request reprint Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotop
    Sven A Lang
    Department of Surgery, University of Regensburg Medical Center, Regensburg, Germany
    Clin Cancer Res 13:6459-68. 2007
    ....